Antoine AbdelMassih, Mervat Haroun, Rasha AbdelRaouf AbdelAziz Afifi, Gehan Hussein, Manal AbdelHameed, Marina G Asaad, Heba Tarabeh, Nourhan E El Din Taha, Nourine Diab, Noura Shebl, Raghda Fouda, Marianne E Yassa, Mohamed Ghobashy, Hala Agha
BACKGROUND: Sickle Cell Disease (SCD) is not a hematologic disease that occurs in isolation; it results in multi-organ complications. There is growing evidence of vascular stiffness as its underlying cause. This study aimed to investigate the relationship between endothelial stiffness and LV dysfunction in SCD patients and to explore its pathophysiology, particularly regarding the depletion of vasodilators such as Nitric Oxide (NO). METHODOLOGY: 32 patients with established criteria for SCD and 40 healthy control subjects were selected for this case-control study...
2024: Journal of the Saudi Heart Association