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Human Fertility: Journal of the British Fertility Society

Joyce C Harper, Jessica Hepburn, Gabby Vautier, Emma Callander, Tian Glasgow, Adam Balen, Jacky Boivin
The Fertility Education Initiative was established in 2016 to provide education on fertility, modern families and reproductive science for young adults, teachers, health professionals, parents and adults. We report on our study to determine the feasibility and acceptability of using the arts to delivery fertility education in schools. The evaluation was mixed methods: (i) two focus groups with young people aged 14-16 and 16-18 were conducted to investigate attitudes to fertility awareness; and (ii) seventeen 16-22 year olds were divided into two groups and each undertook a day of art workshops that consisted of two visual and two theatrical workshops and then completed questionnaires at the end of each workshop and at the end of the day...
March 1, 2019: Human Fertility: Journal of the British Fertility Society
Natalie Weeg, Anat Hershko Klement, Einat Haikin, Aliza Amiel, Adrian Shulman, Tal Biron-Shental, Amir Wiser
Telomeres are a specific base sequence of DNA, responsible for chromosome stability and DNA protection. We aimed to investigate the association between telomere systems and IVF outcomes according to patients' BMI. For all telomere characteristics, there was a distinct trend towards shorter telomeres and activation of telomere shortening compensatory mechanisms in the BMI group >25  kg/m2 , reaching statistical significance for senescence only (r = 0.7, p value <0.01). There was a trend towards a relationship between telomere length and number of oocytes between telomere length and fertilization rate, but these did not reach a statistical significance...
February 17, 2019: Human Fertility: Journal of the British Fertility Society
Patricia E Hershberger, Martha Driessnack, Karen Kavanaugh, Susan C Klock
Few studies have captured oocyte donation (OD) parents' decision processes about intended and actual disclosure over time. Likewise, OD children's perceptions about their family composition during middle childhood are underexplored. To address these gaps, a longitudinally followed cohort of OD recipient families was invited to participate in a qualitative, follow-up study. With an 86% response rate after 12 years, families were composed of oocyte recipient mothers (n = 6) and biological fathers (n = 6) representing 12 donor-oocyte conceived children (10...
February 6, 2019: Human Fertility: Journal of the British Fertility Society
Leila Motamedzadeh, Mohammad Mahdi Mohammadi, Hossein Hadinedoushan, Ehsan Farashahi Yazd, Farzaneh Fesahat
This study determined the association between the levels of interleukin (IL)-17 and IL-23 in follicular fluid (FF), as well as their mRNA levels in cumulus cells from infertile women at risk for ovarian hyperstimulation syndrome (OHSS). In this case-controlled study, the control group (n = 40) was infertile women whose partners had male factor infertility, whereas the case group (n = 40) was infertile women at risk of OHSS. IL-17 and IL-23 concentrations in FF were measured using an enzyme-linked immunosorbent assay method, whereas the mRNA expression levels of IL-17 and IL-23 of cumulus cells were determined using RT-PCR...
February 4, 2019: Human Fertility: Journal of the British Fertility Society
Leila Nazari, Saghar Salehpour, Maryam Sadat Hosseini, Parisa Hashemi Moghanjoughi
Repeated implantation failure is a major challenge in reproductive medicine and despite several methods that have been described for management, there is little consensus on which is the most effective. This study was conducted to evaluate the effectiveness of autologous platelet-rich plasma in improving the pregnancy rate in repeated implantation failure. Between 2016 and 2017, a total of 138 patients who failed to conceive after 3 or more embryo transfers with high quality embryos and candidate for frozen-thawed embryo transfer were assessed for eligibility to enter the study...
February 4, 2019: Human Fertility: Journal of the British Fertility Society
Nervana Bayoumy, Mohamed El-Shabrawi, Hesham Nada
The blood testicular barrier (BTB) is a barrier protecting the testes from damage. It also plays an important role in spermatogenesis. The intracellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin cell adhesion molecule family and is a constituent component of the BTB. This study was carried out to investigate the association between the single nucleotide polymorphism (SNP) rs5498 in the ICAM-1 gene and non-obstructive azoospermia. A total of 100 male patients with non-obstructive azoospermia and 100 fertile males (healthy control) were included in this study...
February 1, 2019: Human Fertility: Journal of the British Fertility Society
Isıl Kasapoglu, Nergis Düzok, Esra Şen, Cihan Çakır, Berrin Avcı, Gürkan Uncu
Although the efficiency of progesterone in providing luteal phase support has been established, the role of oestradiol supplementation during the luteal phase remains controversial. We evaluated pregnancy outcomes of patients who had a ratio of serum E2 levels on the hCG day to the number of oocytes retrieved (oestradiol/oocyte ratio - EOR) levels of <100 pg/ml by supporting them with additional oestradiol during the luteal phase. In total, 150 patients with an EOR < 100 pg/ml of oestradiol undergoing antagonist intracytoplasmic sperm injection (ICSI) cycles were randomly assigned into two groups to receive either oral oestradiol (4 mg/d) plus vaginal progesterone (90 mg, 2 × 1/day) (group 1) or vaginal progesterone (90 mg, 2 × 1/d) alone (group 2)...
January 29, 2019: Human Fertility: Journal of the British Fertility Society
Sophie Bolt, Diny Postema, Anouk van der Heij, A Janneke B M Maas
This study examined the motivations of anonymous Dutch sperm donors to release their identity. It aimed to increase knowledge and encourage donors to become identifiable through a more informed decision, allowing more donor-conceived persons to contact their donors. Since 2010, anonymous sperm donors in the Netherlands can register in the Fiom KID-DNA Database developed by Fiom and Canisius Wilhelmina Hospital (CWZ). An online survey was sent to donors who registered in the database (May 2015-August 2017). A total of 179 male respondents participated in this study...
January 17, 2019: Human Fertility: Journal of the British Fertility Society
Mariano Mascarenhas, Mugdha Kulkarni, Adam Balen
The objective of this study was to investigate the role of Body Mass Index (BMI) in influencing ethnic variation in IVF outcomes. This retrospective cohort study included women (having BMI between 19 to 30 kg/m2 ) undergoing their first IVF cycle with fresh blastocyst transfer at a single IVF unit between 2010 and 2015. In summary, South Asian women had a lower live birth rate (LBR) (27% vs 44.7%, aOR 0.41, 95% CI 0.29 to 0.59) than Caucasian women. Subgroup analysis revealed a significantly lower LBR for South Asian women when their BMI was 25-25...
January 14, 2019: Human Fertility: Journal of the British Fertility Society
Mathew Tomlinson, Karen Pooley, Tracey Kohut, Melanie Atkinson
The increasingly stringent laboratory-approach to diagnosing azoospermia for post-vasectomy semen analysis (PVSA) continues to be at odds with the simpler approach desired by clinicians. This study describes the analysis of 10 years of PVSA and discusses the outcome in relation to risk, cost and assesses whether more stringent procedures are required. PVSA was performed on 4788 patients initially using a 2-test strategy (16 and 20 weeks post-surgery), moving to 1 test during 2013-2014. Azoospermia was confirmed by the analysis of 10 µl of semen followed by 10 µl of centrifuged pellet...
January 11, 2019: Human Fertility: Journal of the British Fertility Society
Attila Mokánszki, Zsuzsanna Molnár, Emese Varga Tóthné, Béla Bodnár, Attila Jakab, Bálint L Bálint, István Balogh
Approximately 15% of couples are unable to conceive after one year of unprotected intercourse. Because sperm can be accessed with ease, it is reasonable to search for non-invasive biomarkers in semen. MicroRNAs are a family of short single-stranded non-coding RNA molecules that are capable of regulating gene expression and causing mRNA degradation. We studied the most common 11 spermatogenesis-related microRNAs expression levels in sperm and seminal plasma from patients with oligozoospermic or asthenozoospermic ejaculates, and in men with normozoospermic ejaculates...
January 11, 2019: Human Fertility: Journal of the British Fertility Society
Elizabeth Weedin, Jonathan Kort, Alexander Quaas, Valerie Baker, Robert Wild, Karl Hansen
We sought to examine current use of, and indications for, progesterone supplementation in the luteal phase of non-in vitro fertilization (non-IVF) infertility treatments among Obstetrician Gynaecologists (OB/GYN) compared to Reproductive Endocrinology and Infertility (REI) Subspecialists. Using a web-based survey, the practices of U.S. REI and OB/GYN physicians practicing infertility from 2014-2016 were assessed. The main outcome measures were frequency of use and indications for progesterone supplementation for luteal-phase support in non-IVF infertility treatments...
January 10, 2019: Human Fertility: Journal of the British Fertility Society
Jun Hagiuda, Nobuyoshi Takasaki, Mototsugu Oya, Hiromichi Ishikawa, Hisashi Narimatsu
Asthenozoospermia is commonly observed in infertile men. However, very few causative gene mutations have been identified because an efficient detection method has not been established. We previously identified a patient with asthenozoospermia carrying a heterozygous point deletion in GALNTL5 by detecting an abnormal reduction in the abundance of GALNTL5 and other marker proteins. To identify other mutations in GALNTL5, we screened sperm samples from 208 infertile men mainly diagnosed with asthenozoospermia using the same method, and conducted next-generation sequencing...
January 10, 2019: Human Fertility: Journal of the British Fertility Society
Eleanor L Stevenson, Lauren Gispanski, Kristin Fields, Maria Cappadora, Melissa Hurt
The objective was to examine what young graduate student women know about preserving fertility/oocyte cryopreservation, and which reproductive resources they use. A prospective, cross-sectional design was used and the study was conducted at a University on the East Coast of the United States. The participants were 278 female graduate students. Participants completed a survey with questions about demographics, fertility knowledge, oocyte cryopreservation, and sources of fertility information. Descriptive statistics were calculated for all variables...
January 9, 2019: Human Fertility: Journal of the British Fertility Society
Riddhi Thaker, Vineet Mishra, Mansi Gor, Rohina Agarwal, Hardik Sheth, Prakruti Kapadia, Sunil Kumar
The study was conducted on a population of 203 women attending the IVF clinic, Ahmedabad, India, to explore the role of stimulation protocol and the number of oocytes retrieved on oxidative stress in follicular fluid and IVF outcome. Follicular fluid was collected during ovum pick-up to determine the oxidative stress markers: superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), total thiols (TT), l-ascorbic acid (AA), total protein, glutathione S-transferase (GST) and glutathione reductase (GRD)...
January 8, 2019: Human Fertility: Journal of the British Fertility Society
Julija Gorodeckaja, Samantha Neumann, Abeo McCollin, Christian S Ottolini, Jinjun Wang, Kamal Ahuja, Alan Handyside, Michael Summers
This study reports the results of a 2-year long IVF programme ('One by One') in which all patients (median age 40 years; range 27-45 years) were offered preimplantation genetic testing for aneuploidy (PGT-A) and had all blastocysts vitrified (freeze-only), followed later by single vitrified-warmed blastocyst transfer (vSET) in managed cycles. Between January 2016 and December 2017, a total of 155 patients started 222 treatment cycles and 99 (45%) cycles resulted in one or more vitrified blastocysts (untested or with normal copy number for all chromosomes) available for transfer...
January 7, 2019: Human Fertility: Journal of the British Fertility Society
(no author information available yet)
No abstract text is available yet for this article.
April 2019: Human Fertility: Journal of the British Fertility Society
Allan A Pacey
No abstract text is available yet for this article.
April 2019: Human Fertility: Journal of the British Fertility Society
Vasanti Jadva, Helen Prosser, Natalie Gamble
This study aimed to explore UK intending parent's reasons for cross-border and domestic surrogacy, their preparations for the birth and the practical and legal challenges faced after the birth. An online survey was completed by 203 participants, of which 132 had a child born through surrogacy, 33 were in the process of surrogacy and 38 were planning a surrogacy arrangement. The most common reason for pursuing surrogacy in the UK was wanting a relationship with the surrogate (43%; n = 17) and for conducting surrogacy in the USA was because of a better legal framework (97%; n = 60)...
December 11, 2018: Human Fertility: Journal of the British Fertility Society
Jung A Kim, Cho Hee Bang, Gwan Gyu Song, Jae-Hoon Kim, Sung Jae Choi, Jae Hyun Jung
Tumour necrosis factor alpha (TNF-α) concentration is associated with recurrent pregnancy loss (RPL). Moreover, TNF-α promoter polymorphisms affect cellular TNF-α concentrations. Although several studies on TNF-α polymorphisms have been reported, these studies only define specific loci and result in conflicting conclusions. The meta-analysis in this study was performed to examine the relationship between various TNF-α polymorphisms and RPL. We searched for articles, using MEDLINE and Embase, and performed meta-analysis of 21 studies involving 3437 cases and 4016 controls...
December 2, 2018: Human Fertility: Journal of the British Fertility Society
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