Miguel Cosenza-Contreras, Agnes Schäfer, Justin Sing, Lena Cook, Maren N Stillger, Chia-Yi Chen, Jose Villacorta Hidalgo, Niko Pinter, Larissa Meyer, Tilman Werner, Darleen Bug, Zeno Haberl, Oliver Kübeck, Kai Zhao, Susanne Stei, Anca Violeta Gafencu, Radu Ionita, Felix M Brehar, Jaime Ferrer-Lozano, Gloria Ribas, Leo Cerdá-Alberich, Luis Martí-Bonmatí, Christopher Nimsky, Alexis Van Straaten, Martin L Biniossek, Melanie Föll, Nina Cabezas-Wallscheid, Jörg Büscher, Hannes Röst, Armelle Arnoux, Jörg W Bartsch, Oliver Schilling
BACKGROUND: There is an urgent need to better understand the mechanisms associated with the development, progression, and onset of recurrence after initial surgery in glioblastoma (GBM). The use of integrative phenotype-focused -omics technologies such as proteomics and lipidomics provides an unbiased approach to explore the molecular evolution of the tumor and its associated environment. METHODS: We assembled a cohort of patient-matched initial (iGBM) and recurrent (rGBM) specimens of resected GBM...
October 26, 2023: Neuro-oncology