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Journal of Asian Natural Products Research

Pham Thi Mai Huong, Nguyen Viet Phong, Nguyen Phuong Thao, Pham Thanh Binh, Do Thi Thao, Nguyen Van Thanh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Do Cong Thung, Chau Van Minh
Using various chromatographic separations, four steroids including one new C20 steroid namely dendrodoristerol (1), were isolated from the Vietnamese nudibranch mollusk Dendrodoris fumata. The structure elucidation was confirmed by combination of spectroscopic experiments including 1D and 2D NMR, HR QTOF MS, and CD. Compound 1 was found to exhibit significant in vitro cytotoxic activity against six human cancer cell lines as HL-60, KB, LU-1, MCF-7, LNCaP, and HepG2. In addition, 1 induced HL-60 cancer cell death by apoptosis and necrosis...
February 13, 2019: Journal of Asian Natural Products Research
Hai-Bo Zhang, Jiang Hu, Jia-Xun Li, Shan-Hu Hao
A phytochemical investigation on the 75% EtOH extract of the aerial parts of Lycopodiastrum casuarinoides resulted in the isolation of three new lycodine alkaloids, 16-hydroxy-9-oxo-lycocasuarinine D (1), 6α-hydroxy-16-dehydroxy-lycocasuarinine A (2), and 6α,16-dihydroxy-lycocasuarinine B (3). Structural elucidation of all the compounds was performed by spectral methods such as 1D- and 2D-NMR, infrared, ultraviolet, and HR-ESI-MS. The isolated alkaloids were tested in vitro for cytotoxic potential against six lung cancer cell lines...
February 10, 2019: Journal of Asian Natural Products Research
Xiao-Jing Wang, Qi Zhang, Yu-Ru Peng, Li Li, Jing Qu, Yun-Bao Liu, Song Xu, Shuang-Gang Ma, Yong Li, Zhong-Mei Zou, Ru-Bing Wang, Shi-Shan Yu
Two new azafluoranthene alkaloids (1 and 2), and a new phytoecdysone (3), were isolated from the stems of Cyclea barbata Miers, together with six known compounds (4-9). Their structures were elucidated by spectroscopic data analysis and comparison with published data. This is the first report of azafluoranthene alkaloids (1 and 2) and phytoecdysones (3, 8, and 9) from Cyclea genus. In in vitro bioassay, four isolates (3, 5, 6, and 9) showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells...
February 9, 2019: Journal of Asian Natural Products Research
Fa-Wu Dong, Liu Yang, Chen-Ting Zi, Bao-Jing Li, Hui-Yuan Li, Wen-Jie Li, Yu-Lin Yang, Jiang-Miao Hu, Hong-Ping He
Four new monoterpenoids, including two new acyclic monoterpenoids (2R, 6R)-2, 6-dimethyl-8-isovaleroxyoctan-1-ol (1) and (2S, 6S)-2, 6-dimethyl-8-isovaleroxyoctan-1-ol (2), as well as two new iridoids stenopterins F-G (3 and 4), together with fifteen known compounds (5-19), were isolated from whole dried material of Valeriana stenoptera. Stenopterin F was the first reported iridoids with n-butoxyl in the Valerianaceae family. The structures of new compounds were established on the basis of extensive spectroscopic analysis...
February 7, 2019: Journal of Asian Natural Products Research
Sukanya Unson, Chanaporn Kongsaden, Piyanuch Wonganan
Mutant p53 is primarily responsible for ineffectiveness of many anticancer drugs. The present study showed that cepharanthine alone or combined with 5-fluorouracil effectively controlled the growth of HT-29 human colorectal cancer cells harboring mutant p53 both in vitro and in vivo. The combination of cepharanthine and 5-fluorouracil additively induced apoptotic and necrotic cell death. Their combination significantly upregulated the expression of BAK and cleaved PARP in tumor tissues. Moreover, cepharanthine could prevent 5-fluorouracil-induced BCRP and MRP1 expression...
January 29, 2019: Journal of Asian Natural Products Research
Hao Zhang, Ying Zhang, Meng-Yue Wang, Shuo Chen, Xiao-Bo Li
Phytochemical investigation of Urtica fissa seed led to the isolation of a new secolignan (1) and a new glycoalkaloid (2), together with 16 known compounds (3-18). The subsequent active evaluation indicated that two lignans (1, 12), two ceramides (3, 4), and the glycoalkaloid (2) possessed the significant cytotoxicity. They could obviously inhibit the proliferation of tumor cells HeLa and CCRF-CEM cells, with IC50 values as low as 1.5 μM.
January 29, 2019: Journal of Asian Natural Products Research
Lan Li, Mei-Ping Xie, Hua Sun, An-Qi Lu, Bo Zhang, Dan Zhang, Su-Juan Wang
Two rarely phenolic acid-substituted alloses (1, 2) and one new glucoside (3), as well as nine known compounds (4-12) were isolated from rhizomes of Cibotium barometz (L.) J. Sm. Structures of 1-3 were established by extensively spectroscopic analyses (NMR, MS, etc.) and acid hydrolysis. All compounds were evaluated for the hepatoprotective activities against APAP-induced HepG2 cell damage. Compounds 1, 4-7, 10 exhibited significant hepatoprotective activities, even more strongly than positive control, bicycol...
January 29, 2019: Journal of Asian Natural Products Research
Gui-Hua Tang, Na Lu, Wei Li, Min Wu, Yun-Yun Chen, Hai-Ying Zhang, Shao-Yun He
Mannosylxylarinolide (1), a new 3,4-seco-ergostane-type steroidal saponin featuring a β-d-mannose moiety, was isolated from the culture of the endophytic fungus Xylaria sp. that had been isolated from an ornamental plant of Hoya sp. The gross structure was determined by spectroscopic data, and the absolute configuration of the new 3,4-seco-ergostane-type steroidal saponin (1) was determined by X-ray diffraction analysis.
January 29, 2019: Journal of Asian Natural Products Research
Ran Wen, Hai-Ning Lv, Yong Jiang, Peng-Fei Tu
A phytochemical study on the roots of Pongamia pinnata afforded 11 pterocarpanoids, including three new compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and HRESIMS data. The absolute configurations of the new compounds were assigned via analysis of the specific rotations and electronic circular dichroism (ECD) spectra. The isolates were evaluated for their inhibitory effects on nitric oxide (NO) production in LPS-stimulated BV-2 microglial cells. Six compounds exhibited inhibitory effects against NO production, and compound 5 showed the best activity with an IC50 value at 12...
January 24, 2019: Journal of Asian Natural Products Research
Ming-Yan Chai
A new coumestan named bavacoumestan D (1), together with five known compounds (2-6), was isolated from EtOAc-soluble extract of seeds of Psoralea corylifolia. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All compounds were evaluated for in vitro inhibitory activity against DGAT1, DGAT2 and α-glucosidase. Among them, compounds 1-2, 5-6 showed potential inhibitory activity on DGAT1 with IC50 values ranging from 52.3 ± 1.3 to 81.0 ± 1.0 μM. Compounds 1-3, 6 displayed the significant inhibitory activity on α-glucosidase with IC50 values ranging from 31...
January 24, 2019: Journal of Asian Natural Products Research
Yu-Xun Zhu, Zhao-Xin Zhang, Huan-Ping Zhang, Li-Sha Chai, Li Li, Shuang-Gang Ma, Yong Li
The phytochemical study of the ethanol extract of the leaves and twigs of Rhododendron decorum afforded a new ascorbic acid derivative (1), a new ionone analogue (2), a new ursane-type triterpenoid glucoside (3), and four known compounds (4-7). The structures were elucidated by spectroscopic analyses, including HRESIMS, 1D, and 2D NMR. The anti-neuroinflammatory activities of the compounds were evaluated by measuring inhibitory effects of LPS-induced NO production in BV2 cells.
January 22, 2019: Journal of Asian Natural Products Research
Gang Ni, Jia-Yuan Li, De-Quan Yu
Two new iridal-type triterpenoids, named forrestins A and B (1 and 2), were isolated from Iris forrestii Dykes by comprehensive chromatographic methods. The structures of 1 and 2 were elucidated by interpretation of extensive spectroscopic data including 1D and 2D NMR and HRESIMS.
January 21, 2019: Journal of Asian Natural Products Research
Bing-You Yang, Hai-Bing Jiang, Yan Liu, Jing Chen, Hai-Xue Kuang
Two new steroids meteloside F (1) and meteloside G (2), together with six known ones (3-8), were isolated and identified from the seeds of Datura metel L. The chemical constituents were isolated by silica gel, ODS chromatogram columns. and preparative HPLC. The structures of these compounds were established by one- and two-dimensional NMR spectra and HR-ESI-MS. The compounds exhibited inhibition on the nitric oxide release of lipopolysaccharide-induced RAW 264.7 cells with IC50 values from 30.2 to 44.8 μM...
January 21, 2019: Journal of Asian Natural Products Research
Lei Fang, Tian-Tian He, Kong-Kai Zhu, Miao Zhang, Jie Zhou, Hua Zhang
One new aspidosperma-type alkaloid, melotenine A (1), together with five known ones (2-6), was isolated from the leaves of Melodinus axillaris. Their structures were elucidated by detailed spectroscopic analysis and quantum chemical ECD calculation. The isolated aspidosperma-type alkaloids were evaluated for their cytotoxicity against four human cancer cell lines and melotenine A showed significant cytotoxicity against all cells with IC50 values ranging from 0.6 to 1.5 μM.
January 20, 2019: Journal of Asian Natural Products Research
Xiao Liu, Xiu-Li Su, Shu Xu, Min Yin, Yu Chen, Qi-Zhi Wang, Xu Feng
Tetradium trichotomum Lour., is a plant species endemic to tropical South East Asia with particular medicinal importance. However, very little analysis in this plant has been studied up to now from a phytochemical viewpoint. One new amide alkaloid (wuchuyuamide V, 1), as well as two known amide alkaloids-wuchuyuamide III (2), and wuchuyuamide I (3) were obtained from the fruits of T. trichotomum for the first time. The structures of wuchuyuamide V (1) and wuchuyuamide III (2) were unambiguously elucidated by 1D and 2D-NMR spectra, mass spectrometry, and single-crystal X-ray diffraction...
January 20, 2019: Journal of Asian Natural Products Research
Ling-Yan Wang, Ye Tian, Yu-Hong Qu, Yu-Zhuo Wu, Yan-Cheng Li, Rui Li, Peng-Cheng Lin, Xiao-Ya Shang, Sheng Lin
A new sesquiterpenoid ester glycoside (1) and a new monoterpenoid ester glycoside (2) have been isolated from an ethanol extract of the twigs of Litsea cubeba. Their structures were elucidated by extensive 1D- and 2D-NMR experiments, and the absolute configurations were determined by chemical methods, specific rotation, and a combination of experimental and theoretically calculated electronic circular dichroism spectra. Compound 1 exhibited selective cytotoxicity against A549 and HCT-8 cell lines with the IC50 values of 8...
January 8, 2019: Journal of Asian Natural Products Research
Xin-Yu Li, Yuan-Yuan Zu, Wei Ning, Ming-Xu Tang, Chi Gong, Sheng-Li Niu, Hui-Ming Hua
A new xanthyletin-type coumarin, neopeucedalactone (1), was isolated from the roots of Peucedanum praeruptorum Dunn. Its chemical structure was elucidated based on extensive spectroscopic interpretation. The absolute configurations of xanthyletin-type coumarin were determined by comparing experimental and calculated ECD spectra for the first time. Compound 1 exhibited moderate cell growth inhibitory activities in vitro against human leukemic HL-60, THP-1 cell lines, and human prostate cancer PC-3 cell lines, with IC50 values of 9...
January 8, 2019: Journal of Asian Natural Products Research
Zhi Chen, Chen Li, Yi-Hong Qian, Yang Fu, Zi-Ming Feng
Chondrocyte apoptosis contributes to the pathogenesis of cartilage degeneration in osteoarthritis (OA). We found that isopsoralen pretreatment significantly reversed the increase in DNA fragmentation and apoptosis rate, and significantly decreased the caspase-3 activity and PARP cleavage in IL-1β-treated chondrocytes. Isopsoralen pretreatment markedly inhibited disruption of matrix proteins. Moreover, the expressions of LC3-II and LAMP-1 were markedly increased but the expression of p62/SQSTM1 was remarkably decreased by isopsoralen pretreatment...
January 8, 2019: Journal of Asian Natural Products Research
De-Lin Xu, Yin-Chi Pan, Lin Li, Yan-Ni ShangGuan, She-Bo Zhang, Gui-Yuan Liu, Lei Cheng, Shi-Ji Xiao
A new triphenanthrene compound named 2,2',2'',7,7',7''-hexahydroxy-4,4',4''-trimethoxy-[9,9',9'',10,10',10'']-hexahydro-1,8,1',6''-triphenanthrene (1), together with eleven known compounds (2-12), were isolated from tubers of Bletilla striata. Their structures were determined by analysis of spectroscopic data. [Formula: see text].
January 6, 2019: Journal of Asian Natural Products Research
Yu-Feng Huo, Huai-Li Wang, Er-Hu Wei, Pei-Sheng Jia, Hui-Qiong Liu, Xiao-Lei Fan, Kun-Li Yana
Aiming to investigate the bioactive constituents with anti-inflammatory activity from the roots of Scrophularia ningpoensis, two new compounds (1 and 3) were isolated from the extract of the roots of the plant. Their structures were elucidated on the basis of spectral analyses (UV, IR, NMR, and MS spectroscopy), as well as experimental and calculated electronic circular dichroism (ECD) analyses. All of the isolates were tested for their anti-inflammatory properties in terms of suppressing the production of NO in lipopolysaccharide-induced BV2 cells...
January 6, 2019: Journal of Asian Natural Products Research
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