journal
https://read.qxmd.com/read/38051494/role-of-ifn-%C3%AE-in-rheumatoid-arthritis
#21
REVIEW
Chung M A Lin, John D Isaacs, Faye A H Cooles
PURPOSE OF REVIEW: Type 1 interferons (IFN-I) are of increasing interest across a wide range of autoimmune rheumatic diseases. Historically, research into their role in rheumatoid arthritis (RA) has been relatively neglected, but recent work continues to highlight a potential contribution to RA pathophysiology. RECENT FINDINGS: We emphasise the importance of disease stage when examining IFN-I in RA and provide an overview on how IFN-I may have a direct role on a variety of relevant cellular functions...
December 5, 2023: Current Rheumatology Reports
https://read.qxmd.com/read/38102522/how-to-use-janus-kinase-inhibitors-in-the-treatment-of-rheumatoid-arthritis-a-clinical-assessment-of-risks-and-benefits
#22
REVIEW
Fatima K Alduraibi, Jasvinder A Singh
PURPOSE OF REVIEW: To provide an updated understanding of risks and benefits of Janus kinase inhibitors (JAKi) versus biologic disease-modifying antirheumatic drugs (bDMARDs) in the management of rheumatoid arthritis (RA). RECENT FINDINGS: Shared decision-making is needed in choosing between JAKi and bDMARDs. Cardiovascular disease, malignancy, and thromboembolic events guide this choice. In patients with active RA despite methotrexate use, tumor necrosis factor inhibitor is conditionally favored over JAKi for low-cardiovascular-risk patients and strongly favored in those with pre-existing cardiovascular disease or multiple cardiovascular risk factors...
December 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37950822/hla-b-27-and-ankylosing-spondylitis-50-years-of-insights-and-discoveries
#23
REVIEW
Muhammad A Khan
PURPOSE OF REVIEW: To commemorate the 50th anniversary of the groundbreaking discovery of a remarkably strong association between HLA-B*27 and ankylosing spondylitis (AS). RECENT FINDINGS: In addition to HLA-B*27, more than 116 other recognized genetic risk variants have been identified, while epigenetic factors largely remain unexplored in this context. Among patients with AS who carry the HLA-B*27 gene, clonally expanded CD8 + T cells can be found in their bloodstream and within inflamed tissues...
December 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37776482/a-review-of-difficult-to-treat-rheumatoid-arthritis-definition-clinical-presentation-and-management
#24
REVIEW
Carly Conran, Jason Kolfenbach, Kristine Kuhn, Christopher Striebich, Larry Moreland
PURPOSE OF REVIEW: A subset of patients with rheumatoid arthritis (RA) who fail multiple biologic therapies are deemed to have "difficult-to-treat" (D2T) RA. In 2021, a European Alliance of Associations for Rheumatology (EULAR) task force proposed a clinical definition of D2T RA. Here we review RA phenotypes and clinical assessment of RA, propose a different definition of D2T RA, discuss possible D2T RA risk factors, and summarize existing literature on the management of D2T RA. RECENT FINDINGS: High disease activity at the time of diagnosis or prior to treatment with a biologic is associated with the development of D2T RA...
December 2023: Current Rheumatology Reports
https://read.qxmd.com/read/38015334/cardiovascular-disease-in-anti-neutrophil-cytoplasm-antibody-associated-vasculitis
#25
REVIEW
Matthew Sayer, Gavin B Chapman, Matthew Thomas, Neeraj Dhaun
PURPOSE OF REVIEW: Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a rare, multisystem, autoimmune disease characterised by microvascular inflammation. Over the past 20 years, advances in immunological management have improved short-term patient outcomes. Longer-term patient outcomes remain poor with cardiovascular disease now the leading cause of death in AAV. Here, we examine the potential pathways that contribute to the increased risk of cardiovascular disease in AAV and the current evidence to manage this risk...
November 28, 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37995046/multimorbidity-in-rheumatoid-arthritis-literature-review-and-future-directions
#26
REVIEW
Jonathan Katz, Christie M Bartels
PURPOSE OF REVIEW: To offer a narrative review of literature and an update on rheumatoid arthritis (RA) multimorbidity research over the past five years as well as future directions. RECENT FINDINGS: Patients with RA experience higher prevalence of multimorbidity (31-86% vs 18-71% in non-RA) and faster accumulation of comorbidities. Patients with multimorbidity have worse outcomes compared to non-RA multimorbid patients and RA without multimorbidity including mortality, cardiac events, and hospitalizations...
November 23, 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37995045/disease-and-treatment-specific-complications-of-beh%C3%A3-et-syndrome
#27
REVIEW
Sinem Nihal Esatoglu, Yesim Ozguler, Gulen Hatemi
PURPOSE OF REVIEW: We aimed to highlight disease-related and treatment-related complications of Behçet syndrome (BS) based on previous and recent studies and our own experience. RECENT FINDINGS: The Behçet's Disease Overall Damage Index is a newly developed instrument to assess damage in BS. Validation studies showed that damage is already present in some patients at diagnosis and continues to progress during the follow-up, mainly related to treatment complications...
November 23, 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37971581/the-role-of-environmental-factors-in-the-development-of-idiopathic-inflammatory-myopathies-a-narrative-review
#28
REVIEW
Shintaro Yamamoto, Akira Yoshida, Takahisa Gono, Masataka Kuwana
PURPOSE OF REVIEW: This review aims to evaluate recent findings on the role of environmental factors in the development and clinical presentation of idiopathic inflammatory myopathies (IIMs). RECENT FINDINGS: A targeted literature review was conducted to identify reports relevant to the association between environmental factors and IIMs published over the past three years. There has been an increasing number of publications dealing with the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination with the development of IIMs, highlighting the significant role of the antiviral immune response in the pathogenesis of the disease...
November 16, 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37962833/digital-approaches-for-myositis
#29
REVIEW
Johannes Knitza, Sebastian Kuhn, Latika Gupta
PURPOSE OF REVIEW: This article serves as a comprehensive review, focusing on digital approaches utilized in the diagnosis, monitoring, and treatment of patients with idiopathic inflammatory myopathies (IIM). The authors critically assess the literature published in the last three years, evaluating the advancements and progress achieved in this specific domain. RECENT FINDINGS: Remarkable strides have been made in the realm of digital diagnostic support, particularly in image analysis and clinical prediction models, showing promise in aiding the diagnosis of IIM...
November 14, 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37597102/considerations-for-pharmacologic-management-of-rheumatoid-arthritis-in-the-covid-19-era-a-narrative-review
#30
REVIEW
Rathnam Venkat, Zachary S Wallace, Jeffrey A Sparks
PURPOSE OF REVIEW: To review the impact of disease-modifying antirheumatic drugs (DMARDs) on COVID-19 severity and vaccine immunogenicity and to discuss COVID-19 outcomes in patients with rheumatoid arthritis (RA). RECENT FINDINGS: Rituximab is associated with severe COVID-19 and impaired vaccine immunogenicity via its B cell-depleting mechanism. JAK inhibitors and glucocorticoids have been modestly associated with severe COVID-19 and impaired vaccine immunogenicity...
November 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37561315/machine-learning-approaches-to-the-prediction-of-osteoarthritis-phenotypes-and-outcomes
#31
REVIEW
Liubov Arbeeva, Mary C Minnig, Katherine A Yates, Amanda E Nelson
PURPOSE OF REVIEW: Osteoarthritis (OA) is a complex heterogeneous disease with no effective treatments. Artificial intelligence (AI) and its subfield machine learning (ML) can be applied to data from different sources to (1) assist clinicians and patients in decision making, based on machine-learned evidence, and (2) improve our understanding of pathophysiology and mechanisms underlying OA, providing new insights into disease management and prevention. The purpose of this review is to improve the ability of clinicians and OA researchers to understand the strengths and limitations of AI/ML methods in applications to OA research...
November 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37477841/systemic-lupus-erythematosus-and-covid-19
#32
REVIEW
Maria Pappa, Alexandros Panagiotopoulos, Konstantinos Thomas, Antonis Fanouriakis
PURPOSE OF REVIEW: To describe the current state of knowledge regarding COVID-19 in patients with systemic lupus erythematosus (SLE). We focus on (i) SARS-CoV-2 vaccination uptake, immunogenicity and safety, and (ii) outcomes of COVID-19 in patients with SLE and pertinent risk factors for adverse sequelae. RECENT FINDINGS: Notwithstanding the potential concern of patients about possible post-vaccination side-effects, the safety of anti-SARS-CoV-2 vaccines in patients with SLE has been undisputedly confirmed in numerous studies...
October 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37768405/oral-versus-subcutaneous-methotrexate-in-immune-mediated-inflammatory-disorders-an-update-of-the-current-literature
#33
REVIEW
Eva Vermeer, Renske C F Hebing, Maartje M van de Meeberg, Marry Lin, Tim G J de Meij, Eduard A Struys, Gerrit Jansen, Michael T Nurmohamed, Maja Bulatović Ćalasan, Robert de Jonge
PURPOSE: This review aims to critically evaluate the potential benefit of either oral or subcutaneous administration of methotrexate (MTX) in various immune-mediated inflammatory disorders (IMIDs) through analysis of efficacy, toxicity, pharmacokinetics and pharmacodynamics of both administration routes. RECENT FINDINGS: Recent studies comparing the efficacy of oral versus subcutaneous MTX administration in IMIDs have revealed contradicting results. Some reported higher efficacy with subcutaneous administration, while others found no significant difference...
September 28, 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37737528/possible-role-of-dysbiosis-of-the-gut-microbiome-in-sle
#34
REVIEW
F Naz Cemre Kalayci, Seza Ozen
PURPOSE OF REVIEW: The resident gut microbiota serves as a double-edged sword that aids the host in multiple ways to preserve a healthy equilibrium and serve as early companions and boosters for the gradual evolution of our immune defensive layers; nevertheless, the perturbation of the symbiotic resident intestinal communities has a profound impact on autoimmunity induction, particularly in systemic lupus erythematosus (SLE). Herein, we seek to critically evaluate the microbiome research in SLE with a focus on intestinal dysbiosis...
September 22, 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37656392/the-potential-role-of-probiotics-in-the-management-of-osteoarthritis-pain-current-status-and-future-prospects
#35
REVIEW
Syed Obaidur Rahman, Frédérique Bariguian, Ali Mobasheri
PURPOSE OF REVIEW: This narrative review article comprehensively explains the pathophysiology of osteoarthritis (OA) pain perception, how the gut microbiota is correlated with it, possible molecular pathways involved in probiotics-mediated OA pain reduction, limitations in the current research approaches, and future perspectives. RECENT FINDINGS: The initiation and progression of OA, including the development of chronic pain, is intricately associated with activation of the innate immune system and subsequent inflammatory responses...
September 1, 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37584859/treat-to-target-in-pediatric-rheumatic-diseases
#36
REVIEW
Silvia Rosina, Ana Isabel Rebollo-Giménez, Alessandro Consolaro, Angelo Ravelli
PURPOSE OF REVIEW: To summarize the current evidence on the adoption of the treat-to-target (T2T) strategy in pediatric rheumatic diseases (PRD). RECENT FINDINGS: The recent advances in the management of PRD have markedly increased the ability to achieve disease remission. Complete disease quiescence is regarded as the ideal therapeutic goal because its attainment leads to lesser long-term damage and physical disability, and to optimization of quality of life. Studies in adult rheumatic diseases have shown that patient outcomes are improved if complete suppression of the inflammatory process is aimed for by frequent adjustments of therapy according to quantitative indices...
August 16, 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37261663/intravenous-immunoglobulin-in-idiopathic-inflammatory-myopathies-a-practical-guide-for-clinical-use
#37
REVIEW
Prateek C Gandiga, Daniela Ghetie, Elizabeth Anderson, Rohit Aggrawal
PURPOSE OF REVIEW: Idiopathic inflammatory myopathies (IIM) are a complex family of autoimmune systemic disorders which often affect muscle and/or skin. IIM cause significant morbidity and mortality, but optimal treatment is uncertain. This review provides a practical guide for using intravenous immunoglobulin (IVIG) and subcutaneous immunoglobulin (SCIG) in the management of IIM, including dermatomyositis (DM), polymyositis (PM), immune-mediated necrotizing myositis (IMNM), and spontaneous inclusion body myositis (IBM), based on relevant recent literature and experience...
August 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37505349/emerging-concepts-in-precision-medicine-in-axial-spondyloarthritis
#38
REVIEW
Hugues Allard-Chamard, Quan Li, Proton Rahman
PURPOSE OF REVIEW: Axial spondyloarthritis (AxSpA) is among the rheumatology's most heritable complex diseases, yet precision medicine at clinics still needs to be explored. We reviewed the emerging concepts and recent developments in polygenic risk scores, Mendelian randomization, pharmacogenomics, single-cell sequencing, and spatial transcriptomics. RECENT FINDINGS: Polygenic risk score has resulted in encouraging results with potential diagnostic utility as it appears to outperform current diagnostic tools...
July 28, 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37452914/flares-in-lupus-nephritis-risk-factors-and-strategies-for-their-prevention
#39
REVIEW
Aggelos Banos, George Bertsias
PURPOSE OF REVIEW: Discuss the prognostic significance of kidney flares in patients with lupus nephritis, associated risk factors, and possible preventative strategies. RECENT FINDINGS: Recently performed clinical trials and observational cohort studies underscore the high frequency of relapses of kidney disease, following initial response, in patients with proliferative and/or membranous lupus nephritis. Analysis of hard disease outcomes such as progression to chronic kidney disease or end-stage kidney disease, coupled with histological findings from repeat kidney biopsy studies, have drawn attention to the importance of renal function preservation that should be pursued as early as lupus nephritis is diagnosed...
July 15, 2023: Current Rheumatology Reports
https://read.qxmd.com/read/37300737/neuroimmune-mechanisms-underlying-post-acute-sequelae-of-sars-cov-2-pasc-pain-predictions-from-a-ligand-receptor-interactome
#40
REVIEW
Joseph B Lesnak, Khadijah Mazhar, Theodore J Price
PURPOSE OF REVIEW: Individuals with post-acute sequelae of SARS-CoV-2 (PASC) complain of persistent musculoskeletal pain. Determining how COVID-19 infection produces persistent pain would be valuable for the development of therapeutics aimed at alleviating these symptoms. RECENT FINDINGS: To generate hypotheses regarding neuroimmune interactions in PASC, we used a ligand-receptor interactome to make predictions about how ligands from PBMCs in individuals with COVID-19 communicate with dorsal root ganglia (DRG) neurons to induce persistent pain...
June 10, 2023: Current Rheumatology Reports
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