Marton Kristof Varga, Hanns Moshammer, Oral Atanyazova
Asthma is a multifaceted and multicausal disease. Childhood asthma is strongly influenced by genetic traits and is characterized by hyperreactivity of the airways so that also unspecific triggers including moulds can trigger an asthma attack. Therefore, it is undisputed that moulds in the home can cause asthma attacks in asthmatic children. It is, however, unclear if mould in homes also induce the development of asthma. Because more and more severe attacks in asthmatic children living in mouldy homes might speed up the diagnosis of asthma, cross-sectional studies are not well-suited to differentiate between mould as a causative or only as a precipitating factor...
July 11, 2024: Wiener Klinische Wochenschrift
Maria Anna Smolle, Alfred Maier, Jörg Lindenmann, Christian Porubsky, Franz-Josef Seibert, Andreas Leithner, Freyja-Maria Smolle-Juettner
A 74-year-old male patient was referred with signs of sepsis 5 days after having been diagnosed with a rib fracture following a fall out of bed. Novel hypodensities were visible on thoracic X‑rays and laboratory tests revealed elevated inflammatory parameters. Subsequently performed thoracic computed tomography (CT) scan showed burst fracture of the 3rd thoracic vertebra, posttraumatic esophageal rupture at the same level and mediastinitis. Furthermore, marked degenerative changes of the spinal column (diffuse idiopathic skeletal hyperostosis) were present...
July 10, 2024: Wiener Klinische Wochenschrift
Martin Baumgartner, Michaela Wagner-Menghin, Christian Vajda, Gernot Lecaks, Armin Redzic, Georg Dorffner
PURPOSE: The public medical universities in Austria (educating 11,000 students) developed a joint public distance learning series in which clinicians discussed current digital lighthouse projects in their specialty. This study aims to examine the changes in attitude and knowledge of the participants before and after the lecture series to gain insights for future curriculum developments. METHOD: The lecture series was announced via various channels at the universities, in health newsletters and in social media...
July 10, 2024: Wiener Klinische Wochenschrift
Wolfgang Füreder, Renate Thalhammer, Peter Valent
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematologic disorder characterized by a loss of glycosyl-phosphatidyl-inositol-linked (GPI) proteins on various hematopoietic cells. Some GPI proteins are involved in the regulation of the complement system, and their absence renders erythrocytes susceptible to complement-mediated lysis. Current standard of care in PNH is to block the complement system at the level of C5 using ravulizumab or eculizumab; however, some patients with PNH may develop extravascular hemolysis (EVH) during treatment with C5 inhibitors...
July 1, 2024: Wiener Klinische Wochenschrift
Mingyi Yang, Yani Su, Ke Xu, Pengfei Wen, Jianbin Guo, Zhi Yang, Lin Liu, Peng Xu
OBJECTIVE: To investigate the genetic level causal association among hyperthyroidism, hypothyroidism, and rheumatoid arthritis (RA). METHODS: We utilized the genome-wide association studies (GWAS) summary data for exposure (hyperthyroidism and hypothyroidism) and outcome (RA) from the IEU OpenGWAS database. We used two different sets of data (test cohort and validation cohort) for causal assessment of exposure and outcome. To establish a causal relationship between these conditions, we conducted a two-sample Mendelian randomization (MR) analysis...
June 20, 2024: Wiener Klinische Wochenschrift
Selam Woldemariam, Viktoria K Stein, Sandra Haider, Thomas E Dorner
BACKGROUND: Difficulties in activities of daily living (ADL) and instrumental activities of daily living (IADL) in older adults are associated with diminished quality of life and increased demand for long-term care. The present study examined the prevalence of disability among individuals aged 65 years and older in Austria, using data from the Austrian Health Interview Surveys (ATHIS). METHODS: The ATHIS 2014 and 2019 surveys were used (N = 5853) for the analysis...
June 18, 2024: Wiener Klinische Wochenschrift
Moritz Platzer, David Totschnig, Mario Karolyi, Tamara Clodi-Seitz, Christoph Wenisch, Alexander Zoufaly
BACKGROUND: Antiviral drugs have become crucial in managing COVID-19, reducing complications and mortality. Remdesivir has emerged as an effective therapeutic drug for hospitalized patients at risk of disease progression, especially when alternative treatments are infeasible. While the recommended treatment duration of remdesivir extends up to 7 days post-symptom onset, this study examines how early remdesivir administration impacts clinical outcomes. METHODS: We conducted a retrospective analysis using clinical data from consecutively PCR confirmed SARS-CoV‑2 adult patients (≥ 18 years) who received remdesivir during their hospitalization at the department of infectious diseases, Klinik Favoriten in Vienna...
June 17, 2024: Wiener Klinische Wochenschrift
Christoph Male, Cihan Ay, Richard Crevenna, Sabine Eichinger, Clemens Feistritzer, Robert Füller, Alexander Haushofer, Andreas Kurringer, Peter Neumeister, Stephan Puchner, Thomas Rettl, Thomas Schindl, Gerhard Schuster, Rudolf Schwarz, Michael Sohm, Werner Streif, Katharina Thom, Barbara Wagner, Eva Wissmann, Karl Zwiauer, Ingrid Pabinger
No abstract text is available yet for this article.
June 3, 2024: Wiener Klinische Wochenschrift
Dorian Hirschmann, Danial Nasiri, Christian Joachim Entenmann, Christine Haberler, Thomas Roetzer, Christian Dorfer, Matthias Millesi
OBJECTIVE: To identify factors for tumor relapse and poor outcome in patients with meningiomas in the first two decades of life. METHODS: All patients ≤ 21 years of age who underwent resection of a meningioma at the department of neurosurgery, Medical University of Vienna between 1989 and 2022 were included in this retrospective study. Clinical and radiological data were extracted from the medical records. Outcome and tumor relapse were analyzed for tumor location, histological findings and extent of resection...
May 31, 2024: Wiener Klinische Wochenschrift
Sofie Ronja Petersen, Nathalie Fogh Rasmussen, Agnete Overgaard Donskov, Lau Caspar Thygesen, Kim Rose Olsen, Linda Juel Ahrenfeldt, Vibeke Andersen
BACKGROUND: Low socioeconomic status is associated with disadvantages in health outcomes and delivery of medical care in patients with Inflammatory Bowel Disease (IBD). Inequality in the utilisation of biologic treatment is largely unexplored. AIM: To explore the potential association of socioeconomic status and time to first biologic treatment in a population-based IBD cohort. METHODS: All 37,380 IBD incidences between 2000 and 2017 from the Danish National Patient Register were identified and linked to socioeconomic information including educational level, income and occupational status at diagnosis...
May 24, 2024: Wiener Klinische Wochenschrift
Hans-Peter Hutter, Lisbeth Weitensfelder, Michael Poteser
Micro- and nanoplastics are omnipresent not only in the environment, but have also been detected in human body fluids and tissue. The subsequent commentary provides a perspective about potential risks for human health as well as resulting challenges for medical science.
May 21, 2024: Wiener Klinische Wochenschrift
Martin W Dünser, Matthias Noitz, Thomas Tschoellitsch, Markus Bruckner, Markus Brunner, Bernhard Eichler, Romana Erblich, Stephan Kalb, Marius Knöll, Johannes Szasz, Wilhelm Behringer, Jens Meier
Critical illness is an exquisitely time-sensitive condition and follows a disease continuum, which always starts before admission to the intensive care unit (ICU), in the majority of cases even before hospital admission. Reflecting the common practice in many healthcare systems that critical care is mainly provided in the confined areas of an ICU, any delay in ICU admission of critically ill patients is associated with increased morbidity and mortality. However, if appropriate critical care interventions are provided before ICU admission, this association is not observed...
May 16, 2024: Wiener Klinische Wochenschrift
Katharina Millesi, Monika Killer-Oberpfalzer, Johannes A R Pfaff, J Sebastian Mutzenbach, Christoph J Griessenauer, Michael Sonnberger, Milan Vosko, Judith Wagner, Matthias Millesi, Slaven Pikija, Constantin Hecker
BACKGROUND: Stroke resulting from occlusion of the middle cerebral artery (MCA) can have devastating consequences, potentially leading to a loss of independence. This study aimed to investigate the relationship between the distance to the thrombus (DT) and both ischemic lesion volume (ILV) and clinical outcomes. METHODS: We retrospectively evaluated patients with thromboembolic MCA M1 segment occlusion who underwent neurovascular imaging followed by endovascular thrombectomy (EVT) at two comprehensive stroke centers over a 3-year period (2018-2020)...
May 15, 2024: Wiener Klinische Wochenschrift
Ivan Grgac, Guenther Herzer, Wolfgang G Voelckel, Julio J Secades, Helmut Trimmel
Traumatic brain injuries cause enormous individual and socioeconomic burdens. Survivors frequently struggle with motor handicaps as well as impaired cognition and emotion. In addition to the primary mechanical brain damage, complex secondary mechanisms are the main drivers of functional impairment. Many of these pathophysiological mechanisms are now well known: excitotoxic amino acids, breakdown of the blood-brain barrier, neuroinflammation with subsequent damage to cell organelles and membranes, cerebral edema, and apoptotic processes triggering neuronal death; however, paracrine resilience factors may counteract these processes...
May 15, 2024: Wiener Klinische Wochenschrift
Florian Wenzel-Schwarz, Ulrike Wittig, Elena Nemecek, Rudolf Ganger, Till Bader, Wolfgang Huf, Reinhard Schuh
BACKGROUND: The Broström procedure is an established procedure in cases of primary lateral ankle ligament repair (LALR). To improve postoperative stability an augmentation device, InternalBrace™ (Arthrex, Naples, FL) has been introduced. This study evaluates remodelling of the anterior talofibular ligament (ATFL) in patients undergoing a tape augmented Broström technique as well as clinical outcomes. METHODS: In this study 32 patients with chronic lateral ankle instability (CLAI) receiving augmented LALR were included...
May 14, 2024: Wiener Klinische Wochenschrift
Magdalena Ratz, Johannes B Vogel, Heike Kührer, Christoph H Säly, Axel Mündlein, Alexander Vonbank, Arthur Mader, Peter Fraunberger, Andreas Leiherer, Heinz Drexel
BACKGROUND AND AIM: Guidelines on dyslipidemia and lipid-lowering therapy (LLT) over the years recommend lower low-density lipoprotein cholesterol (LDL-C) goals by more intense therapy. Nevertheless, LDL‑C has increased in the general population. Real-world trends of LLT medication as well as of LDL‑C levels in cardiovascular high-risk patients are unclear. METHODS: From 2158 patients who were referred for elective coronary angiography, lipid medication was analyzed at admission in three cardiovascular observational studies (OS) over the last 25 years: OS1: 1999-2000, OS2: 2005-2008 and OS3: 2022-2023...
May 14, 2024: Wiener Klinische Wochenschrift
Anastasia Pantazidou, Chryssa Grylli, Sophie Klomfar, Eva Mora-Theuer, Johanna Schöggl, Sarah Macura, Laura Schaller, Iulia Pokorny, Susanne Greber-Platzer
The global population was affected by the unprecedented coronavirus COVID-19 pandemic. The impact of the pandemic on children who suffer child maltreatment has not been explored sufficiently. Child abuse is known to increase in stressful circumstances, and therefore potentially during this pandemic.We aimed to identify and measure the impact of pandemic-related stress in families with a suspicion or confirmed child maltreatment. In addition, other parameters were determined, including resilience factors and family dynamics...
May 10, 2024: Wiener Klinische Wochenschrift
Cihan Ay, Andreas Reinisch
INTRODUCTION: Gene therapy is an emerging topic in medicine. The first products have already been licensed in the European Union for the treatment of immune deficiency, spinal muscular atrophy, hemophilia, retinal dystrophy, a rare neurotransmitter disorder and some hematological cancers, while many more are being assessed in preclinical and clinical trials. OBJECTIVE: The purpose of this review is to provide an overview of the core principles of gene therapy along with information on challenges and risks...
May 7, 2024: Wiener Klinische Wochenschrift
Stefan Riss, Christopher Dawoud
Fecal incontinence (FI) is a common disease with higher incidence rates in the elderly population. Treatment of affected patients remains challenging and ranges from conservative management to surgical techniques. Despite all efforts patients often undergo several therapeutic measurements to achieve reasonable functional improvements.Although sacral neuromodulation still remains a key therapy with success rates up to 80%, a significant number of patients do not respond sufficiently and require further treatment...
May 7, 2024: Wiener Klinische Wochenschrift
Jianzheng Cai, Zhina Gong, Yingying Zhang, Haifang Wang, Chunyan Niu, Yinuo Dai
BACKGROUND AND OBJECTIVE: Presbyphagia is defined as structural, physiological and innervational alterations in the swallowing process as a result of aging and is considered to be involved in the etiology of dysphagia. This systematic review and meta-analysis aimed to estimate the prevalence of presbyphagia in older adults without disease-related dysphagia. METHODS: In this study five databases were searched in October 2023 with no time limitation. Combined effect sizes of presbyphagia prevalence were calculated using random effect models...
May 1, 2024: Wiener Klinische Wochenschrift
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