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Epilepsy & Behavior: E&B

Lorenzo Ferro Desideri, Fabio Barra, Simone Ferrero
No abstract text is available yet for this article.
April 11, 2019: Epilepsy & Behavior: E&B
Panayiotis Patrikelis, Athanasia Alexoudi, Maria Takoussi, Evangelia Liouta, Giuliana Lucci, Stefanos Korfias, Anastasia Verentzioti, Damianos Sakas, Stylianos Gatzonis
BACKGROUND: Emotional disturbances have been reported in patients with epilepsy. Although conflicting results emanate from relevant studies, depressive symptoms are seen more often in temporal lobe epilepsy (TLE) whereas, hypomanic/manic symptoms usually accompany frontal lobe epilepsy (FLE); the above psychiatric symptoms are especially seen in refractory epilepsy. However, neocortical TLE and medial TLE are considered as distinct epileptic syndromes, and there is limited literature on comparison of affective traits in medial TLE (MTLE) and FLE...
April 10, 2019: Epilepsy & Behavior: E&B
Wessel Woldman, Mark J Cook, John R Terry
At least one-third of all people with epilepsy have seizures that remain poorly controlled despite an increasing number of available anti-epileptic drugs (AEDs). Often, there is an initial good response to a newly introduced AED, which may last up to months, eventually followed by the return of seizures thought to be due to the development of tolerance. We introduce a framework within which the interplay between AED response and brain networks can be explored to understand the development of tolerance. We use a computer model for seizure generation in the context of dynamic networks, which allows us to generate an 'in silico' electroencephalogram (EEG)...
April 10, 2019: Epilepsy & Behavior: E&B
Paresh Zanzmera, Arvind Sharma, Krishnakant Bhatt, Tinkal Patel, Mehul Luhar, Anjali Modi, Vipul Jani
BACKGROUND: Psychogenic nonepileptic seizures (PNES), the commonest nonepileptic event, represent 20-30% of drug-resistant epilepsy. Correct identification of PNES avoids unnecessary hospitalization and exposure of antiepileptic drugs (AEDs), and helps implement appropriate psychological treatment. Long-term video-electroencephalography (LTVEEG) is the gold standard test to diagnose PNES. However, in a poor-resource country like India, hypothetically, short-term video-electroencephalography (STVEEG) may substitute it, as its usefulness is established in attack disorders...
April 10, 2019: Epilepsy & Behavior: E&B
Peter Wolf, Elza Márcia Yacubian
Towards the end of the 19th century, two writers who are considered the uppermost representatives of their respective national literatures, Dostoyevsky of Russia and Machado de Assis of Brazil had epilepsy, probably both temporal lobe epilepsy, but their attitudes were opposite. Dostoyevsky was as open about his diagnosis as Machado was secretive, but both included seizure experiences in their works. Two of Dostoyevsky's many epileptic characters, Prince Myshkin in The Idiot and Kirillov in Devils, report the same ecstatic aura as Dostoyevsky did privately...
April 9, 2019: Epilepsy & Behavior: E&B
Ying Xu, Zien Zhou, Janani Shanthosh, Maree L Hackett, Craig S Anderson, Nick Glozier, Ernest Somerville
INTRODUCTION: Epilepsy influences the ability to drive. We aimed to systematically summarize factors associated with driving, holding a driver's license, and traffic accidents among people with seizures. MATERIAL AND METHODS: Eight databases were searched (from their inception to 27 June 2018). We included all published observational studies, except for case reports and studies with fewer than 50 participants. Pooled mean differences and pooled risk ratios (pRRs) with corresponding confidence intervals (CIs) were calculated using random effects...
April 9, 2019: Epilepsy & Behavior: E&B
Ann Subota, Sundus Khan, Colin B Josephson, Sofiya Manji, Sara Lukmanji, Pamela Roach, Samuel Wiebe, Jeffrey Buchhalter, Paolo Federico, G Campbell Teskey, Diane L Lorenzetti, Nathalie Jetté
OBJECTIVE: The postictal period has many physical, behavioral, and cognitive manifestations associated with it. These signs and symptoms are common, can be quite debilitating, and can have a continued impact long after the seizure has ended. The purpose of this systematic review was to quantify the occurrence of postictal signs and symptoms, along with their frequency and duration in persons with epilepsy. METHODS: Cochrane Database of Systematic Reviews, CINAHL, EMBASE, MEDLINE, PsycINFO, Web of Science, and Scopus were searched from inception to November 29, 2017...
April 9, 2019: Epilepsy & Behavior: E&B
Francesca Felicia Operto, Roberta Mazza, Grazia Maria Giovanna Pastorino, Stella Campanozzi, Lucia Margari, Giangennaro Coppola
OBJECTIVE: The objective of the study was to explore stress levels in the parents of children with idiopathic epilepsy at different time points of the disease, specifically, at the time of diagnosis, during follow-up, and 1 and 2 years after discontinuation of antiepileptic drugs. METHODS: Our study included 50 patients between 5 and 14 years of age, who were diagnosed with childhood absence epilepsy or idiopathic focal epilepsy with Rolandic paroxysms. Parents of the participants independently completed the Parenting Stress Index-Short Form at the time of initial diagnosis, and when the children started antiepileptic drugs (Time 0), and at 1 year (Time 1) and 2 years (Time 2) after discontinuation of therapy...
April 9, 2019: Epilepsy & Behavior: E&B
Mehmet Hamamcı, Yunus Hacimusalar, Ozgul Karaaslan, Levent Ertuğrul İnan
OBJECTIVE: The objective of this study was to evaluate the spouses of people with epilepsy with and without a history of seizures during sleep in terms of depression, anxiety, and sleep quality. METHODS AND MATERIALS: This prospective, cross-sectional study was conducted in three groups of 18-55 year olds, who were at least primary school graduates. The 1st group consisted of healthy spouses of 30 healthy volunteers with age and sex matched with the other groups...
April 9, 2019: Epilepsy & Behavior: E&B
Robin E McGee, Martha Sajatovic, Rakale C Quarells, Erika K Johnson, Hongyan Liu, Tanya M Spruill, Robert T Fraser, Mary Janevic, Cam Escoffery, Nancy J Thompson
Depression and worse quality of life (QOL) are significantly associated with epilepsy. However, limited descriptive data on depression and quality of life among African Americans with epilepsy are available. This study sought to describe the prevalence of depression among African Americans with epilepsy participating in self-management studies and to examine the relationship between depression and QOL. Using data from the Managing Epilepsy Well (MEW) research network, a subgroup of African Americans with epilepsy were selected for the analytic sample...
April 8, 2019: Epilepsy & Behavior: E&B
Yfke Huber-Mollema, Frans J Oort, Dick Lindhout, Roos Rodenburg
PURPOSE: The purpose of the study was to examine whether mothers with epilepsy experience family problems and to investigate the possible mediating role of distinct family factors in the relationship between maternal epilepsy and child behavioral problems, in which it is also investigated whether more proximal family factors mediate the more distal family factors. METHODS: In an observational study, with children identified from the European Registry of Antiepileptic Drugs and Pregnancy database in the Netherlands (EURAP-NL), parents completed questionnaires on maternal epilepsy, family factors (proximal, distal, contextual, global), and child behavior...
April 8, 2019: Epilepsy & Behavior: E&B
Qian Li, Li-Na Zhu, Hai-Jiao Wang, Xu Lin, Da Xu, Deng Chen, Yu Zhang, Ling Liu
OBJECTIVE: The objective of this study was to validate the Chinese version of the Neurological Disorders Depression Inventory for Epilepsy (NDDIE) as a suicidality screening tool in Chinese people with epilepsy (PWE). METHODS: A consecutive cohort of PWE was recruited from West China Hospital and 363 Hospital. Each patient received a psychiatric evaluation with the Mini International Neuropsychiatric Interview (MINI) and the Chinese version of the NDDIE (C-NDDIE)...
April 8, 2019: Epilepsy & Behavior: E&B
Tim J Veersema, Monique M J van Schooneveld, Cyrille H Ferrier, Pieter van Eijsden, Peter H Gosselaar, Peter C van Rijen, Wim G M Spliet, Angelika Mühlebner, Eleonora Aronica, Kees P J Braun
Mild malformation of cortical development (mMCD) and focal cortical dysplasia (FCD) subtypes combined are by far the most common histological diagnoses in children who undergo surgery as treatment for refractory epilepsy. In patients with refractory epilepsy, a substantial burden of disease is due to cognitive impairment. We studied intelligence quotient (IQ) or developmental quotient (DQ) values and their change after epilepsy surgery in a consecutive series of 42 children (median age at surgery: 4.5, range: 0-17...
April 8, 2019: Epilepsy & Behavior: E&B
Alceste Deli, Neha Kinariwalla, Carmen Calvello, Valentina Capelli, Marcus Neale, Russett Henderson, Maggie Tristram, Arjune Sen
OBJECTIVES: The primary objective of this study was to measure the psychosocial burden for persons with epilepsy (PWEs) and for their spouses and to compare and correlate this with the clinical burden of seizures. A secondary objective was to examine the presence of gender-specific differences in the perception of psychosocial burdens by both PWE and their spouses, as well as in the factors that may influence this perception. We also sought to delineate differences in perceived stigmatization if the onset of epilepsy was within matrimony or if seizure onset was prior to marriage...
April 8, 2019: Epilepsy & Behavior: E&B
Wuqiong Zhang, Xue Wang, Na Shao, Rui Ma, Hongmei Meng
OBJECTIVES: The objective of this study was to report seizure characteristics, long-term outcome, and potential factors associated with persistent seizures in patients with autoimmune synaptic encephalitis (ASE). METHOD: Clinical data and courses of 52 patients with ASE who presented with seizures at the Department of Neurology of the First Hospital of Jilin University from January 2015 to August 2017 were reviewed. Seizure outcomes were assessed with a median follow-up duration of 30 months (8-40 months)...
April 8, 2019: Epilepsy & Behavior: E&B
Christopher M DeGiorgio, Dieter Hertling, Ashley Curtis, Diana Murray, Daniela Markovic
PURPOSE: Preclinical and early clinical research indicates that Vitamin D3 may reduce seizures in both animal models and open-label clinical trials. METHODS: This is an initial report of an ongoing pilot study of oral Vitamin D3 5000 IU/day in subjects with drug-resistant epilepsy. After Institutional Review Board (IRB) approval and informed consent, subjects with ;less than one focal onset or generalized tonic-clonic seizure per month were enrolled. Subjects entered a 4-week baseline, followed by a 12-week treatment period...
April 7, 2019: Epilepsy & Behavior: E&B
Elizabeth Stewart, Mary Lou Smith
In children with epilepsy, the impact of surgery including or sparing the mesial temporal lobes (TLs) on visuospatial memory has not been thoroughly investigated, and a clear pattern of hemispheric lateralization has not been observed. The primary aim of this study was to examine visuospatial learning and memory outcomes in children with epilepsy prior to and one year after surgical excision, to determine whether outcomes differed as a function of the localization and lateralization of surgical excisions. Forty-six children who underwent unilateral TL surgery with sparing of the mesial structures (TL group, N = 21, 16 left) or including mesial structures (TL + M group, N = 25 children, 12 left) were retrospectively recruited...
April 7, 2019: Epilepsy & Behavior: E&B
Guido Pablo Korman, Mercedes Sarudiansky, Alejandra Inés Lanzillotti, María Marta Areco Pico, Cristina Tenreyro, Gabriela Valdez Paolasini, Luciana D'Alessio, Laura Scevola, Silvia Kochen, Lorna Myers
OBJECTIVE: The objective of the present study was to perform a long-term follow-up of economically disadvantaged Latin American patients diagnosed as having psychogenic nonepileptic seizures (PNES) and contribute to the field's understanding of outcome in this population. BACKGROUND: A handful of studies have examined outcome of patients once the diagnosis of PNES has been communicated. However, the vast majority of these have been conducted in the first world countries with samples that were predominantly Caucasian...
April 5, 2019: Epilepsy & Behavior: E&B
Chiara Del Bianco, Fabio Placidi, Claudio Liguori, Luisa Mari, Martina Ulivi, Raffaele Ornello, Antonio Pisani, Nicola Biagio Mercuri, Francesca Izzi
OBJECTIVES: Epilepsy management in elderly patients is often complex because of several concomitant comorbidities that may limit the use of some antiepileptic drugs (AEDs). Levetiracetam (LEV) is a second-generation AED widely used in elderly patients with epilepsy while lacosamide (LCM), which has been recently approved in European Union (EU) as monotherapy for the treatment of focal onset seizures, is affected by a scarcity of data in such frail population. This study is aimed at assessing the efficacy and the tolerability of LCM as monotherapy in elderly patients affected by focal onset epilepsy compared with those receiving LEV...
April 5, 2019: Epilepsy & Behavior: E&B
Barbora Novakova, Peter R Harris, Gregg H Rawlings, Markus Reuber
PURPOSE: Many patients with epilepsy or psychogenic nonepileptic seizures (PNES) experience high levels of stress. Although psychological interventions have been developed for seizure disorders, few patients can currently access them. We aimed to assess the acceptability and feasibility of a self-help intervention targeting stress in patients with seizures, and to provide preliminary evidence for its effectiveness. METHOD: Patients were recruited from outpatient neurology clinics and randomized to an immediate intervention group (n = 39), who received the intervention at baseline, or a delayed intervention group (n = 43), who received the intervention one-month postbaseline...
April 5, 2019: Epilepsy & Behavior: E&B
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