journal
https://read.qxmd.com/read/32719554/a-pan-cancer-analysis-reveals-nonstop-extension-mutations-causing-smad4-tumour-suppressor-degradation
#1
Sonam Dhamija, Chul Min Yang, Jeanette Seiler, Ksenia Myacheva, Maiwen Caudron-Herger, Angela Wieland, Mahmoud Abdelkarim, Yogita Sharma, Marisa Riester, Matthias Groß, Jochen Maurer, Sven Diederichs
Nonstop or stop-loss mutations convert a stop into a sense codon, resulting in translation into the 3' untranslated region as a nonstop extension mutation to the next in-frame stop codon or as a readthrough mutation into the poly-A tail. Nonstop mutations have been characterized in hereditary diseases, but not in cancer genetics. In a pan-cancer analysis, we curated and analysed 3,412 nonstop mutations from 62 tumour entities, generating a comprehensive database at http://NonStopDB.dkfz.de. Six different nonstop extension mutations affected the tumour suppressor SMAD4, extending its carboxy terminus by 40 amino acids...
July 27, 2020: Nature Cell Biology
https://read.qxmd.com/read/32719553/cell-stretching-is-amplified-by-active-actin-remodelling-to-deform-and-recruit-proteins-in-mechanosensitive-structures
#2
Sophie Massou, Filipe Nunes Vicente, Franziska Wetzel, Amine Mehidi, Dan Strehle, Cecile Leduc, Raphaël Voituriez, Olivier Rossier, Pierre Nassoy, Grégory Giannone
Detection and conversion of mechanical forces into biochemical signals controls cell functions during physiological and pathological processes. Mechanosensing is based on protein deformations and reorganizations, yet the molecular mechanisms are still unclear. Using a cell-stretching device compatible with super-resolution microscopy and single-protein tracking, we explored the nanoscale deformations and reorganizations of individual proteins inside mechanosensitive structures. We achieved super-resolution microscopy after live stretching on intermediate filaments, microtubules and integrin adhesions...
July 27, 2020: Nature Cell Biology
https://read.qxmd.com/read/32719552/oncogenic-splicing-regulated-by-phase-separation
#3
Bo Liu, Omar Abdel-Wahab
No abstract text is available yet for this article.
July 27, 2020: Nature Cell Biology
https://read.qxmd.com/read/32719551/biophysical-properties-of-akap95-protein-condensates-regulate-splicing-and-tumorigenesis
#4
Wei Li, Jing Hu, Bi Shi, Francesco Palomba, Michelle A Digman, Enrico Gratton, Hao Jiang
It remains unknown if biophysical or material properties of biomolecular condensates regulate cancer. Here we show that AKAP95, a nuclear protein that regulates transcription and RNA splicing, plays an important role in tumorigenesis by supporting cancer cell growth and suppressing oncogene-induced senescence. AKAP95 forms phase-separated and liquid-like condensates in vitro and in nucleus. Mutations of key residues to different amino acids perturb AKAP95 condensation in opposite directions. Importantly, the activity of AKAP95 in splice regulation is abolished by disruption of condensation, significantly impaired by hardening of condensates, and regained by substituting its condensation-mediating region with other condensation-mediating regions from irrelevant proteins...
July 27, 2020: Nature Cell Biology
https://read.qxmd.com/read/32690888/regulated-ifn-signalling-preserves-the-stemness-of-intestinal-stem-cells-by-restricting-differentiation-into-secretory-cell-lineages
#5
Taku Sato, Shun Ishikawa, Jumpei Asano, Hirona Yamamoto, Masayuki Fujii, Toshiro Sato, Kouhei Yamamoto, Keisuke Kitagaki, Takumi Akashi, Ryuichi Okamoto, Toshiaki Ohteki
Intestinal stem cells (ISCs) are located at the crypt base and fine-tune the balance of their self-renewal and differentiation1,2 , but the physiological mechanism involved in regulating that balance remains unknown. Here we describe a transcriptional regulator that preserves the stemness of ISCs by restricting their differentiation into secretory-cell lineages. Interferon regulatory factor 2 (IRF2) negatively regulates interferon signalling3 , and mice completely lacking Irf24 or with a selective Irf2 deletion in their intestinal epithelial cells have significantly fewer crypt Lgr5hi ISCs than control mice...
July 20, 2020: Nature Cell Biology
https://read.qxmd.com/read/32681125/beth-levine-1960-2020
#6
Anna Katharina Simon, Noboru Mizushima
No abstract text is available yet for this article.
July 17, 2020: Nature Cell Biology
https://read.qxmd.com/read/32661339/persistence-of-a-regeneration-associated-transitional-alveolar-epithelial-cell-state-in-pulmonary-fibrosis
#7
Yoshihiko Kobayashi, Aleksandra Tata, Arvind Konkimalla, Hiroaki Katsura, Rebecca F Lee, Jianhong Ou, Nicholas E Banovich, Jonathan A Kropski, Purushothama Rao Tata
Stem cells undergo dynamic changes in response to injury to regenerate lost cells. However, the identity of transitional states and the mechanisms that drive their trajectories remain understudied. Using lung organoids, multiple in vivo repair models, single-cell transcriptomics and lineage tracing, we find that alveolar type-2 epithelial cells undergoing differentiation into type-1 cells acquire pre-alveolar type-1 transitional cell state (PATS) en route to terminal maturation. Transitional cells undergo extensive stretching during differentiation, making them vulnerable to DNA damage...
July 13, 2020: Nature Cell Biology
https://read.qxmd.com/read/32641767/protein-homeostasis-from-the-outside-in
#8
Brant M Webster, Holly K Gildea, Andrew Dillin
No abstract text is available yet for this article.
July 8, 2020: Nature Cell Biology
https://read.qxmd.com/read/32601372/unrestrained-escrt-iii-drives-micronuclear-catastrophe-and-chromosome-fragmentation
#9
Marina Vietri, Sebastian W Schultz, Aurélie Bellanger, Carl M Jones, Louise I Petersen, Camilla Raiborg, Ellen Skarpen, Christeen Ramane J Pedurupillay, Ingrid Kjos, Eline Kip, Romy Timmer, Ashish Jain, Philippe Collas, Roland L Knorr, Sushma N Grellscheid, Halim Kusumaatmaja, Andreas Brech, Francesca Micci, Harald Stenmark, Coen Campsteijn
The ESCRT-III membrane fission machinery maintains the integrity of the nuclear envelope. Although primary nuclei resealing takes minutes, micronuclear envelope ruptures seem to be irreversible. Instead, micronuclear ruptures result in catastrophic membrane collapse and are associated with chromosome fragmentation and chromothripsis, complex chromosome rearrangements thought to be a major driving force in cancer development. Here we use a combination of live microscopy and electron tomography, as well as computer simulations, to uncover the mechanism underlying micronuclear collapse...
June 29, 2020: Nature Cell Biology
https://read.qxmd.com/read/32587343/starve-a-cold-and-perhaps-a-cancer
#10
Daniel Haensel, Anthony E Oro
No abstract text is available yet for this article.
June 25, 2020: Nature Cell Biology
https://read.qxmd.com/read/32572169/spin90-associates-with-mdia1-and-the-arp2-3-complex-to-regulate-cortical-actin-organization
#11
Luyan Cao, Amina Yonis, Malti Vaghela, Elias H Barriga, Priyamvada Chugh, Matthew B Smith, Julien Maufront, Geneviève Lavoie, Antoine Méant, Emma Ferber, Miia Bovellan, Art Alberts, Aurélie Bertin, Roberto Mayor, Ewa K Paluch, Philippe P Roux, Antoine Jégou, Guillaume Romet-Lemonne, Guillaume Charras
Cell shape is controlled by the submembranous cortex, an actomyosin network mainly generated by two actin nucleators: the Arp2/3 complex and the formin mDia1. Changes in relative nucleator activity may alter cortical organization, mechanics and cell shape. Here we investigate how nucleation-promoting factors mediate interactions between nucleators. In vitro, the nucleation-promoting factor SPIN90 promotes formation of unbranched filaments by Arp2/3, a process thought to provide the initial filament for generation of dendritic networks...
June 22, 2020: Nature Cell Biology
https://read.qxmd.com/read/32555433/author-correction-sting-and-irf3-in-stromal-fibroblasts-enable-sensing-of-genomic-stress-in-cancer-cells-to-undermine-oncolytic-viral-therapy
#12
Esther N Arwert, Emma L Milford, Antonio Rullan, Stefanie Derzsi, Steven Hooper, Takuya Kato, David Mansfield, Alan Melcher, Kevin J Harrington, Erik Sahai
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
June 18, 2020: Nature Cell Biology
https://read.qxmd.com/read/32541879/neural-metabolic-imbalance-induced-by-mof-dysfunction-triggers-pericyte-activation-and-breakdown-of-vasculature
#13
Bilal N Sheikh, Sukanya Guhathakurta, Tsz Hong Tsang, Marius Schwabenland, Gina Renschler, Benjamin Herquel, Vivek Bhardwaj, Herbert Holz, Thomas Stehle, Olga Bondareva, Nadim Aizarani, Omar Mossad, Oliver Kretz, Wilfried Reichardt, Aindrila Chatterjee, Laura J Braun, Julien Thevenon, Herve Sartelet, Thomas Blank, Dominic Grün, Dominik von Elverfeldt, Tobias B Huber, Dietmar Vestweber, Sergiy Avilov, Marco Prinz, Joerg M Buescher, Asifa Akhtar
Mutations in chromatin-modifying complexes and metabolic enzymes commonly underlie complex human developmental syndromes affecting multiple organs. A major challenge is to determine how disease-causing genetic lesions cause deregulation of homeostasis in unique cell types. Here we show that neural-specific depletion of three members of the non-specific lethal (NSL) chromatin complex-Mof, Kansl2 or Kansl3-unexpectedly leads to severe vascular defects and brain haemorrhaging. Deregulation of the epigenetic landscape induced by the loss of the NSL complex in neural cells causes widespread metabolic defects, including an accumulation of free long-chain fatty acids (LCFAs)...
June 15, 2020: Nature Cell Biology
https://read.qxmd.com/read/32541877/the-protein-kinase-akt-acts-as-a-coat-adaptor-in-endocytic-recycling
#14
Jia-Wei Hsu, Ming Bai, Kunhua Li, Jia-Shu Yang, Nam Chu, Philip A Cole, Michael J Eck, Jian Li, Victor W Hsu
Coat proteins have a central role in vesicular transport by binding to cargoes for their sorting into intracellular pathways. Cargo recognition is mediated by components of the coat complex known as adaptor proteins1-3 . We previously showed that Arf-GAP with coil-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) functions as an adaptor for a clathrin coat complex that has a function in endocytic recycling4-6 . Here, we show that the protein kinase Akt acts as a co-adaptor in this complex, and is needed in conjunction with ACAP1 to bind to cargo proteins to promote their recycling...
June 15, 2020: Nature Cell Biology
https://read.qxmd.com/read/32528125/author-correction-chromosomal-translocation-derived-aberrant-rab22a-drives-metastasis-of-osteosarcoma
#15
Dan Liao, Li Zhong, Junqiang Yin, Cuiling Zeng, Xin Wang, Xingchuan Huang, Jinna Chen, Hong Zhang, Ruhua Zhang, Xin-Yuan Guan, Xintao Shuai, Jianhua Sui, Song Gao, Wuguo Deng, Yi-Xin Zeng, Jing-Nan Shen, Jian Chen, Tiebang Kang
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
June 11, 2020: Nature Cell Biology
https://read.qxmd.com/read/32504031/author-correction-a-hypoxia-responsive-traf6-atm-h2ax-signalling-axis-promotes-hif1%C3%AE-activation-tumorigenesis-and-metastasis
#16
Abdol-Hossein Rezaeian, Chien-Feng Li, Ching-Yuan Wu, Xian Zhang, Jorge Delacerda, M James You, Fei Han, Zhen Cai, Yun Seong Jeong, Guoxiang Jin, Liem Phan, Ping-Chieh Chou, Mong-Hong Lee, Mien-Chie Hung, Dos Sarbassov, Hui-Kuan Lin
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
June 5, 2020: Nature Cell Biology
https://read.qxmd.com/read/32499616/publisher-correction-rock-mediated-selective-activation-of-perk-signalling-causes-fibroblast-reprogramming-and-tumour-progression-through-a-creld2-dependent-mechanism
#17
Sarah Theresa Boyle, Valentina Poltavets, Jasreen Kular, Natasha Theresa Pyne, Jarrod John Sandow, Alexander Charles Lewis, Kendelle Joan Murphy, Natasha Kolesnikoff, Paul Andre Bartholomew Moretti, Melinda Nay Tea, Vinay Tergaonkar, Paul Timpson, Stuart Maxwell Pitson, Andrew Ian Webb, Robert John Whitfield, Angel Francisco Lopez, Marina Kochetkova, Michael Susithiran Samuel
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
June 4, 2020: Nature Cell Biology
https://read.qxmd.com/read/32483388/sting-and-irf3-in-stromal-fibroblasts-enable-sensing-of-genomic-stress-in-cancer-cells-to-undermine-oncolytic-viral-therapy
#18
Esther N Arwert, Emma L Milford, Antonio Rullan, Stefanie Derzsi, Steven Hooper, Takuya Kato, David Mansfield, Alan Melcher, Kevin J Harrington, Erik Sahai
Cancer-associated fibroblasts (CAFs) perform diverse roles and can modulate therapy responses1 . The inflammatory environment within tumours also influences responses to many therapies, including the efficacy of oncolytic viruses2 ; however, the role of CAFs in this context remains unclear. Furthermore, little is known about the cell signalling triggered by heterotypic cancer cell-fibroblast contacts and about what activates fibroblasts to express inflammatory mediators1,3 . Here, we show that direct contact between cancer cells and CAFs triggers the expression of a wide range of inflammatory modulators by fibroblasts...
June 1, 2020: Nature Cell Biology
https://read.qxmd.com/read/32483387/chromosomal-translocation-derived-aberrant-rab22a-drives-metastasis-of-osteosarcoma
#19
Dan Liao, Li Zhong, Junqiang Yin, Cuiling Zeng, Xin Wang, Xingchuan Huang, Jinna Chen, Hong Zhang, Ruhua Zhang, Xin-Yuan Guan, Xintao Shuai, Jianhua Sui, Song Gao, Wuguo Deng, Yi-Xin Zeng, Jing-Nan Shen, Jian Chen, Tiebang Kang
Osteosarcoma is a type of aggressive malignant bone tumour that frequently metastasizes to lungs, resulting in poor prognosis. However, the molecular mechanisms of lung metastasis of osteosarcoma remain poorly understood. Here we identify exon-intron fusion genes in osteosarcoma cell lines and tissues. These fusion genes are derived from chromosomal translocations that juxtapose the coding region for amino acids 1-38 of Rab22a (Rab22a1-38 ) with multiple inverted introns and untranslated regions of chromosome 20...
June 1, 2020: Nature Cell Biology
https://read.qxmd.com/read/32483386/assembly-of-a-persistent-apical-actin-network-by-the-formin-frl-fmnl-tunes-epithelial-cell-deformability
#20
Benoit Dehapiot, Raphaël Clément, Hervé Alégot, Gabriella Gazsó-Gerhát, Jean-Marc Philippe, Thomas Lecuit
Tissue remodelling during Drosophila embryogenesis is notably driven by epithelial cell contractility. This behaviour arises from the Rho1-Rok-induced pulsatile accumulation of non-muscle myosin II pulling on actin filaments of the medioapical cortex. While recent studies have highlighted the mechanisms governing the emergence of Rho1-Rok-myosin II pulsatility, little is known about how F-actin organization influences this process. Here, we show that the medioapical cortex consists of two entangled F-actin subpopulations...
June 1, 2020: Nature Cell Biology
journal
journal
34728
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"