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Breast Cancer: the Journal of the Japanese Breast Cancer Society

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https://read.qxmd.com/read/30993643/reproductive-history-and-breast-cancer-survival-a-prospective-patient-cohort-study-in-japan
#1
Yuko Minami, Yoshikazu Nishino, Masaaki Kawai, Hiroshi Tada, Seiki Kanemura, Minoru Miyashita, Takanori Ishida, Yoichiro Kakugawa
BACKGROUND: Reproductive factors may influence breast cancer progression and patient survival; however, evidence has been limited. METHODS: The associations of reproductive factors with tumor characteristics and patient survival were analyzed among 1468 breast cancer patients diagnosed during 1997-2013 at a single institute in Japan. The patients were followed until 2016. During a median follow-up period of 8.6 years, 272 all-cause and 199 breast cancer deaths were documented...
April 15, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30989585/pim1-is-responsible-for-il-6-induced-breast-cancer-cell-emt-and-stemness-via-c-myc-activation
#2
Xueqiang Gao, Xiangping Liu, Yangyong Lu, Yu Wang, Weihong Cao, Xiaoyi Liu, Haiyan Hu, Haibo Wang
BACKGROUND: Interleukin-6 (IL-6) has been demonstrated to be a critical factor for breast cancer malignancy. However, the molecular mechanisms by which IL-6 induce breast cancer cells epithelial-mesenchymal-transition (EMT) and stemness remain elusive. METHODS: Breast cancer cell lines T47D and MCF7 were exposed to IL-6, the expression of PIM1 was examined by quantitative real-time PCR (qRT-PCR) and western blot. Luciferase reporter assay was used to determine the transcriptional modulation of PIM1 by IL-6 and STAT3 inhibitor...
April 15, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30980249/five-screening-detected-breast-cancer-cases-in-initially-disease-free-brca1-or-brca2-mutation-carriers
#3
Satoko Shimada, Reiko Yoshida, Eri Nakashima, Dai Kitagawa, Naoya Gomi, Rie Horii, Sayoko Takeuchi, Yuumi Ashihara, Mizuho Kita, Futoshi Akiyama, Shinji Ohno, Mitsue Saito, Masami Arai
Individuals carrying pathogenic BRCA1 or BRCA2 mutations have an increased lifetime risk of breast and/or ovarian cancer. The incidence of breast cancer amongst disease-free BRCA mutation carriers under surveillance and the clinical and pathological characteristics of those who subsequently develop the disease remain unclear in Japan. We reviewed the records of 155 individuals with BRCA1 or BRCA2 mutations identified by genetic testing between January 2000 and December 2016. At the time of genetic testing, 26 individuals with one of these mutations had no history of breast cancer and were therefore enrolled in a surveillance program that included biannual ultrasonography, clinical breast examination, annual mammography, and conditional magnetic resonance imaging for the early detection of primary breast cancer...
April 12, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30963461/clinical-application-of-ceramide-in-cancer-treatment
#4
REVIEW
Kazuki Moro, Masayuki Nagahashi, Emmanuel Gabriel, Kazuaki Takabe, Toshifumi Wakai
Development of innovative strategies for cancer treatment is a pressing public health issue. Despite recent advances, the mechanisms of cancer progression and the resistance to cancer treatment have not been fully elucidated. Sphingolipids, including ceramide and sphingoshin-1-phosphate, are bioactive mediators that regulate cancer cell death and survival through the dynamic balance of what has been termed the 'sphingolipid rheostat'. Specifically, ceramide, which acts as the central hub of sphingolipid metabolism, is generated via three major pathways by many stressors, including anti-cancer treatments, environmental stresses, and cytokines...
April 8, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30955172/paving-the-way-for-changing-perceptions-in-breast-surgery-a-systematic-literature-review-focused-on-oncological-and-aesthetic-outcomes-of-oncoplastic-surgery-for-breast-cancer
#5
REVIEW
I G Papanikolaou, C Dimitrakakis, F Zagouri, S Marinopoulos, A Giannos, E Zografos, C G Zografos, D Kritikou, A Rodolakis, G C Zografos, D Loutradis
BACKGROUND: The emphasis on aesthetic outcomes and quality of life after breast cancer surgery has motivated breast surgeons to develop oncoplastic breast conserving surgery (OPS). Training programs are still rare in most countries, and there is little standardization, which challenges the scientific evaluation of these techniques. This systematic review aims to assess oncological and cosmetic outcomes of OPS. METHODS: After a strict selection process with precise inclusion and exclusion criteria, oncologic and aesthetic outcomes of oncoplastic surgery were searched, using the MEDLINE database up to September 30th, 2017...
April 6, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30949915/patients-preferences-for-postmenopausal-hormone-receptor-positive-human-epidermal-growth-factor-receptor-2-negative-advanced-breast-cancer-treatments-in-japan
#6
Yukie Omori, Sotaro Enatsu, Zhihong Cai, Hiroshi Ishiguro
BACKGROUND: This study aimed to identify factors affecting patients' preferences for postmenopausal hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer treatments, their relative importance, and impact of sociodemographic/clinical characteristics. METHODS: Japanese postmenopausal patients with HR+ breast cancer chose between 2 hypothetical treatments for HR+/HER2- advanced breast cancer using an online discrete choice experiment, defined by different levels of 5 attributes: progression-free survival (PFS), incidence of diarrhea (IOD), frequency of loose stools of grade 1-3 severity (FOS), duration of diarrhea (DOD), and route/frequency of administration (RFA)...
April 4, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30937834/predicting-metastasis-in-clinically-negative-axillary-lymph-nodes-with-minimum-apparent-diffusion-coefficient-value-in-luminal-a-like-breast-cancer
#7
Fumi Kato, Kohsuke Kudo, Hiroko Yamashita, Motoi Baba, Ai Shimizu, Noriko Oyama-Manabe, Rumiko Kinoshita, Ruijiang Li, Hiroki Shirato
BACKGROUND: We investigated the usefulness of the minimum ADC value of primary breast lesions for predicting axillary lymph node (LN) status in luminal A-like breast cancers with clinically negative nodes in comparison with the mean ADC. METHODS: Forty-four luminal A-like breast cancers without axillary LN metastasis at preoperative clinical evaluation, surgically resected with sentinel LN biopsy, were retrospectively studied. Mean and minimum ADC values of each lesion were measured and statistically compared between LN positive (n = 12) and LN negative (n = 32) groups...
April 1, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30927244/diabetes-as-a-prognostic-factor-in-her-2-positive-breast-cancer-patients-treated-with-targeted-therapy
#8
Anbok Lee, Sunmi Jo, Changhu Lee, Hyun-Hee Shin, Tae Hyun Kim, Ki Jung Ahn, Sung-Kwang Park, Heunglae Cho, Hye-Kyoung Yoon, Woo Gyeong Kim, Jiyoung Park, Yunseon Choi
PURPOSE: Recent studies revealed that metabolic stress influences the outcomes of breast cancer treatment. We sought to evaluate the prognostic effect of type 2 diabetes and find the molecular mechanism of relapses in postoperative HER-2+ breast cancer patients treated with HER-2 targeted therapy. MATERIALS AND METHODS: We evaluated 190 HER-2+ breast cancer patients (pT1-4N0-2M0) who were treated with surgical resection and trastuzumab (HER-2 targeted therapy) between 2006 and 2015...
March 29, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30927243/correction-to-breast-cancer-cell-motility-is-promoted-by-14-3-3%C3%AE
#9
Emiko Hiraoka, Takahiro Mimae, Masaoki Ito, Takayuki Kadoya, Yoshihiro Miyata, Akihiko Ito, Morihito Okada
The correct name of the corresponding author should be ''Takahiro Mimae'', and not ''Emiko Hiraoka'' as given in the original publication of the article.
March 29, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30903404/sentinel-node-mapping-and-ductal-carcinoma-in-situ
#10
Samara E Pollock, Jondavid Pollock, Scott Nestor, Rosemarie Hardin, David Ghaphery
BACKGROUND: Pure ductal carcinoma in situ (DCIS) is typically unassociated with a risk of regional lymph node involvement. Retrospective series maintain that larger tumors or high-grade histopathology may harbor a risk of lymph node involvement. PURPOSE: Our community hospital retrospectively reviewed a series wherein women with DCIS were subjected to sentinel lymph node biopsy based on large tumor size and/or high-grade histopathology. MATERIALS AND METHODS: 232 consecutive women with a diagnosis of pure DCIS were evaluated independently by two breast surgeons, one who typically offers sentinel node mapping to patients with tumors larger than 10 mm and the other who offers sentinel node mapping to women with grade 3 tumors...
March 22, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30888580/oncologic-outcomes-and-radiation-safety-of-nipple-sparing-mastectomy-with-intraoperative-radiotherapy-for-breast-cancer
#11
Lingxiao Pan, Changsheng Ye, Lun Chen, Wei Tang, Xiaoshen Zhang, Jin Gao, Rui Wu, Xigang Ye, Weige Tan, Minghui Wan, Wenbo Zheng
BACKGROUND: Nipple-sparing mastectomy combined with breast reconstruction helps to optimize the contour of the breast after mastectomy. However, the indications for nipple-sparing mastectomy are still controversial. Local radiation to the nipple-areola complex may play some roles in improving the oncological safety of this procedure. METHODS: From January 2014 to December 2017, 41 consecutive patients who underwent nipple-sparing mastectomy combined with Intrabeam intraoperative radiotherapy to the nipple-areola complex flap and breast reconstruction were enrolled in this prospective study...
March 19, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30887287/discrepancies-of-current-recommendations-in-breast-cancer-follow-up-a-systematic-review
#12
Anastasios Kyriazoglou, Flora Zagouri, Despina Fotiou, Constantinos Dimitrakakis, Spyros Marinopoulos, Roubini Zakopoulou, Maria Kaparelou, Anna Zygogianni, Meletios Athanasios Dimopoulos
INTRODUCTION: Management and optimal follow-up of early breast cancer survivors remain up to this day a challenge due to the lack of well-established guidelines. Multiple medical societies, organizations and working groups have provided recommendations for follow-up but there is no uniform, globally approved algorithm to guide clinical practice. METHODS: A systematic review was performed to identify and evaluate discrepancies between available guidelines for the follow-up of breast cancer survivors...
March 18, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30877449/c677t-and-a1298c-methylenetetrahydrofolate-reductase-polymorphisms-and-breast-cancer-susceptibility-among-latinos-a-meta-analysis
#13
Perla Meneses-Sanchez, Samantha C Garcia-Hernandez, Leonardo M Porchia, Ricardo Pérez-Fuentes, Enrique Torres-Rasgado, Alejandra Del Angel Soto, M Elba Gonzalez-Mejia
BACKGROUND: Previous meta-analyses have shown an ethnic dependency of the C677T and the A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms, with no focus on the Latino population. For Latinos, many studies have examined these polymorphisms and breast cancer susceptibility, yielding no concise result. Therefore, we undertook this meta-analysis to determine the effect these polymorphisms have on breast cancer risk for Latinos. METHODS: PubMed, EBSCO, LILACS, Scopus, and Latin American-specific databases were searched for studies exploring the association between the MTHFR polymorphisms and breast cancer susceptibility in Latinos until January 2019...
March 15, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30868399/novel-tumor-infiltrating-lymphocytes-ultrasonography-score-based-on-ultrasonic-tissue-findings-predicts-tumor-infiltrating-lymphocytes-in-breast-cancer
#14
Kayo Fukui, Norio Masumoto, Noriyuki Shiroma, Akiko Kanou, Shinsuke Sasada, Akiko Emi, Takayuki Kadoya, Michiya Yokozaki, Koji Arihiro, Morihito Okada
BACKGROUND: The presence of tumor-infiltrating lymphocytes (TILs) is a prognostic factor for breast cancer. However, because of tumor tissue heterogeneity, an accurate and simple evaluation method is needed. We determined if preoperative characteristic ultrasonography (US) image findings are predictive of lymphocyte-predominant breast cancer (LPBC). METHODS: We evaluated 191 patients with invasive breast cancer treated by curative surgery between January 2014 and December 2017...
March 13, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30847663/lateral-thoracoaxillar-dermal-fat-flap-for-breast-conserving-surgery-the-changes-of-the-indication-and-long-term-results
#15
Hiroshi Nakagomi, Masayuki Inoue, Haruka Nakada, Masato Ohmori, Yuko Nakayama, Kazushige Furuya, Hideki Watanabe, Kou Ikegame, Koichi Kobayashi
BACKGROUND: Oncoplastic breast conserving surgery had been challenged to achieve both of local control and the cosmetic appearance of preserved breast. We developed the lateral thoracoaxillar dermal-fat flap (LTDF) as an oncoplastic procedure to fill the defect of breast-conserving surgery in 1999. METHODS: A total of 2338 breast cancer patients underwent surgery from January, 2000 to December, 2017. Mastectomy was performed in 706 patients (30%), and breast conservative surgery (BCS) was performed in 1634 patients (70%)...
March 7, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30830684/breast-cancer-cell-motility-is-promoted-by-14-3-3%C3%AE
#16
Emiko Hiraoka, Takahiro Mimae, Masaoki Ito, Takayuki Kadoya, Yoshihiro Miyata, Akihiko Ito, Morihito Okada
PURPOSE: Pseudopodia are actin-rich ventral protrusions associated with cell motility and cancer cell invasion. We previously applied our established method of using excimer laser cell etching to isolate pseudopodial proteins from MDA-MB-231 breast cancer cells. We later identified 14-3-3γ as an oncogenic molecule among 46 candidate proteins that are specific to pseudopodia. The present study aimed to determine the function of 14-3-3γ in the motility of breast cancer cells. METHODS: MDA-MB-231 cells were cultured on 3-µm porous membranes and double stained to localize 14-3-3γ and phalloidin in pseudopodia using confocal imaging...
March 4, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30820924/the-clinical-impact-of-mri-screening-for-brca-mutation-carriers-the-first-report-in-japan
#17
Wakana Murakami, Mitsuhiro Tozaki, Seigo Nakamura, Yoshimi Ide, Mayuko Inuzuka, Yuko Hirota, Kouzou Murakami, Noritsugu Takahama, Yoshimitsu Ohgiya, Takehiko Gokan
BACKGROUND: There is no consensus on the appropriate surveillance for high-risk women with breast cancer in Japan. We investigated their imaging features and pathological characteristics to build a proper surveillance system for asymptomatic high-risk individuals in the future. METHODS: We retrospectively reviewed 93 female (median age 43 years) BRCA1 and BRCA2 mutation carriers from our institutional clinical database from 2011 to 2017. The study population was composed of 112 breast cancers...
February 28, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30810967/impact-of-germinal-center-associated-nuclear-protein-polymorphisms-on-breast-cancer-risk-and-prognosis-in-a-japanese-population
#18
Haruru Kotani, Hidemi Ito, Kazuhiko Kuwahara, Kiyotaka Kuzushima, Hiroji Iwata, Nobuyuki Tsunoda, Masato Nagino, Keitaro Matsuo
BACKGROUND: Germinal center-associated nuclear protein (GANP) is a phosphoprotein involved in mRNA export and regulation of DNA recombination. Although GANP expression in human breast cancer tissue is associated with breast cancer prognosis, the association between the genetic background of GANP and susceptibility and prognosis of breast cancer is unclear. METHODS: We selected 694 breast cancer cases and 1376 age- and menopausal status-matched non-cancer controls from the Hospitable-based Epidemiologic Research Program, conducted at Aichi Cancer Center between 2001 and 2005...
February 27, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30747373/relationships-among-personality-coping-and-concurrent-health-related-quality-of-life-in-women-with-breast-cancer
#19
Hui-Ling Lai, Chun-I Chen, Chu-Yun Lu, Yu-Chun Yao, Chiung-Yu Huang
BACKGROUND: Theory has suggested that personality plays an important role related to health behavior and results in health outcomes, but inconsistent with the findings exist. Moreover, limited research has focused on style of coping with personality traits and health-related quality of life (HRQOL) for patients with breast cancer. We tested how ways of coping and personality traits are associated with HRQOL in patients with breast cancer, after controlling for age, education, disease severity, and sleep disorders...
February 12, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30737616/comparison-of-the-efficacy-of-trastuzumab-emtansine-between-patients-with-metastatic-human-epidermal-growth-factor-receptor-2-positive-breast-cancers-previously-treated-with-combination-trastuzumab-and-pertuzumab-and-with-trastuzumab-only-in-japanese-population
#20
Shoko Noda-Narita, Akihiko Shimomura, Asuka Kawachi, Hitomi Sumiyoshi-Okuma, Kazuki Sudo, Tatsunori Shimoi, Emi Noguchi, Kan Yonemori, Chikako Shimizu, Yasuhiro Fujiwara, Kenji Tamura
BACKGROUND: Trastuzumab emtansine (T-DM1) has been approved since 2013 for patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) who had received trastuzumab (Tmab) and taxane. However, no clinical trial has evaluated the efficacy of T-DM1 in those who have previously received pertuzumab (Pmab). This study aimed to compare the efficacy of T-DM1 between patients who had received Tmab and Pmab and those who had received Tmab only in Japanese population...
February 8, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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