Rachel K Vanderschelden, Jacob A Jerome, Daniel Gonzalez, Lindsey Seigh, Gloria J Carter, Beth Z Clark, Esther Elishaev, Jeffrey Louis Fine, Lakshmi Harinath, Mirka W Jones, Tatiana M Villatoro, Thing Rinda Soong, Jing Yu, Chengquan Zhao, Doug Hartman, Rohit Bhargava
The clinical utility of the proliferation marker Ki67 in breast cancer treatment and prognosis is an active area of research. Studies have suggested that differences in pre-analytic and analytic factors contribute to low analytical validity of the assay, with scoring methods accounting for a large proportion of this variability. Use of standard scoring methods is limited, in part due to the time intensive nature of such reporting protocols. Therefore, use of digital image analysis tools may help to both standardize reporting and improve workflow...
November 6, 2023: Applied Immunohistochemistry & Molecular Morphology: AIMM