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Journals World Journal of Gastroenterol...

World Journal of Gastroenterology : WJG

https://read.qxmd.com/read/38983964/-aspergillus-niger-prolyl-endopeptidase-in-celiac-disease
#1
EDITORIAL
Marica Colella, Concetta Cafiero, Raffaele Palmirotta
We comment here on the article by Stefanolo et al entitled "Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet", published in the World Journal of Gastroenterology . Celiac disease is a well-recognized systemic autoimmune disorder. In genetically susceptible people, the most evident damage is located in the small intestine, and is caused and worsened by the ingestion of gluten. For that reason, celiac patients adopt a gluten-free diet (GFD), but it has some limitations, and it does not prevent re-exposure to gluten...
June 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38983963/risk-of-hepatitis-b-virus-reactivation-in-cancer-patients-undergoing-treatment-with-tyrosine-kinase-inhibitors
#2
EDITORIAL
Bansi P Savaliya, Ramin Shekouhi, Fatima Mubarak, Harsheen K Manaise, Paola Berrios Jimenez, Gabrielle Kowkabany, Reed A Popp, Kyle Popp, Emmanuel Gabriel
This editorial commented on an article in the World Journal of Gastroenterology titled "Risks of Reactivation of Hepatitis B Virus in Oncological Patients Using Tyrosine Kinase-Inhibitors: Case Report and Literature Analysis" by Colapietro et al . In this editorial, we focused on providing a more comprehensive exploration of hepatitis B virus reactivation (HBVr) associated with the usage of tyrosine kinase inhibitors (TKIs). It includes insights into the mechanisms underlying HBV reactivation, the temporal relationship between TKIs and HBV reactivation, and preventive measures...
June 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38983962/colorectal-cancer-screening-modalities-and-adherence
#3
EDITORIAL
Georgios Metaxas, Athena Papachristou, Martha Stathaki
In the last decade, several studies have explored various modalities and strategies for colorectal cancer (CRC) screening, taking into account epidemiological data, individual characteristics, and socioeconomic factors. In this editorial, we comment further on a retrospective study by Agatsuma et al published in the recent issue of the World Journal of Gastroenterology . Our focus is on screening trends, particularly in relation to efforts to improve the currently suboptimal uptake among the general population worldwide, aiming to enhance early diagnosis rates of CRC...
June 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38983961/managing-immune-checkpoint-inhibitor-associated-gastritis-insights-and-strategies
#4
REVIEW
Li-Li Yu, Zhi-Lin He, Xin-Lai Qian
Immune checkpoint inhibitors (ICIs) are widely used due to their effectiveness in treating various tumors. Immune-related adverse events (irAEs) are defined as adverse effects resulting from ICI treatment. Gastrointestinal irAEs are a common type of irAEs characterized by intestinal side effects, such as diarrhea and colitis, which may lead to the discontinuation of ICIs.
June 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38983960/development-and-validation-of-a-prognostic-immunoinflammatory-index-for-patients-with-gastric-cancer
#5
JOURNAL ARTICLE
Zhi-Chang Ba, Xi-Qing Zhu, Zhi-Guo Li, Yuan-Zhou Li
BACKGROUND: Studies have demonstrated the influence of immunity and inflammation on the development of tumors. Although single biomarkers of immunity and inflammation have been shown to be clinically predictive, the use of biomarkers integrating both to predict prognosis in patients with gastric cancer remains to be investigated. AIM: To investigate the prognostic and clinical significance of inflammatory biomarkers and lymphocytes in patients undergoing surgical treatment for gastric cancer...
June 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38983959/harnessing-autophagy-a-potential-breakthrough-in-digestive-disease-treatment
#6
REVIEW
Mukaddes Esrefoglu
Autophagy, a conserved cellular degradation process, is crucial for various cellular processes such as immune responses, inflammation, metabolic and oxidative stress adaptation, cell proliferation, development, and tissue repair and remodeling. Dysregulation of autophagy is suspected in numerous diseases, including cancer, neurodegenerative diseases, digestive disorders, metabolic syndromes, and infectious and inflammatory diseases. If autophagy is disrupted, for example, this can have serious consequences and lead to chronic inflammation and tissue damage, as occurs in diseases such as Chron's disease and ulcerative colitis...
June 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38983958/effect-and-mechanism-of-qingre-huashi-decoction-on-drug-resistant-helicobacter-pylori
#7
JOURNAL ARTICLE
Miao-Miao Lin, Shan-Shan Yang, Qiu-Yue Huang, Guang-Hui Cui, Xiao-Fen Jia, Yao Yang, Zong-Ming Shi, Hui Ye, Xue-Zhi Zhang
BACKGROUND: Helicobacter pylori (HP), the most common pathogenic microorganism in the stomach, can induce inflammatory reactions in the gastric mucosa, causing chronic gastritis and even gastric cancer. HP infection affects over 4.4 billion people globally, with a worldwide infection rate of up to 50%. The multidrug resistance of HP poses a serious challenge to eradication. It has been de-monstrated that compared to bismuth quadruple therapy, Qingre Huashi decoction (QHD) combined with triple therapy exhibits comparable eradication rates but with a lower incidence of adverse reactions; in addition, QHD can directly inhibit and kill HP in vitro...
June 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38983957/mapping-global-research-trends-nutrition-associations-with-nonalcoholic-fatty-liver-disease-a-scopus-bibliometric-analysis
#8
JOURNAL ARTICLE
Muna Shakhshir, Sa'ed H Zyoud
BACKGROUND: Several bibliometric analyses have been carried out to identify research hotspots and trends in nonalcoholic fatty liver disease (NAFLD) research. Nonetheless, there are still significant knowledge gaps that must be filled to advance our understanding of and ability to treat NAFLD. AIM: To evaluate, through bibliometric and visual analysis, the current status of related research, related research frontiers, and the developmental trends in the field of diet and NAFLD...
June 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38983956/-helicobacter-pylori-infection-alters-gastric-microbiota-structure-and-biological-functions-in-patients-with-gastric-ulcer-or-duodenal-ulcer
#9
JOURNAL ARTICLE
Ling-Xiao Jin, Yu-Peng Fang, Chen-Mei Xia, Teng-Wei Cai, Qian-Qian Li, Yu-Yin Wang, Hai-Fan Yan, Xia Chen
BACKGROUND: Helicobacter pylori (H. pylori) infection is closely associated with gastrointestinal diseases. Our preliminary studies have indicated that H. pylori infection had a significant impact on the mucosal microbiome structure in patients with gastric ulcer (GU) or duodenal ulcer (DU). AIM: To investigate the contributions of H . pylori infection and the mucosal microbiome to the pathogenesis and progression of ulcerative diseases. METHODS: Patients with H ...
June 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38983955/gastric-microbiota-transplantation-as-a-potential-treatment-for-immune-checkpoint-inhibitor-associated-gastritis
#10
REVIEW
Bo-Tong Ma, Li-Xuan Sang, Bing Chang
Immune-related adverse events (irAEs) are complications of the use of immune checkpoint inhibitors (ICIs). ICI-associated gastritis is one of the main irAEs. The gastric microbiota is often related to the occurrence and development of many gastric diseases. Gastric microbiota adjustment may be used to treat gastric disorders in the future. Faecal microbiota transplantation can alter the gut microbiota of patients and has been used for treating ICI-associated colitis. Therefore, we propose gastric microbiota transplantation as a supplementary treatment for patients with ICI-associated gastritis who do not respond well to conventional therapy...
June 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38983954/alanine-aminotransferase-predicts-incident-steatotic-liver-disease-of-metabolic-etiology-long-life-to-the-old-biomarker
#11
EDITORIAL
Amedeo Lonardo
Alanine aminotransferase (ALT) serum levels increase because of hepatocellular damage. Metabolic dysfunction-associated fatty liver disease (MAFLD), which identifies steatotic liver disease (SLD) associated with ≥ 2 metabolic abnormalities, has prominent sexual differences. The Metabolic Syndrome defines a cluster comprising abdominal obesity, altered glucose metabolism, dyslipidemia, and hypertension. Male sex, body mass index, glucose, lipids, ferritin, hypertension, and age independently predict ALT levels among blood donors...
June 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38983953/fecal-calprotectin-and-endoscopic-scores-the-cornerstones-in-clinical-practice-for-evaluating-mucosal-healing-in-inflammatory-bowel-disease
#12
EDITORIAL
Marcia Henriques de Magalhães Costa, Ligia Yukie Sassaki, Júlio Maria Fonseca Chebli
Managing inflammatory bowel disease (IBD) is becoming increasingly complex and personalized, considering the advent of new advanced therapies with distinct mechanisms of action. Achieving mucosal healing (MH) is a pivotal therapeutic goal in IBD management and can prevent IBD progression and reduce flares, hospitalization, surgery, intestinal damage, and colorectal cancer. Employing proactive disease and therapy assessment is essential to achieve better control of intestinal inflammation, even if subclinical, to alter the natural course of IBD...
June 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38946877/understanding-the-molecular-crossroads-in-acute-liver-failure-a-pathway-to-new-therapies
#13
REVIEW
Chun-Yao Cheng, Wen-Rui Hao, Tzu-Hurng Cheng
In this editorial we comment on the article published in a recent issue of the World Journal of Gastroenterology . Acute liver failure (ALF) is a critical condition characterized by rapid hepatocellular injury and organ dysfunction, and it often necessitates liver transplant to ensure patient survival. Recent research has elucidated the involvement of distinct cell death pathways, namely ferroptosis and pyroptosis, in the pathogenesis of ALF. Ferroptosis is driven by iron-dependent lipid peroxidation, whereas pyroptosis is an inflammatory form of cell death; both pathways contribute to hepatocyte death and exacerbate tissue damage...
June 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38946876/double-contrast-enhanced-ultrasonography-improves-diagnostic-accuracy-of-t-staging-compared-with-multi-detector-computed-tomography-in-gastric-cancer-patients
#14
COMPARATIVE STUDY
Yan-Fen Xu, Hui-Yun Ma, Gui-Ling Huang, Yu-Ting Zhang, Xue-Yan Wang, Ming-Jie Wei, Xiao-Qing Pei
BACKGROUND: Gastric cancer (GC) is the most common malignant tumor and ranks third for cancer-related deaths among the worldwide. The disease poses a serious public health problem in China, ranking fifth for incidence and third for mortality. Knowledge of the invasive depth of the tumor is vital to treatment decisions. AIM: To evaluate the diagnostic performance of double contrast-enhanced ultrasonography (DCEUS) for preoperative T staging in patients with GC by comparing with multi-detector computed tomography (MDCT)...
June 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38946875/from-macroautophagy-to-mitophagy-unveiling-the-hidden-role-of-mitophagy-in-gastrointestinal-disorders
#15
EDITORIAL
Duo-Lun Gao, Meng-Ran Lin, Nan Ge, Jin-Tao Guo, Fan Yang, Si-Yu Sun
In this editorial, we comment on an article titled "Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases", which was published in a recent issue of the World Journal of Gastroenterology . We focused on the statement that "autophagy is closely related to the digestion, secretion, and regeneration of gastrointestinal cells". With advancing research, autophagy, and particularly the pivotal role of the macroautophagy in maintaining cellular equilibrium and stress response in the gastrointestinal system, has garnered extensive study...
June 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38946874/role-of-gut-liver-axis-and-glucagon-like-peptide-1-receptor-agonists-in-the-treatment-of-metabolic-dysfunction-associated-fatty-liver-disease
#16
REVIEW
Jakub Rochoń, Piotr Kalinowski, Ksenia Szymanek-Majchrzak, Michał Grąt
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a hepatic manifestation of the metabolic syndrome. It is one of the most common liver diseases worldwide and shows increasing prevalence rates in most countries. MAFLD is a progressive disease with the most severe cases presenting as advanced fibrosis or cirrhosis with an increased risk of hepatocellular carcinoma. Gut microbiota play a significant role in the pathogenesis and progression of MAFLD by disrupting the gut-liver axis. The mechanisms involved in maintaining gut-liver axis homeostasis are complex...
June 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38946873/early-colorectal-cancer-screening-no-time-to-lose
#17
EDITORIAL
Ying Wang, Zheng-Long Wu, Yi-Gang Wang, Hui Wang, Xiao-Yuan Jia
In this editorial, we comment on the article entitled "Stage at diagnosis of colorectal cancer through diagnostic route: Who should be screened?" by Agatsuma et al . Colorectal cancer (CRC) is emerging as an important health issue as its incidence continues to rise globally, adversely affecting the quality of life. Although the public has become more aware of CRC prevention, most patients lack screening awareness. Some poor lifestyle practices can lead to CRC and symptoms can appear in the early stages of CRC...
June 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38946872/close-relationship-between-mediators-of-inflammation-and-pancreatic-cancer-our-experience
#18
EDITORIAL
Francesca Vescio, Michele Ammendola, Giuseppe Currò, Silvia Curcio
In this editorial, we focus specifically on the mechanisms by which pancreatic inflammation affects pancreatic cancer. Cancer of the pancreas remains one of the deadliest cancer types. The highest incidence and mortality rates of pancreatic cancer are found in developed countries. Trends of pancreatic cancer incidence and mortality vary considerably worldwide. A better understanding of the etiology and identification of the risk factors is essential for the primary prevention of this disease. Pancreatic tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this niche...
June 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38946871/gastroesophageal-reflux-after-per-oral-endoscopic-myotomy-management-literature
#19
EDITORIAL
Ahmed Tawheed, Ibrahim Halil Bahcecioglu, Mehmet Yalniz, Mohamed El-Kassas
In this editorial, we respond to a review article by Nabi et al , in which the authors discussed gastroesophageal reflux (GER) following peroral endoscopic myotomy (POEM). POEM is presently the primary therapeutic option for achalasia, which is both safe and effective. A few adverse effects were documented after POEM, including GER. The diagnostic criteria were not clear enough because approximately 60% of patients have a long acid exposure time, while only 10% experience reflux symptoms. Multiple predictors of high disease incidence have been identified, including old age, female sex, obesity, and a baseline lower esophageal sphincter pressure of less than 45 mmHg...
June 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38946870/fifty-five-cases-of-hepatic-alveolar-echinococcosis-combined-with-lymph-node-metastasis-a-retrospective-study
#20
JOURNAL ARTICLE
Yilizhati Aimaitijiang, Tie-Min Jiang, Ying-Mei Shao, Tuerganaili Aji
BACKGROUND: Lymph node metastasis is a specific type of metastasis in hepatic alveolar echinococcosis (AE). Currently, there is a scarcity of describing the clinical characteristics and lymph node metastasis rules of patients with hepatic AE combined with lymph node metastasis and its mechanism and management are still controversial. Radical hepatectomy combined with regional lymph node dissection is a better treatment. AIM: To analyse the clinical features of hepatic AE combined with lymph node metastasis to explore its treatment and efficacy...
June 21, 2024: World Journal of Gastroenterology: WJG
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