Eva Vermeer, Renske C F Hebing, Maartje M van de Meeberg, Marry Lin, Tim G J de Meij, Eduard A Struys, Gerrit Jansen, Michael T Nurmohamed, Maja Bulatović Ćalasan, Robert de Jonge
PURPOSE: This review aims to critically evaluate the potential benefit of either oral or subcutaneous administration of methotrexate (MTX) in various immune-mediated inflammatory disorders (IMIDs) through analysis of efficacy, toxicity, pharmacokinetics and pharmacodynamics of both administration routes. RECENT FINDINGS: Recent studies comparing the efficacy of oral versus subcutaneous MTX administration in IMIDs have revealed contradicting results. Some reported higher efficacy with subcutaneous administration, while others found no significant difference...
September 28, 2023: Current Rheumatology Reports