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Journals Transplant Infectious Disease ...

Transplant Infectious Disease : An Official Journal of the Transplantation Society

https://read.qxmd.com/read/36929619/high-titer-post-vaccine-covid-19-convalescent-plasma-for-immunocompromised-patients-during-the-first-omicron-surge
#1
JOURNAL ARTICLE
Ralph Tayyar, Lisa Kanata Wong, Alex Dahlen, Elaine Shu, Suchitra Pandey, Anne Y Liu
BACKGROUND: Transplant and hematologic malignancy patients have high Coronavirus disease 2019 (COVID-19) mortality and impaired vaccination responses. Omicron variant evades several monoclonal antibodies previously used in immunocompromised patients. Polyclonal COVID-19 convalescent plasma (CCP) may provide broader neutralizing capacity against new variants at high titers. Vaccination increases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) titer in convalescent donors. METHODS: We conducted a retrospective chart review of hospitalized immunocompromised patients with COVID-19 who received high-titer CCP during the first omicron surge, collected from vaccinated donors within 6 months of pre-omicron COVID-19...
March 16, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36929539/invasive-aspergillosis-in-liver-transplant-recipients
#2
REVIEW
Cléa Melenotte, Vishukumar Aimanianda, Monica Slavin, José María Aguado, Darius Armstrong-James, Yee-Chun Chen, Shahid Husain, Christian Van Delden, Faouzi Saliba, Agnès Lefort, Francoise Botterel, Olivier Lortholary
BACKGROUND: Liver transplantation is increasing worldwide with underlying pathologies dominated by metabolic and alcoholic diseases in developed countries. METHODS: We provide a narrative review of invasive aspergillosis (IA) in liver transplant (LT) recipients. We searched PubMed and Google Scholar for references without language and time restrictions. RESULTS: The incidence of IA in LT recipients is low (1.8%), while mortality is high (∼50%)...
March 16, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36908212/adenovirus-infection-diagnosed-by-metagenomic-next-generation-sequencing-after-haploidentical-hematopoietic-stem-cell-transplantation-a-multicenter-study-in-china
#3
JOURNAL ARTICLE
Qiong Wu, Yanjun Wu, Ye Zhao, Yanming Zhang, Junjie Cao, Depei Wu, Juying Zhou, Feng Chen
OBJECTIVE: This study aims to observe and analyze the clinical characteristics and prognosis of adenovirus (ADV) infection diagnosed by metagenomic next-generation sequencing (mNGS) after haploidentical hematopoietic stem cell transplantation (Haplo-HSCT), which was performed following Beijing Protocol. METHODS: The clinical data of patients who developed ADV infection diagnosed by mNGS after Haplo-HSCT between January 2019 and March 2021, recorded in three transplantation centers, were retrospectively analyzed...
March 12, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36884207/association-between-pirche-ii-scores-and-de-novo-allosensitization-after-reduction-of-immunosuppression-during-sars-cov-2-infection-in-kidney-transplant-recipients
#4
JOURNAL ARTICLE
Kai Castrezana-Lopez, Ronja Malchow, Jakob Nilsson, Sanna M Kokkonen, Elena Rho, Seraina von Moos, Thomas F Mueller, Thomas Schachtner
BACKGROUND: Before the availability of mRNA vaccines, many transplant centers chose to significantly reduce maintenance immunosuppression in kidney transplant recipients (KTRs) with SARS-CoV-2 infection. The extent to which this increases the risk of allosensitization is unclear. METHODS: In this observational cohort study, we analyzed 47 KTRs from March 2020 to February 2021 who underwent substantial reduction of maintenance immunosuppression during SARS-CoV-2 infection...
March 8, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36882963/pneumocystis-prophylaxis-in-french-heart-transplant-centers-a-nationwide-survey
#5
LETTER
Dahlia Aggoun, Alexandre Bleibtreu, Eva Desiré, Lucien Lecuyer, Pascal Leprince, Shaida Varnous, Guillaume Coutance, Mickael Lescroart
No abstract text is available yet for this article.
March 7, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36880576/validation-of-the-increment-sot-cpe-score-in-a-large-cohort-of-liver-transplant-recipients-with-carbapenem-resistant-enterobacterales-infection
#6
JOURNAL ARTICLE
Matteo Rinaldi, Cecilia Bonazzetti, Mena Gallo, Giuseppe Ferraro, Maristela Freire, Débora Raquel Benedita Terrabuio, Francesco Tandoi, Renato Romagnoli, Francesco Giuseppe De Rosa, Alessandra Mularoni, Alberto Ferrarese, Patrizia Burra, Marcia Halpern, Elizabeth Balbi, Jacques Simkins, Lilian Abbo, Ignacio Morrás, Mireia Cantero, Laura Alagna, Alessandra Bandera, Wanessa Trinidade Clemente, Maricela Valerio, Ainhoa Fernández, Patricia Muñoz, Liran Statlender, Dafna Yahav, Luis Fernando Aranha Camargo, Evelyne Santana Girão, Paolo Grossi, Pierluigi Viale, Stefania Curti, Maddalena Giannella
BACKGROUND: Management of infections due to carbapenemase-resistant Enterobacterales (CRE) in solid organ transplant (SOT) recipients remains a difficult challenge. The INCREMENT-SOT-CPE score has been specifically developed from SOT recipients to stratify mortality risk, but an external validation is lacking. METHODS: Multicenter retrospective cohort study of liver transplant (LT) recipients colonized with CRE infection who developed infection after transplant over 7-year period...
March 7, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36880572/successful-restoration-of-protective-immunity-against-measles-mumps-and-rubella-following-mmr-vaccination-in-adult-hematopoietic-cell-transplant-recipients
#7
JOURNAL ARTICLE
Rick Y Lin, Anthony D Anderson, Michele I Morris, Mohammed Raja, Krishna V Komanduri, Jose F Camargo
BACKGROUND: The optimal number of doses as well as the role for measurement of postvaccination titers after measles, mumps, rubella (MMR) vaccination in adult hematopoietic cell transplantation (HCT) recipients remains unknown. METHODS: In the present study, we assessed humoral immunity against measles, mumps and rubella before and after MMR vaccination in 187 adults who received at least one dose of the MMR vaccine after HCT. RESULTS: Among those with baseline titers, posttransplant prevaccination seroprotection rates were 56%, 30%, and 54% for measles, mumps, and rubella, respectively; and significantly lower in allogeneic versus autologous HCT recipients for measles (39% vs...
March 7, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36879517/a-worldwide-survey-on-perioperative-antimicrobial-prophylaxis-for-heart-transplantation-from-theory-to-clinical-practice
#8
JOURNAL ARTICLE
Elena Seminari, Giulia Sofia Ladini, Marta Colaneri, Jennifer Chow, Raffaele Bruno
BACKGROUND: The aim of our survey was to analyze the current attitudes toward antimicrobial prophylaxis in heart transplanting centers worldwide. METHODS: The survey was composed of a total of 50 questions, it consisted of four different sections as follows. The first section collected physicians' personal data and centers' general characteristics, second assessed the approach to patients colonized with multidrug-resistant organisms (MDROs), while the third consisted of the infection risk related to cardiovascular devices, and antimicrobial treatment data, the last focused on donor's colonization...
March 6, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36879496/successful-bilateral-lung-transplantation-from-a-recent-sars-cov-2-pcr-positive-donor
#9
LETTER
Soma S S K Jyothula, Jayeshkumar Patel, Abhay Dhand
No abstract text is available yet for this article.
March 6, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36864824/phage-therapy-in-a-lung-transplant-recipient-with-cystic-fibrosis-infected-with-multidrug-resistant-burkholderia-multivorans
#10
JOURNAL ARTICLE
Ghady Haidar, Benjamin K Chan, Shu-Ting Cho, Kailey Hughes Kramer, Hayley R Nordstrom, Nathan R Wallace, Madison E Stellfox, Mische Holland, Ellen G Kline, Jennifer M Kozar, Silpa D Kilaru, Joseph M Pilewski, John J LiPuma, Vaughn S Cooper, Ryan K Shields, Daria Van Tyne
BACKGROUND: There is increased interest in bacteriophage (phage) therapy to treat infections caused by antibiotic-resistant bacteria. A lung transplant recipient with cystic fibrosis and Burkholderia multivorans infection was treated with inhaled phage therapy for 7 days before she died. METHODS: Phages were given via nebulization through the mechanical ventilation circuit. Remnant respiratory specimens and serum were collected. We quantified phage and bacterial deoxyribonucleic acid (DNA) using quantitative polymerase chain reaction, and tested phage neutralization in the presence of patient serum...
March 2, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36864672/use-of-live-viral-vaccines-after-hct-still-a-lot-to-learn
#11
EDITORIAL
Paula Moreira da Silva Sabaini, Clarisse M Machado
Revaccination program after HCT is necessary due to the loss of lifelong immunity acquired by previous vaccination or infections. The program is complex and even in a favourable scenario, it takes more than 2 years to be completed. As the complexity of HCT increases (alternative donors, diversity of monoclonal antibodies), studies evaluating the response to vaccination in this population are welcome, especially those that evaluate live attenuated vaccines given their scarcity. Furthermore, measles, mumps, rubella and even yellow fever, and poliomyelitis outbreaks have perplexed infectious diseases clinicians and epidemiologists globally, most of them due to the decline in vaccination coverage rates in children and adults, because of the growth of antivaccine movements around the world...
March 2, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36864666/optn-required-sars-cov-2-lower-respiratory-testing-for-lung-donors-striking-the-balance
#12
LETTER
Sarah E Booker, Courtney Jett, Cole Fox, Judith A Anesi, Gerald J Berry, Kelly E Dunn, Cynthia E Fisher, Jason D Goldman, Chak-Sum Ho, Michelle Kittleson, Dong Heun Lee, Deborah J Levine, Charles C Marboe, Gary Marklin, Carlos Martinez, Raymund R Razonable, Marty T Sellers, Sarah Taimur, Helen S Te, Anil J Trindade, R Patrick Wood, Ann E Woolley, Lorenzo Zaffiri, David K Klassen, Marian G Michaels, Stephanie M Pouch, Lara Danziger-Isakov, Ricardo M La Hoz
No abstract text is available yet for this article.
March 2, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36864665/isavuconazole-as-an-alternative-for-antifungal-prophylaxis-in-patients-with-hematological-malignancies-is-the-signal-sufficient-to-support-clinical-practice
#13
EDITORIAL
Armelle Perez-Cortes Villalobos, Eric J Bow
No abstract text is available yet for this article.
March 2, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36864644/use-of-tecovirimat-for-mpox-infection-followed-by-jynneos-vaccination-postinfection-in-a-liver-transplant-recipient
#14
JOURNAL ARTICLE
Jae Hyung Jung, Eric Bhaimia, Nancy Reau
No abstract text is available yet for this article.
March 2, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36856447/incidence-of-breakthrough-fungal-infections-on-isavuconazole-prophylaxis-compared-to-posaconazole-and-voriconazole
#15
JOURNAL ARTICLE
Sara A Scott, Cory Perry, Zahra Mahmoudjafari, Grace A Martin, Samuel Boyd, Jeffrey Thompson, Beth Thomas
BACKGROUND: Invasive fungal infections (IFIs) are a common infectious complication during the treatment of acute myeloid leukemia (AML), high-risk myelodysplastic syndrome (MDS) or post hematopoietic cell transplantation (HCT). For these patients, the National Comprehensive Cancer Network recommends posaconazole or voriconazole for IFI prophylaxis. In clinical practice, however, there has been increased use of isavuconazole due to favorable pharmacokinetic and pharmacodynamic parameters despite limited data for this indication...
March 1, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36856443/mortality-due-to-carbapenemase-producing-gnb-in-transplantation-are-risk-scores-useful
#16
EDITORIAL
Rafael San-Juan, José María Aguado
No abstract text is available yet for this article.
March 1, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36856346/transplantation-and-immigration-comparing-infectious-complications-and-outcomes-between-foreign-born-and-us-born-kidney-transplant-recipients-in-minnesota
#17
JOURNAL ARTICLE
Eloy E Ordaya, Megan Shaughnessy, Baila Elkin, Rachel L Husmann, Jacob C Stauffer, Elizabeth M Luengas, Bickey H Chang, Katelyn M Tessier, Patricia F Walker, William M Stauffer
BACKGROUND: Foreign-born kidney transplant recipients (FBKTRs) are at increased risk for reactivation of latent infections that may impact outcomes. We aimed to compare the etiology of infections and outcomes between FBKTR and United States KTRs (USKTR). METHODS: We performed a retrospective study of patients who underwent kidney transplantation between January 1, 2014 and December 31, 2018 at two transplant centers in Minnesota. Frequency and etiology of infections as well as outcomes (graft function, rejection, and patient survival) at 1-year post-transplant between FBKTR and USKTR were compared...
March 1, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36852755/medlar-bodies-of-chromoblastomycosis
#18
JOURNAL ARTICLE
Kiran Gajurel, William A Ahrens
No abstract text is available yet for this article.
February 28, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36852753/immunomodulators-for-severe-coronavirus-disease-2019-in-transplant-patients-do-they-increase-the-risk-of-secondary-infection
#19
JOURNAL ARTICLE
Maria A Mendoza, Nischal Ranganath, Supavit Chesdachai, Zachary A Yetmar, Raymund Razonable, Omar Abu Saleh
BACKGROUND: Current guidelines recommend immunomodulators, tocilizumab or baricitinib, for the management of severe coronavirus disease-2019 (COVID-19) in patients with increasing oxygen requirements. Given their immunosuppressive effects, there is a concern for higher rates of infection among transplant recipients. METHODS: A retrospective cohort study of transplant patients with severe COVID-19 between April 2020 and January 2022 was performed at the Mayo Clinic...
February 28, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36847419/-saving-lives-with-nirmatrelvir-ritonavir-one-transplant-patient-at-a-time
#20
JOURNAL ARTICLE
Katherine A Belden, Sarah Yeager, Jamie Schulte, Maria P Martinez Cantarin, Sean Moss, Tricia Royer, Dagan Coppock
BACKGROUND: Solid organ transplant (SOT) recipients are at risk of complications from COVID-19. Nirmatrelvir/ritonavir (Paxlovid) can reduce mortality from COVID-19 but is contraindicated in patients receiving calcineurin inhibitors (CI), which depend on cytochrome p4503A (CY3PA). In this study, we aim to show the feasibility of nirmatrelvir/ritonavir administration to SOT recipients receiving CI with coordination of medication management and limited tacrolimus trough monitoring. METHODS: We reviewed adult SOT recipients treated with nirmatrelvir/ritonavir from 4/14 to 11/1/2022 and assessed for changes in tacrolimus trough and serum creatinine after therapy...
February 27, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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