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Egyptian Journal of Immunology

Khalid M Salah, Hadeel M Abd-Elrahman, Ahmed E Fakhr, Mohamed I Marghany
Bronchial asthma is one of the most prevailed non-communicable diseases among Egyptian children. Genetic-environmental interaction can influence the nature of asthma and β2 agonists are the most commonly prescribed bronchodilators for relieving asthma symptoms. This study was conducted to investigate the possible relationship between Gln27/Glu polymorphism of ADRβ2 and bronchial asthma susceptibility, severity and responsiveness to Albuterol in Egyptian children. A case control study of one hundred Egyptian children, where all contributors were genotyped using allele-specific Polymerase chain reaction (AS-PCR)...
June 2018: Egyptian Journal of Immunology
Nearmeen M Rashad, Reham M El-Shabrawy, Hanan M Sabry, Hala A Fathy, Dina Said, Mohammed S Yousef
The number of obese individuals is surging in developed and developing countries. Obesity predisposes to many serious illnesses. Peripheral neuropathy (PN) is one of its major complications. Interleukin-6 (IL-6) is a pro-inflammatory cytokine secreted by the adipose tissue and is believed to play a principal role in obesity complications. Meanwhile, hs-CRP is a known inflammatory biomarker. This study was designed to detect the role of serum IL-6 and hs-CRP as inflammatory biomarkers in early diagnosis of peripheral neuropathy (PN) in non-diabetic obese patients...
June 2018: Egyptian Journal of Immunology
Helal F Hetta, Manal E Ez-Eldeen, Ghada A Mohamed, Marwa A Gaber, Hala M ElBadre, Esraa A Ahmed, Rasha B Abdellatief, Rehab M Abd-ElBaky, Azza Elkady, Amany M Nafee, Asmaa M Zahran, Mohammad Ahmad
Visfatin, an adipocytokine with insulin-mimetic activity, has been previously reported to associate with obesity. Herein, we aimed to investigate the serum level of visfatin and association with proinflammatory markers and insulin resistance in obese type 2 diabetic patients. A case control study was carried out among 80 diabetics and 40 non-diabetic healthy controls, after obtaining Anthropometric measurements and blood pressure. Serum level of visfatin and C-reactive protein (CRP) were measured by Enzyme Immunoassay...
June 2018: Egyptian Journal of Immunology
Lobna A El-Korashi, Manar H Soliman, Enayat M Attwa, Nana A Mohamed
Chronic spontaneous urticaria (CSU) is a popular disease, affects patients' life. Its etiologic agents are not well known so; treatment of the patients is difficult. CD203c is a marker that is only present on basophils. Statins are drugs used to lower cholesterol. Nowadays, it is well known that they have immunomodulatory effects. This study evaluated the efficacy of a statin, atorvastatin, in combination with antihistamines in treating CSU patients. Forty CSU patients were divided equally into two groups. The first group was treated with antihistamines and atorvastatin, while the second group was treated with antihistamines and placebo...
June 2018: Egyptian Journal of Immunology
Alia A El-Shahaway, Emad A Morad, Mohammad E Abd-Elbary
About 30 % of people are affected by allergic rhinitis (AR). Allergic rhinitis is an inflammatory condition defined by a disturbance of immunoregulation generating an amplified T helper "Th-2" response. An inflammatory mechanism mediated by HLA-G is thought to be involved through initiation of Th2 cytokine profile releasing "interleukin IL-3, IL-4, and IL-10". We evaluated levels of soluble HLA-G "sHLA-G" and studied its association with "allergen specific IgE" in AR patients...
June 2018: Egyptian Journal of Immunology
Mona Z Nasser, Dina A Ezzat
Genetic polymorphism of Tumor necrosis factor alpha (TNF-α)-308 G/A is one of the potential markers involved in bronchial asthma pathogenesis. This highly polymorphic gene can influence TNF-α serum levels which has major biological effects on airway inflammation, remodeling, and hyper responsiveness. This study was designed to evaluate the association between TNF-α-308 G/A polymorphism, serum levels of TNF-α and the susceptibility to bronchial asthma in children. The study included 102 pediatric patients with bronchial asthma recruited from Pediatric Allergy and Pulmonology Clinic, Specialized Pediatric Beni Suef University Hospital...
June 2018: Egyptian Journal of Immunology
Reham Sabry, Asmaa A El-Madbouly, Hanaa E Abozeid, Marwa M Hassan
Rheumatoid arthritis (RA) is the most common inflammatory joint disease leading to severe disability and premature mortality. Current blood biomarkers for assessing RA activity are invasive and are not highly sensitive or specific to changes in disease activity. Therefore, there is a need for new biomarkers that can accurately indicate disease activity. The present study evaluated the use of urinary orosomucoid (ORM) - 2 and soluble CD14 (sCD14) as non-invasive biomarkers for precise assessment of disease activity of RA, in order to improve treatment outcomes in RA patients...
June 2018: Egyptian Journal of Immunology
Sahar Z Elazab, Waheed F Hessam, Amal H Gomaa
Atopic dermatitis (AD) is a chronic IgE-mediated skin disorder. Clinical usefulness of allergen-specific immunotherapy in the treatment of AD is still controversial. We assessed the effect of cluster allergen-specific subcutaneous immunotherapy (SCIT) in patients with AD sensitive to house dust mite. The study included 43 patients (32 with mild to moderate AD and 11 with severe AD). Disease severity was assessed by SCORAD index. Patients were treated by cluster SCIT for 8 weeks. SCORAD index, total IgE serum level and blood eosinophilic count (BEC) were assessed at the baseline visit and after the end of immunotherapy...
June 2018: Egyptian Journal of Immunology
Nagwa M Abo-ElMagd, Shimaa A Abdel-Salam, Yasmin A Aly, Noha A Fahim
Neonatal sepsis remains a major cause of mortality and morbidity in neonates, Traditional methods for diagnosis like blood culture has a low sensitivity and delayed results in neonates. This study aimed to measure the level of interleukin-27 (IL-27) in sera of patients with neonatal sepsis to determine its potential role as a biomarker for diagnosis of bacterial sepsis. This prospective study included 90 neonates with suspected neonatal sepsis. Plasma levels of IL-27 were measured using an ELISA; blood culture, 16s r DNA and C-reactive protein (CRP) level were done to diagnose sepsis...
June 2018: Egyptian Journal of Immunology
Amal H Abou-Saif, Eman A Alkholy, Reham H Hammad, Azza H Hassan
Immunological alteration has been suggested as a cause of unexplained early recurrent pregnancy loss (RPL). Natural killers (NKs) have been reported to play a role in vascular remodeling of decidual vessels. We aimed to find out if there is a relationship between peripheral blood NKs (pbNKs) and uterine radial artery (uRA) blood flow, and if low molecular weight heparin (LMWH) is effective in improving uRA blood flow in RPL cases and pregnancy outcome. The study was conducted on 30 pregnant women (5-7 weeks gestation) with ≥ 2 RPL and control group including 30 healthy pregnant women...
June 2018: Egyptian Journal of Immunology
Noha T Abou El-Khier, Dina Elhammady, Mona M Arafa, Dina Shahin, Entsar Eladl, Nashwa K Abousamra, Omar Sharaf-Eldeen, Gehan Shaker, Mohammed E Esmael
Limited data exists on the role of Th17 cells in chronic HCV infected patients, particularly with regard to hepatic inflammation and fibrosis. We aimed to investigate the relationship between circulating and intrahepatic frequency of Th17 cells and IL-17 serum level and degrees of hepatic inflammation and fibrosis in chronic HCV patients, as well as to evaluate the effect of successful anti-viral therapy on these parameters. This nested longitudinal case control study included 30 treatment-naïve chronic HCV patients and 20 healthy individuals as control...
June 2018: Egyptian Journal of Immunology
Osama A Elfeky, Neveen T Abed, Sherin M Emam, Heba A Elsayed
Asthma is a complex inflammatory disease, characterized by airway hyperresponsiveness, inflammation, and reversible airway obstruction. Interleukin-37 (IL-37), functions as a fundamental inhibitor of innate inflammatory and immune responses, and it is an important cytokine in the control of asthma by suppressing the production of inflammatory cytokines. This study aimed to reveal the possible role of IL-37 in asthma through assessment of its serum level in controlled and uncontrolled asthmatic children as compared to controls...
June 2018: Egyptian Journal of Immunology
Asmaa M Zahran, Mona M Abdel-Meguid, Ahmed M Ashmawy, Amal Rayan, Azza Elkady, Nahla M Elsherbiny, Helal F Hetta
A complex role of the immune system has been highlighted in the development and progression of hepatocellular carcinoma (HCC). Natural Killer cells (NK) and natural killer T cells (NKT) cells are among the innate immune lymphocytes that predominate in the liver and can prevent tumor growth and metastasis. The aim of the study was to measure the percentages of NK and NKT cells among a sample of Egyptian patients with HCC and to find the association between their frequencies and disease progression. The study included 2 groups; the HCC patient group (n=40) and the healthy control group (n=20)...
June 2018: Egyptian Journal of Immunology
Noha F Abdel-Aleem, Ashraf S Sorour, Yasmine S Elkholy, Amira M Sabry
Neonatal sepsis is an important cause of morbidity and mortality among neonates. Early diagnosis leads to better prognosis. CD64 can be used as an early marker to detect neonatal sepsis with promising results. Advances in flow cytometry have made it possible to assess its level on different white blood cells rapidly, precisely and with minimal blood. The aim of the present work was to assess the role of CD64 expressed on neutrophils, monocytes and lymphocytes in establishing diagnosis of neonatal sepsis as well as to compare its diagnostic value with CRP in diagnosis of neonatal sepsis...
June 2018: Egyptian Journal of Immunology
Enas A Daef, Nahla M Elsherbiny, Michael N Agban, Khalid F Riad, Lamia F Mohammed
The diagnosis of blood steam infections (BSIs) in febrile neutropenic pediatric cancer patients (FNPCP) remains a challenge. Although blood culture is the most accurate method; yet the delay in results has urged the need for reliable biomarkers for early diagnosis. The objectives of this study were to identify the bacterial causes of BSIs in FNPCP at SECI and their antimicrobial susceptibility patterns. Also, to assess the value of procalcitonin (PCT), interleukin 6 (IL6), and interleukin 10 (IL 10) for early diagnosis of BSIs...
June 2018: Egyptian Journal of Immunology
Asmaa H Ibrahim, Hanan H Omar, Amal M Imam, Amany M Hassan, Hamdy Omar
Diabetes mellitus is a metabolic disease that is characterized by chronic hyperglycemia. Type 2 diabetes is a global health problem and leading to many dangerous complications. Diabetic nephropathy is a significant microvascular complication resulting from diabetes mellitus that is affecting up to 50% of patients with end stage renal disease. Vitamin D deficiency may occur due to many different factors and is associated with many serious diseases as diabetic nephropathy. To investigate the 25-hydroxyvitamin D deficiency and predictive factors in patients with diabetic nephropathy in type 2 diabetes mellitus...
June 2018: Egyptian Journal of Immunology
Abeer A Aboelazm, Sherin M Emam, Gehan G Elolemy, Rasha M Fawzy
Rheumatoid arthritis (RA) is a common chronic inflammatory disease, affecting about 1% of the general population. Conflicting data are available regarding the etiologic association of human parvovirus B19 (B19) infection with RA. This study aimed to determine the prevalence of B19 infection in patients with RA compared to healthy controls and to assess its possible association with disease activity or severity. The study included 40 RA patients and 40 age and sex matched apparently healthy controls. Detection of B19 DNA by nested PCR and the detection of anti-B19 IgM and IgG by ELISA) were performed for patients and controls...
June 2018: Egyptian Journal of Immunology
Thorya S El-Deeb, Sally M Bakkar, Lobna Eltoony, Madeha M Zakhary, Amira A Kamel, Amany M Nafee, Helal F Hetta
Chemerin and fetuin-A are recently discovered as metabolic regulator hormone in obesity and type 2 diabetes mellitus. However, elevated levels of chemerin and fetuin-A have been associated with insulin resistance and systemic inflammation. The present study aimed to investigate the significance of serum chemerin and fetuin-A levels in obese diabetic patients. Also, to determine whether, chemerin and fetuin-A along with markers of inflammation (IL6 and CRP) and obesity-related parameters in T2DM patients. Serum levels of chemerin and fetuin-A were evaluated using ELISA in 71 T2DM patients and 14 apparently healthy controls...
January 2018: Egyptian Journal of Immunology
Mohammed Khalil, Omnia El-Badawy, Abeer Sharaf-Eldin, Ahmed Sadek, Ayman Sabry
This study evaluates the usefulness of interleukins 1 alpha and 12 in predicting disease progression in diabetic HCV and HCV related liver diseases compared to non-diabetics. The study included 76 hepatitis C virus-infected patients [38 diabetics, 38 none (with, without cirrhosis)]. Serum levels of IL-1α and IL-12 were measured by ELISA. Serum levels of IL-1α and IL12 were higher in cirrhotic than non -cirrhotic patients and higher in the diabetic patients. Significant correlations were detected between IL-1α, prothrombin time (PT), and severity scores in cirrhotic patients...
January 2018: Egyptian Journal of Immunology
Noha B Hassan, Nagwa M Abo-ElMagd, Noha O Ahmed
Discriminating bacterial from nonbacterial acute exacerbation chronic obstructive pulmonary disease (AE-COPD) is difficult. In this study, we evaluated T/NK-cells' subsets in peripheral blood of both stable COPD and AE-COPD patients for identifying their rule in the pathogenesis of the disease and highlighting rule of laboratory biomarkers as total and differential leukocytic count, different T/NK lymphocytes' subsets, CD64 neutrophil expression and high sensitive C-reactive protein (CRP) in discriminating bacterial versus nonbacterial AE-COPD to limit overuse of antibiotics...
January 2018: Egyptian Journal of Immunology
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