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Diabetes/metabolism Research and Reviews

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https://read.qxmd.com/read/30997951/differential-associations-of-ferritin-and-25-hydroxyvitamin-d-with-fasting-glucose-and-diabetes-risk-in-community-dwelling-older-men
#1
Simon Carrivick, Helman Alfonso, Jonathan Golledge, Paula Clancy, Leon Flicker, Jenny E Gunton, Graeme J Hankey, Osvaldo P Almeida, Paul E Norman, Bu B Yeap
AIMS: We examined associations of ferritin and 25-hydroxyvitamin D with fasting glucose and prevalent diabetes in older men. METHODS: Cross-sectional analysis of 4,153 community-dwelling men aged 70-89 years in Western Australia. Plasma ferritin, 25-hydroxyvitamin D and glucose were assayed. Diabetes was ascertained from self-report, medications and fasting glucose. RESULTS: There were 577 men with diabetes (13.9%). In the whole cohort, ferritin was associated with fasting glucose (0...
April 18, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30997935/sglt2-inhibition-to-address-the-unmet-needs-in-diabetic-nephropathy
#2
REVIEW
F Barutta, S Bernardi, G Gargiulo, M Durazzo, G Gruden
Current treatment of diabetic nephropathy is effective; however, substantial gaps in care still remain and new therapies are urgently needed to reduce the global burden of the complication. Desirable properties of an "ideal" new drug should include: primary prevention of microalbuminuria, additive/synergistic anti-proteinuric effect in combination therapy with renin angiotensin system blockers, reduction of chronic kidney disease progression to lower the risk of end-stage renal disease, and cardiovascular protection...
April 18, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30983141/effects-of-sglt2-inhibitors-on-fractures-and-bone-mineral-density-in-type-2-diabetes-mellitus-an-updated-meta-analysis
#3
Xiaoyu Li, Ting Li, Ying Cheng, Yunhong Lu, Mei Xue, Linxin Xu, Xiangyang Liu, Xiaochen Yu, Bei Sun, Liming Chen
AIMS: To update and determine the effects of sodium glucose co-transporter 2 (SGLT2) inhibitor therapy on fracture and bone mineral density (BMD) in type 2 diabetes mellitus (T2DM) patients. MATERIALS AND METHODS: We identified 27 eligible randomized controlled trials (RCTs) that compared the efficacy and safety of SGLT2 inhibitors to a placebo in 20895 T2DM participants, with an average duration of 64.22 weeks. The relative risk (RR) of bone fracture and weighted mean difference (WMD) of changes in the BMD from baseline were determined to evaluate the risk of fracture...
April 15, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30974510/effects-of-sodium-glucose-cotransporter-sglt-inhibitors-in-addition-to-insulin-therapy-on-glucose-control-and-major-safety-outcomes-in-adults-with-type-1-diabetes-a-meta-analysis-of-randomized-controlled-trials
#4
REVIEW
Jingli Lu, Lijuan Tang, Haiyang Meng, Junjie Zhao, Yan Liang
Sodium-glucose cotransporter (SGLT) inhibitors added to insulin therapy have been proposed as a treatment strategy for type 1 diabetes (T1D). We thus conducted a meta-analysis of randomized controlled trials (RCTs) to assess the efficacy and adverse effects of this combination in T1D. We searched the PubMed, EMBASE, and Cochrane Library databases and ClinicalTrials.gov for RCTs. Statistical analyses were performed using STATA 15. Ten eligible placebo-controlled trials involving 5961 patients were included. Compared with placebo, SGLT inhibitors were associated with a reduction in HbA1c of -0...
April 11, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30974038/exenatide-modulates-visual-cortex-responses
#5
Paola Binda, Roy Eldor, Claudia Huerta, John Adams, John Lancaster, Peter Fox, Stefano Del Prato, Ralph DeFronzo, Muhammad Abdul-Ghani, Giuseppe Daniele
AIMS: Increasing evidence suggests that metabolism affects brain physiology. Here we examine the effect of GLP-1 on simple visual-evoked fMRI responses in cortical areas. MATERIAL AND METHODS: Lean (n=10) and non-diabetic obese (n=10) subjects received exenatide (a GLP-1 agonist) or saline infusion and fMRI responses to visual stimuli (food and nonfood images) were recorded. We analyzed the effect of exenatide on fMRI signals across the cortical surface with special reference to the visual areas...
April 11, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30974033/glucagon-like-peptide-1-receptor-agonists-and-risk-of-bone-fracture-in-patients-with-type-2-diabetes-mellitus-a-meta-analysis-of-randomized-controlled-trials
#6
Liang Cheng, Yun Hu, Yun-Yun Li, Xin Cao, Ning Bai, Ting-Ting Lu, Guo-Qing Li, Na Li, An-Ning Wang, Xiao-Ming Mao
AIMS: To evaluate the association between glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and the risk of bone fracture in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: We conducted a systematic literature search in PubMed, Embase, the Cochrane Library, and Web of Science from inception to February 28, 2018, and identified eligible randomized controlled trials. The following data were extracted from each study: first author, year of publication, sample size, patient characteristics, study design, intervention drug, control drug, follow-up time, and incident bone fracture events...
April 11, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30963685/treat-to-target-hba1c-and-lipid-profile-to-prolong-%C3%AE-cell-mass-function-and-optimize-treatment-goal-attainment
#7
Juan J Gagliardino, Jorge Elgart, Luján Forti, Guaita María Silvina, Jean M Chantelot
AIM: To evaluate the relation between different serum lipid fractions and other known barriers to attain the HbA1c ≤ 7.0% (53 mmol/mol) target. METHODS: Data on 2719 patients with type 2 diabetes were collected from the five waves of the International Diabetes Mellitus Practice Study implemented in Argentina (2006 to 2012) including: demographic/socioeconomic profile, clinical, metabolic (HbA1c and serum lipids) data, and treatment type; also, percentage of treatment goal attainment...
April 8, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30953392/risk-factors-for-amputation-in-diabetic-foot-infections-a-meta-analysis
#8
Pinar Sen, Tuna Demirdal, Busra Emir
AIMS: Knowledge of risk factors is crucial to develop management and treatment protocols for the prevention of lower extremity amputation for patients with diabetic foot infections (DFI). MATERIALS AND METHODS: We searched the research literature for studies reporting risk factors for lower extremity amputation in patients with DFI. The main outcome variables included both minor and major amputations. This study was reported in accordance with the PRISMA guidelines and the protocol was registered in PROSPERO (CRD42018118543)...
April 5, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30945418/metformin-reduces-maternal-weight-gain-in-obese-pregnant-women-a-systematic-review-and-meta-analysis-of-two-randomized-controlled-trials
#9
REVIEW
Valentina D'Ambrosio, Roberto Brunelli, Flaminia Vena, Daniele Di Mascio, Claudia Marchetti, Chiara Boccherini, Maria Grazia Piccioni, Pierluigi Benedetti Panici, Antonella Giancotti
Obese pregnant women are likely to face several gestational and neonatal complications. Metformin is an effective oral anti-hyperglycemic agent that is considered to be effective during pregnancy. The aim of our study was to evaluate the effect of metformin on obstetric and perinatal outcomes in obese pregnant women. Electronic databases were searched (MEDLINE, EMBASE, Web of Science, Scopus, ClinicalTrials.gov, OVID and Cochrane Library). The selection criteria included only randomized clinical trials (RCTs) of obese pregnant women randomized to a daily metformin regimen or to a placebo condition...
April 3, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30939629/hypertriglyceridaemia-predicts-the-subsequent-long-term-risk-of-cardiovascular-events-in-chinese-adults-results-from-a-23-year-follow-up-of-the-daqing-diabetes-study
#10
Jinping Wang, Xiaoxia Shen, Siyao He, Yali An, Qiuhong Gong, Hui Li, Bo Zhang, Ying Shuai, Yanyan Chen, Yinghua Hu, Guangwei Li
BACKGROUND: Limited information is available on the long-term risk of cardiovascular disease (CVD) associated with hypertriglyceridaemia (HTG) in the Chinese population. We estimated this risk over a 23-year period in participants recruited from among those included in the Da Qing Diabetes Study. METHODS: A total of 833 Chinese adults including 379 with normal glucose levels and 454 with hyperglycaemia were identified by their oral glucose tolerance in 1986 in Da Qing, China...
April 2, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30931541/vitamin-d-concentration-is-associated-with-diabetes-peripheral-neuropathy-in-older-but-not-in-young-and-middle-aged-patients
#11
Yang Niu, Ji Li, Rong-Xia Peng, Xuelin Zhao, Jiang Wu, Qingya Tang
BACKGROUND: The relationship between vitamin D and diabetes peripheral neuropathy (DPN) is not consistent among epidemiologic studies. Thus, we aimed to investigate this relationship in different age groups. METHODS: In this cross-sectional study, 1,461 patients admitted to the Department of Endocrinology at Xinhua Hospital from June 2016 to September 2017 were divided into three age groups: a Youth group (24-44 y, n=127), a Middle-age group (45-64 y, n=779) and an Elderly group (≥65 y, n=555)...
April 1, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30916434/global-recurrence-rates-in-diabetic-foot-ulcers-a-systematic-review-and-meta-analysis
#12
REVIEW
Xue-Lei Fu, Hui Ding, Wei-Wei Miao, Chun-Xing Mao, Min-Qi Zhan, Hong-Lin Chen
Recurrence rates of diabetic foot ulcers vary widely in the published literature. The aim of this systematic review is to estimate recurrence rates of diabetic foot ulcers. We did a PubMed search, and performed a review of reference lists for studies reporting recurrence of diabetic foot ulcers. The weighted relative risk (RR) and corresponding 95% confidence interval (CI) for recurrence was estimated. 49 studies reporting recurrence of diabetic foot ulcers were included. A pooled estimate for recurrence rate was 22...
March 27, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30912290/visceral-adiposity-index-vai-outperforms-common-anthropometric-indices-in-predicting-10-year-diabetes-risk-results-from-the-attica-study
#13
E Koloverou, D B Panagiotakos, I Kyrou, C Stefanadis, C Chrysohoou, E N Georgousopoulou, I Skoumas, D Tousoulis, C Pitsavos
AIMS: Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals, and compare its T2DM predictive ability against common anthropometric indices. MATERIALS AND METHODS: in 2001-02, the ATTICA study (Greece) recruited a random sample of 1514 and 1528 CVD-free men (18-87 years old) and women (18-89 years old), respectively...
March 25, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30909316/diabetic-lung-an-underrated-complication-from-restrictive-functional-pattern-to-pulmonary-hypertension
#14
Leonello Fuso, Dario Pitocco, Raffaele Antonelli Incalzi
In patients with type 1 and type 2 diabetes mellitus (DM), respiratory function abnormalities have been reported with regard to lung volumes, pulmonary diffusing capacity, control of ventilation, bronchomotor tone, and neuroadrenergic bronchial innervation. Indeed, the decrease in lung volumes and the impairment of diffusing capacity might have important clinical implications. Furthermore, there is an increasing evidence of a link between DM and pulmonary hypertension (PH) related to an involvement of the pulmonary vascular structures...
March 25, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30908791/standards-of-medical-care-for-type-2-diabetes-in-china-0027
#15
REVIEW
Weiping Jia, Jianping Weng, Dalong Zhu, Linong Ji, Juming Lu, Zhiguang Zhou, Dajin Zou, Lixin Guo, Qiuhe Ji, Li Chen, Liming Chen, Jingtao Dou, Xiaohui Guo, Hongyu Kuang, Ling Li, Qifu Li, Xiaoying Li, Jing Liu, Xingwu Ran, Lixin Shi, Guangyao Song, Xinhua Xiao, Liyong Yang, Zhigang Zhao
The prevalence of diabetes in China has increased rapidly from 0.67% in 1980 to 10.4% in 2013, with the aging of the population and westernization of life style. Since its foundation in 1991, the Chinese Diabetes Society (CDS) has been dedicated to improving academic exchange and the academic level of diabetes research in China. From 2003 to 2014, four versions of Chinese diabetes care guidelines have been published. The guidelines have played an important role in standardizing clinical practice and improving the status quo of diabetes prevention and control in China...
March 25, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30901133/prevalence-of-diabetes-in-liver-cirrhosis-a-systematic-review-and-meta-analysis
#16
REVIEW
Wai Gin Lee, Cameron I Wells, John L McCall, Rinki Murphy, Lindsay D Plank
An association between diabetes mellitus (DM) and liver cirrhosis is well known but estimates of the prevalence of DM in patients with liver cirrhosis vary widely. A systematic review was undertaken to determine the prevalence of DM in adult patients with liver cirrhosis. The Medline, EMBASE and Cochrane Library databases were searched for peer-reviewed studies published in English (1979-2017) that investigated the prevalence of diabetes in adult patients with cirrhosis. Pooled estimates of prevalence of DM were determined for all eligible patients and according to etiology and severity of liver disease...
March 22, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30892820/independent-markers-of-non-alcoholic-fatty-liver-disease-in-a-gentrifying-population-based-chinese-cohort
#17
Xianghai Zhou, Yufeng Li, Xiuying Zhang, Ying Ying Guan, Yindra Puentes, Fang Zhang, Elizabeth K Speliotes, Linong Ji
AIMS: Prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing in developing countries but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China. MATERIALS AND METHODS: We randomized cluster sampled 4002 Pinggu residents aged 26-76 years. Data from 1238 men and 1928 women without significant alcohol drinking or hepatitis virus B or C infection were analyzed...
March 20, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30892801/diabetic-kidney-disease-a-systematic-review-on-the-role-of-epigenetics-as-diagnostic-and-prognostic-marker
#18
REVIEW
Sangeeta Singh, Satyendra Kumar Sonkar, Gyanendra Kumar Sonkar, Abbas Ali Mahdi
Diabetic kidney disease is one of the most serious microvascular complications and among the leading causes of end stage renal disease. Persistently increasing albuminuria has been considered to be central hallmark of nephropathy. However, albuminuria can indicate kidney damage for clinicians, it is not a specific biomarker for prediction of diabetic kidney disease prior to the onset of this devastating complication and in fact all individuals with microalbuminuria do not progress to overt nephropathy. Controlled glycemia is unable to prevent nephropathy in all diabetic individuals indicating the role of other factors in progression of diabetic kidney disease...
March 20, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30889626/inositol-and-antioxidant-supplementation-safety-and-efficacy-in-pregnancy
#19
REVIEW
Gloria Formoso, Maria P A Baldassarre, Federica Ginestra, Maria Assunta Carlucci, Ines Bucci, Agostino Consoli
Pregnancies complicated by diabetes have largely increased in number over the last 50 years. Pregnancy is characterized by a physiologic increase in insulin resistance which, associated with increased oxidative stress and inflammations, could induce alterations of glucose metabolism and diabetes. If not optimally controlled, these conditions have a negative impact on maternal and foetal outcomes. To date, one can resort only to diet and lifestyle to treat obesity and insulin resistance during pregnancy and insulin remains the only therapeutic option to manage diabetes during pregnancy...
March 19, 2019: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/30884138/undiagnosed-diabetes-among-hispanic-and-white-adults-with-elevated-hemoglobin-a1c-levels
#20
Elaine Russell, Kyeung Mi Oh, Xiaoquan Zhao
AIMS: To compare the frequency and correlates of undiagnosed diabetes between Hispanic and White American adults ages 20 and older with known diabetes or elevated HbA1c. METHODS: Using 2007-2012 National Health and Nutrition Survey data, 1,792 White and Hispanic Americans ages 20 and older with known diabetes or elevated HbA1c (≥ 6.5 %) were included in the analysis. Undiagnosed diabetes was defined as elevated HbA1c ≥ 6.5 % without prior diabetes diagnosis...
March 18, 2019: Diabetes/metabolism Research and Reviews
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