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Journals Clinical Immunology : the Offi...

Clinical Immunology : the Official Journal of the Clinical Immunology Society

https://read.qxmd.com/read/37678720/should-we-be-targeting-type-1-interferons-in-antiphospholipid-syndrome
#21
JOURNAL ARTICLE
Gabrielle de Mello, Artur Saldanha, Fernanda A Orsi
Systemic autoimmune diseases are characterized by increased production of type I interferon (IFN-1) and upregulation of IFN-1-inducible genes, suggesting an important role of the IFN-1 pathway in their pathogenesis. Recent studies have demonstrated increased IFN-1 expression in both primary and secondary antiphospholipid syndrome (APS), along with increased toll-like receptor type 9 activity and plasmacytoid dendritic cell function. The increasing knowledge of the association between IFN-1 and APS pathology may provide a rationale for conducting clinical trials to assess the efficacy of IFN-1-targeting drugs in reducing APS-related complications...
September 5, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37678719/who-s-your-data-primary-immune-deficiency-differential-diagnosis-prediction-via-machine-learning-and-data-mining-of-the-usidnet-registry
#22
JOURNAL ARTICLE
Jose Alfredo Méndez Barrera, Samuel Rocha Guzmán, Elisa Hierro Cascajares, Elizabeth K Garabedian, Ramsay L Fuleihan, Kathleen E Sullivan, Saul O Lugo Reyes
PURPOSE: There are currently more than 480 primary immune deficiency (PID) diseases and about 7000 rare diseases that together afflict around 1 in every 17 humans. Computational aids based on data mining and machine learning might facilitate the diagnostic task by extracting rules from large datasets and making predictions when faced with new problem cases. In a proof-of-concept data mining study, we aimed to predict PID diagnoses using a supervised machine learning algorithm based on classification tree boosting...
September 5, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37678718/markers-of-terminally-differentiated-t-cells-as-predictors-of-vascular-health-in-renal-transplant-recipients-and-healthy-adults
#23
JOURNAL ARTICLE
Silvia Lee, HuiJun Chih, Jacquita Affandi, Shelley Waters, Ashley Irish, Patricia Price
Meta-analyses confirm a link between persistent human cytomegalovirus (HCMV) infections and cardiovascular disease, but the mechanisms are unclear. We assess whether proportions of T-cell populations are reliable predictors of subclinical atherosclerosis and/or reflect the burden of HCMV in healthy adults and renal transplant recipients (RTR). Samples were collected from healthy adults and RTR at baseline (T0) and after 32 (24-40) months (T1). Left carotid intima media thickness (cIMT) and proportions of T-cells expressing CD57, LIR-1 or the TEMRA phenotype increased in healthy adults and RTR...
September 5, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37678717/heterogeneity-and-mitochondrial-vulnerability-configurate-the-divergent-immunoreactivity-of-human-induced-microglia-like-cells
#24
JOURNAL ARTICLE
Kousuke Yonemoto, Fumihiko Fujii, Ryoji Taira, Masahiro Ohgidani, Katsuhide Eguchi, Sayaka Okuzono, Yuko Ichimiya, Yuri Sonoda, Pin Fee Chong, Hironori Goto, Hikaru Kanemasa, Yoshitomo Motomura, Masataka Ishimura, Yuhki Koga, Keita Tsujimura, Takao Hashiguchi, Hiroyuki Torisu, Ryutaro Kira, Takahiro A Kato, Yasunari Sakai, Shouichi Ohga
Microglia play versatile roles in progression of and protection against neuroinflammatory diseases. Little is known, however, about the mechanisms underlying the diverse reactivity of microglia to inflammatory conditions. We investigated how human induced microglia-like (iMG) cells respond to innate immune ligands. Quantitative PCR showed that poly-I:C and lipopolysaccharide (LPS) activated the expression of IL1B and TNF. Immunoreactivity of iMG did not differ between controls (n = 11) and patients with neuroinflammatory diseases (n = 24)...
September 5, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37678716/next-generation-sequencing-ngs-based-approach-to-diagnosing-algerian-patients-with-suspected-inborn-errors-of-immunity-ieis
#25
JOURNAL ARTICLE
Xiao P Peng, Moudjahed Saleh Al-Ddafari, Andres Caballero-Oteyza, Pavla Mrovecova, Saad Eddin Dib, Zoheir Massen, Chahrazed El Mezouar, Mohammed Chems-Eddine Smahi, Alddafari Faiza, Rafik Terki Hassaïne, Gérard Lefranc, Mourad Aribi, Bodo Grimbacher
The advent of next-generation sequencing (NGS) technologies has greatly expanded our understanding of both the clinical spectra and genetic landscape of inborn errors of immunity (IEIs). Endogamous populations may be enriched for unique, ancestry-specific disease-causing variants, a consideration that significantly impacts molecular testing and analysis strategies. Herein, we report on the application of a 2-step NGS-based testing approach beginning with targeted gene panels (TGPs) tailored to specific IEI subtypes and reflexing to whole exome sequencing (WES) if negative for Northwest Algerian patients with suspected IEIs...
September 5, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37678715/transcriptomic-and-proteomic-profiling-reveals-distinct-pathogenic-features-of-peripheral-non-classical-monocytes-in-systemic-lupus-erythematosus
#26
JOURNAL ARTICLE
Eirini Maria Stergioti, Theodora Manolakou, George Sentis, Martina Samiotaki, Noemin Kapsala, Antonis Fanouriakis, Dimitrios T Boumpas, Aggelos Banos
Peripheral blood monocytes propagate inflammation in systemic lupus erythematosus (SLE). Three major populations of monocytes have been recognized namely classical (CM), intermediate (IM) and non-classical monocytes (NCM). Herein, we performed a comprehensive transcriptomic, proteomic and functional characterization of the three peripheral monocytic subsets from active SLE patients and healthy individuals. Our data demonstrate extensive molecular disruptions in circulating SLE NCM, characterized by enhanced inflammatory features such as deregulated DNA repair, cell cycle and heightened IFN signaling combined with differentiation and developmental cues...
September 5, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37678714/tyro3-receptor-tyrosine-kinase-contributes-to-pathogenic-phenotypes-of-fibroblast-like-synoviocytes-in-rheumatoid-arthritis-and-disturbs-immune-cell-balance-in-experimental-arthritis
#27
JOURNAL ARTICLE
Ziye Wang, Zhen Zhao, Zhichang Li, Liling Xu, Hongchao Li, Huaqun Zhu, Gong Cheng, RanRan Yao, Wenwen Pei, Ruyu Liang, Renge Liang, Hua Ye, Shan Jiang, Haitao Niu, Xiaolin Sun, Yin Su
Rheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by synovitis and joint damage, the underlying causes of which remain unclear. Our prior investigations revealed a notable correlation between the expression of Tyro3 Protein Tyrosine Kinase (Tyro3TK) and the progression of RA. To further elucidate the pathogenic role of Tyro3TK in RA, we analyzed the influence of Tyro3TK on pathogenic phenotypes of RA fibroblast like synoviocyte (FLS) in vitro and compared disease severity, joint damages and immunological parameters of K/BxN serum transfer arthritis (STA) in Tyro3TK-/- deficient mice and wild type controls...
September 5, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37673227/a-novel-mutation-in-eros-cybc1-causes-chronic-granulomatous-disease
#28
JOURNAL ARTICLE
Paige M Mortimer, Esme Nichols, Joe Thomas, Rachna Shanbhag, Neha Singh, Eve L Coomber, Talat H Malik, Matthew C Pickering, Lyra Randzavola, William Rae, Sagar Bhattad, David C Thomas
Chronic Granulomatous Disease (CGD) is an inborn error of immunity characterised by opportunistic infection and sterile granulomatous inflammation. CGD is caused by a failure of reactive oxygen species (ROS) production by the phagocyte NADPH oxidase. Mutations in the genes encoding phagocyte NADPH oxidase subunits cause CGD. We and others have described a novel form of CGD (CGD5) secondary to lack of EROS (CYBC1), a highly selective chaperone for gp91phox. EROS-deficient cells express minimal levels of gp91phox and its binding partner p22phox, but EROS also controls the expression of other proteins such as P2X7...
September 4, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37673226/the-expression-of-antibodies-to-z-dna-in-the-blood-of-patients-with-systemic-lupus-erythematosus-relationship-to-autoantibodies-to-b-dna
#29
JOURNAL ARTICLE
Diane M Spencer, Elisabet Svenungsson, Iva Gunnersson, Roberto Caricchio, David S Pisetsky
To explore the antibody response to Z-DNA, a DNA conformation with a zig zag structure, blood of patients with systemic lupus erythematosus (SLE) and otherwise healthy individuals (NHS) were assayed by ELISA using brominated poly(dGdC), a synthetic Z-DNA antigen. These studies showed that SLE patients commonly express antibodies to Z-DNA; NHS also had binding in this assay. In SLE blood, levels of antibodies to Z-DNA were related to those to B-DNA using calf thymus DNA as a source of B-DNA; cross-reactivity was demonstrated by adsorption experiments using DNA cellulose...
September 4, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37673225/the-impact-of-bnt162b2-mrna-vaccine-on-adaptive-and-innate-immune-responses
#30
JOURNAL ARTICLE
Konstantin Föhse, Büsra Geckin, Martijn Zoodsma, Gizem Kilic, Zhaoli Liu, Rutger J Röring, Gijs J Overheul, Josephine van de Maat, Ozlem Bulut, Jacobien Hoogerwerf, Jaap Ten Oever, Elles Simonetti, Heiner Schaal, Ortwin Adams, Lisa Müller, Philipp Niklas Ostermann, Frank L van de Veerdonk, Leo A B Joosten, Bart L Haagmans, Reinout van Crevel, Ronald P van Rij, Corine GeurtsvanKessel, Marien I de Jonge, Yang Li, Jorge Domínguez-Andrés, Mihai G Netea
The mRNA-based BNT162b2 protects against severe disease and mortality caused by SARS-CoV-2 via induction of specific antibody and T-cell responses. Much less is known about its broad effects on immune responses against other pathogens. Here, we investigated the adaptive immune responses induced by BNT162b2 vaccination against various SARS-CoV-2 variants and its effects on the responsiveness of immune cells upon stimulation with heterologous stimuli. BNT162b2 vaccination induced effective humoral and cellular immunity against SARS-CoV-2 that started to wane after six months...
September 4, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37673223/farnesol-brain-transcriptomics-in-cns-inflammatory-demyelination
#31
JOURNAL ARTICLE
William J Doyle, Dana Walters, Xutong Shi, Kristina Hoffman, Krisztian Magori, Jean-Baptiste Roullet, Javier Ochoa-Repáraz
BACKGROUND: Farnesol (FOL) prevents the onset of experimental autoimmune encephalitis (EAE), a murine model of multiple sclerosis (MS). OBJECTIVE: We examined the transcriptomic profile of the brains of EAE mice treated with daily oral FOL using next-generation sequencing (RNA-seq). METHODS: Transcriptomics from whole brains of treated and untreated EAE mice at the peak of EAE was performed. RESULTS: EAE-induced mice, compared to naïve, healthy mice, overall showed increased expression in pathways for immune response, as well as an increased cytokine signaling pathway, with downregulation of cellular stress proteins...
September 4, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37660744/systems-analysis-reveals-differential-expression-of-endocervical-genes-in-african-women-randomized-to-dmpa-im-lng-implant-or-cu-iud
#32
JOURNAL ARTICLE
Prachi Mehrotra Gupta, Christina Balle, Gregory K Tharp, Sydney A Nelson, Melanie A Gasper, Bryan Brown, Arghavan Alisoltani, Maricianah Onono, Thesla Palanee-Phillips, Gonsagrie Nair, Hosseana Ayele, Laura Noel-Romas, Jo-Ann S Passmore, Adam D Burgener, Renee Heffron, Heather B Jaspan, Steven E Bosinger
Although effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract (FGT). A comparative analysis of the effects of the most common contraceptives on the FGT have not been evaluated in a randomized clinical trial setting. Here, we evaluated the effect of three long-acting contraceptive methods: depot medroxyprogesterone acetate(DMPA-IM), levonorgestrel(LNG) implant, and a copper intrauterine device (Cu-IUD), on the endocervical host transcriptome in 188 women from the Evidence for Contraceptive Options and HIV Outcomes Trial (ECHO) trial...
September 1, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37660743/similarities-and-differences-between-myocarditis-following-covid-19-mrna-vaccine-and-multiple-inflammatory-syndrome-with-cardiac-involvement-in-children
#33
JOURNAL ARTICLE
Donato Amodio, Giuseppe Rubens Pascucci, Nicola Cotugno, Chiara Rossetti, Emma Concetta Manno, Chiara Pighi, Elena Morrocchi, Annamaria D'Alessandro, Marco Alfonso Perrone, Alessandra Valentini, Alessio Franceschini, Marcello Chinali, Annalisa Deodati, Chiara Azzari, Paolo Rossi, Stefano Cianfarani, Marco Andreani, Ottavia Porzio, Paolo Palma
Despite the multiple benefits of vaccination, cardiac adverse Events Following COVID-19 Immunization (c-AEFI) have been reported. These events as well as the severe cardiac involvement reported in Multisystem inflammatory syndrome in children (MIS-C) appear more frequent in young adult males. Herein, we firstly report on the inflammatory profiles of patients experiencing c-AEFI in comparison with age, pubertal age and gender matched MIS-C with cardiac involvement. Proteins related to systemic inflammation were found higher in MIS-C compared to c-AEFI, whereas a higher level in proteins related to myocardial injury was found in c-AEFI...
September 1, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37657525/efficacy-and-safety-of-tripterygium-wilfordii-hook-f-plus-tnf-inhibitor-for-active-rheumatoid-arthritis-a-multicentre-randomized-double-blind-triple-dummy-controlled-trial
#34
JOURNAL ARTICLE
Xuan Zhang, Huaxia Yang, Xiaoxia Zuo, Lijun Wu, Jiangyun Peng, Zhenbin Li, Hongbin Li, Wei Ji, Liyun Zhang, Xiaomei Li, Lie Dai, Liangjing Lu, Niansheng Yang, Wei Wei, Zongwen Shuai, Ying Jiang, Yudong Liu, Peter E Lipsky, Hua Chen
An investigator-initiated, multicentre, randomized, double-blind, triple-dummy, controlled trial was conducted at 14 tertiary rheumatology centers in China to evaluate the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) with recombinant human TNF receptor IgGFc fusion protein (rhTNFR-Fc) in active Rheumatoid Arthritis (RA). Primary endpoint was the proportion of patients achieved a 50% improvement of American College of Rheumatology criteria (ACR50) in TwHF+rhTNFR-Fc vs. methotrexate (MTX) group at week 12...
August 30, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37652172/punctate-inner-choroidopathy-in-common-variable-immunodeficiency-associated-with-a-pathogenic-variant-in-the-tumour-necrosis-factor-receptor-superfamily-13b-tnfrsf13b-gene-case-report-and-review-of-the-literature
#35
JOURNAL ARTICLE
Hiba Salih, Kelvin Cheng Kah Wai, Justin McKee, Charu Chopra
BACKGROUND: Common variable immunodeficiency (CVID) has been recognised as the most common primary immunodeficiency in adulthood, and is characterised by increased susceptibility to infection, autoimmunity and increased risk of malignancies. Although ocular manifestations are not common in CVID, rare associated inflammatory eye conditions have been reported including submacular choroiditis. OBJECTIVE: To report a case of punctate inner choroidopathy in a patient with common variable immunodeficiency...
August 29, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37634854/rfsav-promotes-staphylococcus-aureus-infected-bone-defect-healing-via-il-13-mediated-m2-macrophage-polarization
#36
JOURNAL ARTICLE
Yanhao Zhang, Feng Yang, Dong Sun, Limin Xu, Yaojia Shi, Leilei Qin, Liqun Zhao, Liting Wang, Wei Sun, Hongri Wu, Dongshui Lu, Weijun Zhang, Ping Luo, Ping Cheng, Quanming Zou, Hao Zeng
Staphylococcus aureus (S. aureus) contamination commonly occurs in orthopedic internal fixation operations, leading to a delayed healing of the defected bone tissue. However, antibiotic treatments are ineffective in dealing with S. aureus bone infections due to the rise in multiple antimicrobial resistances. Here, we reported the protective effects of a recombinant five-antigen S. aureus vaccine (rFSAV) in an S. aureus infected bone defect model. In this study, we found the number of M2 macrophages markedly increased in the defect site and played a critical role in the healing of defected bone mediated by rFSAV...
August 25, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37625670/the-pathogenesis-of-obstetric-aps-a-2023-update
#37
REVIEW
Chieko Mineo, Philip W Shaul, Bonnie L Bermas
The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the persistent presence of antibodies directed against phospholipids and phospholipid-binding proteins that are associated with thrombosis and pregnancy-related morbidity. The latter includes fetal deaths, premature birth and maternal complications. In the early 1990s, a distinct set of autoantibodies, termed collectively antiphospholipid antibodies (aPL), were identified as the causative agents of this disorder. Subsequently histological analyses of the placenta from APS pregnancies revealed various abnormalities, including inflammation at maternal-fetal interface and poor placentation manifested by reduced trophoblast invasion and limited uterine spiral artery remodeling...
August 23, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37625669/mitochondrial-mediated-inflammation-and-platelet-activation-in-giant-cell-arteritis
#38
JOURNAL ARTICLE
Despina Michailidou, Peter C Grayson, Payton Hermanson, Jorge Armando Gonzalez Chapa, David Cuthbertson, Nader A Khalidi, Curry L Koening, Carol A Langford, Carol A McAlear, Larry W Moreland, Christian Pagnoux, Philip Seo, Antoine G Sreih, Kenneth J Warrington, Paul A Monach, Peter A Merkel, Christian Lood
Markers of extracellular mitochondria are present in giant cell arteritis (GCA) patients. However, their role in promoting inflammation and platelet activation is no known. To investigate this, isolated mitochondria were opsonized with plasma from GCA patients or healthy individuals and incubated with peripheral blood mononuclear cells (PBMCs) or platelets and assessed for inflammatory cytokine production and platelet activation. Plasma from GCA patients promoted increased mitochondrial-mediated cytokine production by PBMCs as compared to healthy controls (p < 0...
August 23, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37611838/antiretrovirals-to-ccr5-crispr-cas9-gene-editing-a-paradigm-shift-chasing-an-hiv-cure
#39
REVIEW
Amber Khan, Nandagopal Paneerselvam, Brian R Lawson
The evolution of drug-resistant viral strains and anatomical and cellular reservoirs of HIV pose significant clinical challenges to antiretroviral therapy. CCR5 is a coreceptor critical for HIV host cell fusion, and a homozygous 32-bp gene deletion (∆32) leads to its loss of function. Interestingly, an allogeneic HSCT from an HIV-negative ∆32 donor to an HIV-1-infected recipient demonstrated a curative approach by rendering the recipient's blood cells resistant to viral entry. Ex vivo gene editing tools, such as CRISPR/Cas9, hold tremendous promise in generating allogeneic HSC grafts that can potentially replace allogeneic ∆32 HSCTs...
August 21, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37604356/distinct-nod2-mutations-reported-in-three-families-with-blau-syndrome-bs-from-a-single-center-in-india-case-series-and-review-of-literature
#40
JOURNAL ARTICLE
Ritasman Baisya, Ramesh Manthri, Mudit Tyagi, Shantveer G Uppin, Liza Rajasekhar
OBJECTIVE: Blau syndrome (BS), considered a rare pediatric autoinflammatory disease, is characterised by a triad of granulomatous arthritis, dermatitis and uveitis. Here we present a tale of three families visited in our outpatient department in the last two years (2020-2022) where more than one member was affected with either skin, ophthalmological and joint involvement with either biopsy-proven granuloma or genetic mutation at NOD2 gene suggesting the diagnosis of BS. CASE SERIES: The first family had three affected members where the mother and her two children had skin changes, polyarthritis and a pathogenic mutation in NOD2 gene (exon 4, c...
August 19, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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