Journals Diabetes/metabolism Research a...

Diabetes/metabolism Research and Reviews
Frans Pouwer, Byron Perrin, Andy Lavender, Bijan Najafi, Khalida Ismail, Loretta Vileikyte
Diabetic foot ulceration (DFU) is common and highly recurrent, negatively impacting the individuals' quality of life. The 2023 guidelines of the International Working Group on the Diabetic Foot emphasise that adherence to foot self-care recommendations is one of the most important factors in DFU prevention. These guidelines also briefly mention that depression and other psychosocial problems can hamper treatment and ulcer healing. Moreover, a new clinical question was added on psychological interventions for ulcer prevention, although the evidence regarding the role of psychological and social factors is still limited...
December 1, 2023: Diabetes/metabolism Research and Reviews
Ignacio Hormazábal-Aguayo, Yasmin Ezzatvar, Nidia Huerta-Uribe, Robinson Ramírez-Vélez, Mikel Izquierdo, Antonio García-Hermoso
AIMS: The aim of this study was to determine the global incidence of type 1 diabetes mellitus (T1DM) in children and adolescents under 20 years of age from 2000 to 2022. MATERIALS AND METHODS: Two reviewers searched three electronic databases (PubMed, Web of Science, and CINAHL) for studies published between January 2000 and November 2022. Pooled estimates of T1DM incidence with a 95% confidence interval (CI) per 100,000 person-years were calculated by country/region, sex, age, and COVID-19 pandemic period (pre-COVID-19 and pandemic)...
December 1, 2023: Diabetes/metabolism Research and Reviews
Giovanni Rossini, Renata Risi, Lavinia Monte, Biagio Sancetta, Maria Quadrini, Massimiliano Ugoccioni, Davide Masi, Rebecca Rossetti, Rossella D'Alessio, Rossella Mazzilli, Giuseppe Defeudis, Carla Lubrano, Lucio Gnessi, Mikiko Watanabe, Silvia Manfrini, Dario Tuccinardi
Post-bariatric hypoglycaemia (PBH) is a metabolic complication of bariatric surgery (BS), consisting of low post-prandial glucose levels in patients having undergone bariatric procedures. While BS is currently the most effective and relatively safe treatment for obesity and its complications, the development of PBH can significantly impact patients' quality of life and mental health. The diagnosis of PBH is still challenging, considering the lack of definitive and reliable diagnostic tools, and the fact that this condition is frequently asymptomatic...
November 28, 2023: Diabetes/metabolism Research and Reviews
Rui Wang, Shuoming Luo, Zilin Xiao, Zhiguang Zhou
BACKGROUND: The efficacy and safety of fixed-ratio combination insulin degludec/liraglutide (IDegLira) for type 2 diabetes (T2DM) were extensively investigated by the global DUAL trials. However, the evidence on its efficacy and safety in T2DM has not been systematically reviewed. METHODS: Randomized controlled trials published in English that compared IDegLira with placebo or GLP-1 agonists or insulin in patients with T2DM were selected up to December 2022. Data on the study characteristics, efficacy and safety outcomes were extracted...
November 27, 2023: Diabetes/metabolism Research and Reviews
Peter A Lazzarini, Katherine M Raspovic, Marco Meloni, Jaap J van Netten
The 1989 Saint Vincent Declaration established a goal of halving global diabetes-related amputation rates. A generation later, this goal has been achieved for major but not minor amputations. However, diabetic foot disease (DFD) is not only a leading cause of global amputation but also of hospitalisation, poor quality of life (QoL) and disability burdens. In this paper, we review latest estimates on the global disease burden of DFD and the next generation care of DFD that could reduce this burden. We found DFD causes 2% of the global disease burden...
November 24, 2023: Diabetes/metabolism Research and Reviews
Ming-I Wei, Wen-Bin Yeh, Renin Chang
No abstract text is available yet for this article.
November 21, 2023: Diabetes/metabolism Research and Reviews
Shimin Jiang, Tianyu Yu, Dingxin Di, Ying Wang, Wenge Li
BACKGROUND: Diabetes places a significant burden on personal and public health. However, a comprehensive assessment of the burden of diabetes in older adults is lacking. We aimed to estimate the global burden of diabetes and explore trends for the population aged ≥70 from 1990 to 2019. METHODS: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, the prevalence, mortality, and disability-adjusted life-years (DALYs) of diabetes among people aged ≥70 were estimated by sex and age group in 2019...
November 9, 2023: Diabetes/metabolism Research and Reviews
Aaron Drovandi, Leonard Seng, Jonathan Golledge
This systematic review and meta-analysis pooled evidence from randomised controlled trials (RCTs) on the effectiveness of educational programs for people with or at risk of diabetes-related foot disease (DFD). A systematic search identified RCTs evaluating the effectiveness of educational programs in preventing or managing DFD. The primary outcome was risk of developing a foot ulcer. Secondary outcomes included any amputation, mortality, changes in cardiovascular risk factors, foot-care knowledge and self-care behaviours...
November 5, 2023: Diabetes/metabolism Research and Reviews
Adrienn Kovacs, Stefania Bunduc, Daniel S Veres, Daniel Palinkas, Endre B Gagyi, Peter J Hegyi, Balint Eross, Emese Mihaly, Peter Hegyi, Nora Hosszufalusi
AIMS: Ketosis-prone type 2 diabetes was defined by the World Health Organization in 2019. According to the literature, the diagnosis is based on the presence of ketosis, islet autoantibody negativity and preserved insulin secretion. Our meta-analysis assessed the prevalence and clinical characteristics of ketosis-prone type 2 diabetes among patients hospitalised with diabetic ketoacidosis (DKA) or ketosis. METHODS: The systematic search was performed in five main databases as of 15 October 2021 without restrictions...
October 27, 2023: Diabetes/metabolism Research and Reviews
Maria J Redondo, Kylie K Harrall, Deborah H Glueck, Mustafa Tosur, Serife Uysal, Andrew Muir, Elizabeth G Atkinson, Melanie R Shapiro, Liping Yu, William E Winter, Michael Weedon, Todd M Brusko, Richard Oram, Kendra Vehik, William Hagopian, Mark A Atkinson, Dana Dabelea
AIMS: Determining diabetes type in children has become increasingly difficult due to an overlap in typical characteristics between type 1 diabetes (T1D) and type 2 diabetes (T2D). The Diabetes Study in Children of Diverse Ethnicity and Race (DISCOVER) programme is a National Institutes of Health (NIH)-supported multicenter, prospective, observational study that enrols children and adolescents with non-secondary diabetes. The primary aim of the study was to develop improved models to differentiate between T1D and T2D in diverse youth...
October 27, 2023: Diabetes/metabolism Research and Reviews
Yixin Gong, Sihui Luo, Jie Shi, Tian Wei, Jing Wang, Yujie Liu, Jinhua Yan, Daizhi Yang, Ling Li, Zilin Sun, Xueying Zheng, Jianping Weng
AIMS: To explore the relationship between preconception severe hypoglycemia (PSH) and pregnancy outcomes in pregnancies complicated with type 1 diabetes mellitus (T1DM). MATERIALS AND METHODS: In this multicenter prospective cohort study, women with pregestational T1DM were stratified by episodes of severe hypoglycemia within 1 year before conception: No PSH, sporadic PSH (1-6 times/year), and recurrent PSH (>6 times/year). We analysed the predictive ability of PSH for maternal and neonatal outcomes using log-binomial regression models and receiver operating characteristic (ROC) curve...
October 24, 2023: Diabetes/metabolism Research and Reviews
Hou-Ren Tsai, Yu-Jie Lin, Jih-I Yeh, Yu-Chi Huang, Peter Pin-Sung Liu, Carol Chiung-Hui Peng, Jin-Yi Hsu, Yuan-Chieh Lee, Ching-Hui Loh, Shu-Man Lin, Huei-Kai Huang
AIMS: Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) have off-target effects on haemoconcentration and anti-inflammation. The impact of SGLT-2i on the risk of venous thromboembolism (VTE) in patients with diabetes mellitus (DM) remains unclear. This study aimed to evaluate the risk of newly diagnosed VTE in patients with DM using SGLT-2i in comparison to dipeptidyl peptidase-4 inhibitors (DPP-4i) or glucagon-like peptide-1 receptor agonists (GLP-1RA). MATERIALS AND METHODS: In this nationwide retrospective cohort study, we used data from Taiwan's National Health Insurance Research Database...
October 20, 2023: Diabetes/metabolism Research and Reviews
Tien-Ching Lee, Pei-Shan Ho
No abstract text is available yet for this article.
October 20, 2023: Diabetes/metabolism Research and Reviews
Kay Hon, Frank Nobels, Éric Senneville, Ilker Uckay, Mario Maas, Robert Fitridge
Diabetes-related foot disease is a serious and common complication for people with diabetes mellitus. The gold standard care for a person with diabetes-related foot disease is the involvement of a multidisciplinary foot team engaged in evidence-based care. To date, there are seven International Working Group on the Diabetic Foot (IWGDF) guidelines published to assist healthcare providers in managing diabetes-related foot disease around the world. This review discusses the acute management of diabetes-related foot infection with insights from experts of various specialities (internal medicine, infectious disease, vascular surgery, radiology) with a discussion on the implementation of IWGDF guidelines in real life practice and the challenges that healthcare providers may face...
October 19, 2023: Diabetes/metabolism Research and Reviews
Giovanni Petralli, Antonio Salvati, Domenico Tricò, Gabriele Ricco, Piero Colombatto, Maurizia Rossana Brunetto, Anna Solini
AIMS: Insulin resistance (IR) plays a pivotal role in the pathogenesis of Metabolic dysfunction-Associated Fatty Liver Disease (MAFLD), which can progress to liver fibrosis. We examined the relationship of different IR scores with markers of MAFLD severity in obese individuals. MATERIALS AND METHODS: In this retrospective observational study, 346 non-diabetic, overweight/obese individuals with newly diagnosed MAFLD (age 50.2 ± 13.3 years, 34% females, BMI 30...
October 15, 2023: Diabetes/metabolism Research and Reviews
Boquan Qin, Qi Peng, Hongxian Dong, Lei Lei, Shizhou Wu
Diabetes mellitus is associated with a wide range of neuropathies, vasculopathies, and immunopathies, resulting in many complications. More than 30% of diabetic patients risk developing diabetic foot ulcers (DFUs). Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play essential roles in various biological functions in the hyperglycaemic environment that determines the development of DFU. Ulceration results in tissue breakdown and skin barrier scavenging, thereby facilitating bacterial infection and biofilm formation...
October 15, 2023: Diabetes/metabolism Research and Reviews
Massimiliano Copetti, Marco Giorgio Baroni, Raffaella Buzzetti, Maria Gisella Cavallo, Efiso Cossu, Paola D'Angelo, Salvatore De Cosmo, Frida Leonetti, Susanna Morano, Lelio Morviducci, Nicola Napoli, Sabrina Prudente, Giuseppe Pugliese, Antonio Fernando Savino, Vincenzo Trischitta
CONTEXT: Mortality in type 2 diabetes is twice that of the normoglycemic population. Unravelling biomarkers that identify high-risk patients for referral to the most aggressive and costly prevention strategies is needed. OBJECTIVE: To validate in type 2 diabetes the association with all-cause mortality of a 14-metabolite score (14-MS) previously reported in the general population and whether this score can be used to improve well-established mortality prediction models...
October 15, 2023: Diabetes/metabolism Research and Reviews
Tomader Ali, Nader Lessan
Every year, healthy adult Muslims practice dawn to sunset fasting for a whole lunar month. No food or fluid is allowed for the fasting time window. After sunset, eating is allowed. The dramatic change in the timing of meals is accompanied by changes in sleeping hours and thus alterations in circadian rhythms. Hormonal mechanisms mainly determined by the latter also change. These include shifts in cortisol and melatonin. Food-dependent hormones such as Ghrelin and leptin also show changes. A well-established principle of chrononutrition is that the timing of eating may be as or more important than the content of food...
October 13, 2023: Diabetes/metabolism Research and Reviews
Yan Wang, Jingwu Wang, Si-Yu Tao, Zhengting Liang, Rong Xie, Nan-Nan Liu, Ruxue Deng, Yuelin Zhang, Deqiang Deng, Guangjian Jiang
The pathogenesis of diabetes is accompanied by increased levels of inflammatory factors, also known as "metabolic inflammation", which runs through the whole process of the occurrence and development of the disease. Mitochondria, as the key site of glucose and lipid metabolism, is often accompanied by mitochondrial function damage in type 2 diabetes mellitus (T2DM). Damaged mitochondria release pro-inflammatory factors through damage-related molecular patterns that activate inflammation pathways and reactions to oxidative stress, further aggravate metabolic disorders, and form a vicious circle...
October 12, 2023: Diabetes/metabolism Research and Reviews
Liangkai Chen, Qiang Wang, Yanling Lv, Wenyuan Xu, Guanhua Jiang, Yonggang Li, Ping Luo, Ruikun He, Liegang Liu
AIMS: Population-based evidence regarding circulating advanced glycation end-products (AGEs) and the risk of type 2 diabetes (T2D) is conflicting and insufficient. We aimed to examine the association of plasma AGEs and plasma soluble receptors for AGEs (sRAGE) with T2D. MATERIALS AND METHODS: We conducted a hospital-based case-control study including 1072 pairs (53.9 ± 9.7 years, 56.0% male) of newly diagnosed T2D and age- and sex-matched controls...
October 10, 2023: Diabetes/metabolism Research and Reviews
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