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Applied Physics Letters

Haina Jia, Te-Wei Tsai, Shoujun Xu
Atomic magnetometry and ultrasound, as individual techniques, have been used extensively in various physical, chemical, and biomedical fields. Their combined application, however, has been rare. We report that super-resolution force spectroscopy, which is based on the integration of the two techniques, can find unique biophysical applications in studying drug-DNA interactions. The precisely controlled ultrasound generates acoustic radiation force on the biological systems labeled with magnetic microparticles...
November 5, 2018: Applied Physics Letters
Jiamiao Yang, Lei Gong, Yuecheng Shen, Lihong V Wang
An ultra-long light needle is highly desired in optical microscopy for its ability to improve the lateral resolution over a large depth of field (DOF). However, its use in image acquisition usually relies on mechanical raster scanning, which compromises between imaging speed and stability and thereby restricts imaging performance. Here, we propose a synthetic Bessel light needle (SBLN) that can be generated and scanned digitally by complex field modulation using a digital micromirror device. In particular, the SBLN achieves a 45-fold improvement in DOF over its counterpart Gaussian focus...
October 29, 2018: Applied Physics Letters
Ethan Y Cho, Hao Li, Jay C LeFebvre, Yuchao W Zhou, R C Dynes, Shane A Cybart
Direct write patterning of high-transition temperature (high- T C ) superconducting oxide thin films with a focused helium ion beam is a formidable approach for the scaling of high- T C circuit feature sizes down to the nanoscale. In this letter, we report using this technique to create a sensitive micro superconducting quantum interference device (SQUID) magnetometer with a sensing area of about 100 × 100  μ m2 . The device is fabricated from a single 35-nm thick YBa2 Cu3 O7- δ film. A flux concentrating pick-up loop is directly coupled to a 10 nm × 20  μ m nano-slit SQUID...
October 15, 2018: Applied Physics Letters
Ang Li, Guang Zeng, Congwu Du, Huiping Zhang, Yingtian Pan
Optical coherence tomography angiography (OCTA) is a promising tool for imaging subsurface microvascular networks owing to its micron-level resolution and high sensitivity. However, it is not uncommon that OCTA imaging suffers from strip artifacts induced by tissue motion. Although various algorithms for motion correction have been reported, a method that enables motion correction on a single en face OCTA image remains a challenge. In this study, we propose a motion correction approach based on microvasculature detection and broken gap filling...
September 3, 2018: Applied Physics Letters
Antonios N Pouliopoulos, Mark T Burgess, Elisa E Konofagou
Therapeutic ultrasound combined with preformed circulating microbubbles has enabled non-invasive and targeted drug delivery into the brain, tumors, and blood clots. Monitoring the microbubble activity is essential for the success of such therapies; however, skull and tissues limit our ability to detect low acoustic signals. Here, we show that by emitting consecutive therapeutic pulses of inverse polarity, the sensitivity in the detection of weak bubble acoustic signals during blood-brain barrier opening is enhanced compared to therapeutic pulses of the same polarity...
July 23, 2018: Applied Physics Letters
Oumeng Zhang, Jin Lu, Tianben Ding, Matthew D Lew
Fluorescence photons emitted by single molecules contain rich information regarding their rotational motions, but adapting single-molecule localization microscopy (SMLM) to measure their orientations and rotational mobilities with high precision remains a challenge. Inspired by dipole radiation patterns, we design and implement a Tri-spot point spread function (PSF) that simultaneously measures the three-dimensional orientation and the rotational mobility of dipole-like emitters across a large field of view...
July 16, 2018: Applied Physics Letters
Qiang Yang, Yusi Miao, Tiancheng Huo, Yan Li, Emon Heidari, Jiang Zhu, Zhongping Chen
Multiple scattering in biomedical tissue limits the imaging depth within a range of 1-2 mm for conventional optical imaging techniques. To extend the imaging depth into the scattering medium, a computational method based on the reflection matrix measurement has been developed to retrieve the singly back-scattered signal light from the dominant detrimental multiple-scattered background. After applying singular value decomposition on the measured matrix in the post-process, the target image underneath the turbid media is clearly recovered...
July 2, 2018: Applied Physics Letters
Alok Ghanekar, Matthew Ricci, Yanpei Tian, Otto Gregory, Yi Zheng
In this theoretical study, we present a near-field thermal modulator that exhibits change in radiative heat transfer when subjected to mechanical stress/strain. The device has two terminals at different temperatures separated by vacuum: one fixed and one stretchable. The stretchable side contains one-dimensional grating. When subjected to mechanical strain, the effective optical properties of the stretchable side are affected upon deformation of the grating. This results in modulation of surface waves across the interfaces influencing near-field radiative heat transfer...
June 11, 2018: Applied Physics Letters
Eitan Edrei, Giuliano Scarcelli
Brillouin spectroscopy is a powerful optical technique for non-contact viscoelastic characterizations which has recently found applications in three-dimensional mapping of biological samples. Brillouin spectroscopy performances are rapidly degraded by optical aberrations and have therefore been limited to homogenous transparent samples. In this work, we developed an adaptive optics (AO) configuration designed for Brillouin scattering spectroscopy to engineer the incident wavefront and correct for aberrations...
April 16, 2018: Applied Physics Letters
Jordan S Lum, David M Stobbe, Mark A Borden, Todd W Murray
Phospholipid-coated microbubbles are being developed for several biomedical applications, but little is known about the effect of temperature on the viscoelastic properties of the shell. Here, we report on the use of a photoacoustic technique to study the shell properties of individual microbubbles as a function of temperature. The microbubbles were driven into small-amplitude oscillations by ultrasound waves generated from the absorption of an intensity-modulated infrared laser, and these oscillations were detected by forward-light scattering of a second blue laser...
March 12, 2018: Applied Physics Letters
Shuaa Alotaibi, Joshua Samba, Sabin Pokharel, Yucheng Lan, Kelechi Uradu, Ayodeji Afolabi, Ilyas Unlu, Gobind Basnet, Kadir Aslan, Bret N Flanders, Abdellah Lisfi, Birol Ozturk
AC electric fields were utilized in the growth of individual high-aspect ratio cobalt nanowires from simple salt solutions using the Directed Electrochemical Nanowire Assembly method. Nanowire diameters were tuned from the submicron scale to 40 nm by adjusting the AC voltage frequency and the growth solution concentration. The structural properties of the nanowires, including shape and crystallinity, were identified using electron microscopy. Hysteresis loops obtained along different directions of an individual nanowire using vibrating sample magnetometry showed that the magnetocrystalline anisotropy energy has the same order of magnitude as the shape anisotropy energy...
February 26, 2018: Applied Physics Letters
Brennan Mace, Zach Harrell, Chonglin Chen, Erik Enriquez, Aiping Chen, Quanxi Jia
The role of temperature and the oxygen content in the structural transformation and electrical conductivity of epitaxial double perovskite LaBaCo2 O5+δ (0≤ δ ≤ 1) thin films was systematically investigated. Reciprocal space mapping and ω-2θ x-ray diffraction performed at different temperatures in vacuum indicate that oxygen vacancies in the films become ordered at high temperature in a reducing environment. The changes of the oxygen content and the degree of oxygen vacancy ordering in the films result in a strong in-plane anisotropic lattice deformation and a large thermal expansion coefficient along the c-axis direction...
February 12, 2018: Applied Physics Letters
Fan Xiao, Ximiao Wen, Xing Haw Marvin Tan, Pei-Yu Chiou
A plasmonic micropillar platform with self-organized gold nanospheres is reported for the precision cell traction force measurement across a large field-of-view (FOV). Gold nanospheres were implanted into the tips of polymer micropillars by annealing gold microdisks with nanosecond laser pulses. Each gold nanosphere is physically anchored in the center of a pillar tip and serves as a strong, point-source-like light scattering center for each micropillar. This allows a micropillar to be clearly observed and precisely tracked even under a low magnification objective lens for the concurrent and precision measurement across a large FOV...
January 15, 2018: Applied Physics Letters
Zachary A Steelman, Andrew C Weems, Andrew J Traverso, Jason M Szafron, Duncan J Maitland, Vladislav V Yakovlev
Emerging medical devices which employ shape memory polymers (SMPs) require precise measurements of the glass transition temperature (Tg ) to ensure highly controlled shape recovery kinetics. Conventional techniques like differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) have limitations that prevent utilization for certain devices, including limited accuracy and the need for sacrificial samples. In this report, we employ an approach based on Brillouin spectroscopy to probe the glass transition of SMPs rapidly, remotely, and nondestructively...
December 11, 2017: Applied Physics Letters
Emilio A Nanni, Sudheer Jawla, Samantha M Lewis, Michael A Shapiro, Richard J Temkin
We report the amplification of 250 GHz pulses as short as 260 ps without observation of pulse broadening using a photonic-band-gap circuit gyrotron traveling-wave-amplifier. The gyrotron amplifier operates with a device gain of 38 dB and an instantaneous bandwidth of 8 GHz. The operational bandwidth of the amplifier can be tuned over 16 GHz by adjusting the operating voltage of the electron beam and the magnetic field. The amplifier uses a 30 cm long photonic-band-gap interaction circuit to confine the desired TE03 -like operating mode while suppressing lower order modes which can result in undesired oscillations...
December 4, 2017: Applied Physics Letters
B Dober, D T Becker, D A Bennett, S A Bryan, S M Duff, J D Gard, J P Hays-Wehle, G C Hilton, J Hubmayr, J A B Mates, C D Reintsema, L R Vale, J N Ullom
Key performance characteristics are demonstrated for the microwave SQUID multiplexer (µmux) coupled to transition edge sensor (TES) bolometers that have been optimized for cosmic microwave background (CMB) observations. In a 64-channel demonstration, we show that the µmux produces a white, input referred current noise level of [Formula: see text] at -77 dB microwave probe tone power, which is well below expected fundamental detector and photon noise sources for a ground-based CMB-optimized bolometer. Operated with negligible photon loading, we measure [Formula: see text] in the TES-coupled channels biased at 65% of the sensor normal resistance...
December 2017: Applied Physics Letters
Ashton S Hemphill, Yuecheng Shen, Yan Liu, Lihong V Wang
In biological applications, optical focusing is limited by the diffusion of light, which prevents focusing at depths greater than ∼1 mm in soft tissue. Wavefront shaping extends the depth by compensating for phase distortions induced by scattering and thus allows for focusing light through biological tissue beyond the optical diffusion limit by using constructive interference. However, due to physiological motion, light scattering in tissue is deterministic only within a brief speckle correlation time. In in vivo tissue, this speckle correlation time is on the order of milliseconds, and so the wavefront must be optimized within this brief period...
November 27, 2017: Applied Physics Letters
Jiamiao Yang, Yuecheng Shen, Yan Liu, Ashton S Hemphill, Lihong V Wang
Optical scattering prevents light from being focused through thick biological tissue at depths greater than ∼1 mm. To break this optical diffusion limit, digital optical phase conjugation (DOPC) based wavefront shaping techniques are being actively developed. Previous DOPC systems employed spatial light modulators that modulated either the phase or the amplitude of the conjugate light field. Here, we achieve optical focusing through scattering media by using polarization modulation based generalized DOPC...
November 13, 2017: Applied Physics Letters
Jiang Zhu, Buyun Zhang, Li Qi, Ling Wang, Qiang Yang, Zhuqing Zhu, Tiancheng Huo, Zhongping Chen
Incorporating different data processing methods, optical coherence tomography (OCT) has the ability for high-resolution angiography and quantitative flow velocity measurements. However, OCT angiography cannot provide quantitative information of flow velocities, and the velocity measurement based on Doppler OCT requires the determination of Doppler angles, which is a challenge in a complex vascular network. In this study, we report on a relative standard deviation OCT (RSD-OCT) method which provides both vascular network mapping and quantitative information for flow velocities within a wide range of Doppler angles...
October 30, 2017: Applied Physics Letters
Zida Li, Xufeng Xue, Feng Lin, Yize Wang, Kevin Ward, Jianping Fu
Advances in stretchable electronics offer the possibility of developing skin-like motion sensors. Carbon nanotubes (CNTs), owing to their superior electrical properties, have great potential for applications in such sensors. In this paper, we report a method for deposition and patterning of CNTs on soft, elastic polydimethylsiloxane (PDMS) substrates using capillary action. Micropillar arrays were generated on PDMS surfaces before treatment with plasma to render them hydrophilic. Capillary force enabled by the micropillar array spreads CNT solution evenly on PDMS surfaces...
October 23, 2017: Applied Physics Letters
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