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Journals Clinical Immunology : the Offi...

Clinical Immunology : the Official Journal of the Clinical Immunology Society

https://read.qxmd.com/read/37119951/triple-immune-modulator-therapy-for-aberrant-hyperinflammatory-responses-in-severe-covid-19
#21
JOURNAL ARTICLE
June-Young Koh, Jae-Hoon Ko, So Yun Lim, Seongman Bae, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Chi Ryang Chung, Sung-Han Kim, Kyong Ran Peck, Jeong Seok Lee
A dysregulated hyperinflammatory response is a key pathogenesis of severe COVID-19, but optimal immune modulator treatment has not been established. To evaluate the clinical effectiveness of double (glucocorticoids and tocilizumab) and triple (plus baricitinib) immune modulator therapy for severe COVID-19, a retrospective cohort study was conducted. For the immunologic investigation, a single-cell RNA sequencing analysis was performed in serially collected PBMCs and neutrophil specimens. Triple immune modulator therapy was a significant factor in a multivariable analysis for 30-day recovery...
April 27, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37100338/pre-existing-humoral-immunity-and-cd4-t-cell-response-correlate-with-cross-reactivity-against-sars-cov-2-omicron-subvariants-after-heterologous-prime-boost-vaccination
#22
JOURNAL ARTICLE
Ching-Fen Shen, Yi-Chen Fu, Tzong-Shiann Ho, Po-Lin Chen, Nan-Yao Lee, Bo-Yang Tsai, Pei-Jane Tsai, Wen-Chien Ko, Ching-Chuan Liu, Chao-Min Cheng, Chi-Chang Shieh
BACKGROUND: Information regarding the heterologous prime-boost COVID vaccination has been fully elucidated. The study aimed to evaluate both humoral, cellular immunity and cross-reactivity against variants after heterologous vaccination. METHODS: We recruited healthcare workers previously primed with Oxford/AstraZeneca ChAdOx1-S vaccines and boosted with Moderna mRNA-1273 vaccine boost to evaluate the immunological response. Assay used: anti-spike RBD antibody, surrogate virus neutralizing antibody and interferon-γ release assay...
April 24, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37100337/outcome-measures-in-beh%C3%A3-et-syndrome
#23
JOURNAL ARTICLE
Gülen Hatemi, Yusuf Yazici
Disease assessment has been challenging in Behçet syndrome due to the heterogeneous disease course and multiorgan involvement with variable treatment response. There have been several recent improvements regarding outcome measures including development of a Core Set of Domains for Behçet syndrome and novel instruments for assessing specific organs and overall damage. This review focuses on the current state of outcome measures in Behçet syndrome, unmet needs, and a research agenda towards the development of standardized and validated outcome measure instruments...
April 24, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37100336/identification-of-a-single-cell-based-signature-for-predicting-prognosis-risk-and-immunotherapy-response-in-patients-with-glioblastoma
#24
JOURNAL ARTICLE
Ziyu Dai, Nan Zhang, Ran Zhou, Hao Zhang, Liyang Zhang, Zeyu Wang, Wenjing Zeng, Peng Luo, Jian Zhang, Zhixiong Liu, Quan Cheng
This study constructed a novel gene pair signature based on bulk and single-cell sequencing samples in relative expression order within the samples. The subsequent analysis included glioma samples from Xiangya Hospital. Gene pair signatures possessed a solid ability to predict the prognosis of glioblastoma and pan-cancer. Samples having different malignant biological hallmarks were distinguished by the algorithm, with the high gene pair score group featuring classic copy number variations, oncogenic mutations, and extensive hypomethylation, mediating poor prognosis...
April 24, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37098355/gathering-expert-consensus-to-inform-a-proposed-trial-in-chronic-nonbacterial-osteomyelitis-cno
#25
JOURNAL ARTICLE
C M Hedrich, M W Beresford, F Dedeoglu, G Hahn, S R Hofmann, A F Jansson, R M Laxer, P Miettunen, H Morbach, C E Pain, A V Ramanan, E Roberts, A Schnabel, A Theos, L Whitty, Y Zhao, P J Ferguson, H J Girschick
Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease that primarily affects children and adolescents. CNO is associated with pain, bone swelling, deformity, and fractures. Its pathophysiology is characterized by increased inflammasome assembly and imbalanced expression of cytokines. Treatment is currently based on personal experience, case series and resulting expert recommendations. Randomized controlled trials (RCTs) have not been initiated because of the rarity of CNO, expired patent protection of some medications, and the absence of agreed outcome measures...
April 23, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37088297/blocking-activation-of-cd4-cd8-t-cells-modulates-their-cytotoxic-potential-and-decreases-the-expression-of-inflammatory-and-chemotactic-receptors
#26
JOURNAL ARTICLE
Eula Graciele Amorim Neves, Carolina Cattoni Koh, Pedro Paulo Diniz Lucinda, Thaiany Goulart Souza-Silva, Nayara I Medeiros, Alexandre Pantaleão, Antônio Mutarelli, Juliana de Assis Silva Gomes, Silvana de Araújo Silva, Kenneth John Gollob, Maria do Carmo Pereira Nunes, Walderez Ornelas Dutra
CD4- CD8- (double negative - DN) T cells represent a small fraction of circulating T lymphocytes but are a major source of pro-inflammatory cytokines in patients with infectious diseases, including chronic Chagas cardiomyopathy (CCC), one of the deadliest cardiopathies known. Chagas disease is caused by an infection with the protozoan parasite Trypanosoma cruzi and can lead to either an asymptomatic form or a high-mortality cardiac disease. While circulating DN T cells represent a major inflammatory cytokine-expressing cell population in Chagas disease, their potential to be recruited to the heart and to perform cytotoxicity has not been determined...
April 23, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37094742/-untargeting-autoantibodies-using-genome-editing-a-proof-of-concept-study
#27
JOURNAL ARTICLE
Gerson Dierley Keppeke, Larissa Diogenes, Kethellen Gomes, Luis Eduardo Coelho Andrade
Autoantibodies (AAbs) are useful biomarkers and many have direct pathogenic role. Current standard therapies for elimination of specific B/plasma-cell clones are not fully efficient. We apply CRISPR/Cas9 genome-editing to knockout V(D)J rearrangements that produce pathogenic AAbs in vitro. HEK293T cell-lines were established stably expressing a humanized anti-dsDNA Ab (clone 3H9) and a human-derived anti-nAChR-α1 Ab (clone B12L). For each clone, five CRISPR/Cas9 heavy-chain's CDR2/3-targeting guided-RNAs (T-gRNAs) were designed...
April 22, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37088298/crosstalk-between-microglia-and-neural-stem-cells-influences-the-relapse-of-glioblastoma-in-gbm-immunological-microenvironment
#28
JOURNAL ARTICLE
Xingliang Dai, Lei Ye, Huaixu Li, Xuchen Dong, Haotiao Tian, Peng Gao, Jun Dong, Hongwei Cheng
Interactions between immunocytes and Neural Stem Cells (NSCs) in glioblastoma multiforme still remains unclear. Here, microglial cells and NSCs in peri-tumoral tissue were analyzed via single-cell whole-transcriptome sequencing. Results showed that two clusters of putative NSCs (the EGFR+ BCAN+ cell cluster, and the FABPT+ H19+ cell cluster) exhibited immune-related functions. Two clusters of putative microglia (the XIST+ PDK4+ and APOC1+ CCL3+ cell clusters) exhibited the function of glial cell activation...
April 21, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37086957/manufacturing-regulatory-t-cells-for-adoptive-cell-therapy-in-immune-diseases-a-critical-appraisal
#29
REVIEW
Kumar Abhishek, Malavika Nidhi, Srinandhini Chandran, Sergey S Shevkoplyas, Chandra Mohan
Regulatory T cells (Tregs) are a unique subset of lymphocytes that play a vital role in regulating the immune system by suppressing unwanted immune responses and thus preventing autoimmune diseases and inappropriate inflammatory reactions. In preclinical and clinical trials, these cells have demonstrated the ability to prevent and treat graft vs. host disease, alleviate autoimmune symptoms, and promote transplant tolerance. In this review, we provide a background on Treg cells with a focus on important Treg cell markers and Treg subsets, and outline the methodology currently used for manufacturing adoptive regulatory T cell therapies (TRACT)...
April 20, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37075950/prostaglandin-e2-ep4-axis-is-upregulated-in-spondyloarthritis-and-contributes-to-radiographic-progression
#30
JOURNAL ARTICLE
Daniele Mauro, Archita Srinath, Giuliana Guggino, Vicky Nicolaidou, Stefania Raimondo, Jonathan J Ellis, Jessica M Whyte, Maria Maddalena Nicoletti, Marco Romano, Tony John Kenna, Juan Cañete, Riccardo Alessandro, Aroldo Rizzo, Matthew Arthur Brown, Nicole J Horwood, Nigil Haroon, Francesco Ciccia
Ankylosing spondylitis (AS) is an inflammatory disease leading to spine ankylosis; however, the mechanisms behind new bone formation are still not fully understood. Single Nucleotide Polymorphisms (SNPs) in PTGER4, encoding for the receptor EP4 of prostaglandin E2 (PGE2), are associated with AS. Since the PGE2-EP4 axis participates in inflammation and bone metabolism, this work aims at investigating the influence of the prostaglandin-E2 axis on radiographic progression in AS. In 185 AS (97 progressors), baseline serum PGE2 predicted progression, and PTGER4 SNP rs6896969 was more frequent in progressors...
April 17, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37075949/serum-proteome-and-metabolome-uncover-novel-biomarkers-for-the-assessment-of-disease-activity-and-diagnosing-of-systemic-lupus-erythematosus
#31
JOURNAL ARTICLE
Jingquan He, Donger Tang, Dongzhou Liu, Xiaoping Hong, Chiyu Ma, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Jie Du, Lin Kang, Lianghong Yin, Qianjin Lu, Yong Dai
Systemic lupus erythematosus (SLE) is an autoimmune disease affecting thousands of people. There are still no effective biomarkers for SLE diagnosis and disease activity assessment. We performed proteomics and metabolomics analyses of serum from 121 SLE patients and 106 healthy individuals, and identified 90 proteins and 76 metabolites significantly changed. Several apolipoproteins and the metabolite arachidonic acid were significantly associated with disease activity. Apolipoprotein A-IV (APOA4), LysoPC(16:0), punicic acid and stearidonic acid were correlated with renal function...
April 17, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37061149/cd169-expression-on-monocytes-as-a-marker-for-assessing-type-i-interferon-status-in-pediatric-inflammatory-diseases
#32
JOURNAL ARTICLE
Naoto Sakumura, Tadafumi Yokoyama, Masaaki Usami, Yuiko Hosono, Natsumi Inoue, Yusuke Matsuda, Yuko Tasaki, Taizo Wada
BACKGROUND: Evaluation of type I interferons (IFNs) in inflammatory or autoimmune diseases is challenging because of their rapid clearance in peripheral blood. The IFN gene expression signature has recently been used to evaluate the IFN status; however, this is often a labor-intensive and time-consuming procedure. Therefore, we assessed the feasibility of measuring expression of an IFN-inducible protein, CD169 (Siglec-1), on monocytes and circulating levels of soluble CD169 as alternative markers for type I IFN status in various pediatric inflammatory diseases...
April 13, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37055004/characterization-of-ar-cgd-female-patient-with-a-novel-homozygous-deletion-in-cybc1-gene-presenting-with-unusual-clinical-phenotype
#33
JOURNAL ARTICLE
Maria Chiriaco, Arianna De Matteis, Cristina Cifaldi, Gigliola Di Matteo, Beatrice Rivalta, Chiara Passarelli, Chiara Perrone, Antonio Novelli, Fabrizio De Benedetti, Antonella Insalaco, Paolo Palma, Andrea Finocchi
Chronic granulomatous disease (CGD) is a human IEI caused by mutations in genes encoding the NADPH oxidase subunits, the enzyme responsible for the respiratory burst. CGD patients have severe life-threatening infections, hyperinflammation and immune dysregulation. Recently, an additional autosomal recessive (AR)-CGD (type 5) caused by mutations in CYBC1/EROS gene was identified. We report a AR-CGD5 patient with a novel loss of function (LOF) homozygous deletion c.8_7del in the CYBC1 gene including the initiation ATG codon that leads to failure of CYBC1/EROS protein expression and presenting with an unusual clinical manifestation of childhood-onset sarcoidosis-like disease requiring multiple immunosuppressive therapies...
April 11, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37037268/il-27-attenuates-il-23-mediated-inflammatory-arthritis
#34
JOURNAL ARTICLE
Ritu Sarin, Ran Gu, Zahra Jalali, Emanual Maverakis, Maria Tsokos, Iannis E Adamopoulos
Interleukin 27 has both pro-inflammatory and anti-inflammatory properties in autoimmunity. The anti-inflammatory effects of IL-27 are linked with inhibition of Th17 differentiation but the IL-27 effect on myeloid cells is less studied. Herein we demonstrate that IL-27 inhibits IL-23-induced inflammation associated not only with Th17 cells but also with myeloid cell infiltration in the joints and splenic myeloid populations of CD11b+ GR1+ and CD3- CD11b+ CD11c- GR1- cells. The IL-27 anti-inflammatory response was associated with reduced levels of myeloid cells in the spleen and bone marrow...
April 8, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37030526/donor-graft-mettl3-gene-transfer-ameliorates-rat-liver-transplantation-ischemia-reperfusion-injury-by-enhancing-ho-1-expression-in-an-m-6-a-dependent-manner
#35
JOURNAL ARTICLE
Song Xiang, Yihua Wang, Dengliang Lei, Yunhai Luo, Dadi Peng, Kezhen Zong, Yanyao Liu, Zuotian Huang, Shaojiang Mo, Xingyu Pu, Jinli Zheng, Zhongjun Wu
Ischemia-reperfusion injury (IRI) is one of the most common complications in liver transplantation. METTL3 regulates inflammation and various cellular stress responses via modulating RNA m6A modification level. Here, the study aimed to investigate the role and mechanism of METTL3 in IRI after rat orthotopic liver transplantation. Firstly, m6A dot blot assay showed that total RNA m6A modification level in grafts was down-regulated, which echoed with the downregulation of METTL3. Furthermore, METTL3 pretreatment in donor significantly reduced liver grafts necrosis formation, apoptosis, improved liver function and depressed the proinflammatory cytokine/chemokine expression...
April 6, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37030525/pold3-deficiency-is-associated-with-severe-combined-immunodeficiency-neurodevelopmental-delay-and-hearing-impairment
#36
JOURNAL ARTICLE
Cybel Mehawej, Eliane Chouery, Shirine Azar-Atallah, Wassim Shebaby, Valerie Delague, Issam Mansour, Mirna Mustapha, Gerard Lefranc, Andre Megarbane
Combined immunodeficiency diseases (CID) represent the most severe forms of inborn errors of immunity. Defective T cell development and/or function, leading to an impairment in adaptive immunity are responsible for these diseases. The DNA polymerase δ complex is important for genome duplication and maintenance and consists of the catalytic subunit POLD1, and the accessory subunits POLD2 and POLD3 which stabilizes the complex. Mutations in POLD1 and POLD2 have been recently shown to be associated with a syndromic CID characterized by T cell lymphopenia with or without intellectual deficiency and sensorineural hearing loss...
April 6, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37030524/reduced-quantity-and-function-of-pneumococcal-antibodies-are-associated-with-exacerbations-of-copd-in-spiromics
#37
JOURNAL ARTICLE
David C LaFon, Han Woo, Neal Fedarko, Antoine Azar, Harry Hill, Anne E Tebo, Thomas B Martins, MeiLan K Han, Jerry A Krishnan, Victor E Ortega, Igor Barjaktarevic, Robert J Kaner, Annette Hastie, Wanda K O'Neal, David Couper, Prescott G Woodruff, Jeffrey L Curtis, Nadia N Hansel, Moon H Nahm, Mark T Dransfield, Nirupama Putcha
While hypogammaglobulinemia is associated with COPD exacerbations, it is unknown whether frequent exacerbators have specific defects in antibody production/function. We hypothesized that reduced quantity/function of serum pneumococcal antibodies correlate with exacerbation risk in the SPIROMICS cohort. We measured total pneumococcal IgG in n = 764 previously vaccinated participants with COPD. In a propensity-matched subset of n = 200 with vaccination within five years (n = 50 without exacerbations in the previous year; n = 75 with one, n = 75 with ≥2), we measured pneumococcal IgG for 23 individual serotypes, and pneumococcal antibody function for 4 serotypes...
April 6, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37024024/pancreatic-sympathetic-innervation-disturbance-in-type-1-diabetes
#38
REVIEW
Senlin Li, Huimin Yuan, Keshan Yang, Qing Li, Ming Xiang
Pancreatic sympathetic innervation can directly affect the function of islet. The disorder of sympathetic innervation in islets during the occurrence of type 1 diabetes (T1D) has been reported to be controversial with the inducing factor unclarified. Several studies have uncovered the critical role that sympathetic signals play in controlling the local immune system. The survival and operation of endocrine cells can be regulated by immune cell infiltration in islets. In the current review, we focused on the impact of sympathetic signals working on islets cell regulation, and discussed the potential factors that can induce the sympathetic innervation disorder in the islets...
April 4, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37024023/elevated-exosome-transferrable-lncrna-epb41l4a-as1-in-cd56-bright-nk-cells-is-responsible-for-the-impaired-nk-function-in-neuroblastoma-patients-by-suppressing-cell-glycolysis
#39
JOURNAL ARTICLE
Wenjia Chai, Xiaolin Wang, Zhengjing Lu, Shihan Zhang, Wei Wang, Hui Wang, Chenghao Chen, Wei Yang, Haiyan Cheng, Huanmin Wang, Jun Feng, Shen Yang, Qiliang Li, Wenqi Song, Fang Jin, Hui Zhang, Yan Su, Jingang Gui
NK cells are one of key immune components in neuroblastoma (NB) surveillance and eradication. Glucose metabolism as a major source of fuel for NK activation is exquisitely regulated. Our data revealed a diminished NK activation and a disproportionally augmented CD56bright subset in NB. Further study showed that NK cells in NB presented with an arrested glycolysis accompanied by an elevated expression of the long noncoding RNA (lncRNA) EPB41L4A-AS1, a known crucial participant in glycolysis regulation, in the CD56bright NK subset...
April 4, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37024022/intima-media-thickness-of-common-femoral-vein-is-increased-in-beh%C3%A3-et-s-disease
#40
JOURNAL ARTICLE
Gizem Sevik, Rabia Ergelen, Seda Kutluğ Ağaçkıran, Haner Direskeneli, Fatma Alibaz-Oner
The histopathological data about vascular inflammation in Behçet's disease(BD) mainly comprises patients with arterial involvement. Inflammatory cell infiltration was mainly observed around the vasa vasorum and adventitial layer of the aneurysmatic vessels, and only a few cells were seen in the intimal layer during active arteritis. There is limited data for the histopathology of venous inflammation. We recently showed that increased common femoral vein(CFV) wall thickness is a specific sign of vein wall inflammation in BD...
April 4, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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