David C LaFon, Han Woo, Neal Fedarko, Antoine Azar, Harry Hill, Anne E Tebo, Thomas B Martins, MeiLan K Han, Jerry A Krishnan, Victor E Ortega, Igor Barjaktarevic, Robert J Kaner, Annette Hastie, Wanda K O'Neal, David Couper, Prescott G Woodruff, Jeffrey L Curtis, Nadia N Hansel, Moon H Nahm, Mark T Dransfield, Nirupama Putcha
While hypogammaglobulinemia is associated with COPD exacerbations, it is unknown whether frequent exacerbators have specific defects in antibody production/function. We hypothesized that reduced quantity/function of serum pneumococcal antibodies correlate with exacerbation risk in the SPIROMICS cohort. We measured total pneumococcal IgG in n = 764 previously vaccinated participants with COPD. In a propensity-matched subset of n = 200 with vaccination within five years (n = 50 without exacerbations in the previous year; n = 75 with one, n = 75 with ≥2), we measured pneumococcal IgG for 23 individual serotypes, and pneumococcal antibody function for 4 serotypes...
April 6, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society