Mustafa Al-Chalabi, Prajwal Hegde, Sara R Moore, Yasmeen Abouainain, Myles Keener, Hira Parvez, Jeremy Eid, Sidra Saleem, Ajaz Sheikh
OBJECTIVES: Isaac syndrome (IS) is a condition characterized by peripheral nerve hyperexcitability caused by voltage-gated potassium channel (VGKC)-complex antibodies. Muscle twitching, stiffness, hypertrophy, and dysautonomic characteristics, such as hyperhidrosis, are common manifestations. The syndrome can be autoimmune or paraneoplastic, with thymoma being a common cause of paraneoplastic IS. Furthermore, this condition could be handed down from one generation to another. However, there is limited information regarding outcomes, relapses, associated syndromes, associated malignancies (other than thymoma), and treatment options...
December 1, 2023: Journal of Clinical Neuromuscular Disease