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Journals Neoplasia : An International J...

Neoplasia : An International Journal for Oncology Research

https://read.qxmd.com/read/39029162/corrigendum-to-protein-phosphatase-2a-negatively-regulates-eukaryotic-initiation-factor-4e-phosphorylation-and-eif4f-assembly-through-direct-dephosphorylation-of-mnk-and-eif4e-neoplasia-volume-12-issue-10-2010-848-855
#1
Yikun Li, Ping Yue, Xingming Deng, Takeshi Ueda, Rikiro Fukunaga, Fadlo R Khuri, Shi-Yong Sun
No abstract text is available yet for this article.
July 17, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/39024777/efficacy-and-safety-of-pyrotinib-based-regimens-in-her2-positive-metastatic-breast-cancer-a-retrospective-real-world-data-study
#2
JOURNAL ARTICLE
Lanyi Dai, Ting Gao, Rong Guo, Yuyuan Chen, Jiankui Wang, Shaoqiang Zhou, Yiyin Tang, Dedian Chen, Sheng Huang
OBJECTIVE: Pyrotinib is a novel irreversible tyrosine kinase inhibitor that has shown efficacy for human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC). This study explored the efficacy and safety of pyrotinib in the treatment of HER2-positive MBC patients in the real world. METHODS: From September 2018 to February 2022, 137 female patients with HER2-positive MBC treated in this center were enrolled in this study. The follow-up period ended on January 12, 2023...
July 17, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38996538/characterization-and-integrated-analysis-of-extrachromosomal-dna-amplification-in-hematological-malignancies
#3
JOURNAL ARTICLE
Hao Zhang, Bei Liu, Juan Cheng, Zijian Li, Mingfeng Jia, Ming Li, Long Zhao, Lina Wang, Yaming Xi
The study of extrachromosomal DNA (ecDNA), an element existing beyond classical chromosomes, contributes to creating a more comprehensive map of the cancer genome. In hematological malignancies, research on ecDNA has lacked comprehensive investigation into its frequency, structure, function, and mechanisms of formation. We re-analyzed WGS data from 208 hematological cancer samples across 11 types, focusing on ecDNA characteristics. Amplification of ecDNA was observed in 7 of these cancer types, with no instances found in normal blood cells...
July 11, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38991376/grp78-inhibitor-yum70-upregulates-4e-bp1-and-suppresses-c-myc-expression-and-viability-of-oncogenic-c-myc-tumors
#4
JOURNAL ARTICLE
Vicky Yamamoto, Dat P Ha, Ze Liu, Miller Huang, Soma Samanta, Nouri Neamati, Amy S Lee
The 78-kDa glucose regulated protein (GRP78) commonly upregulated in a wide variety of tumors is an important prognostic marker and a promising target for suppressing tumorigenesis and treatment resistance. While GRP78 is well established as a major endoplasmic reticulum (ER) chaperone with anti-apoptotic properties and a master regulator of the unfolded protein response, its new role as a regulator of oncoprotein expression is just emerging. MYC is dysregulated in about 70 % of human cancers and is the most commonly activated oncoprotein...
July 10, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38972207/metformin-use-and-survival-in-people-with-ovarian-cancer-a-population-based-cohort-study-from-british-columbia-canada
#5
JOURNAL ARTICLE
Paramdeep Kaur, Andrew Berchuck, Anne Chase, Bronwyn Grout, Cindy McKinnon Deurloo, Leigh C Pearce, Malcolm C Pike, Jean Richardson, Kathryn L Terry, Penelope M Webb, Gillian E Hanley
OBJECTIVES: There is an active debate regarding whether metformin use improves survival in people with ovarian cancer. We examined this issue using methods designed to avoid immortal time bias-as bias that occurs when participants in a study cannot experience the outcome for a certain portion of the study time. METHODS: We used time-dependent analyses to study the association between metformin use for all 4,951 patients diagnosed with ovarian cancer in 1997 through 2018 in the province of British Columbia, Canada...
July 6, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38944914/grin3a-a-biomarker-associated-with-a-cribriform-pattern-and-poor-prognosis-in-prostate-cancer
#6
JOURNAL ARTICLE
Mari Bogaard, Jonas M Strømme, Susanne G Kidd, Bjarne Johannessen, Anne C Bakken, Ragnhild A Lothe, Karol Axcrona, Rolf I Skotheim, Ulrika Axcrona
Prostate cancer with a cribriform pattern, including invasive cribriform carcinoma (ICC) and/or intraductal carcinoma (IDC) is associated with a poor prognosis, and the underlying mechanisms are unclear. Therefore, we aimed to identify biomarkers for this feature. Using a radical prostatectomy cohort, we performed within-patient differential expression analyses with RNA sequencing data to compare samples with a cribriform pattern to those with non-cribriform Gleason pattern 4 (NcGP4; n=13). ACSM1, GRIN3A, PCDHB2, and REG4 were identified as differentially expressed, and validation was performed using real-time reverse transcription polymerase chain reaction (n=99; 321 RNA samples) and RNA in situ hybridization on tissue microarrays (n=479; 2047 tissue cores)...
June 29, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38944913/onc206-targeting-clpp-induces-mitochondrial-dysfunction-and-protective-autophagy-in-hepatocellular-carcinoma-cells
#7
JOURNAL ARTICLE
Jiahao Cao, Fei Cao, Chuanzheng Wang, Zhen Jiao, Yuting You, Xiaomin Wang, Wenxiu Zhao
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for approximately 90 % of all cases. ONC201, a member of the imipridone drug family, has shown promising therapeutic potential and a good safety profile in both malignant pediatric central nervous system tumors (diffuse midline glioma [DMG]) and hematologic malignancies. ONC206 is a more potent analog of ONC201. However, the ONC206 potential and mechanism of action in HCC remain to be elucidated. We found that ONC206 hindered HCC growth by suppressing cell proliferation and inducing apoptosis...
June 29, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38943997/glycolysis-in-gastrointestinal-stromal-tumor-a-brief-overview
#8
REVIEW
Takafumi Shima, Kohei Taniguchi, Yosuke Inomata, Jun Arima, Sang-Woong Lee
Gastrointestinal stromal tumor (GIST) is the most prevalent mesenchymal tumor of the digestive tract. Its growth is primarily influenced by mutations in KIT or PDGFRA. Surgery is the primary treatment option for GIST; however, KIT inhibitors, such as imatinib, are used for inoperable cases. Resistance to imatinib is an upcoming challenge, especially because the effectiveness of alternative drugs is limited. Enhancement of the glycolysis pathway in cancer cells has been identified as a key feature in cancer...
June 28, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38943996/image-based-deep-learning-model-using-dna-methylation-data-predicts-the-origin-of-cancer-of-unknown-primary
#9
JOURNAL ARTICLE
Jinha Hwang, Yeajina Lee, Seong-Keun Yoo, Jong-Il Kim
Cancer of unknown primary (CUP) is a rare type of metastatic cancer in which the origin of the tumor is unknown. Since the treatment strategy for patients with metastatic tumors depends on knowing the primary site, accurate identification of the origin site is important. Here, we developed an image-based deep-learning model that utilizes a vision transformer algorithm for predicting the origin of CUP. Using DNA methylation dataset of 8,233 primary tumors from The Cancer Genome Atlas (TCGA), we categorized 29 cancer types into 18 organ classes and extracted 2,312 differentially methylated CpG sites (DMCs) from non-squamous cancer group and 420 DMCs from squamous cell cancer group...
June 28, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38943995/corrigendum-to-characterizing-the-therapeutic-potential-of-a-potent-bet-degrader-in-merkel-cell-carcinoma-neoplasia-volume-21-issue-3-2019-322-330
#10
Jae Eun Choi, Monique E Verhaegen, Sahr Yazdani, Rohit Malik, Paul W Harms, Doris Mangelberger, Jean Tien, Xuhong Cao, Yuping Wang, Marcin Cieślik, Jonathan Gurkan, Mishaal Yazdani, Xiaojun Jing, Kristin Juckette, Fengyun Su, Rui Wang, Bing Zhou, Ingrid J Apel, Shaomeng Wang, Andrzej A Dlugosz, Arul M Chinnaiyan
No abstract text is available yet for this article.
June 28, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38943994/corrigendum-to-combined-phospholipids-adjuvant-augments-anti-tumor-immune-responses-through-activated-tumor-associated-dendritic-cells-neoplasia-39-2023-100893
#11
Yifang Shui, Xin Hu, Hiroshi Hirano, Hirotake Tsukamoto, Wen-Zhi Guo, Kenichiro Hasumi, Fumihiro Ijima, Masayuki Fujino, Xiao-Kang Li
No abstract text is available yet for this article.
June 28, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38878618/emerging-role-of-necroptosis-pyroptosis-and-ferroptosis-in-breast-cancer-new-dawn-for-overcoming-therapy-resistance
#12
REVIEW
Bifei Fu, YuMing Lou, Pu Wu, Xiaofeng Lu, Chaoyang Xu
Breast cancer (BC) is one of the primary causes of death in women worldwide. The challenges associated with adverse outcomes have increased significantly, and the identification of novel therapeutic targets has become increasingly urgent. Regulated cell death (RCD) refers to a type of cell death that can be regulated by several different biomacromolecules, which is distinctive from accidental cell death (ACD). In recent years, apoptosis, a representative RCD pathway, has gained significance as a target for BC medications...
June 14, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38875930/epstein-barr-virus-deubiquitinating-enzyme-bplf1-is-involved-in-ebv-carcinogenesis-by-affecting-cellular-genomic-stability
#13
JOURNAL ARTICLE
Hantao Wu, Bo-Wei Han, Tiancai Liu, Min Zhang, Yingsong Wu, Jing Nie
Increased mutational burden and EBV load have been revealed from normal tissues to Epstein-Barr virus (EBV)-associated gastric carcinomas (EBVaGCs). BPLF1, encoded by EBV, is a lytic cycle protein with deubiquitinating activity has been found to participate in disrupting repair of DNA damage. We first confirmed that BPLF1 gene in gastric cancer (GC) significantly increased the DNA double strand breaks (DSBs). Ubiquitination mass spectrometry identified histones as BPLF1 interactors and potential substrates, and co-immunoprecipitation and in vitro experiments verified that BPLF1 regulates H2Bub by targeting Rad6...
June 13, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38875929/aurkin-a-a-tpx2-aurora-a-small-molecule-inhibitor-disrupts-alisertib-induced-polyploidy-in-aggressive-diffuse-large-b-cell-lymphoma
#14
JOURNAL ARTICLE
Patrick J Conway, Bárbara De La Peña Avalos, Jonathan Dao, Sebastian Montagnino, Dmytro Kovalskyy, Eloise Dray, Daruka Mahadevan
Chemotherapy induced polyploidy is a mechanism of inherited drug resistance resulting in an aggressive disease course in cancer patients. Alisertib, an Aurora Kinase A (AK-A) ATP site inhibitor, induces cell cycle disruption resulting in polyaneuploidy in Diffuse Large B Cell Lymphoma (DLBCL). Propidium iodide flow cytometry was utilized to quantify alisertib induced polyploidy in U2932 and VAL cell lines. In U2932 cells, 1µM alisertib generated 8n+ polyploidy in 48% of the total cell population after 5 days of treatment...
June 13, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38850835/spatial-whole-exome-sequencing-reveals-the-genetic-features-of-highly-aggressive-components-in-lung-adenocarcinoma
#15
JOURNAL ARTICLE
Jianfu Li, Shan Xiong, Ping He, Peng Liang, Caichen Li, Ran Zhong, Xiuyu Cai, Zhanhong Xie, Jun Liu, Bo Cheng, Zhuxing Chen, Hengrui Liang, Shen Lao, Zisheng Chen, Jiang Shi, Feng Li, Yi Feng, Zhenyu Huo, Hongsheng Deng, Ziwen Yu, Haixuan Wang, Shuting Zhan, Yang Xiang, Huiting Wang, Yongmin Zheng, Xiaodong Lin, Jianxing He, Wenhua Liang
In invasive lung adenocarcinoma (LUAD), patients with micropapillary (MIP) or solid (SOL) components had a significantly poorer prognosis than those with only lepidic (LEP), acinar (ACI) or papillary (PAP) components. It is interesting to explore the genetic features of different histologic subtypes, especially the highly aggressive components. Based on a cohort of 5,933 patients, this study observed that in different tumor size groups, LUAD with MIP/SOL components showed a different prevalence, and patients with ALK alteration or TP53 mutations had a higher probability of developing MIP/SOL components...
June 7, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38850836/unveiling-the-role-of-agt-in-lipid-metabolism-and-regulated-cell-death-in-colon-cancer
#16
JOURNAL ARTICLE
Mengdi Wu, Yuyang Zhou, Dongsheng Pei, Shoucui Gao
BACKGROUND: Lipid metabolism and regulated cell death (RCD) play a role in the remodeling of tumor immune microenvironment and regulation of cancer progression. Since the underlying immune mechanisms of colon cancer remain elusive, this study aims to identify potential therapeutic target genes. METHODS: Differential genes related to lipid metabolism and RCD in COAD patients were identified using R language and online tools. Based on the expression of genes, two groups were classified using consensus clustering...
June 6, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38823209/pbi-05204-a-supercritical-co-2-extract-of-nerium-oleander-suppresses-glioblastoma-stem-cells-by-inhibiting-grp78-and-inducing-programmed-necroptotic-cell-death
#17
JOURNAL ARTICLE
Sharmistha Chakraborty, Daoyan Wei, Megan Tran, Frederick F Lang, Robert A Newman, Peiying Yang
Successful treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain neoplasm, mandates the need to develop new therapeutic strategies. In this study, we investigated the potential of PBI-05204 in targeting GBM stem cells (GSCs) and the underlying mechanisms. Treatment with PBI-05204 significantly reduced both the number and size of tumor spheres derived from patient-derived GSCs (GBM9, GSC28 and TS543), and suppressed the tumorigenesis of GBM9 xenografts. Moreover, PBI-05204 treatment led to a significant decrease in the expression of CD44 and NANOG, crucial markers of progenitor stem cells, in GBM9 and GSC28 GSCs...
May 31, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38796932/b7-h4-reduces-the-infiltration-of-cd8-t-cells-and-induces-their-anti-tumor-dysfunction-in-gliomas
#18
JOURNAL ARTICLE
Ying Qi, Lang Hu, Chunxia Ji, Xinyu Yang, Jiakai Yao, Di Chen, Yu Yao
B7-H4 is a promising immune checkpoint molecule in tumor immunotherapy. Our previous study showed that high B7-H4 expression was strongly correlated with deficiency in tumor infiltrated lymphocytes (TILs) in glioma patients. On this basis, we investigated the impact of B7-H4 on CD8+TILs in gliomas and the associated molecular mechanism here. B7-H4-positive tumor samples (n=129) from our glioma cohort were used to assess B7-H4 expression and CD8+TIL quantification by immunohistochemistry. CD8+TILs from five glioma patients cultured with B7-H4 protein were used to evaluate anti-tumor dysfunction by flow cytometry and ELISpot...
May 25, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38761506/enhanced-apc-min-adenoma-formation-after-epithelial-cul4b-deletion-by-recruitment-of-myeloid-derived-suppressor-cells
#19
JOURNAL ARTICLE
Beibei Guo, Yawen Zheng, Yujia Fan, Yang Yang, Yuxing Wang, Liping Qin, Yachun An, Xiaoran Xu, Xiyu Zhang, Gongping Sun, Hao Dou, Changshun Shao, Yaoqin Gong, Baichun Jiang, Huili Hu
Colorectal cancer (CRC) stands as a prevalent malignancy globally. A pivotal event in CRC pathogenesis involves the loss-of-function mutation in the APC gene, leading to the formation of benign polyps. Despite the well-established role of APC, the contribution of CUL4B to CRC initiation in the pre-tumorous stage remains poorly understood. In this investigation, we generated a murine model by crossing ApcMin/+ mice with Cul4bΔIEC mice to achieve specific deletion of Cul4b in the gut epithelium against an ApcMin/+ background...
May 17, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38761505/tumor-marker-based-recisttm-is-superior-to-recist-as-criteria-to-predict-the-long-term-benefits-of-targeted-therapy-in-advanced-non-small-cell-lung-cancer-with-driver-gene-mutations
#20
JOURNAL ARTICLE
Kai Xiong, Yi Yang, Yanan Yang, Zhengbo Wang, Yun Liu, Hong Duo, Xinya Yuan, Yao Xiao, He Xiao, Xueqin Yang
BACKGROUND: Tyrosine kinase inhibitors (TKIs) are standard first-line treatments for advanced non-small-cell lung cancer (NSCLC) with driver gene mutations. The Response Evaluation Criteria in Solid Tumors (RECIST) are limited in predicting long-term patient benefits. A tumour marker-based evaluation criteria, RecistTM, was used to investigate the potential for assessing targeted-therapy efficacy in lung cancer treatment. METHODS: We retrospectively analysed patients with stage IIIA-IV NSCLC and driver gene mutations, whose baseline tumour marker levels exceeded the pre-treatment cut-off value three-fold and who received TKI-targeted therapy as a first-line treatment...
May 17, 2024: Neoplasia: An International Journal for Oncology Research
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