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Journals Clinical Immunology : the Offi...

Clinical Immunology : the Official Journal of the Clinical Immunology Society

https://read.qxmd.com/read/38710348/targeted-metabolomics-combined-with-machine-learning-to-identify-and-validate-new-biomarkers-for-early-sle-diagnosis-and-disease-activity
#21
JOURNAL ARTICLE
Jiabin Liang, Zeping Han, Jie Feng, Fangmei Xie, Wenfeng Luo, Hanwei Chen, Jinhua He
BACKGROUND: The early diagnosis of systemic lupus erythematosus (SLE) and the assessment of disease activity progression remain a great challenge. Targeted metabolomics has great potential to identify new biomarkers of SLE. METHODS: Serum from 44 healthy participants and 89 SLE patients were analyzed using HM400 high-throughput targeted metabolomics. Machine learning (ML) with seven learning models and trained the model several times iteratively selected the two best prediction model in a competitive way, which were independent validated by enzyme-linked immunosorbent (ELISA) with 90 SLE patients...
May 4, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38701960/complement-system-is-overactivated-in-patients-with-iga-nephropathy-after-covid-19
#22
JOURNAL ARTICLE
Wei-Yi Guo, Guo-Qin Wang, Ling-Qiang Kong, Li-Jun Sun, Xiao-Yi Xu, Wen-Rong Cheng, Hong-Rui Dong, Hong Cheng
IgA nephropathy (IgAN), which has been confirmed as a complement mediated autoimmune disease, is also one form of glomerulonephritis associated with COVID-19. Here, we aim to investigate the clinical and immunological characteristics of patients with IgAN after COVID-19. The level of plasma level of C5a (p < 0.001), soluble C5b-9 (p = 0.018), FHR5 (p < 0.001) were all significantly higher in Group CoV (33 patients with renal biopsy-proven IgAN experienced COVID-19) compared with Group non-CoV (44 patients with IgAN without COVID-19), respectively...
May 1, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38697554/absence-of-atm-leads-to-altered-nk-cell-function-in-mice
#23
JOURNAL ARTICLE
Daniela Angela Covino, Maria Giovanna Desimio, Alessandro Giovinazzo, Bruna Sabino Pinho de Oliveira, Matilde Merolle, Daniela Marazziti, Manuela Pellegrini, Margherita Doria
Ataxia-telangiectasia (A-T) is a rare disorder caused by genetic defects of A-T mutated (ATM) kinase, a key regulator of stress response, and characterized by neurodegeneration, immunodeficiency, and high incidence of cancer. Here we investigated NK cells in a mouse model of A-T (Atm-/- ) showing that they are strongly impaired at killing tumor cells due to a block of early signaling events. On the other hand, in Atm-/- littermates with thymic lymphoma NK cell cytotoxicity is enhanced as compared with ATM-proficient mice, possibly via tumor-produced TNF-α...
April 30, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38692449/animal-models-of-studying-the-pathogenesis-of-multi-organ-tissue-damage-in-lupus
#24
REVIEW
Xuefei Wang, Guo-Min Deng
Moderate-to-severe systemic lupus erythematosus (SLE) is characterized by extensive autoantibody deposition and persistent autoinflammation. As the existing animal models are limited in accurately reproducing the pathological characteristics of human SLE, we introduced a novel animal model simulating multi-organ autoinflammation through intra-organ injections. The model closely mimicked key features of SLE, including IgG deposition, inflammation, and tissue damage. The model could be used to assess the roles of IgG, immune cells, cytokines, and Fc gamma receptor (FcγR) in the pathogenesis of autoinflammation...
April 29, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38663494/eosinophil-peroxidase-promotes-bronchial-epithelial-cells-to-secrete-asthma-related-factors-and-induces-the-early-stage-of-airway-remodeling
#25
JOURNAL ARTICLE
Liping Xu, Xuemei Huang, Zhangrong Chen, Meiling Yang, Jingmin Deng
Asthma is a heterogeneous disease characterized by chronic airway inflammation, reversible airflow limitation, and airway remodeling. Eosinophil peroxidase (EPX) is the most abundant secondary granule protein unique to activated eosinophils. In this study, we aimed to illustrate the effect of EPX on the epithelial-mesenchymal transition (EMT) in BEAS-2B cells. Our research found that both EPX and ADAM33 were negatively correlated with FEV1/FVC and FEV1%pred, and positively correlated with IL-5 levels. Asthma patients had relatively higher levels of ADAM33 and EPX compared to the healthy control group...
April 23, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38663493/streptococcus-pneumoniae-endopeptidase-o-induces-trained-immunity-against-numerous-pathogen-infections-a-key-role-for-g-csf
#26
JOURNAL ARTICLE
Wenlong Xu, Yuan Yuan, Zhaoche Shu, Ting Guo, Bichen Liu, Jiangming Xiao, Lian Li, Yibin Yin, Xuemei Zhang
Antibiotic resistance and the surge of infectious diseases during the pandemic present significant threats to human health. Trained immunity emerges as a promising and innovative approach to address these infections. Synthetic or natural fungal, parasitic and viral components have been reported to induce trained immunity. However, it is not clear whether bacterial virulence proteins can induce protective trained immunity. Our research demonstrates Streptococcus pneumoniae virulence protein PepO, is a highly potent trained immunity inducer for combating broad-spectrum infection...
April 23, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38648959/potential-therapies-targeting-metabolic-pathways-in-systemic-lupus-erythematosus
#27
REVIEW
Ryo Hisada, Michihito Kono
The pathophysiology of systemic lupus erythematosus (SLE) is multifactorial and involves alterations in metabolic pathways, including glycolysis, lipid metabolism, amino acid metabolism, and mitochondrial dysfunction. Increased glycolysis in SLE T cells, which is associated with elevated glucose transporter 1 expression, suggests targeting glucose transporters and hexokinase as potential treatments. Abnormalities in lipid metabolism, particularly in lipid rafts and enzymes, present new therapeutic targets. This review discusses how changes in glutaminolysis and tryptophan metabolism affect T-cell function, suggesting new therapeutic interventions, as well as mitochondrial dysfunction in SLE, which increases reactive oxygen species...
April 20, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38643891/cytof-analysis-revealed-platelet-heterogeneity-in-breast-cancer-patients-received-t-dm1-treatment
#28
JOURNAL ARTICLE
Jianli Ma, Yuheng Pang, Yuefeng Shang, Chufei Xie, Xiaoxue Xu, Liujia Chan, Zhiren Zhang, Wenjing Wang
T-DM1 (Trastuzumab Emtansine) belongs to class of Antibody-Drug Conjugates (ADC), where cytotoxic drugs are conjugated with the antibody Trastuzumab to specifically target HER2-positive cancer cells. Platelets, as vital components of the blood system, intricately influence the immune response to tumors through complex mechanisms. In our study, we examined platelet surface proteins in the plasma of patients before and after T-DM1 treatment, categorizing them based on treatment response. We identified a subgroup of platelets with elevated expression of CD63 and CD9 exclusively in patients with favorable treatment responses, while this subgroup was absent in patients with poor responses...
April 19, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38642784/relevance-of-acquired-t-cell-molecular-defects-in-the-immunopathogenesis-of-sle
#29
REVIEW
Florencia Rosetti, Iris K Madera-Salcedo, José C Crispín
Systemic lupus erythematosus (SLE) and other autoimmune diseases are thought to develop in genetically predisposed individuals when triggered by environmental factors. This paradigm does not fully explain disease development, as it fails to consider the delay between birth and disease expression. In this review, we discuss observations described in T cells from patients with SLE that are not related to hereditary factors and have therefore been considered secondary to the disease process itself. Here, we contextualize some of those observations and argue that they may represent a pathogenic layer between genetic factors and disease development...
April 18, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38642783/cutaneous-adverse-reactions-associated-with-covid-19-vaccines-current-evidence-and-potential-immune-mechanisms
#30
REVIEW
Po-Chien Wu, Wan-Chen Lin, Chuang-Wei Wang, Wen-Hung Chung, Chun-Bing Chen
As the number of vaccinated individuals has increased, there have been increasing reports of cutaneous hypersensitivity reactions. The main COVID-19 vaccines administered include messenger ribonucleic acid vaccines, non-replicating viral vector vaccines, inactivated whole-virus vaccines, and protein-based vaccines. These vaccines contain active components such as polyethylene glycol, polysorbate 80, aluminum, tromethamine, and disodium edetate dihydrate. Recent advances in understanding the coordination of inflammatory responses by specific subsets of lymphocytes have led to a new classification based on immune response patterns...
April 18, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38640985/t-cell-involvement-in-antiphospholipid-syndrome
#31
REVIEW
Maria G Tektonidou, Nikolaos I Vlachogiannis, Petros P Sfikakis
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by arterial and venous thrombosis, and obstetric complications in the presence of antiphospholipid antibodies (aPL), including lupus anticoagulant, anticardiolipin and anti-β2-glycoprotein I antibodies. APS manifests as single, often as recurrent events, and rarely as a catastrophic condition. Most studies of APS pathogenesis to date have focused on the prothrombotic role of aPL, while innate immune responses such as monocyte, complement and neutrophil activation have been also recognized as part of the thrombo-inflammatory cascade in APS...
April 18, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38636890/bone-marrow-cd8-trm-cells-induced-by-il-15-and-cd16-monocytes-contribute-to-hspc-destruction-in-human-severe-aplastic-anemia
#32
JOURNAL ARTICLE
Jie Long, Xing You, Qiong Yang, Song-Rong Wang, Ming Zhou, Wei Zhou, Caixia Wang, Huafeng Xie, Yuping Zhang, Shunqing Wang, Zhe-Xiong Lian, Liang Li
Idiopathic severe aplastic anemia (SAA) is a disease of bone marrow failure caused by T-cell-induced destruction of hematopoietic stem and progenitor cells (HSPCs), however the mechanism remains unclear. We performed single-cell RNA sequencing of PBMCs and BMMCs from SAA patients and healthy donors and identified a CD8+ T cell subset with a tissue residency phenotype (Trm) in bone marrow that exhibit high IFN-γ and FasL expression and have a higher ability to induce apoptosis in HSPCs in vitro through FasL expression...
April 16, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38636889/the-abnormal-signaling-of-the-b-cell-receptor-and-coreceptors-of-lupus-b-cells
#33
REVIEW
Stamatis-Nick C Liossis
It is easily understood that studying the physiology and pathophysiology of the BCRtriggered cascade is of importance, particularly in such diseases as systemic lupus erythematosus (SLE) that are considered by many as a "B cell disease". Even though B cells are not considered as the only players in lupus pathogenesis, and other immune and non-immune cells are certainly involved, it is the success of recent B celltargeting treatment strategies that ascribe a critical role to the lupus B cell.
April 16, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38631594/single-cell-sequencing-reveals-distinct-immune-cell-features-in-cutaneous-lesions-of-pemphigus-vulgaris-and-bullous-pemphigoid
#34
JOURNAL ARTICLE
Zhi Hu, Meiling Zheng, Ziyu Guo, Wenhui Zhou, Wenyu Zhou, Nan Yao, Guiying Zhang, Qianjin Lu, Ming Zhao
Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are two common subtypes of autoimmune bullous disease (AIBD). The key role of circulating autoreactive immune cells contributing to skin damage of AIBD has been widely recognized. Nevertheless, the immune characteristics in cutaneous lesions remain unclear. Here, we performed single-cell RNA sequencing (scRNA-seq) and single-cell VDJ sequencing (scRNA-seq) to generate transcriptional profiles for cells and T/B cell clonetype in skin lesions of BP and PV. We found that the proportions of NK&T, macrophages/ dendritic cells, B cells, and mast cells increased in BP and PV lesions...
April 15, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38621471/icos-agonist-vopratelimab-modulates-follicular-helper-t-cells-and-improves-b-cell-function-in-common-variable-immunodeficiency
#35
JOURNAL ARTICLE
Ali Sepahi, Hsi-En Ho, Prapti Vyas, Benjamin Umiker, Katalin Kis-Toth, Dmitri Wiederschain, Lin Radigan, Charlotte Cunningham-Rundles
Common variable immunodeficiency (CVID) is an immune defect characterized by hypogammaglobulinemia and impaired development of B cells into plasma cells. As follicular helper T cells (TFH ) play a central role in humoral immunity, we examined TFH cells in CVID, and investigated whether an inducible T cell co-stimulator (ICOS) agonist, vopratelimab, could modulate TFH , B cell interactions and enhance immunoglobulin production. CVID subjects had decreased TFH17 and increased TFH1 subsets; this was associated with increased transitional B cells and decreased IgG+ B and IgD- IgM- CD27+ memory B cells...
April 13, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38604255/defining-remission-in-childhood-onset-lupus-pres-endorsed-consensus-definitions-by-an-international-task-force
#36
JOURNAL ARTICLE
E M D Smith, A Aggarwal, J Ainsworth, E Al-Abadi, T Avcin, L Bortey, J Burnham, C Ciurtin, C M Hedrich, S Kamphuis, L Lambert, D M Levy, L Lewandowski, N Maxwell, E Morand, S Özen, C E Pain, A Ravelli, C Saad Magalhaes, C Pilkington, D Schonenberg-Meinema, C Scott, K Tullus, M W Beresford, B Goilav, N Goss, L Oni, S D Marks
OBJECTIVE: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. METHODS: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria. RESULTS: The Task Force proposed two definitions of remission: 'cSLE clinical remission on steroids (cCR)' and 'cSLE clinical remission off steroids (cCR-0)'...
April 9, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38599263/p75-ntr-cd64-neutrophils-promote-sepsis-induced-acute-lung-injury
#37
JOURNAL ARTICLE
Di Fu, Shan Gao, Jia-Nan Li, Yan-Hui Cui, Yan-Wei Luo, Yan-Jun Zhong, Qiao Li, Cong Luo, Ru-Ping Dai, Ru-Yi Luo, Zhao-Lan Hu
Patients suffering from sepsis-induced acute lung injury (ALI) exhibit a high mortality rate, and their prognosis is closely associated with infiltration of neutrophils into the lungs. In this study, we found a significant elevation of CD64+ neutrophils, which highly expressed p75 neurotrophin receptor (p75NTR ) in peripheral blood of mice and patients with sepsis-induced ALI. p75NTR+ CD64+ neutrophils were also abundantly expressed in the lung of ALI mice induced by lipopolysaccharide. Conditional knock-out of the myeloid lineage's p75NTR gene improved the survival rates, attenuated lung tissue inflammation, reduced neutrophil infiltration and enhanced the phagocytic functions of CD64+ neutrophils...
April 8, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38582251/wiskott-aldrich-syndrome-protein-wasp-deficient-th1-cells-promote-r-loop-driven-transcriptional-insufficiency-and-transcription-coupled-nucleotide-excision-repair-factor-tc-ner-driven-genome-instability-in-the-pathogenesis-of-t-cell-acute-lymphoblastic-leukemia
#38
JOURNAL ARTICLE
R Pradeep, Sudeshna Rakshit, Geetha Shanmugam, Melvin George, Koustav Sarkar
BACKGROUND: T-ALL is an aggressive hematological tumor that develops as the result of a multi-step oncogenic process which causes expansion of hematopoietic progenitors that are primed for T cell development to undergo malignant transformation and growth. Even though first-line therapy has a significant response rate, 40% of adult patients and 20% of pediatric patients will relapse. Therefore, there is an unmet need for treatment for relapsed/refractory T-ALL to develop potential targeted therapies...
April 4, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38582250/new-and-emerging-therapies-for-systemic-lupus-erythematosus
#39
REVIEW
Eleni Papachristodoulou, Vasileios C Kyttaris
Systemic Lupus Erythematosus (SLE) and lupus nephritis treatment is still based on non-specific immune suppression despite the first biological therapy for the disease having been approved more than a decade ago. Intense basic and translational research has uncovered a multitude of pathways that are actively being evaluated as treatment targets in SLE and lupus nephritis, with two new medications receiving FDA approval in the last 3 years. Herein we provide an overview of targeted therapies for SLE including medications targeting the B lymphocyte compartment, intracellular signaling, co-stimulation, and finally the interferons and other cytokines...
April 4, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38575046/increased-axl-high-myeloid-cells-as-pathognomonic-marker-in-langerhans-cell-histiocytosis-and-langerin-expression-dependence-of-mtor-inhibition
#40
JOURNAL ARTICLE
Cinthia Mariel Olexen, Denise Risnik, María Catalina Lava, Guido Luis Dalla Vecchia, Diego Alfredo Rosso, Andrea Emilse Errasti, Eugenio Antonio Carrera Silva
Langerhans cell histiocytosis (LCH) is characterized by an expansion and accumulation of pathological histiocytes expressing langerin (CD207) and CD1a in different organs under an inflammatory milieu. The origin of pathognomonic precursors of LCH is widely debated, but monocytes and pre dendritic cells (pre-DC) play significant role. Remarkable we found an expansion of AXLhigh cells in the CD11c+ subset of patients with active LCH, which also express the pathognomonic CD207 and CD1a. Moreover, we obtained a monocyte-derived LC-like (mo-LC-like) expressing high levels of AXL when treated with inflammatory cytokine, or plasma of patients with active disease...
April 2, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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