Megan E Farquhar, Kevin Burrage, Rodrigo Weber Dos Santos, Alfonso Bueno-Orovio, Brodie A J Lawson
Fibrosis, the excess of extracellular matrix, can affect, and even block, propagation of action potential in cardiac tissue. This can result in deleterious effects on heart function, but the nature and severity of these effects depend strongly on the localisation of fibrosis and its by-products in cardiac tissue, such as collagen scar formation. Computer simulation is an important means of understanding the complex effects of fibrosis on activation patterns in the heart, but concerns of computational cost place restrictions on the spatial resolution of these simulations...
June 15, 2022: Journal of Computational Physics