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Journals Clinical Immunology : the Offi...

Clinical Immunology : the Official Journal of the Clinical Immunology Society

https://read.qxmd.com/read/36940814/antibodies-against-neutrophil-extracellular-traps-nets-potentiate-clinical-performance-of-anti-double-stranded-dna-antibodies-in-systemic-lupus-erythematosus
#1
JOURNAL ARTICLE
Minghua Zhan, Ziwei Wang, Huizhang Bao, Chun Di, Changsheng Xia, Xuan Zhang, Yudong Liu
Autoantibodies against NETs (ANETA) are present in SLE patients. We aimed to determine the clinical relevance of ANETA in SLE. Serum from 129 SLE patients, 161 patients with various rheumatoid diseases (DC), and 53 healthy controls (HC) were tested by a home-made ANETA ELISA platform. ANETA showed a sensitivity of 35.7% and a specificity of 92.5%, respectively, in the diagnosis of SLE. The combination of ANETA with anti-dsDNA antibody increased the diagnostic sensitivity from 49.6% to 62.8% for SLE. The presence of ANETA potentiates the clinical utility of anti-dsDNA antibodies in identifying a subset of SLE patients with higher disease activity and hematological abnormalities...
March 18, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36934849/pres-endorsed-international-childhood-lupus-t2t-task-force-definition-of-childhood-lupus-low-disease-activity-state-clldas
#2
JOURNAL ARTICLE
E M D Smith, A Aggarwal, J Ainsworth, E Al-Abadi, T Avcin, L Bortey, J Burnham, C Ciurtin, C M Hedrich, S Kamphuis, L Lambert, D M Levy, L Lewandowski, N Maxwell, E Morand, S Ozen, C E Pain, A Ravelli, C Saad Magalhaes, C Pilkington, D Schonenberg-Meinema, C Scott, K Tullus, M W Beresford
OBJECTIVE: To achieve a consensus-based definition of Low Disease Activity (LDA) for use in cSLE trials. METHODS: The International cSLE T2T Task Force, comprising of paediatric rheumatologists/nephrologists, and adult rheumatologists undertook a series of Delphi surveys/consensus meetings to discuss, refine, and vote upon cSLE LDA criteria. RESULTS: The Task Force agreed that LDA should be based upon the adult-SLE Lupus Low Disease Activity State definition (LLDAS), with modifications to make it applicable to cSLE (cLLDAS)...
March 17, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36934848/ppar%C3%AE-inhibits-small-airway-remodeling-through-mediating-the-polarization-homeostasis-of-alveolar-macrophages-in-copd
#3
JOURNAL ARTICLE
Sirong He, Ruoyuan Tian, Xinying Zhang, Qingmei Yao, Quan Chen, Bicui Liu, Lele Liao, Yuxuan Gong, Hua Yang, Dan Wang
The role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in alveolar macrophages(AMs) polarization homeostasis is closely associated with airway remodeling in COPD, but the definite mechanism remains unclear. In this study, elevated percentage of M1-type AMs and the expression of functionally cytokines were found in COPD patients and mice, which closely related to the disease severity. PPARγ was markedly up-regulated in M2-type AMs and down-regulated in M1-type AMs, and was associated with disease severity in COPD...
March 17, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36933629/attenuation-of-renal-injury-by-depleting-cdc1-and-by-repurposing-flt3-inhibitor-in-anti-gbm-disease
#4
JOURNAL ARTICLE
Titi Chen, Qi Cao, Ruifeng Wang, Guoping Zheng, Farhana Azmi, Vincent W Lee, Yuan Ming Wang, Hongqi Li, Di Yu, Natasha M Rogers, Stephen I Alexander, David C H Harris, Yiping Wang
Previous studies found cDC1s to be protective in early stage anti-GBM disease through Tregs, but pathogenic in late stage Adriamycin nephropathy through CD8+ T cells. Flt3 ligand is a growth factor essential for cDC1 development and Flt3 inhibitors are currently used for cancer treatment. We conducted this study to clarify the role and mechanisms of effects of cDC1s at different time points in anti-GBM disease. In addition, we aimed to utilize drug repurposing of Flt3 inhibitors to target cDC1s as a treatment of anti-GBM disease...
March 16, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36931486/peripheral-th-and-nk-cells-are-associated-with-response-to-lenvatinib-plus-pd-1-inhibitor-in-unresectable-hepatocellular-carcinoma
#5
JOURNAL ARTICLE
Yiping Zou, Zhihong Chen, Zhenrong Chen, Yuanpeng Zhang, Zehao Zheng, Fan Wu, Lianqun Xu, Qiao Li, Ye Lin, Ning Shi, Haosheng Jin
The value of peripheral blood lymphocyte subpopulations in predicting responses to lenvatinib combination with programmed death-1 (PD-1) inhibitors in unresectable hepatocellular carcinoma (HCC) was investigated. Fifteen patients received objective responses (OR) and sixteen patients had non-objective responses (NOR) were analyzed. The counts of peripheral blood lymphocyte subpopulations from patients were measured before treatment, second (at week 3), and third doses (at week 6) of the PD-1 inhibitor administration, and correlated with responses...
March 15, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36925027/aberrant-promoter-methylation-of-wnt-inhibitory-factor-1-gene-is-a-potential-target-for-treating-psoriasis
#6
JOURNAL ARTICLE
Liu Liu, Yaqiong Zhou, Dan Luo, Xiaoying Sun, Hongjin Li, Yi Lu, Jiao Wang, Miao Zhang, Naixuan Lin, Chengqian Yin, Xin Li
Psoriasis is a chronic inflammatory skin disease mediated by immune and complex genetic factors. The wingless-related integration site (Wnt) signaling pathway plays a critical role in psoriasis, but how the Wnt pathway is regulated in psoriatic skin and whether it can be exploited for therapeutic benefits is unclear. By comparing biopsies from healthy and psoriatic skin, we found that Wnt inhibitory factor 1 (WIF1), an inhibitor of Wnt signaling, showed reduced expression at both mRNA and protein levels in psoriatic skin...
March 14, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36918041/targeting-immunometabolism-against-acute-lung-injury
#7
REVIEW
Li Ning, Zou Shishi, Wang Bo, Lin Huiqing
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening conditions triggered by multiple intra- and extra-pulmonary injury factors, characterized by complicated molecular mechanisms and high mortality. Great strides have been made in the field of immunometabolism to clarify the interplay between intracellular metabolism and immune function in the past few years. Emerging evidence unveils the crucial roles of immunometabolism in inflammatory response and ALI. During ALI, both macrophages and lymphocytes undergo robust metabolic reprogramming and discrete epigenetic changes after activated...
March 12, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36907540/the-nlrp3-inflammasome-as-a-target-for-sensorineural-hearing-loss
#8
REVIEW
Grace E Gregory, Kevin J Munro, Kevin N Couper, Omar N Pathmanaban, David Brough
Sensorineural hearing loss is the most common type of hearing loss in adults and occurs due to damage of the inner ear caused by a range of factors including ageing, excessive noise, toxins, and cancer. Auto-inflammatory disease is also a cause of hearing loss and there is evidence that inflammation could contribute to hearing loss in other conditions. Within the inner ear there are resident macrophage cells that respond to insults and whose activation correlates with damage. The NLRP3 inflammasome is a multi-molecular pro-inflammatory protein complex that forms in activated macrophages and may contribute to hearing loss...
March 10, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36907539/myelin-basic-protein-and-index-for-neuro-beh%C3%A3-et-s-disease
#9
JOURNAL ARTICLE
Haoting Zhan, Linlin Cheng, Xiaoou Wang, Haiqiang Jin, Yongmei Liu, Haolong Li, Dandan Liu, Xinyao Zhang, Wenjie Zheng, Hongjun Hao, Yongzhe Li
Neuro-Behçet's disease (NBD) contributes to poor prognosis in BD patients which lacks reliable laboratory biomarkers in assessing intrathecal injury. This study aimed to determine the diagnostic value of myelin basic protein (MBP), an indicator of central nervous system (CNS) myelin damage, in NBD patients and disease controls. Paired samples of cerebrospinal fluid (CSF) and serum MBP were measured using ELISA, while IgG and Alb were routinely examined before the MBP index was developed. CSF and serum MBP in NBD were significantly higher than in NIND, which could distinguish NBD from NIND with a specificity exceeding 90%, moreover, they could also be excellent discriminators for acute NBD and chronic progressive ones ...
March 10, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36907538/association-between-glomerular-mtorc1-activation-and-crescents-formation-in-lupus-nephritis-patients
#10
JOURNAL ARTICLE
Ying Ding, Zhong-Qiu Luan, Zhao-Min Mao, Qu Zhen, Yu Feng
OBJECTIVE: This study aims to explore the association between glomerular mammalian target of rapamycin complex 1 (mTORC1) pathway activation and crescents' degree in lupus nephritis (LN) patients. METHODS: A total of 159 biopsy-proven LN patients were enrolled in this retrospective study. The clinical and pathological data of them were collected at the time of renal biopsy. mTORC1 pathway activation was measured by immunohistochemistry, expressed by the mean optical density (MOD) of p-RPS6 (ser235/236), and multiplexed immunofluorescence...
March 10, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36894047/usp25-pkm2-glycolysis-axis-contributes-to-ischemia-reperfusion-induced-acute-kidney-injury-by-promoting-m1-like-macrophage-polarization-and-proinflammatory-response
#11
JOURNAL ARTICLE
Yi Yang, Xiaona Zhan, Cailin Zhang, Jia Shi, Jianliang Wu, Xuan Deng, Yu Hong, Qing Li, Shuwang Ge, Gang Xu, Fan He
M1-like macrophages have been reported to play critical roles in acute kidney injury (AKI). Here, we elucidated the role of ubiquitin-specific protease 25 (USP25) in M1-like macrophages polarization and AKI. High USP25 expression was correlated with a decline in renal function in patients with acute kidney tubular injury and in mice with AKI. In contrast, USP25 knockout reduced M1-like macrophage infiltration, suppressed M1-like polarization, and improved AKI in mice, indicating that USP25 was necessary for M1-like polarization and proinflammatory response...
March 7, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36894046/complement-factors-b-d-c3bbbp-and-risk-of-future-venous-thromboembolism
#12
JOURNAL ARTICLE
Espen W Skjeflo, Line H Evensen, Søren B Jensen, Nadezhda Latysheva, Annika Michelsen, Thor Ueland, Sigrid K Brækkan, Kristian Hindberg, Omri Snir, Tom Eirik Mollnes, John-Bjarne Hansen
The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE). We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured at inclusion, with the risk of future VTE in a nested case-control study; 380 VTE patients and 804 age- and sex-matched controls derived from the Tromsø study. Odds ratios (ORs) with 95% confidence intervals (95% CI) for VTE across tertiles of CF concentrations were estimated using logistic regression...
March 7, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36878421/neutrophil-extracellular-trap-formation-in-anti-neutrophil-cytoplasmic-antibody-associated-and-large-vessel-vasculitis
#13
JOURNAL ARTICLE
Despina Michailidou, Runa Kuley, Ting Wang, Payton Hermanson, Peter C Grayson, David Cuthbertson, Nader A Khalidi, Curry L Koening, Carol A Langford, Carol A McAlear, Larry W Moreland, Christian Pagnoux, Philip Seo, Ulrich Specks, Antoine G Sreih, Kenneth J Warrington, Paul A Monach, Peter A Merkel, Christian Lood
Levels of neutrophil extracellular traps (NETs) were measured in plasma of healthy controls (HC, n = 30) and patients with granulomatosis with polyangiitis (GPA, n = 123), microscopic polyangiitis (MPA, n = 61), Takayasu's arteritis (TAK, n = 58), and giant cell arteritis (GCA, n = 68), at times of remission or activity and correlated with levels of the platelet-derived thrombospondin-1 (TSP-1). Levels of NETs were elevated during active disease in patients with GPA (p < 0...
March 4, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36878420/normal-neonatal-trec-and-krec-levels-in-early-onset-juvenile-idiopathic-arthritis
#14
JOURNAL ARTICLE
Judith Amalia Gudmundsdottir, Sigridur Thorgeirsdottir, Veroniqa Lundbäck, Christina Göngrich, Jenny Lingman Framme, Erik Kindgren, Karin Rydenman, Bjorn Runar Ludviksson, Helga Bjarnadottir, Saga Runarsdottir, Staffan Nilsson, Rolf H Zetterström, Olov Ekwall, Susanne Lindgren
OBJECTIVE: Dysregulated central tolerance predisposes to autoimmune diseases. Reduced thymic output as well as compromised central B cell tolerance checkpoints have been proposed in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim of this study was to investigate neonatal levels of T-cell receptor excision circles (TRECs) and kappa-deleting element excision circles (KRECs), as markers of T- and B-cell output at birth, in patients with early onset JIA. METHODS: TRECs and KRECs were quantitated by multiplex qPCR from dried blood spots (DBS), collected 2-5 days after birth, in 156 children with early onset JIA and in 312 matched controls...
March 4, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36871764/systemic-immune-activation-profiles-in-streptococcal-necrotizing-soft-tissue-infections-a-prospective-multicenter-study
#15
JOURNAL ARTICLE
Eivind Rath, Laura M Palma Medina, Sanjeevan Jahagirdar, Knut A Mosevoll, Jan K Damås, Martin B Madsen, Mattias Svensson, Ole Hyldegaard, Vitor A P Martins Dos Santos, Edoardo Saccenti, Anna Norrby-Teglund, Steinar Skrede, Trond Bruun
No abstract text is available yet for this article.
March 3, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36870379/jak-inhibition-for-cd3-cd4-lymphocytic-variant-hypereosinophilic-syndrome
#16
JOURNAL ARTICLE
Stanislas Faguer, Matthieu Groh, François Vergez, Mathilde Hunault-Berger, Nicolas Duployez, Yves Renaudineau, Carle Paul, Guillaume Lefevre, Jean-Emmanuel Kahn
Alternatives are urgently needed in patients with CD3- CD4+ lymphocytic-variant hypereosinophilic syndrome (L-HES) requiring high-level steroids or who are unresponsive and/or intolerant to conventional alternative therapies. We report five L-HES patients (44-66 years) with cutaneous involvement (n = 5) and persistent eosinophilia (n = 3) despite conventional therapies, who successfully received JAK inhibitors (tofacitinib n = 1, ruxolitinib n = 4)...
March 2, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36863991/corrigendum-to-metabolic-landscape-dysregulation-in-bronchoalveolar-lavage-fluid-of-checkpoint-inhibitor-pneumonitis-clinical-immunology-247-2023-109230
#17
Wenyi Yu, Yukun He, Ying Shang, Tiantian Guo, Keqiang Wang, Hongge Liang, Jianbo Xue, Xinqian Ma, Xinlin Mu, Ran Li, Zhancheng Gao
No abstract text is available yet for this article.
February 28, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36863601/a-spectrum-of-novel-anti-vascular-endothelial-cells-autoantibodies-in-idiopathic-nephrotic-syndrome-patients
#18
JOURNAL ARTICLE
Qing Ye, Dongjie Wang, Chao Zhou, Hanyan Meng, Huihui Liu, Jianhua Mao
Idiopathic nephrotic syndrome (INS) is a common renal disease characterized by disruption of the glomerular filtration barrier. In a previous study, we screened and identified podocyte autoantibodies in nephrotic syndrome patients and proposed the concept of autoimmune podocytopathy. However, circulating podocyte autoantibodies cannot reach podocytes unless glomerular endothelial cells have been damaged. Therefore, we speculate that INS patients may also have autoantibodies against vascular endothelial cells...
February 28, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36822253/difficult-to-treat-beh%C3%A3-et-syndrome-a-therapeutic-approach
#19
JOURNAL ARTICLE
Yusuf Yazici, Gulen Hatemi
Behcet syndrome is a systemic vasculitis which can involve many different organ systems. As such, treatment decisions need to be based on organ system involved. In addition, specific patient characteristics potentially predict milder or more severe course, and all these factors need to be taken into consideration when making treatment decisions. In this paper, we review the current approaches to treating Behcet syndrome patients.
February 21, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36806705/adaptive-immune-dysfunction-in-patients-with-covid-19-and-impaired-kidney-function-during-the-omicron-surge
#20
JOURNAL ARTICLE
Jiayi Yan, Jieying Wang, Li Ding, Shang Liu, Yaping Zhan, Jiayue Lu, Zhenyuan Li, Leyi Gu, Ping Li, Mingli Zhu, Yuan Gao, XingRong Gong, Haiqun Ban, Hong Cai, Shan Mou
BACKGROUND: Little is known about the characteristics of lymphocyte subsets and the association with patient outcomes in COVID-19 with and without impaired kidney function. METHODS: Lymphocyte subsets were compared in COVID-19 patients with or without kidney dysfunction. The primary outcome was a composite of all-cause mortality or intensive care unit admission. Secondary outcomes included duration of viral shedding, length of hospital stay, and acute kidney injury...
February 18, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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