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Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology

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https://read.qxmd.com/read/30722127/can-we-rely-on-body-mass-index-when-predicting-postoperative-outcomes-and-survival-of-esophageal-cancer-patients
#1
Dimitrios Schizas, Irene Lidoriki, Theodore Liakakos
No abstract text is available yet for this article.
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722126/mutational-status-of-lung-cancer-patients-and-survival-outcomes-for-patients-with-limited-brain-metastases
#2
Mutlu Hizal, Mehmet An Sendur, Burak Bilgin, Bulent Yalcin
No abstract text is available yet for this article.
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722125/hyperthermic-intrathoracic-chemotherapy-hithoc-in-ovarian-carcinoma-a-propos-of-a-case
#3
Dejan Stojiljkovic, Srdjan Nikolic, Ana Cvetkovic, Vladimir Jokic, Igor Spurnic, Stevan Jokic, Merima Goran, Milan Kocic, Nebojsa Miletic, Jovan Filipovic, Tanja Stojiljkovic, Branislav Lukac
A female patient aged 42, started chemotherapy for advanced ovarian carcinoma in June 2016. Considering intraoperative findings, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) were performed, followed by adjuvant chemotherapy. In March 2018, computed tomography (CT) examination showed disease progression in the form of pleural carcinomatosis with increased levels of tumor markers. In April 2018, total parietal pleurectomy, partial visceral pleurectomy, and then hyperthermic intrathoracic chemotherapy (HITHOC) with cisplatin were performed...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722124/family-caregiver-beliefs-and-barriers-to-effective-pain-management-of-cancer-patients-in-home-care-settings
#4
Apostolos Konstantis, Triada Exiara
PURPOSE: Pain is one of the most common symptoms in cancer patients, and its management is a significant goal in supportive care. Many barriers interfere with its effective control. Nowadays, with a shift in care from the hospital to the home, there is an increasing tendency to involve family caregivers in pain management. Their beliefs may act as barriers to effective pain management in these homecare settings. This study aimed to validate and explore these beliefs using Barriers Questionnaire II (BQ II)...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722123/thyroid-ultrasonographic-charasteristics-and-bethesda-results-after-fnab
#5
Eleni Triantafillou, Georgios Papadakis, Fotini Kanouta, Styliani Kalaitzidou, Aspasia Drosou, Angeliki Sapera, Dimitra Tampouratzi, Michalis Kotis, Taxiarchis Kyrimis, Anna Dracopoulou, Eirini Veniou, Chrysa Karavasili, Victoria Kaltzidou, Styliani Plyta, Athanasia Tertipi
PURPOSE: Thyroid nodular disease (TND) is a frequent clinical problem and the major concern is the probability of malignancy in a solitary nodule or in one or more nodules of a multinodular goiter. For this purpose, neck ultrasound and fine needle aspiration biopsy (FNAB) under ultrasound guidance have been established as the initial investigation of choice. METHODS: A total of 1113 patients (210 male/903 female) underwent FNABs for the same number of thyroid nodules...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722122/human-v%C3%AE-9v%C3%AE-2-t-cells-show-potent-antitumor-activity-against-zoledronate-sensitized-oscc-cell-lines
#6
Eisuke Domae, Yuya Hirai, Takashi Ikeo, Seiji Goda, Kaname Tsuji
PURPOSE: Vγ9Vδ2 T cells exhibit potent antitumor effects against multiple types of tumors in preclinical models. In the present study, we examined whether human Vγ9Vδ2 T cells can be effective against oral squamous cell carcinoma (OSCC) cell lines in vitro because the interaction between OSCC and Vγ9Vδ2 T cells has not been explored previously. METHODS: Eight OSCC cell lines were analyzed for their expression of ligands that potentially activate Vγ9Vδ2 T cells...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722121/the-role-of-biomarkers-and-echocardiography-in-the-evaluation-of-cardiotoxicity-risk-in-children-treated-for-leukemia
#7
Diana Raluca Maniu, Cristina Blag, Gheorghe Popa, Madalina Bota, Catalin Vlad, Calin Cainap, Ovidiu Balacescu, Laura Pop, Simona Sorana Cainap
PURPOSE: To describe the high-risk profile group, susceptible to develop anthracycline-induced cardiomyopathy in children with acute leukemia. METHODS: The study involved 35 pediatric patients diagnosed with acute lymphoblastic (ALL) or acute myeloblastic leukemia (AML), from March 2014 to December 2016. Serologic markers used for the analysis of cardiac dysfunction were troponin T, NT-proBNP and PCRhs. Also, the patients have had echocardiographic evaluation at the beginning of treatment to determine LVEF, SF and A, E, E' Doppler waves...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722120/comparison-of-gemcitabine-monotherapy-with-gemcitabine-and-cisplatin-combination-in-metastatic-pancreatic-cancer-a-retrospective-analysis
#8
Yakup Ergun, Nuriye Yildirim Ozdemir, Ebru Karci Guner, Ece Esin, Mehmet Ali Sendur, Elif Berna Koksoy, Nebi Serkan Demirci, Tulay Eren, Isa Dede, Ahmet Sezer, Huseyin Engin, Berna Oksuzoglu, Bulent Yalcin, Gungor Utkan, Nurullah Zengin, Yuksel Urun
PURPOSE: Gemcitabine is among the standard first-line agents for the treatment of metastatic pancreatic cancer. However, as the median survival with gemcitabine monotherapy is 6 months, different combinations are being studied for better, prolonged survival. In this multicenter study, we aimed to compare the results of gemcitabine monotherapy with those of gemcitabine and cisplatin combination therapy as first-line treatments for metastatic pancreatic cancer. METHODS: Data of 664 patients diagnosed with metastatic pancreatic cancer between January 2007 and December 2016 from seven oncology centers in Turkey were retrospectively evaluated, and 319 patients with gemcitabine alone (n=138) or gemcitabine and cisplatin combination (n=181) as first-line treatment were included...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722119/effect-of-increased-number-of-neoadjuvant-chemotherapy-cycles-on-tumor-resectability-and-pathologic-response-in-advanced-stage-epithelial-ovarian-cancer
#9
Huseyin Akilli, Samed Rahatli, Yusuf Aytac Tohmal, Latife Atasoy Karakas, Ozden Altundag, Ali Ayhan
PURPOSE: To identify the significance of the number of neoadjuvant chemotherapy (NACT) cycles on pathologic response and to define relationship between multiple cycles of NACT and the timing of interval debulking surgery (IDS) in epithelial ovarian cancer (EOC) patients. METHODS: This retrospective case-control study was carried out at the Baskent University in Ankara between 2007 and 2017. We reviewed 62 patients with advanced stage (IIIC-IV) EOC who received NACT in other institutes and operated in our clinic...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722118/the-impact-of-minimal-invasive-surgery-on-early-complications-and-mortality-after-radical-cystectomy-for-muscle-invasive-urothelial-bladder-cancer
#10
Andrei Boc, Nicolae Crisan, Stefan Cristian Vesa, Ioan Coman, Vasile Dan Stanca, Iulia Andras
PURPOSE: to evaluate the 30-day death rate and the factors associated with short-term complications after radical cystectomy for muscle-invasive urothelial bladder cancer. METHODS: The study included 123 patients (age 64.1±7.9 years; 111 (90.2%) males and 12 (9.8%) females) previously diagnosed with urothelial bladder cancer, admitted for radical cystectomy in a tertiary center. The following data were noted: age, gender, perioperative chemotherapy and radiotherapy, pre- and postoperative hemoglobin and creatinine levels, tumor stage, type of surgery, type of diversion and Clavien classification...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722117/significance-of-survivin-mrna-blood-levels-in-patients-with-melanoma
#11
Michael Samarkos, George Papaxoinis, Kalliopi Athanasoula, Οlga Benopoulou, Spyros Bouros, Amalia Anastasopoulou, Panagiotis Diamantopoulos, Helen Gogas, Marina Mantzourani
PURPOSE: Survivin represents a key anti-apoptotic molecule that is highly expressed in the vast majority of tumors. The aim of the study was to examine the significance of survivin mRNA blood levels in melanoma patients. METHODS: In this prospective translational research study, survivin mRNA blood levels were measured in melanoma patients treated with adjuvant interferon or systemic treatment for advanced disease. RESULTS: Sixty-four patients with melanoma and 40 healthy controls were included...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722116/what-can-preoperative-blood-tests-tell-us-about-colorectal-cancer
#12
Ioannis D Kostakis, Aristeidis G Vaiopoulos, Zoe Garoufalia, Athanasios Papavassiliou, Stylianos Kykalos, Gregory Kouraklis, Gerasimos Tsourouflis
PURPOSE: To study the diagnostic and/or prognostic role of preoperative blood tests in colorectal cancer. METHODS: Preoperative complete blood count tests and lactate dehydrogenase (LDH) serum levels of 167 patients with colorectal adenocarcinoma were examined for associations with clinicopathological parameters, disease-specific survival (DSS) and relapse-free survival (RFS). RESULTS: The following parameters showed high sensitivity (≥85%) in detecting these features: platelet to lymphocyte ratio (PLR) for T4 tumors, white blood cell count (WBC) and neutrophil count (NC) for distant metastases and lymphocyte count (LC) for high-grade tumors...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722115/is-advanced-age-a-hesitation-for-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-colorectal-cancer
#13
Naciye Cigdem Arslan, Tayfun Bisgin, Canan Altay, Tugba Yavuzsen, Aziz Karaoglu, Aras Emre Canda, Sulen Sarioglu, Selman Sokmen
PURPOSE: The purpose of this study was to assess the feasibility and safety of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in elderly patients with peritoneal carcinomatosis of colorectal cancer. METHODS: Patients who underwent curative complete CRS and HIPEC for peritoneal carcinomatosis of colorectal cancer with minimum follow-up of 24 months were included in the analysis. Charlson comorbidity index and ECOG performance status were used to evaluate preoperative condition...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722114/discrepancies-and-misconceptions-of-perceived-colorectal-cancer-screening-barriers-between-primary-health-professionals-and-unscreened-population-a-comparative-study-in-greece
#14
Athanasios Mastrokostas, Magda Gavana, Maria Gkrizioti, Emmanouil Smyrnakis, Evangelos Cholongitas, Alexis Benos, Anna-Bettina Haidich
PURPOSE: Our study aimed to compare the views of healthy eligible unscreened adults, to those of primary care providers in Greece, about colorectal cancer (CRC) screening perceived barriers. METHODS: A sample of 791 unscreened adults (50-75 years) from a recent nationwide health survey in Greece were interviewed about CRC screening barriers, and the main reason for not adhering to colonoscopy and fecal occult blood test (FOBT) was assessed. Results were compared to a concurrent survey of 161 primary care professionals (PCPs) from the same region and the agreement with the general population was assessed with odds ratios (OR) and 95% confidence intervals (CI)...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722113/discordance-of-hormone-receptor-human-epidermal-growth-factor-receptor-2-and-ki-67-between-primary-breast-cancer-and-synchronous-axillary-lymph-node-metastasis
#15
Hiroko Kinoe, Kosho Yamanouchi, Sayaka Kuba, Michi Morita, Chika Sakimura, Kengo Kanetaka, Mitsuhisa Takatsuki, Kuniko Abe, Hiroshi Yano, Megumi Matsumoto, Ryota Otsubo, Naomi Hayashida, Takeshi Nagayasu, Susumu Eguchi
PURPOSE: We herein report the discordance rate between primary breast cancer and synchronous axillary node metastasis, its characteristics and its prognostic impact. METHODS: One hundred and four patients with invasive breast cancer with synchronous axillary node metastasis who underwent surgery were included. Estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor-2 (HER2), and Ki-67 were stained by immunohistochemistry in both primary and node metastasis...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722112/influence-of-soy-isoflavones-in-breast-cancer-angiogenesis-a-multiplex-glass-elisa-approach
#16
Alina Uifalean, Hermann Rath, Elke Hammer, Corina Ionescu, Cristina Adela Iuga, Michael Lalk
PURPOSE: The aim of this study was to evaluate the anti-angiogenic properties of soy isoflavones using two breast cancer cell lines, by measuring the concentration of 30 cytokines involved in angiogenesis using a multiplex glass slide ELISA-based array. METHODS: Estrogen-dependent MCF-7 cells and estrogen-independent MDA-MB-231 cells were exposed to genistein (Gen), daidzein (Dai) and a soy seed extract (Ext) for 72 hrs, at selected concentration levels. The conditioned medium was analyzed using a glass slide, multiplex sandwich ELISA-based platform with fluorescent detection which allowed the identification and the quantification of 30 angiogenesis-related cytokines...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722111/knowledge-attitudes-and-behaviors-of-breast-and-cervical-cancers-and-screenings-of-women-working-in-primary-health-care-services
#17
Serdar Deniz, Ferhat Coskun, Dilek Oztas, Ahmet Oner Kurt
PURPOSE: Determination of information attitudes, behaviors and related factors on breast and cervical cancer screenings of primary health care workers. METHODS: The population of the study consisted of 1,130 female health workers working in health facilities (Community Health Centers, Family Health Centers) that provided primary health care services in the province of Mersin. The fieldwork was carried out in October 2017-February 2018 period. There were 62 questions in the survey form...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722110/personal-and-parental-acceptance-of-human-papillomavirus-vaccination-prior-to-and-during-the-economic-crisis-among-women-in-greece
#18
Vagia Siamanta, Kimon Chatzistamatiou, Dimitrios Vavilis, Evangelia Nena, Εkaterini Chatzaki, Theodoros C Constantinidis, Anastasia Kitsou, Athena Tsertanidou, Alexandros F Lampropoulos, Theodoros Agorastos
PURPOSE: To assess personal and parental human papillomavirus (HPV) vaccination acceptance and how it is influenced by demographic factors prior to (2005-2010) and during (2011-2016) the economic crisis in Greece. METHODS: During 2005-2016, 6,401 women aged 18-65 years, living in different areas of Greece filled in a questionnaire covering demographic characteristics, knowledge of HPV infection's natural history and its consequences and assessing their intention to receive the HPV vaccine for themselves and their children...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722109/household-costs-of-breast-cancer-morbidity-an-empirical-assessment-from-pakistan
#19
Hafiz Zahid Mahmood, Imran Hameed Khaliq, Zafar Iqbal Bhatti, Kimberly J Wilson, Khalid Masood Gondal, Summaira Malik, Shakila Zaman
PURPOSE: Health care costs attributable to breast cancer are substantial. In countries with high poverty, lack of public health infrastructure and low availability of health insurance, the economic burden of disease does not accrue solely to health care, but also on patients and their families. This study was conducted to explore the cost burden (i.e. direct medical costs, direct non-medical costs and indirect non-medical costs) incurred by breast cancer patients and their families over diagnosis and treatment...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30722108/ki-67-and-topoisomerase-iia-proliferation-markers-in-colon-adenocarcinoma
#20
Athanasios Niotis, Evangelos Tsiambas, Panagiotis P Fotiades, Vasileios Ragos, Georgios Polymeneas
Aberrant cell proliferation is a major cause in the development and progression of carcinogenic process. Epithelia characterized by increased mitotic rates accumulate easily gross numerical and structural chromosomes (polysomy/aneuploidy) and specific gene (deletions, amplifications, point mutations, translocations) deregulations that lead to their progressive neoplastic and finally malignant transformation. Molecules that are critical for evaluating the proliferation status of the corresponding tissues include mainly ki-67 (cytogenetic band: 10q26...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
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