Sabrina Alves Dos Reis, Jessica Dias Gonçalves, Karoline Dos Anjos Lima, Thaina Magalhaes Demaria, Emylle Costa-Bartuli, Tiago Araujo Gomes, Meydson Benjamim Carvalho Corrêa, Georgia Correa Atella, Mauro Sola-Penna, Patricia Sammarco Rosa, Maria Cristina Vidal Pessolani, Jyothi Nagajyothi, Flavio Alves Lara
Leprosy is a chronic infectious disease caused by the intracellular bacillus Mycobacterium leprae (M. leprae), which is known to infect skin macrophages and Schwann cells. Although adipose tissue is a recognized site of M. tuberculosis infection, its role in the histopathology of leprosy was, until now, unknown. We analyzed the M. leprae capacity to infect and persist inside adipocytes, characterizing the induction of a lipolytic phenotype in adipocytes, as well as the effect of these infected cells on macrophage recruitment...
December 21, 2023: Microbes and Infection