Ottavia Bellotto, Erica Scarel, Giovanni Pierri, Petr Rozhin, Slavko Kralj, Maurizio Polentarutti, Antonella Bandiera, Barbara Rossi, Attilio V Vargiu, Consiglia Tedesco, Silvia Marchesan
Dipeptides stereoisomers and regioisomers composed of norleucine (Nle) and phenylalanine (Phe) self-assemble into hydrogels under physiological conditions that are suitable for cell culture. The supramolecular behavior, however, differs as the packing modes comprise amphipathic layers or water channels, whose diameter is defined by either four or six dipeptide molecules. A variety of spectroscopy, microscopy, and synchrotron-radiation-based techniques unveil fine details of intermolecular interactions that pinpoint the relationship between the chemical structure and ability to form supramolecular architectures that define soft biomaterials...
March 29, 2024: Biomacromolecules