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Journals Neoplasia : An International J...

Neoplasia : An International Journal for Oncology Research

https://read.qxmd.com/read/38039923/targeting-of-oncogenic-aaa-atpase-trip13-reduces-progression-of-pancreatic-ductal-adenocarcinoma
#1
JOURNAL ARTICLE
Farrukh Afaq, Sumit Agarwal, Prachi Bajpai, Sameer Al Diffalha, Hyung-Gyoon Kim, Shajan Peter, Moh'd Khushman, Subhash C Chauhan, Priyabrata Mukherjee, Sooryanarayana Varambally, Upender Manne
Thyroid hormone receptor-interacting protein 13 (TRIP13) is involved in cancer progression, but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the expression, functional role, and mechanism of action of TRIP13 in PDAC. We further examined the efficacy of TRIP13 inhibitor, DCZ0415, alone or in combination with gemcitabine on malignant phenotypes, tumor progression, and immune response. We found that TRIP13 was overexpressed in human PDACs relative to corresponding normal pancreatic tissues...
November 30, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37976568/evidence-based-on-mendelian-randomization-causal-relationship-between-mitochondrial-biological-function-and-lung-cancer-and-its-subtypes
#2
JOURNAL ARTICLE
Kangle Zhu, Jingwei Shi, Rusong Yang, Chu Zhou, Zhengcheng Liu
OBJECTIVE: This study aimed to investigate the causal relationship between mitochondrial biological function and lung cancer, including its subtypes, via MR. METHODS: SNPs significantly associated with lung cancer and its subtypes were employed as instrumental variables. MR-Egger regression, simple mode, weighted mode, simple median, and weighted median, were utilized to determine the causal relationship between the exposure factor and the occurrence of lung cancer and its subtypes...
November 15, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37976569/hepatocellular-loss-of-mtor-aggravates-tumor-burden-in-nonalcoholic-steatohepatitis-related-hcc
#3
JOURNAL ARTICLE
Andreas Kroh, Jeanette Walter, Athanassios Fragoulis, Diana Möckel, Twan Lammers, Fabian Kiessling, Julia Andruszkow, Christian Preisinger, Maren Egbert, Long Jiao, Roman M Eickhoff, Daniel Heise, Nikolaus Berndt, Thorsten Cramer, Ulf Peter Neumann, Antje Egners, Tom Florian Ulmer
Obesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH became an important driver of hepatocellular carcinoma (HCC) in recent years. Activation of the central metabolic regulator mTOR (mechanistic target of rapamycin) is frequently observed in HCCs. However, mTOR inhibition failed to improve the outcome of HCC therapies, demonstrating the need for a better understanding of the molecular and functional consequences of mTOR blockade. We established a murine NASH-driven HCC model based on long-term western diet feeding combined with hepatocellular mTOR-inactivation...
November 14, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37956532/mitochondrial-adaptation-decreases-drug-sensitivity-of-persistent-triple-negative-breast-cancer-cells-surviving-combinatory-and-sequential-chemotherapy
#4
JOURNAL ARTICLE
Marie Winter, Amina Nait Eldjoudi, Catherine Guette, Hubert Hondermarck, Roland P Bourette, Quentin Fovez, William Laine, Bart Ghesquiere, Eric Adriaenssens, Jérôme Kluza, Xuefen Le Bourhis
Triple negative breast cancer (TNBC) is an aggressive malignancy for which chemotherapy remains the standard treatment. However, between 3 and 5 years after chemotherapy, about half patients will relapse and it is essential to identify vulnerabilities of cancer cells surviving neoadujuvant therapy. In this study, we established persistent TNBC cell models after treating MDA-MB-231 and SUM159-PT TNBC cell lines with epirubicin and cyclophosphamide, and then with paclitaxel, for a total of 18 weeks. The resulting chemo-persistent cell lines were more proliferative, both in vitro and in xenografted mice...
November 11, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37944353/therapeutic-targeting-of-tumor-spheroids-in-a-3d-microphysiological-renal-cell-carcinoma-on-a-chip-system
#5
JOURNAL ARTICLE
Chris P Miller, Megan Fung, Carla A Jaeger-Ruckstuhl, Yuexin Xu, Edus H Warren, Shreeram Akilesh, Scott S Tykodi
Metastatic renal cell carcinoma (RCC) remains an incurable disease for most patients highlighting an urgent need for new treatments. However, the preclinical investigation of new therapies is limited by traditional two-dimensional (2D) cultures which do not recapitulate the properties of tumor cells within a collagen extracellular matrix (ECM), while human tumor xenografts are time-consuming, expensive and lack adaptive immune cells. We report a rapid and economical human microphysiological system ("RCC-on-a-chip") to investigate therapies targeting RCC spheroids in a 3D collagen ECM...
November 7, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37918207/a-sensitive-and-robust-plasma-based-dna-methylation-panel-for-early-detection-of-target-gastrointestinal-cancers
#6
JOURNAL ARTICLE
Yanmiao Dai, Hui Li, Qianqian Wu, Jie Wang, Kai Wang, Sujuan Fei, Bing Pei, Lishuang Song, Guangxia Chen, Yong Ma, Chenjing Xia, Shangmin Xiong, Minxue Zheng, Ying Xue, Guodong Zhao, Hongwei Xu
BACKGROUND: Target gastrointestinal cancers (GICs), encompassing esophageal cancer (EC), gastric cancer (GC), and colorectal cancer (CRC), originate within a single readily accessible luminal organ system and are diagnosable using endoscopy. However, endoscopy is an invasive procedure with low compliance and no plasma-based DNA methylation assay for the early detection of GICs. METHODS: Nine potential DNA methylation markers were identified and evaluated in tissue (n=60) and plasma (n=155) cohorts to select the most suitable markers...
October 31, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37913654/innate-immunity-looking-beyond-t-cells-in-radiation-and-immunotherapy-combinations
#7
JOURNAL ARTICLE
R A McMahon, C D'Souza, P J Neeson, S Siva
Radiation therapy is an established and effective anti-cancer treatment modality. Extensive pre-clinical experimentation has demonstrated that the pro-inflammatory properties of irradiation may be synergistic with checkpoint immunotherapy. Radiation induces double-stranded DNA breaks (dsDNA). Sensing of the dsDNA activates the cGAS/STING pathway, producing Type 1 interferons essential to recruiting antigen-presenting cells (APCs). Radiation promotes cytotoxic CD8 T-cell recruitment by releasing tumour-associated antigens captured and cross-presented by surveying antigen-presenting cells...
October 30, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37913653/acral-melanoma-new-insights-into-the-immune-and-genomic-landscape
#8
REVIEW
Larissa Anastacio DaCosta Carvalho, Flavia C Aguiar, Keiran S M Smalley, Patricia A Possik
Acral melanoma is a rare subtype of melanoma that arises on the non-hair bearing skin of the nail bed, palms of the hand and soles of the feet. It is unique among melanomas in not being linked to ultraviolet radiation (UVR) exposure from the sun, and, as such, its incidence is similar across populations who are of Asian, Hispanic, African and European origin. Although research into acral melanoma has lagged behind that of sun-exposed cutaneous melanoma, recent studies have begun to address the unique genetics and immune features of acral melanoma...
October 30, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37857049/radiotherapy-combined-with-docetaxel-alters-the-immune-phenotype-of-hnscc-cells-and-results-in-increased-surface-expression-of-cd137-and-release-of-hmgb1-of-specifically-hpv-positive-tumor-cells
#9
JOURNAL ARTICLE
Fridolin Grottker, Simon Gehre, Clara M Reichardt, Azzaya Sengedorj, Tina Jost, Thorsten Rieckmann, Markus Hecht, Antoniu-Oreste Gostian, Benjamin Frey, Rainer Fietkau, Udo S Gaipl, Michael Rückert
PURPOSE: Human papilloma virus (HPV) positive head and neck squamous cell carcinoma (HNSCC) tumors respond significantly better to anticancer treatments. It is assumed to be due to a better response to radiotherapy (RT), and presumably to an increased immunogenicity. However, little is known how the immune phenotype of HNSCC tumor cells is modulated by standard treatment, namely by radiochemotherapy (RCT). METHODS: Therefore, we aimed to examine the impact of the HPV status on the immune phenotype of HNSCC cell lines following RCT with 5 × 3Gy or 1 × 19...
October 17, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37852131/time-restricted-feeding-affects-the-fecal-microbiome-metabolome-and-its-diurnal-oscillations-in-lung-cancer-mice
#10
JOURNAL ARTICLE
Gaofeng Fang, Shengquan Wang, Qianyao Chen, Han Luo, Xuemei Lian, Dan Shi
The homeostasis of the gut microbiota and circadian rhythm is critical to host health, and both are inextricably intertwined with lung cancer. Although time-restricted feeding (TRF) can maintain circadian synchronization and improve metabolic disorders, the effects of TRF on the fecal microbiome, metabolome and their diurnal oscillations in lung cancer have not been discussed. We performed 16S rRNA sequencing and untargeted metabonomic sequencing of the feces prepared from models of tumor-bearing BALB/c nude mice and urethane-induced lung cancer...
October 16, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37839160/integration-of-bioinformatics-and-machine-learning-strategies-identifies-apm-related-gene-signatures-to-predict-clinical-outcomes-and-therapeutic-responses-for-breast-cancer-patients
#11
JOURNAL ARTICLE
Hong-Yu Shen, Jia-Lin Xu, Zhen Zhu, Hai-Ping Xu, Ming-Xing Liang, Di Xu, Wen-Quan Chen, Jin-Hai Tang, Zheng Fang, Jian Zhang
BACKGROUND: Tumor antigenicity and efficiency of antigen presentation jointly influence tumor immunogenicity, which largely determines the effectiveness of immune checkpoint blockade (ICB). However, the role of altered antigen processing and presentation machinery (APM) in breast cancer (BRCA) has not been fully elucidated. METHODS: A series of bioinformatic analyses and machine learning strategies were performed to construct APM-related gene signatures to guide personalized treatment for BRCA patients...
October 13, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37813000/targeting-il-23-for-the-interception-of-obesity-associated-colorectal-cancer
#12
JOURNAL ARTICLE
Venkateshwar Madka, Srikanth Chiliveru, Janani Panneerselvam, Gopal Pathuri, Yuting Zhang, Nicole Stratton, Nandini Kumar, Dharambir K Sanghera, Chinthalapally V Rao
Inflammation and obesity are two major factors that promote Colorectal cancer (CRC). Our recent data suggests that interleukin (IL)-23, is significantly elevated in CRC tumors and correlates with patient obesity, tumor grade and survival. Thus, we hypothesize that obesity and CRC may be linked via inflammation and IL-23 may be a potential target for intervention in high-risk patients. TCGA dataset and patient sera were evaluated for IL-23A levels. IL-23A [IL-23 p19-/- ] knockout (KO) mice were crossed to Apcmin/+ mice and progeny were fed low-fat or high-fat diets...
October 7, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37801862/common-and-distinct-patterns-of-acquired-uniparental-disomy-and-homozygous-deletions-between-lung-squamous-cell-carcinomas-and-lung-adenocarcinoma
#13
JOURNAL ARTICLE
Musaffe Tuna, Gordon B Mills, Christopher I Amos
Acquired uniparental disomy (aUPD) is a chromosomal alteration that can lead to homozygosity of existing aberrations. We used data from The Cancer Genome Atlas SNP-based arrays to identify distinct and common aUPD profiles in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Moreover, we tested relevance of aUPD for homozygous deletion (HMD), overall survival (OS), and recurrence-free survival (RFS). Overall, we found significantly higher aUPD (q = 5.34E-09) in LUSC than in LUAD...
October 4, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37778252/%C3%AE-np63-silencing-dna-methylation-shifts-and-epithelial-mesenchymal-transition-resulted-from-tap63-genome-editing-in-squamous-cell-carcinoma
#14
JOURNAL ARTICLE
Iyoko Katoh, Keiichi Tsukinoki, Ryu-Ichiro Hata, Shun-Ichi Kurata
TP63 (p63) is strongly expressed in lower-grade carcinomas of the head and neck, skin, breast, and urothelium to maintain a well-differentiated phenotype. TP63 has two transcription start sites at exons 1 and 3' that produce TAp63 and ΔNp63 isoforms, respectively. The major protein, ΔNp63α, epigenetically activates genes essential for epidermal/craniofacial differentiation, including ΔNp63 itself. To examine the specific role of weakly expressed TAp63, we disrupted exon 1 using CRISPR-Cas9 homology-directed repair in a head and neck squamous cell carcinoma (SCC) line...
September 29, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37769529/abbv-744-induces-autophagy-in-gastric-cancer-cells-by-regulating-pi3k-akt-mtor-p70s6k-and-mapk-signaling-pathways
#15
JOURNAL ARTICLE
Kun Wang, Jiatong Tang, Shengxian Fan, Haochen Su, Ranran Yu, Yixuan Zhang, Hao Wu, Ying Lv, Shu Zhang, Xiaoping Zou
The mortality rates of gastric cancer remain high due to limited therapeutic strategies. As a highly selective inhibitor of the BD2 domain of BET family proteins, ABBV-744 has potent chemotherapeutic activity against various human solid tumors. However, whether ABBV-744 has potential anti-tumor effects in gastric cancer remain largely unknown. In this study, we evaluated the effect of ABBV-744 on gastric cancer cells and explored the possible underlying mechanisms. We found that ABBV-744 inhibited the growth of gastric cancer cells and patient-derived tumor organoids in a dose-dependent manner...
September 26, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37769528/darpp-32-and-t-darpp-in-the-development-of-resistance-to-anti-her2-agents-pre-clinical-evidence-from-the-step-study
#16
JOURNAL ARTICLE
Giulia Bon, Eriseld Krasniqi, Manuela Porru, Lorenzo D'Ambrosio, Stefano Scalera, Marcello Maugeri-Saccà, Francesca Sofia Di Lisa, Lorena Filomeno, Teresa Arcuri, Andrea Botticelli, Daniele Santini, Maria Agnese Fabbri, Giuliana D'Auria, Claudio Pulito, Giovanni Blandino, Caterina Marchiò, Maddalena Barba, Gennaro Ciliberto, Patrizia Vici, Laura Pizzuti
The therapeutic scenario of Human Epidermal Growth Factor Receptor 2 positive advanced breast cancer (ABC) has been recently enriched by a number of innovative agents, which are reshaping treatment sequence. While randomized trials have documented an advantage in terms of efficacy, for the newly available agents we lack effectiveness and tolerability evidence from the real-world setting. Similarly, the identification of predictive biomarkers might improve clinical decision. We herein describe the outline of a prospective/retrospective study which aims to explore the optimal sequence of treatment in HER2+, pertuzumab pre-treated ABC patients treated in II line with anti-HER2 agents in clinical practice...
September 26, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37717471/hsp90-c-terminal-domain-inhibition-promotes-vdac1-oligomerization-via-decreasing-k274-mono-ubiquitination-in-hepatocellular-carcinoma
#17
JOURNAL ARTICLE
Jinxin Zhang, Lixia Liu, Yan Li, Yaling Huang, Senbo Xiao, Zihao Deng, Zhenming Zheng, Jieyou Li, Manfeng Liang, Guantai Xie, Xiao Chen, Yaotang Deng, Wenchong Tan, Hairou Su, Guibing Wu, Chunqing Cai, Xuemei Chen, Fei Zou
Voltage-dependent anion-selective channel protein 1 (VDAC1) is the most abundant protein in the mitochondrial outer membrane and plays a crucial role in the control of hepatocellular carcinoma (HCC) progress. Our previous research found that cytosolic molecular chaperone heat shock protein 90 (Hsp90) interacted with VDAC1, but the effect of the C-terminal and N-terminal domains of Hsp90 on the formation of VDAC1 oligomers is unclear. In this study, we focused on the effect of the C-terminal domain of Hsp90 on VDAC1 oligomerization, ubiquitination, and VDAC1 channel activity...
September 15, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37703626/increased-expression-of-ido1-is-associated-with-improved-survival-and-increased-number-of-tils-in-patients-with-high-grade-serous-ovarian-cancer
#18
JOURNAL ARTICLE
Inga Hoffmann, Mihnea P Dragomir, Nanna Monjé, Carlotta Keunecke, Catarina Alisa Kunze, Simon Schallenberg, Sofya Marchenko, Wolfgang D Schmitt, Hagen Kulbe, Jalid Sehouli, Ioana Elena Braicu, Paul Jank, Carsten Denkert, Silvia Darb-Esfahani, David Horst, Bruno V Sinn, Christine Sers, Philip Bischoff, Eliane T Taube
BACKGROUND: The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) plays a crucial role in regulating the immune system's response to tumors, but its exact role in cancer, especially in high-grade serous ovarian cancer (HGSOC), remains controversial. We aimed to investigate the prognostic impact of IDO1 expression and its correlation with tumor-infiltrating lymphocytes (TILs) in HGSOC. METHODS: Immunohistochemical (IHC) staining and bioimage analysis using the QuPath software were employed to assess IDO1 protein expression in a well-characterized cohort of 507 patients with primary HGSOC...
September 11, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37802557/retraction-notice-to-corrigendum-to-inhibition-of-hdacs-reduces-ewing-sarcoma-tumor-growth-through-ews-fli1-protein-destabilization-neoplasia-31-2022-100805
#19
Gloria Pedot, Joana Graça Marques, Philip P Ambühl, Marco Wachtel, Stephanie Kasper, Quy A Ngo, Felix K Niggli, Beat W Schäfer
No abstract text is available yet for this article.
October 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37802556/retraction-notice-to-inhibition-of-hdacs-reduces-ewing-sarcoma-tumor-growth-through-ews-fli1-protein-destabilization-neoplasia-27-2022-100784
#20
Gloria Pedot, Joana Graça Marques, Philip P Ambühl, Marco Wachtel, Stephanie Kasper, Quy A Ngo, Felix K Niggli, Beat W Schäfer
No abstract text is available yet for this article.
October 2023: Neoplasia: An International Journal for Oncology Research
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