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Japanese Journal of Infectious Diseases

Takako Inoue, Tomoyuki Ohike, Kumiko Ohne, Shigeru Sato, Takaaki Goto, Yasuhito Tanaka
An advanced and fully automated chemiluminescent enzyme immunoassay for hepatitis C virus core antigen (HCVcAg) was recently developed in Japan. We aimed to evaluate its clinical utility. The new Fujirebio assay (Lumipulse Presto HCVcAg [LP-Presto]) was compared with 2 conventional assays (Lumipulse Ortho HCVcAg [LP-Ortho] and Abbott's Architect HCVcAg). Basic assessments of LP-Presto (reproducibility, stability, range of quantitation, and specificity) were performed on 220 frozen sera (83 positive and 137 negative by LP-Ortho) and 206 fresh sera negative by LP-Ortho...
March 26, 2019: Japanese Journal of Infectious Diseases
Hye-Young Lee, Sang-Ho Choi, Tark Kim, Jeonghyun Chang, Sung-Han Kim, Sang Oh Lee, Mi-Na Kim, Heungsup Sung
Subsequent to the increasing use of immunosuppressant therapy, Pneumocystis jirovecii pneumonia (PcP) has emerged as a life-threatening condition in human immunodeficiency virus (HIV)-negative patients. We investigated changes in epidemiological and clinical characteristics among PcP cases with and without HIV infections. Data of 424 patients diagnosed with PcP in a 2,700-bed Korean tertiary care hospital between February 2003 and April 2017 were retrospectively analyzed. The study included patients with compatible clinical findings in whom PcP was confirmed via direct immunofluorescence assay...
March 26, 2019: Japanese Journal of Infectious Diseases
Yoshiyuki Sugishita, Kumiko Soejima, Aya Kayebeta, Mariko Yauchi
During Japan's 2012-2013 rubella epidemic, most transmission in Tokyo occurred at workplaces, especially among men aged 20 to 49. This tendency was likely related to previous rubella immunization policies that prioritized female adolescents. Since 2015, the Tokyo Metropolitan Government has been promoting a project to prevent rubella and other infectious diseases in workplaces. Companies participate by choosing one or more of three options: (I) Acquire fundamental understanding of infectious diseases; (II) Develop a Business Continuity Plan (BCP) for infectious diseases in the workplace; or (III) Increase rubella antibody prevalence in employees...
March 26, 2019: Japanese Journal of Infectious Diseases
Tingyan Kou, Qiuzhen Wang, Wenshan Lv, Boyang Wei, Yufeng Liu, Shanliang Zhao, Xiuping Du, Yue Zou, Limei Sun, Hong Tian, Zhenlei Zhao, Qian Liu, Chunjiang Dong, Guilan Zhang, Xiaoli Gao, Caiting Yu
A case-control study was conducted in Shandong from January to December 2017 to explore the relationship between sleep quality and risk of active pulmonary tuberculosis (PTB). 79 Type 2 diabetes mellitus coincident with newly diagnosed pulmonary tuberculosis (DM-PTB) and age-, sex-, and DM course- frequency-matched 169 controls (DM alone) were enrolled. Univariate and multivariable unconditional logistic regression analysis were used. We further conducted subgroup analyses to explore the relationship between sleep quality and PTB risk, including DM course (≤5, >5 years), age, sex, the present of overweight/obesity (BMI >24)...
March 26, 2019: Japanese Journal of Infectious Diseases
Suat Moi Puah, S D Puthucheary, Kek Heng Chua
There is an alarming increase of extended-spectrum β-lactamases (ESBL) being present mainly in Enterobacteriaceae and other non-fermenting gram-negative bacteria, such as Alcaligenes faecalis which is the only species present in that genus that is clinically relevant. We investigated Alcaligenes species from 7 cases (6 inpatients and 1 outpatient) at our tertiary hospital. Four patients had urinary tract infections and one each with systemic lupus erythematosus, pulmonary stenosis and diabetic ulcer. All 7 isolates were identified as Alcaligenes sp...
March 26, 2019: Japanese Journal of Infectious Diseases
Katsumi Mizuta, Waka Tanaka, Kenichi Komabayashi, Shizuka Tanaka, Junji Seto, Yoko Aoki, Tatsuya Ikeda
We introduced a microplate method for virus isolation in the Department of Microbiology, Yamagata Prefectural Institute of Public Health (YPIPH) in 1999 in Yamagata, Japan. We have since carried out longitudinal epidemiological studies of viral infectious diseases, particularly, respiratory viruses, combining traditional technologies such as virus isolation and serological techniques and newly developed molecular methods. Here, we provide an overview of our activities at YPIPH between 1999 and 2018. During the study period, we observed emerging and re-merging diseases such as echovirus type 13, enterovirus D-68, parechovirus-A3 (PeV-A3), and Saffold virus...
February 28, 2019: Japanese Journal of Infectious Diseases
Haruno Yoshida, Yasuto Fukushima, Mieko Goto, Yuzo Tsuyuki, Takashi Takahashi
We determined the whole genome sequence (WGS) of Streptococcus canis strain TA4 harboring the M-like protein gene (scm), which was isolated from a human patient presenting with bacteremia. The potential of type II-A CRISPR array-based typing was explored and the genetic lineage between spacer genogroups and scm prevalence/polymorphisms in the isolates from 19 diseased companion animals and the human patient was elucidated. The CRISPRFinder/CRISPRCasFinder detected the type II-A locus with the same repeat sequences in TA4 and another WGS of Sc isolated from a cow with mastitis...
February 28, 2019: Japanese Journal of Infectious Diseases
Hajime Kamiya, Ratana Tacharoenmuang, Tomihiko Ide, Manami Negoro, Takaaki Tanaka, Kazutoyo Asada, Haruna Nakamura, Katsumi Sugiura, Masakazu Umemoto, Haruo Kuroki, Hiroaki Ito, Shigeki Tanaka, Mitsue Ito, Saori Fukuda, Riona Hatazawa, Yuya Hara, Ratigorn Guntapong, Takayuki Murata, Kiyosu Taniguchi, Shigeru Suga, Takashi Nakano, Koki Taniguchi, Satoshi Komoto
The emergence of unusual DS-1-like intergenogroup reassortant rotaviruses having the bovine-like G8 genotype (DS-1-like G8P[8] strains) has been reported from several Asian countries. During the rotavirus surveillance program in Japan in 2017, a DS-1-like G8P[8] strain (RVA/Human-wt/JPN/SO1162/2017/G8P[8]) was identified in 43 rotavirus-positive stool samples. Strain SO1162 was shown to have a unique genotype constellation including both genogroup 1 and 2 genes: G8-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Phylogenetic analysis revealed that the VP1 gene of strain SO1162 appeared to have originated from DS-1-like G1P[8] strains from Thailand and Vietnam, while the remaining 10 genes were closely related to those of the previously reported DS-1-like G8P[8] strains...
February 28, 2019: Japanese Journal of Infectious Diseases
Akinobu Taniguchi, Jun-Ichi Kawada, Kiyotaka Go, Naozumi Fujishiro, Yosuke Hosokawa, Yuki Maki, Yuichiro Sugiyama, Michio Suzuki, Takeshi Tsuji, Shin Hoshino, Hideki Muramatsu, Hiroyuki Kidokoro, Fumie Kinoshita, Akihiro Hirakawa, Yoshiyuki Takahashi, Yoshiaki Sato, Jun Natsume
Human metapneumovirus (HMPV) infection and respiratory syncytial virus (RSV) infection are the leading causes of acute respiratory tract infection in children, and clinical manifestations of these virus infections are considered similar. To investigate the differences in clinical characteristics between HMPV and RSV infections in young children, we prospectively enrolled children <3 years old who required hospitalization with acute respiratory tract infection by HMPV or RSV at 10 hospitals in Japan. We enrolled 48 with HMPV infection and 141 children with RSV infection...
February 28, 2019: Japanese Journal of Infectious Diseases
Dongchul Park, Si Hyun Kim, Il Kwon Bae, Na Young Kim, Joong-Ki Kook, Yo-Han Park, Jeong Hwan Shin
The aims of this study were to develop modified SM-PCR primer sets and to evaluate their ability and efficiency for serotype determination. We selected target serotypes for SM-PCR testing according to the prevalence of serotypes as reported in papers published in Asian countries. The modified SM-PCR consisted of six groups of PCRs, with each reaction being carried out using five pairs of primers. We evaluated the efficiency and performance of this modified multiplex PCR using 378 pneumococcal strains by comparing the findings with the results of the Quellung reaction...
February 28, 2019: Japanese Journal of Infectious Diseases
Ken-Ichi Oinuma, Masato Suzuki, Kiyotaka Nakaie, Kanako Sato, Kozo Saeki, Arata Sakiyama, Etsuko Takizawa, Makoto Niki, Mamiko Niki, Koichi Yamada, Keigo Shibayama, Hiroshi Kakeya, Yukihiro Kaneko
The genus Acinetobacter comprises many species that can cause infectious diseases. Despite their importance as nosocomial pathogens, the clinical distributions of individual species or clones are not well understood. In this study, we aimed to characterize 13 Acinetobacter strains isolated from blood cultures from Osaka City University Hospital. We conducted whole-genome sequencing to reveal their genetic background. We also performed PCR-based open reading frame typing (POT) and compared the results with those of multilocus sequence typing (MLST) to confirm its reliability as a genotyping method...
February 28, 2019: Japanese Journal of Infectious Diseases
Wen Kiong Niek, Cindy Shuan Ju Teh, Nuryana Idris, Kwai Lin Thong, Sasheela Ponnampalavanar
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common nosocomial pathogens, causing mild to severe infections. This study aimed to determine the genotypic and phenotypic characteristics of clinical MRSA isolates collected from a teaching hospital from 2014 - 2015. These isolates were genotyped by multilocus sequence typing (MLST), staphylococcal cassette chromosomal mec (SCCmec) typing, virulence genes detection and pulsed-field gel electrophoresis (PFGE) and phenotyped based on their vancomycin susceptibility profiles...
February 28, 2019: Japanese Journal of Infectious Diseases
Hongru Su, Ayaka Sato, Eri Onoda, Hiromi Fujita, Shigetoshi Sakabe, Shigehiro Akachi, Saori Oishi, Fuyuki Abe, Takashi Kanda, Yuko Shimamura, Shuichi Masuda, Norio Ohashi
Anaplasma phagocytophilum is an obligate intracellular bacterium and causes human granulocytic anaplasmosis (HGA), a tick-borne emerging infectious disease. This bacterium expresses a variety of 44-kDa major outer membrane proteins encoded by a p44/msp2 multigene family to avoid host immune defense. We previously detected A. phagocytophilum p44/msp2 from one tick of Haemaphysalis longicornis in Mie Prefecture, Japan in 2008. In this study, we further investigated total 483 H. longicornis ticks (220 adults and 263 nymphs) collected in Mie Prefecture by p44/msp2 targeting PCR assay for the characterization of p44/msp2 multigene family of A...
January 31, 2019: Japanese Journal of Infectious Diseases
Yuichi Fukui, Hisashi Inokuma
The prevalence of Anaplasma infection in 332 dogs from Ibaraki, Japan, was evaluated by serological and molecular surveys. Immunofluorescence antibody assay (IFA) against Anaplasma phagocytophilum indicated that 7 (2.1%) of 328 dogs were positive for A. phagocytophilum. Screening PCR demonstrated that 8 (2.4%) of 331 dogs were positive for Anaplasmataceae. Phylogenetic analysis of the partial 16S rRNA sequence of PCR amplicons revealed that 6 sequences were most similar to the 16S rRNA sequence of Wolbachia sp...
January 31, 2019: Japanese Journal of Infectious Diseases
Sibel Bolukcu, Bilgul Mete, Alper Gunduz, Hayat Kumbasar Karaosmanoglu, Fatma Sargin, Bulent Durdu, Ozlem Altuntas Aydin, Dilek Yildiz, Ilyas Dokmetas, Turan Aslan, Fehmi Tabak
We aimed to assess 24-week virological and immunological success of treatment naive and experienced patients included in ACTHIV-IST database. ACTHIV-IST database were screened retrospectively from January 2012 to January 2014. Data of these patients such as age, sex, being treatment naive or experienced, date of diagnosis, date of commencing antiretroviral therapy, antiretroviral therapy regimen, CD4+ cell count and viral load before and after therapy were analyzed. In the 24th week of antiretroviral therapy, virological and immunological failures were 40 (17...
January 31, 2019: Japanese Journal of Infectious Diseases
Serap Cetin Coban, Fehminaz Temel, Pinar Duman, Yasemin Cosgun, Fatma Ozarslan, Tuba Kayman, Sirin Guven, Handan Bezirganoglu, Omer Gunes, Dilek Yilmaz Ciftdogan, Ese Eda Karadagli, Cemil Kaya, Ates Kara
In Turkey, Measles Elimination Programme has been implemented since 2002. The aim of this research was to evaluate the measles specific antibody levels of mothers who admitted to a hospital for birth and their infants, and to determine the factors influencing the antibody levels of both and to evaluate the transplacental transport ratio. We selected healthy women who came to the hospital for birth and their healthy newborns. We collected blood samples from 1547 mothers and 1529 infants.The protective prevalance of measles antibody levels of mothers was 85% (95%CI:78-82), and the newborns' was 85% (95%CI:83-86)...
January 31, 2019: Japanese Journal of Infectious Diseases
Kasumi Suzuki, Montira Yossapol, Michiyo Sugiyama, Tetsuo Asai
Increase of antimicrobial-resistant (AMR) bacteria caused by antimicrobial usage is a public health problem. We investigated the proportion of cephalexin (LEX)-resistant bacteria in fresh feces obtained from antimicrobial-free broilers in three flocks at <15, 15-40, and >40 days of age. DHL agar plates containing 25 μg/mL LEX (DHL-L) showed LEX-resistant bacteria in all flocks at <15 days of age and in one flock at >40 days of age. The bacterial counts on DHL and DHL-L were 105 -108 colony forming units (CFU)/g feces and <102 -105 CFU/g feces, respectively...
January 31, 2019: Japanese Journal of Infectious Diseases
Akio Yamada, Kohei Makita, Hazumu Kadowaki, Naoto Ito, Makoto Sugiyama, Nigel C L Kwan, Katsuaki Sugiura
Although rabies still kills many people, global eradication of human rabies is considered to be feasible. Because the progress toward eradication may be different among regions with different socio-economic status, states that successfully eradicate this disease must be vigilant for re-emergence of rabies. In this article, we describe arguments over current rabies prevention measures and risk assessment results for rabies introduction and spread in rabies-free Japan. We also summarize the measures taken by representative countries and regions free from rabies...
December 25, 2018: Japanese Journal of Infectious Diseases
Mitsuhito Hirano, Yasunori Ota, Tomohiko Koibuchi, Tomomi Takei, Reina Takeda, Toyotaka Kawamata, Kazuaki Yokoyama, Kaoru Uchimaru, Hiroshi Yotsuyanagi, Yoichi Imai, Arinobu Tojo
Mucormycosis is an opportunistic infection occurring in immunocompromised hosts with hematological malignancies. Mortality due to mucormycosis in patients with hematological malignancy is high. However, the clinical symptoms of mucormycosis are poorly characterized, and diagnosis is difficult due to the lack of specific culture or serological markers or antigens. We present two cases in which nested polymerase chain reaction with specific primers was used in the serum of patients with hematological malignancies...
December 25, 2018: Japanese Journal of Infectious Diseases
Se-Min Hwang, Baeg-Ju Na, Yoo-Mi Jung, Hyun-Suk Lim, Jeong-Eun Seo, Shi-Nae Park, Young-Soo Cho, Eun-Hyang Song, Ji-Yeon Seo, Sung-Ryul Kim, Gang-Young Lee, Soon-Ja Kim, Young-Suk Park, Hae-Suk Seo
There is a paucity of data regarding the differentiating characteristics of patients with laboratory confirmed and those negative for Middle East respiratory syndrome coronavirus (MERS-CoV) in South Korea. This is a hospital-based retrospective study comparing MERS-CoV-positive patients with MERS-CoV-negative patients. A total of 7 positive patients and 55 negative patients with a median age of 43 (P = 0.833) were included. No statistical differences were observed in relation to sex and the presence of comorbidities...
December 25, 2018: Japanese Journal of Infectious Diseases
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