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Journals Journal of B.U.ON. : Official ...

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology

https://read.qxmd.com/read/34761625/relationship-between-survival-outcomes-and-microsatellite-instability-tumor-infiltrating-lymphocytes-and-programmed-cell-death-ligand-1-expression-in-patients-with-bladder-cancer-and-radical-cystectomy
#21
JOURNAL ARTICLE
Deniz Tural, Emre Akar, Halil Firat Baytekin, Didem Canoglu, Mesut Yilmaz, Volkan Tugcu
PURPOSE: Platin-based chemotherapies are first-line treatment methods after surgery in bladder cancer. Recently, novel immunotherapies emerged after platin-based regimens. The purpose of this study was to evaluate the prognostic significance of microsatellite instability (MSI), tumor infiltrating lymphocytes (TILs) and programmed cell death ligand-1 (PD-L1) expression which are used as predictive biomarkers in immunotherapy. METHODS: Clinical and pathological features of bladder cancer patients who underwent radical cystectomy were retrospectively analyzed from their records in this single-center study...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761624/btbd7-accelerates-the-epithelial-mesenchymal-transition-proliferation-and-invasion-of-prostate-cancer-cells
#22
JOURNAL ARTICLE
Bin Chen, Chang Liu, Guohui Bai, Yuhang Zhu, Houqiang Xu
PURPOSE: To investigate the potential function of BTBD7 in prostate cancer (PCa) development and the underlying molecular mechanism. METHODS: Serum levels of BTBD7 in PCa patients were examined by qRT-PCR. Regulatory effects of BTBD7 on viability and invasiveness were detected by CCK-8 and Transwell assay, respectively. Moreover, Western blot analysis was conducted to examine protein levels of epithelial-mesenchymal transition (EMT) markers (E-cadherin and N-cadherin) in PCa cells intervened by BTBD7...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761623/the-evaluation-of-sexual-functions-of-prostate-cancer-patients-receiving-radiotherapy
#23
JOURNAL ARTICLE
Yasemin Guzle Adas, Esra Kekilli, Muzaffer Bedri Altundag
PURPOSE: To evaluate the sexual functions of prostate cancer patients receiving radiotherapy (RT) with curative intent. METHODS: Fifty patients with low-risk prostate cancer who responded to the international index of erectile function (IIEF) questionnaire before and after RT were included in the study Results: Statistically significant decline was observed in sexual functions by the end of RT. While the average sexual desire scores of the patients before RT was 6...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761622/development-and-validation-of-a-nomogram-for-specific-survival-in-osteosarcoma-patients-less-than-60-years-old-a-population-based-study
#24
JOURNAL ARTICLE
Jun Zhao, Jianfei Jiao, Yu Su, Long Mu
PURPOSE: The present study aimed to develop a nomogram to predict the overall survival of patients with osteosarcoma, especially those less than 60 years old. METHODS: 903 osteosarcoma patients less than 60 years old were collected from the Surveillance, Epidemiology, and End Results (SEER) database.Univariate and multivariate analyses identified the independent prognostic factors of osteosarcoma. Nomogram was used to predict 3- and 5-year overall survival (OS) of osteosarcoma...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761621/fat10-stimulates-the-development-of-osteosarcoma-by-regulating-the-jak-stat-signaling-pathway
#25
JOURNAL ARTICLE
Faliang Shi, Longyun Li, Yongjie Cheng
PURPOSE: To investigate the potential function of FAT10 in the development of osteosarcoma (OS) and its mechanism. METHODS: Relative level of FAT10 in OS specimens and cell lines was detected by qRT-PCR. The correlation between FAT10 level and clinical features of OS patients was assessed by χ2 test. After intervention of FAT10 in MG-63 and U2OS cells, changes of FAT10 level, cell viability, clonality and proliferative capacity were respectively detected by qRT-PCR, CCK-8, colony formation and EdU assay...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761620/ddx46-accelerates-the-proliferation-of-glioblastoma-by-activating-the-mapk-p38-signaling
#26
JOURNAL ARTICLE
Ji Ma, Zhenying Gao, Xueni Liu
PURPOSE: To analyze the influence of DDX46 on the proliferative and migratory potentials of glioblastoma (GBM). METHODS: Differential levels of DDX46 in GBM cases and controls were examined by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot. By intervening DDX46 in U87 and U251 cells, proliferative and migratory changes were determined by colony formation assay, 5-Ethynyl-2'- deoxyuridine (EdU) assay and Transwell assay, respectively...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761619/serpin-peptidase-inhibitor-clade-e-nexin-group-1-promotes-cellular-proliferative-capacities-and-malignant-behaviors-in-glioblastoma-through-upregulating-hairy-and-enhancer-of-split-1
#27
JOURNAL ARTICLE
Tao Ma, Kai Qian, Tuoye Xu, Xi Wang, Tengda Qian, Jing Shi, Lixin Li
PURPOSE: Glioblastoma (GBM) remains one of the most fatal malignancy with limited available treatment. Serpin peptidase inhibitor, clade E nexin group 1 (SERPINE1) was found up-regulated in multiple cancers and play crucial roles in facilitating tumor progression and metastasis respectively. However, the role of SERPINE1 in glioblastoma was poorly understood. METHODS: We tested the hypothesis that SERPINE1 mediated malignant behaviors in GBM via regulating hairy and enhancer of split-1 (HES1)...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761618/efficacy-analyses-of-axitinib-and-nivolumab-in-metastatic-renal-cell-carcinoma-after-failure-of-targeted-therapy-which-is-better
#28
JOURNAL ARTICLE
Oktay Halit Aktepe, Fadime Sinem Ardic, Deniz Yuce, Deniz Can Guven, Gurkan Guner, Hasan Cagri Yildirim, Saadettin Kilickap, Alev Turker, Neyran Kertmen, Serkan Akin, Sercan Aksoy, Omer Dizdar, Suayib Yalcin, Mustafa Erman
PURPOSE: The objective of the present study was to compare the efficacy of axitinib and nivolumab in metastatic renal cell carcinoma (mRCC) previously treated with targeted therapy. METHODS: A total of 79 patients were enrolled (39 patients in axitinib group, 40 patients in nivolumab group). Survival outcomes of patients, progression-free survival (PFS), and overall survival (OS) were estimated using the Kaplan-Meier method and compared with the log-rank test. The associations between potential prognostic variables and OS were evaluated in univariate and multivariate Cox regression analyses...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761617/expression-of-mir-410-in-peripheral-blood-of-patients-with-clear-cell-renal-cell-carcinoma-and-its-effect-on-proliferation-and-invasion-of-caki-2-cells
#29
JOURNAL ARTICLE
Zhi Liu, Jun Zhang, Xuechun Hu, Qingyu Ge, Jun Xiao, Chrismis Novalinda Ginting
PURPOSE: To explore the significance of miR-410 expression in clear cell renal cell carcinoma (CCRCC) and its biological function in CCRCC. METHODS: A total of 113 patients with CCRCC admitted to our hospital and 113 healthy individuals over the same period were enrolled. MiR-410 in the tissues and serum of patients with CCRCC was quantified, and the diagnostic value of miR-410 in CCRCC and the relationship between miR-410 and prognosis of patients with CCRCC were analyzed...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761616/analysis-of-ct-mri-imaging-features-of-renal-cell-carcinoma-with-different-histopathological-types
#30
JOURNAL ARTICLE
Xiaoqiang Wang, Weihui Kong, Yanhui Wang, Yuhong Wang, Yueqin Chen, Zhitao Shi, Yanjie Liu
PURPOSE: This study aimed to investigate the computed tomography (CT) and magnetic resonance imaging (MRI) features of different histological types of renal cell carcinoma (RCC) (clear cell RCC (ccRCC), papillary RCC (pRCC), chromophobe RCC (chRCC). METHODS: The clinical data of 67 patients (including 38 patients with ccRCC, 20 patients with pRCC and 9 patients with chRCC) with RCC confirmed pathologically in the Affiliated Hospital of Jining Medical University were retrospectively analyzed...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761615/integrated-analysis-of-hub-gene-expression-in-multiple-myeloma
#31
JOURNAL ARTICLE
Yanping Huang, Jinxiong Huang, Peng Zhang, Jun Luo, Peng Cheng, Liu Miao, Yongrong Lai
PURPOSE: To explore the expression and clinical significance of factors associated with multiple myeloma (MM) and identify new diagnostic markers. METHODS: Two gene expression array data sets (GSE6477 and GSE5900) were downloaded and differentially expressed genes (DEGs) in bone marrow from patients with MM and healthy donors analyzed. Kyoto Encyclopedia of Genes and Genomes pathway enrichment and Gene Ontology annotation of DEGs was conducted and a protein-protein interaction network generated...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761614/regulatory-effects-of-mir-188-5p-xrcc5-on-the-progression-of-natural-killer-t-cell-lymphoma
#32
JOURNAL ARTICLE
Qianqian Huang, Siruiyun Ding, Hui Zhang
PURPOSE: Natural killer/T cell lymphoma (NKTCL) is a malignant condition. The molecular pathological mechanism of NKTCL has not been well studied. In this article we tried to study the role of microRNA-188-5p (miR-188-5p) in NKTCL. METHODS: The expression level of miR-188-5p and XRCC5 was examined by quantitative real-time polymerase chain reaction (qRT-PCR). Cell counting kit-8 (CCK-8) assay and colony formation assay were used to assess the ability of cell proliferation...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761613/combination-of-venetoclax-and-hypomethylating-agents-in-relapsed-refractory-acute-myeloid-leukemia-a-case-series-from-a-single-center
#33
JOURNAL ARTICLE
Sema Secilmis, Mehmet Sinan Dal, Merih Kizil Cakar, Alparslan Merdin, Nuran Ahu Baysal, Fevzi Altuntas
PURPOSE: Venetoclax (VEN) is an oral selective inhibitor of antiapoptotic protein B-cell leukemia/lymphoma-2 (BCL-2). METHODS: We report 7 relapsed/refractory (R/R) acute myeloid leukemia (AML) patients treated with venetoclax and hypomethylating agents (HMA). RESULTS: More than half of the patients could go on with venetoclax for only a few months. CONCLUSION: Using venetoclax combined with HMA in R/R AML should be kept in mind as an alternative salvage option...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761612/meta-analysis-on-the-safety-and-efficacy-of-early-oral-feeding-after-total-laryngectomy
#34
JOURNAL ARTICLE
Xuelian Yi, Chunhong Hu, Yi Peng, Zili Wen, Xue Li, Linlin Ye, Qingsong Huang
PURPOSE: To evaluate the safety and efficacy of early oral feeding (≤ 3 days) and delayed oral feeding (≥ 7 days) following total laryngectomy. METHODS: Relevant literatures on early and delayed oral feeding following total laryngectomy published before January, 2019 were searched in PubMed, EMBASE, Web of Science, Cochrane Library, CNKI and Wanfang Database. Two reviewers were responsible for selecting literatures, extracting data and cross-check. The incidence of pharyngocutaneous fistula (PCF) was evaluated by calculating OR and 95%CI...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761611/oral-mucositis-related-neuropathic-pain-in-head-and-neck-cancer-patients-receiving-radiotherapy-or-chemo-radiotherapy-a-prospective-study
#35
JOURNAL ARTICLE
Maria Kouri, Ourania Nicolatou Galitis, Athina Vadalouca, Vassilis Kouloulias, Erofili Papadopoulou, Emmanouil Vardas, Euthimios Kyrodimos, Miltiadis Trichas, Anna Zygogianni, Zoi Liakouli, Evangelos Galitis, Ioanna Siafaka, Andromachi Kougioumtzopoulou, Amanda Psyrri
PURPOSE: Pain due to oral-mucositis (OM) in head and neck cancer (HNC) patients receiving radiotherapy (RT) /chemo-radiotherapy (CRT) can be nociceptive and/or neuropathic. Neuropathic pain (NP) often remains underdiagnosed and untreated. This study's purpose was to identify the presence of OM-induced NP in HNC patients under RT/CRT. METHODS: Pain was assessed using a 0-10 numeric scale (NRS). At an NRS≥5 score, patients completed the Douleur Neuropathique 4 (DN4) questionnaire, where a score ≥4/10 indicates the presence of NP...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761610/treatment-effect-of-concurrent-chemoradiotherapy-after-surgery-and-its-effect-on-postoperative-swallowing-function-of-patients-with-locally-advanced-hypopharyngeal-carcinoma
#36
JOURNAL ARTICLE
Xiaoxu Wang, Liuzhong Wang, Ling Gao, Xiao Guo, Hua Cao
PURPOSE: To study the treatment effect of concurrent chemoradiotherapy (CCRT) after surgery and its effect on postoperative swallowing function of patients with locally advanced hypopharyngeal carcinoma. METHODS: The clinical data of 84 patients with advanced hypopharyngeal carcinoma treated in our hospital were retrospectively analyzed. The patients were randomly divided into experimental group and control group, with 42 cases in each group. After both groups of patients were treated with radical neck dissection, the control group received adjuvant radiotherapy while the experimental group received CCRT...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761609/comparative-analysis-of-clinicopathologic-characteristics-and-molecular-subtypes-of-invasive-papillary-carcinoma-of-the-breast-and-invasive-ductal-carcinoma-results-from-seer-database
#37
JOURNAL ARTICLE
Shujie Chen, Jie Wang, Li Yang, Min Ji, Sheng Chen
PURPOSE: To investigate the difference of clinicopathologic characteristics and prognosis between invasive papillary carcinoma (IPC) and invasive ductal carcinoma (IDC) in breast cancer patients, and to further confirm the influence of molecular subtype on prognosis of IPC. METHODS: A total of 158,132 eligible patients from 2010 to 2015 were identified from the Surveillance, Epidemiology, and End Results (SEER) database, of which 348 patients were IPC and 157,784 patients were IDC...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761608/the-landscape-of-angiogenesis-subtypes-for-breast-cancer-a-comprehensive-analysis-based-on-the-cancer-genome-atlas
#38
JOURNAL ARTICLE
Xiao-Fei Peng, Fang Lu Qin, Wen Jie Chen, Han Zhang, Zi Yue Mai, Jian Zeng
PURPOSE: Breast cancer is a common malignant tumor in women with a poor prognosis. This study aimed to investigate angiogenesis subtypes of breast cancer and unveil the etiology and molecular features of breast cancer. METHODS: Based on the angiogenesis gene set derived from AmiGO2, and breast cancer data in the Cancer Genome Atlas (TCGA), we define a novel cluster of angiogenesis subtypes for patients by consensus clustering. The gene regulation, immune landscape, molecular characteristics, and clinical features as well as enrichment pathways were explored in the angiogenesis subtypes of breast cancer...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761607/feasibility-of-oncoplastic-surgery-in-breast-cancer-patients-with-associated-in-situ-carcinoma
#39
JOURNAL ARTICLE
Alexandra Caziuc, David Andras, Vlad Fagarasan, George Calin Dindelegan
PURPOSE: Wide surgical margins are needed in order to treat locally the in situ ductal carcinoma of the breast. Breast conserving surgery using oncoplastic techniques in treating in situ ductal carcinoma can be a good option improving cosmetic and pathological outcome. METHODS: Between January 2019 and July 2019, 76 patients with invasive carcinoma associated with in situ ductal carcinoma were eligible for breast conserving surgery and were admitted to Cluj-Napoca First Surgical Clinic...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/34761606/linc00355-triggers-malignant-progression-of-hepatocellular-carcinoma-via-the-sponge-effect-on-mir-217-5p-with-the-involvement-of-the-wnt-%C3%AE-catenin-signaling
#40
JOURNAL ARTICLE
Xuanming Luo, Miyesaier ABudureyimu, Guohuan Yang, Zhe Yan, Xiutao Fu, Pinxiang Lu, Dexiang Zhang, Shulong Zhang, Zhenbin Ding
PURPOSE: To uncover the biological role of LINC00355 in regulating the proliferative and apoptotic potentials in hepatocellular carcinoma (HCC), and the underlying mechanism. METHODS: LINC00355 levels in HCC tissues and cell lines were detected by quantitative real-time polymerase chain reaction (qRT-PCR). After knockdown of LINC00355 or miR-217-5p in Hub7 and Hep3B cells, proliferative and apoptotic potentials were assessed by cell counting kit-8 (CCK-8), colony formation assay and flow cytometry...
September 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
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