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Transplant Infectious Disease: An Official Journal of the Transplantation Society

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https://read.qxmd.com/read/30776166/safety-and-efficacy-of-methenamine-hippurate-for-the-prevention-of-recurrent-urinary-tract-infections-in-adult-renal-transplant-recipients-a-single-center-retrospective-study
#1
Ian Hollyer, Francesca Varias, Bing Ho, Michael Ison
BACKGROUND: Recurrent urinary tract infections (UTI) are an important cause of morbidity and mortality in renal transplant recipients (RTR). METHODS: In this retrospective study we gathered clinical data from patients prescribed methenamine hippurate to prevent recurrent UTI pre- and post-intervention. Thirty-eight RTR ≥18 years old at Northwestern Memorial Hospital from 2006-2017 were included in the final analysis. RESULTS: The median and range for follow-up days were 365 (299-365) pre- vs 314 (105-365) post-methenamine...
February 18, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30756465/effectiveness-of-acyclovir-prophylaxis-against-varicella-zoster-virus-disease-after-allogeneic-hematopoietic-cell-transplantation-a-systematic-review-and-meta-analysis
#2
Yuko Wada-Shimosato, Reo Tanoshima, Kanako Hiratoko, Masanobu Takeuchi, Shin-Ichi Tsujimoto, Norio Shiba, Shinya Ito, Takeharu Yamanaka, Shuichi Ito
BACKGROUND: Varicella zoster virus (VZV) disease is a common complication after hematopoietic cell transplantation (HCT). The mortality rate for disseminated VZV infection is 34%. Acyclovir has been used for the prophylaxis of VZV disease after HCT, but the effectiveness of prophylaxis is controversial. We conducted a meta-analysis of the incidence of VZV disease within the first one year after acyclovir prophylaxis had been discontinued and assessed the risk of VZV disease during acyclovir prophylaxis...
February 13, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30756453/fatal-disseminated-visceral-varicella-zoster-virus-infection-in-a-renal-transplant-recipient
#3
Michael J Loftus, Michelle K Yong, Scott Wilson, Anton Y Peleg
We report a case of fatal disseminated varicella zoster virus (VZV) with delayed-onset rash in a 66-year-old female more than two years following uncomplicated deceased donor renal transplantation. Whilst on a stable regimen of maintenance immunosuppression, the patient presented with chest and abdominal pain with concomitant hepatitis and pancreatitis. After pursuing multiple other potential causes of her symptoms, the correct diagnosis of VZV was only suspected after the development of a widespread vesicular rash - 11 days after her initial symptoms...
February 12, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30753747/cytokine-profile-in-lung-transplant-recipients-with-aspergillus-spp-colonization
#4
Sabina Herrera, Wajiha Gohir, Farid Foroutan, Claire Aguilar, Stephen Juvet, Tereza Martinu, Deepali Kumar, Atul Humar, Coleman Rotstein, Shaf Keshavjee, Lianne G Singer, Shahid Husain
We studied cytokine patterns of LTRs with Aspergillus spp colonization who did not progress to IPA in the absence of antifungal prophylaxis. Retrospective, single center case-control study. BAL samples were analyzed for cytokines. Patients with Aspergillus spp. in BAL who didn't receive prophylaxis and didn't develop IPA were compared to LTRs with Aspergillus spp that received prophylaxis, LTRs with IPA and controls. 21 patients with Aspergillus colonization who did not develop IPA, 7 patients with suspected IPA who received prophylaxis, 4 IPA and 19 controls were included...
February 12, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30737868/the-impact-of-a-multimodal-approach-to-vancomycin-discontinuation-in-hematopoietic-stem-cell-transplant-recipients-hsct-with-febrile-neutropenia-fn
#5
Sarah Perreault, Dayna McManus, Noffar Bar, Francine Foss, Lohith Gowda, Iris Isufi, Stuart Seropian, Maricar Malinis, Jeffrey E Topal
BACKGROUND: Current guidelines recommend adding vancomycin to empiric treatment of FN in patients who meet specific criteria. After 48 hours, the guidelines recommend discontinuing vancomycin if resistant Gram-positive organisms are not identified. Based on these recommendations, a vancomycin stewardship team defined criteria for discontinuation of vancomycin at 48 hours and increased surveillance of vancomycin usage through a multimodal approach. The purpose of this retrospective analysis is to assess the impact of this multimodal approach on the discontinuation of empiric vancomycin at 48 hours in FN...
February 8, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30730102/clinical-utility-of-leflunomide-for-bk-polyomavirus-associated-nephropathy-in-kidney-transplant-recipients-a-multicenter-retrospective-study
#6
Nicolas Keller, Simon Duquennoy, Anne Conrad, Samira Fafi-Kremer, Emmanuel Morelon, Nicolas Bouvier, Bruno Moulin, Bruno Hurault De Ligny, Sophie Caillard
BACKGROUND: BK polyomavirus associated nephropathy (BKPyVAN) is a significant clinical issue in kidney transplant (KT) recipients. No specific therapy is currently available, although treatment with leflunomide may be part of the therapeutic strategy. Here, we sought to examine the impact of leflunomide on the evolution of BKPyVAN. METHODS: This was an observational retrospective study conducted in three French transplant centers. KT recipients who developed BKPyVAN and received leflunomide after failure of other treatment approaches were deemed eligible...
February 7, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30714284/cladophialophora-bantiana-brain-abscess-in-lung-transplant-recipient
#7
LETTER
Sora Yasri, Viroj Wiwanitkit
we would like to discuss and share ideas on the publication entitle "Brain abscesses caused by Cladophialophora bantiana in a lung transplant patient: A case report and review of the literature ." Gschwend et al. mentioned that "This is the second reported case of C. bantiana brain abscesses in a lung transplant recipient, to our knowledge, who experienced a long survival period with medical antifungal treatment alone.1 ". This article is protected by copyright. All rights reserved.
February 3, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30712328/effect-of-polyoma-viremia-on-three-year-allograft-kidney-function
#8
Elias David-Neto, Fabiana Agena, Daisa Silva Ribeiro David, Flavio Jota de Paula, Ligia Camera Pierrotti, Maria Cristina Domingues Fink, Luiz Sergio Fonseca de Azevedo
BACKGROUND: Polyoma viremia is associated with damage to renal tubular and urothelial cells. This may imply that a certain level of viremia, even cleared thereafter, could be associated with long-term renal dysfunction. METHODS: We, retrospectively, analyzed 390 first renal transplants adult recipients (≥18y) who were monitored for BK viremia in the first 12 months and evaluated estimated GFR (MDRD-4 equation) at one month and at the last follow-up (959±392 days)...
February 3, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30693636/infections-and-associated-behaviours-among-deceased-organ-donors-informing-the-assessment-of-risk
#9
Katy L Davison, Ines Ushiro-Lumb, Marcus Lawrance, Patrick Trotter, James J Powell, Susan R Brailsford
BACKGROUND: For infectious disease risk assessment among deceased organ donors, pre-donation clinical, microbiological and behavioural information are reviewed, however, uncertainty may arise due to false negative screening results of recently acquired infections. METHOD: The burden of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV), and residual risks (RR) of undetected virus was estimated, with the impact of more sensitive screening...
January 29, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30689300/use-of-maintenance-therapy-and-incidence-of-recurrent-cytomegalovirus-dnaemia-among-allogeneic-hematopoietic-cell-transplant-recipients
#10
Jose F Camargo, Anthony D Anderson, Rossana Rosa, Erik Kimble, Krishna V Komanduri, Michele I Morris
BACKGROUND: Cytomegalovirus (CMV) infection is the most common infection following hematopoietic cell transplantation (HCT). Preemptive antiviral therapy is highly effective at halting viral replication and preventing CMV disease; however, recurrence rates after clearance of CMV DNAemia are high (50-70%). Current treatment guidelines recommend maintenance therapy after initial clearance. Yet, the effectiveness of this intervention to prevent recurrence is not well defined. OBJECTIVES: We aimed to assess the impact of maintenance therapy on the probability of recurrent CMV in allogeneic HCT recipients with early CMV reactivation...
January 28, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30689291/bacteremias-following-autologous-stem-cell-transplantation-for-multiple-myeloma-risk-factors-and-outcomes
#11
Meera Mohan, Sandra Susanibar-Adaniya, Amy Buros, Juan Carlos Crescencio Rico, Mary J Burgess, Katherine Lusardi, Faith Davies, Gareth Morgan, Frits Vanrhee, Maurizio Zangari, Carolina Schinke, Sharmilan Thanendrarajan, Atul Kothari
BACKGROUND: Autologous stem cell transplantation (ASCT) is a commonly used treatment for multiple myeloma (MM). This retrospective cohort study characterizes the risk factors and outcomes associated with bacteremia following ASCT at a single center. METHODS: We conducted a retrospective analysis in subjects who underwent ASCT for multiple myeloma and other malignancies from May 2014 to March 2015 at a single center. The control cohort included all subjects undergoing ASCT in the same time period who did not develop bacteremia...
January 28, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30689283/outcomes-of-norovirus-diarrheal-infections-and-clostridioides-difficile-infections-in-kidney-transplant-recipients-a-single-center-retrospective-study
#12
Stacey Rolak, Sarah Di Bartolomeo, Margaret R Jorgenson, Christopher M Saddler, Tripti Singh, Brad C Astor, Sandesh Parajuli
Recently, Norovirus has been recognized as an important cause of diarrheal infection in kidney transplant recipients (KTRs). We assessed the risk factors and outcomes of Norovirus diarrheal infections (NVDI) and Clostridioides difficile infection (CDI) on graft and patient survival following kidney transplant (KT). We examined KTRs transplanted at our center between 1994 and 2014, and compared those who suffered from NVDI and CDI with patients that did not develop either infection. Each patient with NVDI or CDI was matched with 5 controls based on time from transplant...
January 28, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30667578/potential-mortality-benefit-from-secondary-prophylaxis-following-cmv-treatment-completion-may-be-due-to-confounding-by-transplant-organ-type
#13
LETTER
Bradley J Gardiner, Jennifer K Chow, David R Snydman
We have read with interest the paper by Serrano-Alonso et al. regarding outcomes in solid organ transplant recipients who did and did not receive secondary prophylaxis (SP) following a treated episode of CMV disease. This study included 126 heart, liver and kidney transplant recipients of whom 103 (83%) received SP for a mean duration of 49 ± 29 days. Consistent with our recently published study and others, there was no overall benefit in terms of CMV relapse with the use of SP. Death, however, occurred in 6/103 (6%) patients who received SP compared to 6/21 (29%) who did not...
January 22, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30663838/failure-to-respond-to-ribavirin-despite-elevated-intra-erythrocyte-zinc-level-in-transplant-patients-with-chronic-hepatitis-e-virus-infection
#14
LETTER
Olivier Marion, Florence Abravanel, Jacques Izopet, Nassim Kamar
Ribavirin was showed to be very effective for treating chronic hepatitis E virus (HEV) infection in immunosuppressed patients, especially in solid-organ-transplant patients in whom it allows to achieve a sustained virological response in nearly 90% of them (1) . However, in some few patients, despite a retreatment by ribavirin for a longer period or adding other anti-viral drugs such as sofosbuvir, HEV RNA remains detectable (2) . Recently, zinc salt, which is known to reduce infections induced by viruses, was tested in vitro against HEV (3) (4) ...
January 21, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30656802/impact-of-cumulative-steroid-dose-on-infectious-diseases-after-allogenic-hematopoietic-stem-cell-transplantation
#15
Mizuki Watanabe, Junya Kanda, Masakatsu Hishizawa, Tadakazu Kondo, Kouhei Yamashita, Akifumi Takaori-Kondo
BACKGROUND: Systemic steroid is used to treat various transplant-related complications after allogenic hematopoietic stem cell transplantation (allo-HSCT). However, measures to evaluate its impact on infections are still limited. Hence, we examined the cumulative steroid dose used within 30 days after transplant as a predictor of future risk of infections. METHODS: This study included 226 patients who underwent their first allo-HSCT at Kyoto University Hospital between 2005 and 2015...
January 17, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30636363/therapeutic-drug-concentrations-of-isavuconazole-following-the-administration-of-isavuconazonium-sulfate-capsules-via-gastro-jejunum-tube-a-case-report
#16
Meagan L Adamsick, Ramy H Elshaboury, Thais Gift, Michael K Mansour, Camille N Kotton, Ronak G Gandhi
Invasive fungal infections are a common complication in immunocompromised patients, such as organ transplant recipients. Isavuconazole is a broad-spectrum azole antifungal for the treatment of aspergillosis and mucormycosis. The package insert for isavuconazole recommends against opening the capsule for administration through enteral feeding tubes. We describe the case of a 68-year-old man with a complex post-lung transplant course receiving isavuconazole for presumed invasive aspergillosis (bronchial alveolar lavage galactomannan index of >3...
January 13, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30615227/direct-acting-antiviral-agents-for-liver-transplant-recipients-with-recurrent-genotype-1-hepatitis-c-virus-infection-systematic-review-and-meta-analysis
#17
REVIEW
Jiaye Liu, Buyun Ma, Wanlu Cao, Meng Li, Wichor M Bramer, Maikel P Peppelenbosch, Qiuwei Pan
BACKGROUND: Comprehensive evaluation of safety and efficacy of different combinations of direct-acting antivirals (DAAs) in liver transplant recipients with genotype 1 (GT1) hepatitis C virus (HCV) recurrence remains limited. Therefore, we performed this systematic review and meta-analysis in order to evaluate clinical outcome of DAA treatment in liver transplant patients with HCV GT1 recurrence. METHODS: Studies were included if they contained information of 12 weeks sustained virologic response (SVR12) after DAA treatment completion as well as treatment related complications for liver transplant recipients with GT1 HCV recurrence...
January 7, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30597699/successful-lung-transplantation-for-chronic-mycobacterium-abscessus-infection-in-advanced-cystic-fibrosis-a-case-series
#18
Daan Raats, Natalie Lorent, Veroniek Saegeman, Robin Vos, Jakko Van Ingen, Geert Verleden, Dirk Van Raemdonck, Lieven Dupont
Pulmonary Mycobacterium abscessus infection in cystic fibrosis (CF) patients is difficult to treat and considered a contra-indication for lung transplantation in most centers. We present four CF patients with chronic pulmonary M. abscessus infection, in whom lung transplantation was performed. Through intensive treatment before transplantation, we achieved control of the infection in all but one patient. After a mean of 16 months of follow up, three patients are doing well, without evidence of local or disseminated recurrence...
December 30, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30586222/atraumatic-splenic-rupture-following-ivig-for-parvovirus-b19-pure-red-cell-aplasia-post-renal-transplant
#19
Mark Tiong, Joshua Casan, Catriona McLean
Parvovirus B19 (PB19) infection is an uncommon but well reported cause of anemia in solid organ transplant recipients. Persistent cases may be treated with intravenous immunoglobulin (IVIg). We report a case of PB19 associated anemia in a renal transplant recipient who subsequently developed an atraumatic splenic rupture after administration of IVIg. Histological examination of the spleen after splenectomy showed evidence of previous extramedullary erythropoiesis (EMH) with the unusual finding of parvovirus infected cells...
December 26, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30585691/a-case-of-verruconis-gallopava-infection-in-a-heart-transplant-recipient-successfully-treated-with-posaconazole
#20
Conor Moran, Nathan L Delafield, Grace Kenny, Kara L Asbury, Brandon T Larsen, Karen L Lambert, Roberto L Patron
Verruconis gallopava is an environmental dematiaceous fungus that is recognized increasingly as a cause of human disease, especially for immunocompromised persons. Infection can range from superficial and localized lesions to pulmonary involvement and disseminated disease, including central nervous system abscesses. Optimal therapy is undefined. We report a patient post cardiac transplant who had pulmonary infection with V gallopava and was treated successfully with posaconazole. This article is protected by copyright...
December 26, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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