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Journals Diabetes/metabolism Research a...

Diabetes/metabolism Research and Reviews

https://read.qxmd.com/read/38686868/cost-effectiveness-of-temperature-monitoring-to-help-prevent-foot-ulcer-recurrence-in-people-with-diabetes-a-multicenter-randomized-controlled-trial
#21
RANDOMIZED CONTROLLED TRIAL
Jaap J Van Netten, Wouter B Aan De Stegge, Marcel G W Dijkgraaf, Sicco A Bus
AIMS: Diabetes-related foot ulcers are common, costly, and frequently recur. Multiple interventions help prevent these ulcers. However, none of these have been prospectively investigated for cost-effectiveness. Our aim was to evaluate the cost-effectiveness of at-home skin temperature monitoring to help prevent diabetes-related foot ulcer recurrence. MATERIALS AND METHODS: Multicenter randomized controlled trial. We randomized 304 persons at high diabetes-related foot ulcer risk to either usual foot care plus daily at-home foot skin temperature monitoring (intervention) or usual care alone (control)...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38661109/estimating-the-effect-of-lipid-lowering-agents-on-novel-subtypes-of-adult-onset-diabetes
#22
JOURNAL ARTICLE
Jianan Ye, Keyu Guo, Jiaqi Li, Xia Li, Zhiguang Zhou, Lin Yang
AIMS: The aims of the present study were to assess the effects of lipid-lowering drugs [HMG-CoA reductase inhibitors, proprotein convertase subtilisin/kexin type 9 inhibitors, and Niemann-Pick C1-Like 1 (NPC1L1) inhibitors] on novel subtypes of adult-onset diabetes through a Mendelian randomisation study. MATERIALS AND METHODS: We first inferred causal associations between lipid-related traits [including high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), apolipoproteins A-I, and apolipoproteins B] and novel subtypes of adult-onset diabetes...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38634501/global-regional-and-national-burden-of-blindness-and-vision-loss-attributable-to-high-fasting-plasma-glucose-from-1990-to-2019-and-forecasts-to-2030-a-systematic-analysis-for-the-global-burden-of-disease-study-2019
#23
JOURNAL ARTICLE
Cong Li, Guangyao Hua, Shunming Liu, Honghua Yu, Xiaohong Yang, Lei Liu
AIMS: To systematically clarify the spatiotemporal trends, and age-sex-specific blindness and vision loss (BVL) burden due to high fasting plasma glucose (HFPG) from 1990 to 2019, and project this burden over the next decade. MATERIALS AND METHODS: We obtained the number and rate of years lived with disability (YLDs) for the BVL burden attributable to HFPG by age, sex, socio-demographic index (SDI), and location between 1990 and 2019 from the Global Burden of Disease (GBD) 2019 database...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38616511/multi-feature-chinese-western-medicine-integrated-prediction-model-for-diabetic-peripheral-neuropathy-based-on-machine-learning-and-shap
#24
JOURNAL ARTICLE
Aijuan Jiang, Jiajie Li, Lujie Wang, Wenshu Zha, Yixuan Lin, Jindong Zhao, Zhaohui Fang, Guoming Shen
BACKGROUND: Clinical studies have shown that diabetic peripheral neuropathy (DPN) has been on the rise, with most patients presenting with severe and progressive symptoms. Currently, most of the available prediction models for DPN are derived from general clinical information and laboratory indicators. Several Traditional Chinese medicine (TCM) indicators have been utilised to construct prediction models. In this study, we established a novel machine learning-based multi-featured Chinese-Western medicine-integrated prediction model for DPN using clinical features of TCM...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38616492/the-unique-multidisciplinarity-of-diabetes-related-foot-disease
#25
EDITORIAL
Jaap J van Netten, Jan Apelqvist, Sicco A Bus, Robert Fitridge, Fran Game, Matilde Monteiro-Soares, Eric Senneville, Nicolaas C Schaper
Few diseases globally require treatment from so many different disciplines as diabetes-related foot disease. At least 25 different professionals may be involved: casting technicians, dermatologists, diabetes (educator) nurses, diabetologists, dieticians, endocrinologists, general practitioners, human movement scientists, infectious diseases experts, microbiologists, nuclear medicine physicians, orthopaedic surgeons, orthotists, pedorthists, physical therapists, plastic surgeons, podiatric surgeons, podiatrists, prosthetists, psychologists, radiologists, social workers, tissue viability physicians, vascular surgeons, and wound care nurses...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38581399/associations-of-birth-weight-plasma-metabolome-in-adulthood-and-risk-of-type-2-diabetes
#26
JOURNAL ARTICLE
Wenxiu Wang, Zhenhuang Zhuang, Yimin Zhao, Zimin Song, Ninghao Huang, Yueying Li, Xue Dong, Wendi Xiao, Tao Huang
AIMS: We aimed to examine the longitudinal associations of birth weight with plasma metabolites in adulthood, and further quantify the proportions of the links between birth weight and incident adult type 2 diabetes (T2D) that were mediated by plasma metabolites. MATERIALS AND METHODS: A total of 62,033 participants with complete nuclear magnetic resonance metabolomics and birth weight data from the UK Biobank were included in this study. Linear regression was used to assess the associations between birth weight and metabolites...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38581397/lada-30th-anniversary-a-growing-form-of-diabetes-with-persistent-unresolved-questions
#27
JOURNAL ARTICLE
Ivy Lee Jia Jia, Raffaella Buzzetti, Richard David Leslie, Paolo Pozzilli
No abstract text is available yet for this article.
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38558269/clusters-of-adipose-tissue-dysfunction-in-adults-with-type-2-diabetes-identify-those-with-worse-lipidomic-profile-despite-similar-glycaemic-control
#28
JOURNAL ARTICLE
Giuseppe Della Pepa, Fabrizia Carli, Silvia Sabatini, Samantha Pezzica, Marco Russo, Marilena Vitale, Maria Masulli, Gabriele Riccardi, Angela A Rivellese, Olga Vaccaro, Lutgarda Bozzetto, Amalia Gastaldelli
AIMS: To investigate clusters of adipose tissue dysfunction, that is, with adipose tissue insulin resistance (ADIPO-IR) and large waist circumference (WC), identify a worse lipidomic profile characterised by a high proportion of lipids rich in saturated fatty acids (SFA). MATERIALS AND METHODS: Hierarchical clustering based on WC and ADIPO-IR (calculated as fasting plasma non-esterified fatty acids times fasting plasma insulin, FFA×INS), was performed in 192 adults with overweight/obesity and type 2 diabetes (T2D) treated with metformin (HbA1c = 7...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38549238/adherence-to-glp1-ra-and-sglt2-i-affects-clinical-outcomes-and-costs-in-patients-with-type-2-diabetes
#29
JOURNAL ARTICLE
Stefano Ciardullo, Laura Savaré, Federico Rea, Gianluca Perseghin, Giovanni Corrao
AIMS: To evaluate the impact of adherence to glucagon like peptide-1 receptor agonists (GLP1-RA) and sodium-glucose transporter two inhibitors (SGLT2-I) on clinical outcomes and costs in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: The 121,115 residents of the Lombardy Region (Italy) aged ≥40 years newly treated with metformin during 2007-2015 were followed to identify those who started therapy with GLP1-RA or SGLT2-I. Adherence to drug therapy over the first year was defined as the proportion of days covered >80%...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38546151/overburden-of-rare-alms1-deleterious-variants-in-chinese-early-onset-type-2-diabetes-with-severe-insulin-resistance
#30
JOURNAL ARTICLE
Simin Zhang, Siqian Gong, Meng Li, Xiaoling Cai, Wei Liu, Yingying Lou, Yumin Ma, Xiuying Zhang, Qian Ren, Yu Zhu, Jing Wu, Lingli Zhou, Yufeng Li, Xianghai Zhou, Xueyao Han, Linong Ji
AIMS: Alström syndrome (AS) is a rare recessive disorder characterised by diabetes, obesity, insulin resistance (IR), and visual and hearing impairments. Mutations in the ALMS1 gene have been identified as the causative agents of AS. This study aimed to explore the relationship between rare ALMS1 variants and clinical features in Chinese patients with early-onset type 2 diabetes (age at diagnosis ≤40 years; EOD). MATERIALS AND METHODS: ALMS1 gene sequencing was performed in 611 Chinese individuals with EOD, 36 with postprandial hyperinsulinemia, and 47 with pre-diabetes and fasting IR...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38546142/association-of-combined-healthy-lifestyle-with-risk-of-adverse-outcomes-in-patients-with-prediabetes
#31
JOURNAL ARTICLE
Xiaoqin Xu, Jiang Li, Yuefeng Yu, Xiao Tan, Fei Xu, Bin Wang, Ningjian Wang, Yingli Lu
OBJECTIVE: Prediabetes and lifestyle factors have been associated with the risks of multiple adverse outcomes, but the effect of a healthy lifestyle on prediabetes-related complications remains unknown. We aimed to investigate whether the risks of multiple adverse outcomes including incident type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and chronic kidney disease (CKD) among individuals with prediabetes can be offset by a broad combination of healthy lifestyle factors...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38546139/elevated-liver-enzymes-in-the-first-trimester-are-associated-with-gestational-diabetes-mellitus-a-prospective-cohort-study
#32
JOURNAL ARTICLE
Lingling Cui, Xiaoli Yang, Zhiqian Li, Yuting Gao, Zhengya Zhang, Dongmei Xu, Xinxin Liu
AIMS: Previous studies have found that a single liver enzyme may predict gestational diabetes mellitus (GDM), but the results have been inconsistent. This study aimed to explore the associations of liver enzymes in early pregnancy with risk of GDM, as well as to independently rank risk factors. METHODS: This prospective cohort study included 1295 women who underwent liver enzyme measurements during early pregnancy and completed GDM assessment in mid-pregnancy. Logistic regression and restricted cubic spline analyses were conducted to assess the relationship between liver enzymes and risk of GDM...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38529788/care-control-and-complications-of-hospitalised-patients-with-type-1-diabetes-in-china-a-nationwide-based-registry-study
#33
JOURNAL ARTICLE
Chao Deng, Yuting Xie, Juan Li, Hongwei Jiang, Xiaohong Niu, Dewen Yan, Heng Su, Hongyu Kuang, Liming Tian, Jing Liu, Sheng Jiang, Huibiao Quan, Jixiong Xu, Xiaohong Wu, Na Tao, Shuguang Sun, Xiaohan Tang, Yan Chen, Li Fan, Xia Li, Zhiguang Zhou
AIMS: To evaluate the status quo of type 1 diabetes (T1D) management and characteristics of hospitalised patients with T1D in China through a nationwide multicentre registry study, the China Diabetes Type 1 Study (CD1S). MATERIALS AND METHODS: Clinical data from the electronic hospital records of all people with T1D were retrospectively collected in 13 tertiary hospitals across 7 regions of China from January 2016 to December 2021. Patients were defined as newly diagnosed who received a diagnosis of diabetes for less than 3 months...
March 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38523292/sglt2-inhibition-and-three-urological-cancers-up-to-date-results
#34
JOURNAL ARTICLE
Lede Lin, Kang Ning, Liyuan Xiang, Liao Peng, Xiang Li
OBJECTIVE: To identify the causal role of sodium-glucose cotransporter 2 (SGLT2) inhibition on three urological cancers. METHODS: Six single nucleotide polymorphisms associated with the expression level of SLC5A2, a proxy for SGLT2 inhibition, from a recent publication were extracted. Three common urological cancers, including bladder cancer, prostate cancer and kidney cancer, were analysed. The main cohort of bladder cancer was derived from UK Biobank (1279 cases and 372,016 controls)...
March 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38517730/interaction-effects-of-mthfr-c677t-and-a1298c-polymorphisms-with-maternal-glycated-haemoglobin-levels-on-adverse-birth-outcomes
#35
JOURNAL ARTICLE
Weixiang Wu, Dan Luo, Cunwei Ji, Fuqiang Diao, Lihong Wu, Xiaolin Ruan, Chunming Gu, Mingyong Luo
AIMS: The role of maternal genetic factors in the association between high glycated haemoglobin (HbA1c) levels and adverse birth outcomes remains unclear. MATERIALS AND METHODS: In this study, the maternal HbA1c levels of 5108 normoglycemic pregnant women in China were measured, and A1298C and C677T polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene were genotyped. RESULTS: Elevated HbA1c levels during the second trimester were associated with increased risks of macrosomia, large-for-gestational age (LGA), preterm birth (PTB), and reduced gestational age (p < 0...
March 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38517704/influence-of-sphingolipid-enzymes-on-blood-glucose-levels-development-of-diabetes-and-involvement-of-pericytes
#36
JOURNAL ARTICLE
Karsten Buschard, Knud Josefsen, Lars Krogvold, Ivan Gerling, Knut Dahl-Jørgensen, Flemming Pociot
AIMS: Sulfatide is a chaperone for insulin manufacturing in beta cells. Here we explore whether the blood glucose values normally could be associated with this sphingolipid and especially two of its building enzymes CERS2 and CERS6. Both T1D and T2D have low blood sulfatide levels, and insulin resistance on beta cells at clinical diagnosis. Furthermore, we examined islet pericytes for sulfatide, and beta-cell receptors for GLP-1, both of which are related to the insulin production. MATERIALS AND METHODS: We examined mRNA levels in islets from the DiViD and nPOD studies, performed genetic association analyses, and histologically investigated pericytes in the islets for sulfatide...
March 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38507616/effectiveness-of-interventions-to-enhance-healing-of-chronic-foot-ulcers-in-diabetes-a-systematic-review
#37
JOURNAL ARTICLE
Pam Chen, Nalini Campillo Vilorio, Ketan Dhatariya, William Jeffcoate, Ralf Lobmann, Caroline McIntosh, Alberto Piaggesi, John Steinberg, Prash Vas, Vijay Viswanathan, Stephanie Wu, Fran Game
BACKGROUND: It is critical that interventions used to enhance the healing of chronic foot ulcers in diabetes are backed by high-quality evidence and cost-effectiveness. In previous years, the systematic review accompanying guidelines published by the International Working Group of the Diabetic Foot performed 4-yearly updates of previous searches, including trials of prospective, cross-sectional and case-control design. AIMS: Due to a need to re-evaluate older studies against newer standards of reporting and assessment of risk of bias, we performed a whole new search from conception, but limiting studies to randomised control trials only...
March 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38501707/clinical-metabolomics-characteristics-of-diabetic-kidney-disease-a-meta-analysis-of-1875-cases-with-diabetic-kidney-disease-and-4503-controls
#38
JOURNAL ARTICLE
Yu Yuan, Liping Huang, Lulu Yu, Xingxu Yan, Siyu Chen, Chenghao Bi, Junjie He, Yiqing Zhao, Liu Yang, Li Ning, Hua Jin, Rongrong Yang, Yubo Li
AIMS: Diabetic Kidney Disease (DKD), one of the major complications of diabetes, is also a major cause of end-stage renal disease. Metabolomics can provide a unique metabolic profile of the disease and thus predict or diagnose the development of the disease. Therefore, this study summarises a more comprehensive set of clinical biomarkers related to DKD to identify functional metabolites significantly associated with the development of DKD and reveal their driving mechanisms for DKD. MATERIALS AND METHODS: We searched PubMed, Embase, the Cochrane Library and Web of Science databases through October 2022...
March 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38500307/erratum-to-adherence-to-an-energy-restricted-mediterranean-diet-is-associated-with-the-presence-and-burden-of-carotid-atherosclerosis-in-people-with-type-1-diabetes
#39
(no author information available yet)
No abstract text is available yet for this article.
March 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38461408/non-invasive-assessment-of-hepatic-steatosis-by-ultrasound-derived-fat-fraction-in-individuals-at-high-risk-for-metabolic-dysfunction-associated-steatotic-liver-disease
#40
JOURNAL ARTICLE
Federica Tavaglione, Valentina Flagiello, Francesca Terracciani, Paolo Gallo, Emma Capparelli, Chiara Spiezia, Antonio De Vincentis, Andrea Palermo, Sara Scriccia, Giovanni Galati, Nicola Napoli, Samuel J Daniels, Jenny E Blau, Björn Carlsson, Yeganeh M Khazrai, Raffaele Antonelli Incalzi, Antonio Picardi, Umberto Vespasiani-Gentilucci
AIMS: Given the increasing number of individuals developing metabolic dysfunction-associated steatotic liver disease (MASLD) and the low rate of those with progressive liver disease, there is a pressing need to conceive affordable biomarkers to assess MASLD in general population settings. Herein, we aimed to investigate the performance of the ultrasound-derived fat fraction (UDFF) for hepatic steatosis in high-risk individuals. METHODS: A total of 302 Europeans with obesity, type 2 diabetes, or a clinical history of hepatic steatosis were included in the analyses...
March 2024: Diabetes/metabolism Research and Reviews
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