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Journals Diabetes/metabolism Research a...

Diabetes/metabolism Research and Reviews

https://read.qxmd.com/read/38873748/the-long-term-effect-of-bariatric-metabolic-surgery-versus-pharmacologic-therapy-in-type-2-diabetes-mellitus-patients-a-systematic-review-and-meta-analysis
#1
REVIEW
Yumeng Yang, Chuhan Miao, Yingli Wang, Jianxun He
Metabolic/bariatric surgery as a treatment for obesity and related diseases, such as type 2 diabetes mellitus (T2DM), has been increasingly recognised in recent years. However, compared with conventional pharmacologic therapy, the long-term effect (≥ 5 years) of metabolic surgery in T2DM patients is still unclear. This study aimed to evaluate the diabetes remission rate, incidence of diabetic microvascular complications, incidence of macrovascular complications, and mortality in T2DM patients who received metabolic surgery versus pharmacologic therapy more than 5 years after the surgery...
July 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38872492/associations-between-multiple-neurological-biomarkers-and-distal-sensorimotor-polyneuropathy-kora-f4-ff4-study
#2
JOURNAL ARTICLE
Christian Herder, Barbara Thorand, Alexander Strom, Wolfgang Rathmann, Margit Heier, Wolfgang Koenig, Helen Morrison, Dan Ziegler, Michael Roden, Annette Peters, Gidon J Bönhof, Haifa Maalmi
AIMS: The aim of this study was to assess associations between neurological biomarkers and distal sensorimotor polyneuropathy (DSPN). MATERIALS AND METHODS: Cross-sectional analyses were based on 1032 participants aged 61-82 years from the population-based KORA F4 survey, 177 of whom had DSPN at baseline. The prevalence of type 2 diabetes was 20%. Prospective analyses used data from 505 participants without DSPN at baseline, of whom 125 had developed DSPN until the KORA FF4 survey...
July 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38859687/stuttering-in-adolescence-and-the-risk-for-dysglycemia-in-early-adulthood
#3
JOURNAL ARTICLE
Alexandra Rabotin, Yair Schwarz, Orit Pinhas-Hamiel, Ofer Amir, Estela Derazne, Dorit Tzur, Gabriel Chodick, Arnon Afek, Avishai M Tsur, Gilad Twig
AIMS: To investigate the association between stuttering during adolescence and the onset of dysglycemia (prediabetes or type 2 diabetes) in early adulthood among men and women. MATERIALS AND METHODS: This cohort study included Maccabi Health Services members assessed for mandatory military service at ages 16-19 during 1990-2019 and followed until 31 December 2020. Stuttering status was recorded in the baseline medical evaluation. Incident cases of dysglycemia were identified systematically using prediabetes and diabetes registries...
July 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38850100/fasting-pancreatic-polypeptide-predicts-incident-microvascular-and-macrovascular-complications-of-type-2-diabetes-an-observational-study
#4
JOURNAL ARTICLE
Amir H Sam, Adam J Buckley, Brian Y H Lam, Gavin A Bewick, Paul R Bech, Karim Meeran, Maha T Barakat, Stephen R Bloom, Giles S H Yeo, Nader G Lessan, Kevin G Murphy
AIMS: Pancreatic polypeptide (PP) is elevated in people with vascular risk factors such as type 2 diabetes or increased visceral fat. We investigated potential relationships between PP and microvascular and macrovascular complications of diabetes. MATERIALS AND METHODS: Animal study: Subcutaneous PP infusion for 4 weeks in high fat diet mouse model. Retinal mRNA submitted for Ingenuity Pathway Analysis. Human study: fasting PP measured in 1478 participants and vascular complications recorded over median 5...
July 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38837532/prevalence-and-factors-associated-with-thyroid-autoimmunity-among-children-newly-diagnosed-with-type-1-diabetes-before-and-during-the-covid-19-pandemic-evidence-from-kuwait
#5
JOURNAL ARTICLE
Dalia Al-Abdulrazzaq, Ahmed Najeeb Albatineh, Doaa Khalifa, Anwaar Alrefae, Ebaa Al-Awadhi, Abdullah Alkandari, Doha Alhomaidah, Solveig Argeseanu Cunningham, Hessa Al-Kandari
AIMS: This study reports the prevalence and characteristics related to the development of thyroid autoimmunity among children newly diagnosed with type I diabetes (T1D) during the COVID-19 pandemic in Kuwait. MATERIALS AND METHODS: This is a prospective observational study of all children under age 14 years newly diagnosed with T1D in Kuwait. We define the duration of the COVID-19 pandemic from the official declaration of the first identified positive COVID-19 case on 24 February 2020 until 31 December 2022...
July 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38837323/the-circadian-syndrome-is-a-predictor-for-cognition-impairment-in-middle-aged-adults-comparison-with-the-metabolic-syndrome
#6
COMPARATIVE STUDY
Zumin Shi, Naftali Stern, Jianghong Liu, Jaakko Tuomilehto, Noga Kronfeld-Schor, Assam El-Osta, George Alberti, Zhonglin Chai, Carmel Bilu, Haim Einat, Yonit Marcus, Paul Zimmet
AIMS: Circadian syndrome (CircS) is considered a better predictor for cardiovascular disease than the metabolic syndrome (MetS). We aim to examine the associations between CircS and MetS with cognition in Chinese adults. METHOD: We used the data of 8546 Chinese adults aged ≥40 years from the 2011 China Health and Retirement Longitudinal Study. MetS was defined using harmonised criteria. CircS included the components of MetS plus short sleep and depression...
July 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38824455/time-in-tight-range-in-children-and-adolescents-with-type-1-diabetes-a-cross-sectional-observational-single-centre-study-evaluating-efficacy-of-new-advanced-technologies
#7
JOURNAL ARTICLE
Riccardo Schiaffini, Alessandra Lumaca, Mariangela Martino, Novella Rapini, Annalisa Deodati, Maria Elisa Amodeo, Paolo Ciampalini, Maria Cristina Matteoli, Valentina Pampanini, Stefano Cianfarani
INTRODUCTION: Early and tight glycaemic control is crucial to prevent long-term complications of Type 1 Diabetes (T1D). The aim of our study was to compare glucose metrics, including Time In Tight Range (TITR), in a real-world setting. METHODS: We performed a single-centre cross-sectional study in 534 children and adolescents with T1D. Participants were divided into four groups (multiple daily injections + real-time Continuous glucose monitoring (CGM), multiple daily injections + intermittently scanned CGM, sensor augmented pump (SAP), and Advanced Hybrid Closed-Loop (AHCL)...
July 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38821874/monogenic-diabetes-in-a-chinese-population-with-young-onset-diabetes-a-17-year-prospective-follow-up-study-in-hong-kong
#8
JOURNAL ARTICLE
Sandra T F Tsoi, Cadmon Lim, Ronald C W Ma, Eric S H Lau, Baoqi Fan, Elaine Chow, Alice P S Kong, Juliana C N Chan, Andrea O Y Luk
AIMS: Asians have a high prevalence of young-onset diabetes, but the pattern of monogenic diabetes is unknown. We aimed to determine the prevalence of monogenic diabetes in Chinese patients with young-onset diabetes and compare the clinical characteristics and outcome between patients with and without monogenic diabetes. MATERIALS AND METHODS: We sequenced a targeted panel of 33 genes related to monogenic diabetes in 1021 Chinese patients with non-type 1 diabetes diagnosed at age ≤40 years...
July 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38769695/gestational-diabetes-mellitus-is-associated-with-distinct-folate-related-metabolites-in-early-and-mid-pregnancy-a-prospective-cohort-study
#9
JOURNAL ARTICLE
Wei Zheng, Yujie Zhang, Puyang Zhang, Tengda Chen, Xin Yan, Lin Li, Lijun Shao, Zhiru Song, Weiling Han, Jia Wang, Junhua Huang, Kaiwen Ma, Ruihua Yang, Yuru Ma, Lili Xu, Kexin Zhang, Xianxian Yuan, Guanghui Li
AIMS: This study aimed to evaluate the association between gestational diabetes mellitus (GDM) and circulating folate metabolites, folic acid (FA) intake, and the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genotype. MATERIALS AND METHODS: A prospective pregnancy cohort study was conducted in Beijing, China, from 2022 to 2023. Circulating folate metabolites, including red blood cell (RBC) 5-methyltetrahydrofolate (5-MTHF), 5, 10-methylene-tetrahydrofolate (5,10-CH2-THF), 5- formyltetrahydrofolate (5-CHO-THF), and unmetabolised folic acid (UMFA), and plasma homocysteine (HCY), 5-MTHF, and methylmalonic acid (MMA), were determined at 6-17 weeks and 20-26 weeks of gestation...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38767128/severe-dawn-phenomenon-predicts-long-term-risk-of-all-cause-mortality-in-patients-with-type-2-diabetes
#10
JOURNAL ARTICLE
Jinghao Cai, Peng Peng, Jingyi Lu, Yun Shen, Chunfang Wang, Yifei Mo, Wei Lu, Wei Zhu, Tian Xia, Jian Zhou
AIMS: The dawn phenomenon (DP) is an abnormal early morning blood glucose rise without nocturnal hypoglycaemia, which can be more easily and precisely assessed with continuous glucose monitoring (CGM). This prospective study aimed to explore the association between DP and the risk of all-cause mortality in patients with type 2 diabetes. MATERIALS AND METHODS: A total of 5542 adult inpatients with type 2 diabetes in a single centre were analysed. The magnitude of DP (ΔG) was defined as the increment in the CGM-determined glucose value from nocturnal nadir (after 24:00) to prebreakfast...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38757431/mafld-and-glomerular-hyperfiltration-in-subjects-with-normoglycemia-prediabetes-and-type-2-diabetes-a%C3%A2-cross-sectional-population-study
#11
JOURNAL ARTICLE
Manuela Abbate, Aneliya Parvanova, Ángel Arturo López-González, Aina M Yañez, Miquel Bennasar-Veny, José Ignacio Ramírez-Manent, Elia Reseghetti, Piero Ruggenenti
BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD, 2020 diagnostic criteria) and glomerular hyperfiltration share common risk factors, including obesity, insulin resistance, impaired glucose tolerance, diabetes, dyslipidemia, and hypertension. AIMS: To assess the prevalence of MAFLD and its association with glomerular hyperfiltration and age-related worsening of kidney function in subjects with normoglycemia, prediabetes and type 2 diabetes mellitus (T2DM)...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38757421/efficacy-of-teplizumab-for-treatment-of-type-1-diabetes-a%C3%A2-meta-analysis-of-randomized-controlled-trials
#12
JOURNAL ARTICLE
Ehsan Heidari, Arman Shafiee, Shahab Noorian, Mohammad Ali Rafiei, Mohammad Abbasi, Mohammad Javad Amini, Omid Safari, Fatemeh Aghamahdi, Mahmood Bakhtiyari
BACKGROUND: The management of Type 1 Diabetes Mellitus (T1DM) is a significant clinical challenge. This study evaluated the efficacy of teplizumab, an immunomodulatory drug, in patients with T1DM, using a systematic review and meta-analysis approach. METHODS: We systematically searched multiple databases including Medline, Scopus, and others up to 10 January 2024, without language or regional restrictions. We included randomized controlled trials (RCTs) comparing teplizumab with placebo in T1DM patients...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38751148/t-cell-immunity-against-severe-acute-respiratory-syndrome-coronavirus-2-proteins-in-patients-with-type-1-diabetes
#13
JOURNAL ARTICLE
Camillo Palmieri, Gianluca Santamaria, Costanza Maria Cristiani, Cinzia Garofalo, Christine Y L Tham, Antonio Abatino, Antonio Cutruzzolà, Martina Parise, Ilenia Aversa, Donatella Malanga, Raffaella Gallo, Giovanni Cuda, Giuseppe Viglietto, Francesco Costanzo, Antonio Bertoletti, Agostino Gnasso, Concetta Irace
AIMS: Individuals with type 1 diabetes (T1D) do not appear to have an elevated risk of severe Coronavirus Disease 19 (COVID-19). Pre-existing immune reactivity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in unexposed individuals may serve as a protective factor. Hence, our study was designed to evaluate the existence of T cells with reactivity against SARS-CoV-2 antigens in unexposed patients with T1D. MATERIALS AND METHODS: Peripheral blood mononuclear cells (PBMCs) were collected from SARS-CoV-2 unexposed patients with T1D and healthy control subjects...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38738481/optical-coherence-tomography-angiography-for-detection-of-microvascular-changes-in-early-diabetes-a-systematic-review-and-meta-analysis
#14
JOURNAL ARTICLE
Fan Yang, Weijie Zou, Zhiwei Li, Yuanyuan Du, Weiyun Gao, Ji Zhang, Xiaoyan Ji, Jiang Huang
AIMS: To evaluate the effectiveness of optical coherence tomography angiography (OCTA) in detecting early intraocular microvascular changes in diabetic patients. MATERIALS AND METHODS: A systematic study search was performed on PubMed, Medline, Embase, and the Cochrane Library, ranging from January 2012 to March 2023. Controlled studies compared diabetes mellitus (DM) patients with non-diabetic retinopathy (NDR) or patients with mild non-proliferative diabetic retinopathy (mild NPDR) to healthy people...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38711301/correspondence-to-association-of-sleep-patterns-and-cardiovascular-disease-risk-is-modified-by-glucose-tolerance-status
#15
LETTER
Ssu-Yu Chen, Ting-An Lin, Cheuk-Kwan Sun, Renin Chang
After reading the article written by Wang et al., we have encountered several concerns that may compromise the credibility of the article. There are some factors, such as changes in sleep patterns, glucose tolerance status, and the use of hypnotics, which may interfere with the research results. Additionally, the design of the sleep pattern could lead to biased outcomes. Therefore, we are writing this letter to recommend that further research should take these concerns into consideration.
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38708843/the-role-of-long-non-coding-rnas-in-the-development-of-diabetic-kidney-disease-and-the-involved-clinical-application
#16
REVIEW
Qizhuo Hou, Bin Yi
Diabetic kidney disease (DKD), one of the common microvascular complications of diabetes, is increasing in prevalence worldwide and can lead to End-stage renal disease. However, there are still gaps in our understanding of the pathophysiology of DKD, and both current clinical diagnostic methods and treatment strategies have drawbacks. According to recent research, long non-coding RNAs (lncRNAs) are intimately linked to the developmental process of DKD and could be viable targets for clinical diagnostic decisions and therapeutic interventions...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38686868/cost-effectiveness-of-temperature-monitoring-to-help-prevent-foot-ulcer-recurrence-in-people-with-diabetes-a-multicenter-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Jaap J Van Netten, Wouter B Aan De Stegge, Marcel G W Dijkgraaf, Sicco A Bus
AIMS: Diabetes-related foot ulcers are common, costly, and frequently recur. Multiple interventions help prevent these ulcers. However, none of these have been prospectively investigated for cost-effectiveness. Our aim was to evaluate the cost-effectiveness of at-home skin temperature monitoring to help prevent diabetes-related foot ulcer recurrence. MATERIALS AND METHODS: Multicenter randomized controlled trial. We randomized 304 persons at high diabetes-related foot ulcer risk to either usual foot care plus daily at-home foot skin temperature monitoring (intervention) or usual care alone (control)...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38661109/estimating-the-effect-of-lipid-lowering-agents-on-novel-subtypes-of-adult-onset-diabetes
#18
JOURNAL ARTICLE
Jianan Ye, Keyu Guo, Jiaqi Li, Xia Li, Zhiguang Zhou, Lin Yang
AIMS: The aims of the present study were to assess the effects of lipid-lowering drugs [HMG-CoA reductase inhibitors, proprotein convertase subtilisin/kexin type 9 inhibitors, and Niemann-Pick C1-Like 1 (NPC1L1) inhibitors] on novel subtypes of adult-onset diabetes through a Mendelian randomisation study. MATERIALS AND METHODS: We first inferred causal associations between lipid-related traits [including high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), apolipoproteins A-I, and apolipoproteins B] and novel subtypes of adult-onset diabetes...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38634501/global-regional-and-national-burden-of-blindness-and-vision-loss-attributable-to-high-fasting-plasma-glucose-from-1990-to-2019-and-forecasts-to-2030-a-systematic-analysis-for-the-global-burden-of-disease-study-2019
#19
JOURNAL ARTICLE
Cong Li, Guangyao Hua, Shunming Liu, Honghua Yu, Xiaohong Yang, Lei Liu
AIMS: To systematically clarify the spatiotemporal trends, and age-sex-specific blindness and vision loss (BVL) burden due to high fasting plasma glucose (HFPG) from 1990 to 2019, and project this burden over the next decade. MATERIALS AND METHODS: We obtained the number and rate of years lived with disability (YLDs) for the BVL burden attributable to HFPG by age, sex, socio-demographic index (SDI), and location between 1990 and 2019 from the Global Burden of Disease (GBD) 2019 database...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38616511/multi-feature-chinese-western-medicine-integrated-prediction-model-for-diabetic-peripheral-neuropathy-based-on-machine-learning-and-shap
#20
JOURNAL ARTICLE
Aijuan Jiang, Jiajie Li, Lujie Wang, Wenshu Zha, Yixuan Lin, Jindong Zhao, Zhaohui Fang, Guoming Shen
BACKGROUND: Clinical studies have shown that diabetic peripheral neuropathy (DPN) has been on the rise, with most patients presenting with severe and progressive symptoms. Currently, most of the available prediction models for DPN are derived from general clinical information and laboratory indicators. Several Traditional Chinese medicine (TCM) indicators have been utilised to construct prediction models. In this study, we established a novel machine learning-based multi-featured Chinese-Western medicine-integrated prediction model for DPN using clinical features of TCM...
May 2024: Diabetes/metabolism Research and Reviews
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