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Clinical Immunology: the Official Journal of the Clinical Immunology Society

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https://read.qxmd.com/read/30858051/rethinking-newborn-screening-for-severe-combined-immunodeficiency-lessons-from-an-international-partnership-for-patients-with-primary-immunodeficiencies-in-pakistan
#1
LETTER
Jacqueline G Wallace, Hamid Nawaz Tipu, Kelsey Stafstrom, Mohammed F Alosaimi, Michel J Massaad, Wayne Bainter, Raif S Geha, Janet Chou
No abstract text is available yet for this article.
March 8, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30849494/cell-mediated-immune-responses-elicited-in-volunteers-following-immunization-with-candidate-live-oral-salmonella-enterica-serovar-paratyphi-a-attenuated-vaccine-strain-cvd-1902
#2
Rezwanul Wahid, Karen L Kotloff, Myron M Levine, Marcelo B Sztein
The incidence of Salmonella enterica serovar Paratyphi A (PA) infection is on the rise and no licensed vaccines are available. We evaluated cell mediated immune (CMI) responses elicited in volunteers following immunization with a single dose (109 or 1010  cfu) of a novel attenuated live oral PA-vaccine strain (CVD 1902). Results showed increases in PA-lipopolysaccharide-specific IgG- and/or IgA B-memory cells and production of IFN-γ, TNF-α, IL-10, IL-23 and RANTES following stimulation with PA-antigens by peripheral blood mononuclear cells obtained 28 days post immunization...
March 5, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30844443/crosstalk-between-macrophage-and-t-cell-in-atherosclerosis-potential-therapeutic-targets-for-cardiovascular-diseases
#3
REVIEW
Meiying Song, Shixin Xu, Aiqin Zhong, Junping Zhang
No abstract text is available yet for this article.
March 4, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30844442/repository-corticotropin-injection-reverses-critical-elements-of-the-tlr9-b-cell-receptor-activation-response-in-human-b-cells-in-vitro
#4
Nancy J Olsen, Ann L Benko, Carl A McAloose, Patrice M Becker, Dale Wright, Teresa Sunyer, Yuka Imamura Kawasawa, William J Kovacs
We sought evidence for direct effects of repository corticotropin (RCI; an FDA-approved treatment for selected cases of SLE) on isolated human B lymphocytes activated by engagement of TLR9 and B cell receptors. ODN 2395/αIgM treatment was found to result in induction of 162 distinct mRNAs and suppression of 80 mRNAs at 24 h. RCI treatment resulted in suppression of 14 of the ODN 2395/αIgM -induced mRNAs (mean suppression to 23.6 ± 3.1% of stimulated value). The RCI-suppressed mRNAs included two critical regulators of class switch recombination, AICDA and BATF...
March 4, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30831253/compendium-of-synovial-signatures-identifies-pathologic-characteristics-for-predicting-treatment-response-in-rheumatoid-arthritis-patients
#5
Ki-Jo Kim, Minseung Kim, Iannis Adamopoulos, Ilias Tagkopoulos
Rheumatoid arthritis (RA) is therapeutically challenging due to patient heterogeneity and variability. Herein we describe a novel integration of RA synovial genome-scale transcriptomic profiling of different patient cohorts that can be used to provide predictive insights on drug responses. A normalized compendium consisting of 256 RA synovial samples that cover an intersection of 11,769 genes from 11 datasets was build and compared with similar datasets derived from OA patients and healthy controls. Differentially expression genes (DEGs) that were identified in three independent methods were fed into functional network analysis, with subsequent grouping of the samples based on a non-negative matrix factorization method...
March 1, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30817999/initial-safety-analysis-of-a-randomized-phase-ii-trial-of-nelipepimut-s-gm-csf-and-trastuzumab-compared-to-trastuzumab-alone-to-prevent-recurrence-in-breast-cancer-patients-with-her2-low-expressing-tumors
#6
Clifton G Travis, M Peace Kaitlin, P Holmes Jarrod, J Vreeland Timothy, F Hale Diane, S Herbert Garth, K Litton Jennifer, K Murthy Rashmi, Lukas Jason, E People George, A Mittendorf Elizabeth
The development of HER2-targeted therapy has decreased recurrence rates and improved survival, transforming the natural history of HER2-positive breast cancer. However only a minority of breast cancer patients benefit as these agents are not used in patients with tumors expressing low levels of HER2. Preclinical data suggests a synergistic action of HER2-targeted vaccination with trastuzumab. We report the initial safety interim analysis of a phase II trial that enrolled patients with HER2 low-expressing (IHC 1+/2+) breast cancer who were clinically disease-free after standard therapy...
February 25, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30817998/aberrant-natural-killer-nk-cell-activation-and-dysfunction-among-art-treated-hiv-infected-adults-in-an-african-cohort
#7
Rose Nabatanzi, Lois Bayigga, Stephen Cose, Sarah Rowland-Jones, Glenda Canderan, Moses Joloba, Damalie Nakanjako
BACKGROUND: We examined NK cell phenotypes and functions after seven years of ART and undetectable viral loads (<50 copies/ml) with restored CD4 T-cell counts (≥500 cells/μl) and age-matched healthy-HIV-uninfected individuals from the same community. METHODS: Using flow-cytometry NK cell phenotypes were described using lineage markers (CD56+/- CD16+/- ). NK cell activation was determined by expression of activation receptors (NKG2D, NKp44 and NKp46) and activation marker CD69...
February 25, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30807831/identification-and-mutational-analysis-of-continuous-immunodominant-epitopes-of-the-major-oyster-allergen-crag-1
#8
Lei Fang, Guoming Li, Jiangtao Zhang, Ruizeng Gu, Muyi Cai, Jun Lu
Shellfish, including oysters, often cause allergic reactions in children and adults. Oysters are inevitably consumed because of its delicacy and nutritional benefit, leading to frequent occurrence of severe clinical symptoms observed in patients with oyster hypersensitivity. We aimed to identify the immunodominant epitopes of oyster tropomyosin and crucial amino acids for IgE binding, which will help us to further understand the immunochemical characteristics of Cra g 1. The potential epitopes were predicted by immunoinformatics tools and the resultant immunodominant epitopes were identified by inhibition ELISA with pooled sera and individual serum from oyster allergic patients...
February 23, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30776520/increased-proportions-of-%C3%AE-%C3%AE-t-lymphocytes-in-atypical-scid-associate-with-disease-manifestations
#9
Inga Tometten, Kerstin Felgentreff, Manfred Hönig, Fabian Hauck, Michael H Albert, Tim Niehues, Ruy Perez, Sujal Ghosh, Capucine Picard, Jan Stary, Renata Formankova, Austen Worth, Pere Soler-Palacín, Marina García-Prat, Luis M Allende, Luis Ignacio Gonzalez-Granado, Polina Stepensky, Silvia Di Cesare, Alessia Scarselli, Caterina Cancrini, Carsten Speckmann, Kimberly Gilmour, Luigi Notarangelo, Stephan Ehl, Jan Rohr
Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of γδ T lymphocytes have been reported. However, it is unknown whether these γδ T cells modulate or reflect the patient's clinical phenotype. We investigated the frequency of elevated γδ T cell proportions and associations with clinical disease manifestations in a cohort of 76 atypical SCID patients. Increased proportions of γδ T lymphocytes were present in approximately 60% of these patients...
February 15, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30772599/cytokines-growth-factors-and-proteases-in-medium-and-large-vessel-vasculitis
#10
Cornelia M Weyand, Ryu Watanabe, Hui Zhang, Mitsuhiro Akiyama, Gerald J Berry, Jörg J Goronzy
Giant cell arteritis and Takayasu arteritis are autoimmune vasculitides that cause aneurysm formation and tissue infarction. Extravascular inflammation consists of an intense acute phase response. Deeper understanding of pathogenic events in the vessel wall has highlighted the loss of tissue protective mechanisms, the intrusion of immune cells into "forbidden territory", and the autonomy of self-renewing vasculitic infiltrates. Adventitial vasa vasora critically control vessel wall access and drive differentiation of tissue-invasive T cells...
February 14, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30772598/stratum-corneum-interleukin-33-expressions-correlate-with-the-degree-of-lichenification-and-pruritus-in-atopic-dermatitis-lesions
#11
LETTER
Naomi Nakamura, Risa Tamagawa-Mineoka, Risa Yasuike, Koji Masuda, Hiroshi Matsunaka, Yumi Murakami, Emiko Yokosawa, Norito Katoh
No abstract text is available yet for this article.
February 14, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30771501/bcg-induced-formation-of-neutrophil-extracellular-traps-play-an-important-role-in-bladder-cancer-treatment
#12
Kangkang Liu, Erlin Sun, Mingde Lei, Limin Li, Jingda Gao, Xuewu Nian, Lining Wang
Bacillus Calmette-Guerin (BCG) is one of the most effective treatments for bladder cancer. Little attention has been paid to the possible role of neutrophils in BCG immunotherapy. In this study, we examined neutrophil extracellular traps (NETs) formation induced by BCG stimulation, and found that BCG-induced NETs exerted cytotoxicity, induced apoptosis and cell-cycle arrest, and inhibited migration in bladder tumor cells. BCG-activated tumor cells but not non-activated ones elicited NETs formation, in which IL-8 and TNF-α from activated tumor cells both took effect...
February 13, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30771500/elevated-kynurenine-levels-in-diffuse-cutaneous-and-anti-rna-polymerase-iii-positive-systemic-sclerosis
#13
Corrado Campochiaro, Simon Lytton, Svetlana Nihtyanova, Dietmar Fuchs, Voon H Ong, Christopher P Denton
Systemic sclerosis (SSc) is a systemic disease characterized by vasculopathy, progressive fibrosis and autoimmune activation. Tryptophan (Trp) metabolism has been linked to altered immune cell function and to malignancy. We have investigated the role of Trp metabolic pathway in SSc measuring serum Trp, Kynurenine (Kyn) and Trp/Kyn ratio in a cohort of 97 SSc patients and 10 healthy controls. Association with disease characteristics was evaluated. We found that Trp levels in SSc patients were significantly lower compared to HCs...
February 13, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30742971/novel-multiple-heterozygous-nudt15-variants-cause-an-azathioprine-induced-severe-leukopenia-in-a-patient-with-systemic-lupus-erythematosus
#14
LETTER
Mizuna Otsuka, Tomohiro Koga, Remi Sumiyoshi, Kaori Fukukawa, Momoko Okamoto, Yushiro Endo, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Takashi Igawa, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Atsushi Kawakami
No abstract text is available yet for this article.
February 8, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30742970/cd25-deficiency-a-new-conformational-mutation-prevents-the-receptor-expression-on-cell-surface
#15
Marina Vignoli, Sara Ciullini Mannurita, Antonella Fioravanti, Manuela Tumino, Alessia Grassi, Graziella Guariso, Claudio Favre, Mario M D'Elios, Eleonora Gambineri
CD25 deficiency is a very rare autosomal recessive disorder that shows a clinical phenotype highly overlapping IPEX syndrome with an increased susceptibility to viral, bacterial, and fungal infections. It is due to mutations in the IL2Rα gene that codes for the α subunit of the IL2 receptor complex. Here we report the characterization of a novel IL2Rα gene mutation leading to a severe protein conformational alteration that abrogates its cell surface expression in a child presenting with early-onset IPEX-like disorder...
February 8, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30738143/genetic-and-inflammatory-factors-associated-with-psoriatic-arthritis-relevance-to-diagnosis-and-management
#16
REVIEW
Daniel E Furst, Jennifer Belasco, James S Louie
Psoriatic arthritis (PsA) is a heterogeneous chronic inflammatory musculoskeletal condition with complex pathophysiology. In recent years, understanding of the pathogenesis of PsA has improved substantially. Several genetic and inflammatory factors have been identified and studied as targets for new biologic disease-modifying therapies. This review presents findings from a detailed literature assessment conducted to identify genes and biomarkers associated with PsA and its most common comorbidities. This literature assessment identifies genes and biomarkers that may be predictive of the onset and severity of PsA, places them in the context of our understanding of PsA pathogenesis, and explores potential connections between the pathways involved in PsA and current biologic therapeutics used to treat PsA...
February 6, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30735729/immune-aging-in-diabetes-and-its-implications-in-wound-healing
#17
REVIEW
J Moura, P Madureira, E C Leal, A C Fonseca, E Carvalho
Immune systems have evolved to recognize and eliminate pathogens and damaged cells. In humans, it is estimated to recognize 109 epitopes and natural selection ensures that clonally expanded cells replace unstimulated cells and overall immune cell numbers remain stationary. But, with age, it faces continuous repertoire restriction and concomitant accumulation of primed cells. Changes shaping the aging immune system have bitter consequences because, as inflammatory responses gain intensity and duration, tissue-damaging immunity and inflammatory disease arise...
February 5, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30731209/caspse-11-gsdmd-pathway-is-required-for-serum-ferritin-secretion-in-sepsis
#18
Dan Wang, Songlin Yu, Yening Zhang, Lingmin Huang, Yiting Tang, Kai Zhao, Ben Lu
Ferritin is the major iron storage molecule of vertebrates, which can be detected in serum under numerous conditions, including inflammatory, neurodegenerative, and malignant diseases. Given this character, serum ferritin is frequently used as a biomarker in clinical settings. How the ferritin secreted to the serum has attracted much attention. Although some studies have found ferritin was mediated via the endoplasmic reticulum (ER)-Golgi secretion pathway or secretory lysosomes trafficking pathway under normal conditions, the secretion pathway of ferritin under pathological conditions, especially in sepsis is not very clear...
February 4, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30710693/kir-gene-haplotype-a-is-associated-with-hospital-mortality-in-patients-with-sepsis
#19
LETTER
Luciana M Oliveira, Pamela Portela, Joice Merzoni, Jaqueline Beppler, Fernando S Dias, Pietra Graebin, Clarice S Alho, Gilberto Schwartsmann, Felipe Dal-Pizzol, Luiz Fernando Jobim, Mariana Jobim, Rafael Roesler
No abstract text is available yet for this article.
January 30, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30710692/the-potential-role-of-cd4-cd52-lo-t-cell-populations-in-systemic-lupus-erythematosus
#20
LETTER
Kunihiro Ichinose, Masataka Umeda, Tomohiro Koga, Atsushi Kawakami
No abstract text is available yet for this article.
January 30, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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