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Journals Clinical Immunology : the Offi...

Clinical Immunology : the Official Journal of the Clinical Immunology Society

https://read.qxmd.com/read/38636891/-1-s-aureus-biofilm-properties-correlate-with-immune-b-cell-subset-frequencies-and-severity-of-chronic-rhinosinusitis
#1
JOURNAL ARTICLE
Gohar Shaghayegh, Clare Cooksley, George Bouras, Beula Subashini Panchatcharam, Sholeh Feizi, Shari Javadian, Mahnaz Ramezanpour, Kevin Aaron Fenix, Peter-John Wormald, Alkis James Psaltis, Sarah Vreugde
Staphylococcus aureus mucosal biofilms are associated with recalcitrant chronic rhinosinusitis (CRS). However, S. aureus colonisation of sinus mucosa is frequent in the absence of mucosal inflammation. This questions the relevance of S. aureus biofilms in CRS etiopathogenesis. This study aimed to investigate whether strain-level variation in in vitro-grown S. aureus biofilm properties relates to CRS disease severity, in vitro toxicity, and immune B cell responses in sinonasal tissue from CRS patients and non-CRS controls...
April 16, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38636890/bone-marrow-cd8-trm-cells-induced-by-il-15-and-cd16-monocytes-contribute-to-hspc-destruction-in-human-severe-aplastic-anemia
#2
JOURNAL ARTICLE
Jie Long, Xing You, Qiong Yang, Song-Rong Wang, Ming Zhou, Wei Zhou, Caixia Wang, Huafeng Xie, Yuping Zhang, Shunqing Wang, Zhe-Xiong Lian, Liang Li
Idiopathic severe aplastic anemia (SAA) is a disease of bone marrow failure caused by T-cell-induced destruction of hematopoietic stem and progenitor cells (HSPCs), however the mechanism remains unclear. We performed single-cell RNA sequencing of PBMCs and BMMCs from SAA patients and healthy donors and identified a CD8+ T cell subset with a tissue residency phenotype (Trm) in bone marrow that exhibit high IFN-γ and FasL expression and have a higher ability to induce apoptosis in HSPCs in vitro through FasL expression...
April 16, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38636889/the-abnormal-signaling-of-the-b-cell-receptor-and-coreceptors-of-lupus-b-cells
#3
REVIEW
Stamatis-Nick C Liossis
It is easily understood that studying the physiology and pathophysiology of the BCRtriggered cascade is of importance, particularly in such diseases as systemic lupus erythematosus (SLE) that are considered by many as a "B cell disease". Even though B cells are not considered as the only players in lupus pathogenesis, and other immune and non-immune cells are certainly involved, it is the success of recent B celltargeting treatment strategies that ascribe a critical role to the lupus B cell.
April 16, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38631594/single-cell-sequencing-reveals-distinct-immune-cell-features-in-cutaneous-lesions-of-pemphigus-vulgaris-and-bullous-pemphigoid
#4
JOURNAL ARTICLE
Zhi Hu, Meiling Zheng, Ziyu Guo, Wenhui Zhou, Wenyu Zhou, Nan Yao, Guiying Zhang, Qianjin Lu, Ming Zhao
Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are two common subtypes of autoimmune bullous disease (AIBD). The key role of circulating autoreactive immune cells contributing to skin damage of AIBD has been widely recognized. Nevertheless, the immune characteristics in cutaneous lesions remain unclear. Here, we performed single-cell RNA sequencing (scRNA-seq) and single-cell VDJ sequencing (scRNA-seq) to generate transcriptional profiles for cells and T/B cell clonetype in skin lesions of BP and PV. We found that the proportions of NK&T, macrophages/ dendritic cells, B cells, and mast cells increased in BP and PV lesions...
April 15, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38621471/icos-agonist-vopratelimab-modulates-follicular-helper-t-cells-and-improves-b-cell-function-in-common-variable-immunodeficiency
#5
JOURNAL ARTICLE
Ali Sepahi, Hsi-En Ho, Prapti Vyas, Benjamin Umiker, Katalin Kis-Toth, Dmitri Wiederschain, Lin Radigan, Charlotte Cunningham-Rundles
Common variable immunodeficiency (CVID) is an immune defect characterized by hypogammaglobulinemia and impaired development of B cells into plasma cells. As follicular helper T cells (TFH ) play a central role in humoral immunity, we examined TFH cells in CVID, and investigated whether an inducible T cell co-stimulator (ICOS) agonist, vopratelimab, could modulate TFH , B cell interactions and enhance immunoglobulin production. CVID subjects had decreased TFH17 and increased TFH1 subsets; this was associated with increased transitional B cells and decreased IgG+ B and IgD- IgM- CD27+ memory B cells...
April 13, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38608995/porto-sinusoidal-vascular-disorder-and-nephrotic-range-proteinuria-due-to-venous-vasculitis-in-beh%C3%A3-et-s-disease
#6
JOURNAL ARTICLE
M E Annink, T B van der Houwen, J J T H Roelofs, R B Takkenberg, J A M van Laar, N C van der Weerd, A E Hak, A J Kwakernaak
Behçet's disease (BD) is an autoinflammatory disease of multifactorial and polygenic etiology, potentially involving arteries and veins of any size resulting in variable vessel vasculitis. We report a case of an Iranian male that presented with porto-sinusoidal vascular disorder due to venous vasculitis as initial manifestation of BD. Despite immunosuppression and anticoagulation, he subsequently developed severe nephrotic-range proteinuria that mimicked a primary renal disease but was completely and immediately ameliorated by stenting of the vena cava...
April 10, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38604255/defining-remission-in-childhood-onset-lupus-pres-endorsed-consensus-definitions-by-an-international-task-force
#7
JOURNAL ARTICLE
E M D Smith, A Aggarwal, J Ainsworth, E Al-Abadi, T Avcin, L Bortey, J Burnham, C Ciurtin, C M Hedrich, S Kamphuis, L Lambert, D M Levy, L Lewandowski, N Maxwell, E Morand, S Özen, C E Pain, A Ravelli, C Saad Magalhaes, C Pilkington, D Schonenberg-Meinema, C Scott, K Tullus, M W Beresford, B Goilav, N Goss, L Oni, S D Marks
OBJECTIVE: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. METHODS: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria. RESULTS: The Task Force proposed two definitions of remission: 'cSLE clinical remission on steroids (cCR)' and 'cSLE clinical remission off steroids (cCR-0)'...
April 9, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38599263/p75-ntr-cd64-neutrophils-promote-sepsis-induced-acute-lung-injury
#8
JOURNAL ARTICLE
Di Fu, Shan Gao, Jia-Nan Li, Yan-Hui Cui, Yan-Wei Luo, Yan-Jun Zhong, Qiao Li, Cong Luo, Ru-Ping Dai, Ru-Yi Luo, Zhao-Lan Hu
Patients suffering from sepsis-induced acute lung injury (ALI) exhibit a high mortality rate, and their prognosis is closely associated with infiltration of neutrophils into the lungs. In this study, we found a significant elevation of CD64+ neutrophils, which highly expressed p75 neurotrophin receptor (p75NTR ) in peripheral blood of mice and patients with sepsis-induced ALI. p75NTR+ CD64+ neutrophils were also abundantly expressed in the lung of ALI mice induced by lipopolysaccharide. Conditional knock-out of the myeloid lineage's p75NTR gene improved the survival rates, attenuated lung tissue inflammation, reduced neutrophil infiltration and enhanced the phagocytic functions of CD64+ neutrophils...
April 8, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38582251/wiskott-aldrich-syndrome-protein-wasp-deficient-th1-cells-promote-r-loop-driven-transcriptional-insufficiency-and-transcription-coupled-nucleotide-excision-repair-factor-tc-ner-driven-genome-instability-in-the-pathogenesis-of-t-cell-acute-lymphoblastic-leukemia
#9
JOURNAL ARTICLE
R Pradeep, Sudeshna Rakshit, Geetha Shanmugam, Melvin George, Koustav Sarkar
BACKGROUND: T-ALL is an aggressive hematological tumor that develops as the result of a multi-step oncogenic process which causes expansion of hematopoietic progenitors that are primed for T cell development to undergo malignant transformation and growth. Even though first-line therapy has a significant response rate, 40% of adult patients and 20% of pediatric patients will relapse. Therefore, there is an unmet need for treatment for relapsed/refractory T-ALL to develop potential targeted therapies...
April 4, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38582250/new-and-emerging-therapies-for-systemic-lupus-erythematosus
#10
REVIEW
Eleni Papachristodoulou, Vasileios C Kyttaris
Systemic Lupus Erythematosus (SLE) and lupus nephritis treatment is still based on non-specific immune suppression despite the first biological therapy for the disease having been approved more than a decade ago. Intense basic and translational research has uncovered a multitude of pathways that are actively being evaluated as treatment targets in SLE and lupus nephritis, with two new medications receiving FDA approval in the last 3 years. Herein we provide an overview of targeted therapies for SLE including medications targeting the B lymphocyte compartment, intracellular signaling, co-stimulation, and finally the interferons and other cytokines...
April 4, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38575046/increased-axl-high-myeloid-cells-as-pathognomonic-marker-in-langerhans-cell-histiocytosis-and-langerin-expression-dependence-of-mtor-inhibition
#11
JOURNAL ARTICLE
Cinthia Mariel Olexen, Denise Risnik, María Catalina Lava, Guido Luis Dalla Vecchia, Diego Alfredo Rosso, Andrea Emilse Errasti, Eugenio Antonio Carrera Silva
Langerhans cell histiocytosis (LCH) is characterized by an expansion and accumulation of pathological histiocytes expressing langerin (CD207) and CD1a in different organs under an inflammatory milieu. The origin of pathognomonic precursors of LCH is widely debated, but monocytes and pre dendritic cells (pre-DC) play significant role. Remarkable we found an expansion of AXLhigh cells in the CD11c+ subset of patients with active LCH, which also express the pathognomonic CD207 and CD1a. Moreover, we obtained a monocyte-derived LC-like (mo-LC-like) expressing high levels of AXL when treated with inflammatory cytokine, or plasma of patients with active disease...
April 2, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38575045/duodenal-mucosa-of-untreated-celiac-disease-patients-has-altered-expression-of-the-gas6-and-pros1-and-the-negative-regulator-tyrosine-kinase-tam-receptors-subfamily
#12
JOURNAL ARTICLE
Federico Perez, María Luz Iribarren, Cinthia Mariel Olexen, Carolina Naymé Ruera, Andrea Emilse Errasti, Luciana Guzman, Laura Garbi, Eugenio Antonio Carrera-Silva, Fernando Gabriel Chirdo
Celiac disease (CD) is an immune-driven disease characterized by tissue damage in the small intestine of genetically-susceptible individuals. We evaluated here a crucial immune regulatory pathway involving TYRO3, AXL, and MERTK (TAM) receptors and their ligands PROS1 and GAS6 in duodenal biopsies of controls and CD patients. We found increased GAS6 expression associated with downregulation of PROS1 and variable TAM receptors levels in duodenum tissue of CD patients. Interestingly, CD3+ lymphocytes, CD68+ , CD11c+ myeloid and epithelial cells, showed differential expressions of TAM components comparing CD vs controls...
April 2, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38575044/integration-of-metalloproteome-and-immunoproteome-reveals-a-tight-link-of-iron-related-proteins-with-covid-19-pathogenesis-and-immunity
#13
JOURNAL ARTICLE
Ying Zhou, Tianfan Cheng, Kaiming Tang, Hongyan Li, Cuiting Luo, Fu Yu, Fan Xiao, Lijian Jin, Ivan Fan-Ngai Hung, Liwei Lu, Kwok-Yung Yuen, Jasper Fuk-Woo Chan, Shuofeng Yuan, Hongzhe Sun
Increasing clinical data show that the imbalance of host metallome is closely associated with different kinds of disease, however, the intrinsic mechanisms of action of metals in immunity and pathogenesis of disease remain largely undefined. There is lack of multiplexed profiling system to integrate the metalloproteome-immunoproteome information at systemic level for exploring the roles of metals in immunity and disease pathogenesis. In this study, we build up a metal-coding assisted multiplexed proteome assay platform for serum metalloproteomic and immunoproteomic profiling...
April 2, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38575043/identification-of-connective-tissue-disease-autoantibodies-and-a-novel-autoantibody-anti-annexin-a11-in-patients-with-idiopathic-interstitial-lung-disease
#14
JOURNAL ARTICLE
Sarah L Tansley, Fionnuala McMorrow, Caroline V Cotton, Huzaifa Adamali, Shaney L Barratt, Zoe E Betteridge, Janire Perurena-Prieto, Michael A Gibbons, Raman Kular, Aravinthan Loganathan, Janine A Lamb, Hui Lu, Robert P New, Diane Pratt, Pilar Rivera-Ortega, Ross Sayers, Matthew Steward, Lachlan Stranks, Edward Vital, Lisa G Spencer, Neil J McHugh, Robert G Cooper
BACKGROUND: Autoantibodies are a hallmark feature of Connective Tissue Diseases (CTD). Their presence in patients with idiopathic interstitial lung disease (ILD) may suggest covert CTD. We aimed to determine the prevalence of CTD autoantibodies in patients diagnosed with idiopathic ILD. METHODS: 499 patient sera were analysed: 251 idiopathic pulmonary fibrosis (IPF), 206 idiopathic non-specific interstitial pneumonia (iNSIP) and 42 cryptogenic organising pneumonia (COP)...
April 2, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38570004/methylation-levels-of-the-il10-gene-in-peripheral-blood-are-related-to-the-intractability-of-graves-disease
#15
JOURNAL ARTICLE
Riku Kinoshita, Naoya Inoue, Yoshinori Iwatani, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe
The prognosis of autoimmune thyroid diseases (AITDs), including Hashimoto's disease (HD) and Graves' disease (GD), is difficult to predict. DNA methylation regulates gene expression of immune mediating factors. Interleukin (IL)-10 is a Th2 cytokine that downregulates inflammatory cytokines produced by Th1 cells. To clarify the role of methylation of the IL10 gene in the prognosis of AITD, we evaluated the methylation levels of two CpG sites in the IL10 promoter using pyrosequencing. The methylation levels of the -185 CpG site of the IL10 gene were related to age and GD intractability in GD patients...
April 1, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38565329/macrophage-migration-inhibitory-factor-mediates-skin-aging-via-cd74-insights-from-single-cell-and-bulk-rna-sequencing-data
#16
JOURNAL ARTICLE
Songjiang Wu, Yujie Ouyang, Yibo Hu, Ling Jiang, Chuhan Fu, Li Lei, Yushan Zhang, Haoran Guo, Jinhua Huang, Jing Chen, Qinghai Zeng
Cell-cell communication is crucial for regulating signaling and cellular function. However, the precise cellular and molecular changes remain poorly understood in skin aging. Based on single-cell and bulk RNA data, we explored to assess the role of cell-cell ligand-receptor interaction in skin aging. We found that the macrophage migration inhibitory factor (MIF)/CD74 was significantly upregulated and frequent interactions were observed on fibroblasts in aged skin. Enrichment analysis and in vitro experiment revealed a close association of the activation of the MIF/CD74 with inflammatory pathways and immune response...
March 31, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38555222/retraction-notice-to-prevention-of-carrageenan-induced-pleurisy-in-mice-by-anti-cd30-ligand-monoclonal-antibody-clin-immunol-113-1-2004-64-73
#17
Rosanna Di Paola, Roberto Di Marco, Emanuela Mazzon, Tiziana Genovese, Klaus Bendtzen, Battesimo Macri, Ferdinando Nicoletti, Salvatore Cuzzocrea
No abstract text is available yet for this article.
March 29, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38555221/retraction-notice-to-glycogen-synthase-kinase-3%C3%AE-inhibition-attenuates-the-degree-of-arthritis-caused-by-type-ii-collagen-in-the-mouse-clin-immunol-120-1-2006-57-67
#18
Salvatore Cuzzocrea, Emanuela Mazzon, Rosanna Di Paola, Carmelo Muià, Concetta Crisafulli, Laura Dugo, Marika Collin, Domenico Britti, Achille P Caputi, Christoph Thiemermann
No abstract text is available yet for this article.
March 29, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38508295/type-i-interferon-associated-epistasis-may-contribute-to-early-disease-onset-and-high-disease-activity-in-juvenile-onset-lupus
#19
REVIEW
Yves Renaudineau, Amandine Charras, Valentina Natoli, Mathieu Fusaro, Eve M D Smith, Michael W Beresford, Christian M Hedrich
Pathologic type I interferon (T1IFN) expression is a key feature in systemic lupus erythematosus (SLE) that associates with disease activity. When compared to adult-onset disease, juvenile-onset (j)SLE is characterized by increased disease activity and damage, which likely relates to increased genetic burden. To identify T1IFN-associated gene polymorphisms (TLR7, IRAK1, miR-3142/miR-146a, IRF5, IRF7, IFIH1, IRF8, TYK2, STAT4), identify long-range linkage disequilibrium and gene:gene interrelations, 319 jSLE patients were genotyped using panel sequencing...
March 18, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38494058/cd32-fc%C3%AE-riib-expression-is-low-on-cd21-low-b-cells-from-systemic-sclerosis-patients-with-digital-ulcers-interstitial-lung-disease-and-anti-topoisomerase-i-autoantibodies
#20
JOURNAL ARTICLE
Evangeli Kourkouni, Sotirios G Tsiogkas, Athanasios Mavropoulos, Theodora Simopoulou, Christina G Katsiari, Dimitrios P Bogdanos, Lazaros I Sakkas
CD21low B cells have recently been found increased in SSc-associated digital ulcers (DUs) or interstitial lung disease (ILD). To further characterize CD21low B cells which encompass autoreactive cells, we analyzed their expression of the inhibitory CD32 receptor in SSc. Peripheral blood mononuclear cells from 27 patients with SSc and 15 age-and sex-matched healthy controls (HCs) were analyzed with multicolor flow cytometry. CD21low B cells were significantly increased in patients with DUs (51.3%) compared to HCs (28...
March 15, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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