journal
MENU ▼
Read by QxMD icon Read
search

Current Treatment Options in Gastroenterology

journal
https://read.qxmd.com/read/30796604/predictors-of-progression-in-barrett-s-esophagus
#1
REVIEW
Subhankar Chakraborty, Prasad G Iyer
PURPOSE OF REVIEW: To review recently published data on factors that predict the risk of progression of Barrett's esophagus (BE) to high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). RECENT FINDINGS: Computer models have been developed that could help predict the risk of progression with greater accuracy. The progression of BE score (PIB) is one such model based on clinical and endoscopic features, while a second uses automated image analysis of formalin-fixed and paraffin-embedded tissues looking for morphologic features and immunostaining patterns for molecular markers...
February 22, 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30746593/optical-diagnosis-of-colorectal-polyps-recent-developments
#2
REVIEW
Roupen Djinbachian, Anne-Julie Dubé, Daniel von Renteln
PURPOSE OF REVIEW: Optical diagnosis of diminutive colorectal polyps has been recently proposed as an alternative to histopathologic diagnosis. Recent developments in imaging techniques, new classification systems, and the use of artificial intelligence have allowed for increased viability of optical diagnosis. This review provides an up-to-date overview of optical diagnosis recommendations, classifications, outcomes, and recent developments. RECENT FINDINGS: There are currently seven major classification systems and three major society recommendations for quality benchmarks for optical diagnosis of diminutive polyps...
February 12, 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30734894/overlap-between-gerd-and-functional-esophageal-disorders-a-pivotal-mechanism-for-treatment-failure
#3
REVIEW
Ofer Z Fass, Ronnie Fass
ᅟRefractory GERD is very common, and while many different underlying mechanisms have been identified, the main focus has remained on residual reflux (acidic or non-acidic). Recently, Rome IV introduced two new concepts with important impact on patients with refractory GERD. They include the introduction of the reflux hypersensitivity group and the proposal that GERD can overlap with a functional esophageal disorder. Recent studies have demonstrated that the latter affects approximately three quarters of the GERD patients who failed PPI once daily...
February 8, 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30712157/colorectal-cancer-in-young-adults
#4
REVIEW
Anand Venugopal, Elena M Stoffel
PURPOSE OF REVIEW: Routine screening for colorectal cancer (CRC) in adults > 50 years of age has led to overall reductions in CRC incidence and CRC-related mortality. Yet CRC incidence among young adults age < 50 continues to increase without a clear explanation. This review examines the changing epidemiology of CRC and emerging evidence regarding the influence of genetic and lifestyle factors on risk for colorectal neoplasia. RECENT FINDINGS: Young-onset CRC (yCRC), defined as CRC diagnosed in individuals younger than age 50, is a heterogeneous disease...
February 2, 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30712156/new-developments-in-esophageal-motility-testing
#5
REVIEW
Rena Yadlapati, Glenn T Furuta, Paul Menard-Katcher
PURPOSE OF REVIEW: The purpose of this review is to present the latest developments in esophageal motility testing and summarize the current paradigm of esophageal motility disorders. RECENT FINDINGS: While high-resolution esophageal pressure topography interpreted according to the Chicago Classification represents the gold standard to evaluate esophageal motility, recent studies highlight the additional value of novel manometric applications. Novel applications include provocative measures to assess for obstructive physiology at the esophagogastric junction (EGJ), esophageal peristaltic reserve, and rumination and supragastric belching disorders...
February 2, 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30707411/new-developments-in-the-diagnosis-and-treatment-of-eosinophilic-esophagitis
#6
REVIEW
Quan M Nhu, Fouad J Moawad
PURPOSE OF REVIEW: Eosinophilic esophagitis (EoE) is a chronic, allergen-driven, immune-mediated disease of the esophagus that progresses to esophageal fibrostenosis if left untreated. The aim of this review is to provide a concise update on recent clinically relevant advances in the development of diagnostic and therapeutic approaches for EoE. RECENT FINDINGS: Current diagnostic and disease monitoring protocols for EoE rely on repetitive endoscopic evaluations and esophageal tissue acquisition for histopathologic analysis...
February 1, 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30701454/new-advances-in-the-treatment-of-acute-pancreatitis
#7
REVIEW
Mahya Faghih, Christopher Fan, Vikesh K Singh
PURPOSE OF REVIEW: Despite the increasing incidence of acute pancreatitis, the overall mortality of AP has decreased. RECENT FINDINGS: The findings of recent studies on fluid therapy, analgesics, antibiotics, and enteral nutrition as well as the management of AP complications have led to improvements in clinical care. However, there are still no pharmacologic treatment(s) for AP. Experimental studies have revealed many potential therapeutic targets, but these will need to be further developed and tested before they can be assessed in randomized controlled trials with important clinical endpoints...
January 30, 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30684151/advances-in-the-diagnosis-and-treatment-of-gerd-new-tricks-for-an-old-disease
#8
REVIEW
Rishi D Naik, Lauren Evers, Michael F Vaezi
PURPOSE OF REVIEW: Gastroesophageal reflux disease (GERD) is a common diagnosis encountered by both primary care providers and specialists, but despite its prevalence, there are limitations in the current diagnostic tests for GERD. Once an accurate diagnosis is made, treatment options can be offered, and this field continues to burgeon with options. In this review, we seek to review the recent advances in GERD diagnostics and subsequent treatment options. RECENT FINDINGS: Novel impedance markers and novel techniques (mucosal impedance testing, salivary pepsin, high-resolution manometry, and narrow-band imaging) have shown promise in diagnosing GERD...
January 25, 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30680599/advances-in-therapeutic-drug-monitoring-for-small-molecule-and-biologic-therapies-in-inflammatory-bowel-disease
#9
REVIEW
Christopher Ma, Robert Battat, Vipul Jairath, Niels Vande Casteele
PURPOSE OF REVIEW: Therapeutic drug monitoring (TDM) is increasingly utilized as a strategy to optimize inflammatory bowel disease (IBD) therapeutics. As management paradigms have evolved towards treat-to-target strategies, there has been growing interest in expanding the role of TDM to guide drug optimization for achieving objective endpoints. This review summarizes the evidence for using TDM with biologic and oral small-molecule therapies, evaluates the role of reactive versus proactive TDM in treatment algorithms, and identifies potential future applications for TDM...
January 25, 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30663018/challenges-in-endoscopic-therapy-of-dysplastic-barrett-s-esophagus
#10
REVIEW
Aurada Cholapranee, Arvind J Trindade
PURPOSE OF REVIEW: Barrett's esophagus (BE) is the only known measurable factor associated with esophageal adenocarcinoma. The development of endoscopic eradication therapy (EET) has transformed the way BE is managed. Given the fairly recent development of EET, its role in BE is still evolving. RECENT FINDINGS: This paper discusses the challenges that endoscopists face at the preprocedural, intraprocedural, and postprocedural stages of BE management. These include challenges in risk stratification, dysplasia detection, ablation methods and dosimetry, choice of resection technique, and management of refractory disease...
January 19, 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30661163/the-gut-microbiome-as-a-target-for-ibd-treatment-are-we-there-yet
#11
REVIEW
Natalie C Knox, Jessica D Forbes, Gary Van Domselaar, Charles N Bernstein
PURPOSE OF REVIEW: This review aims to highlight recent research on the gut microbiome in IBD and the application of microbiome-modulating therapies for the treatment of IBD including the use of the microbiome as an indicator for disease severity and treatment response. RECENT FINDINGS: Despite the high number of gut microbiome studies and emerging evidence supporting the gut microbiome's involvement in disease pathogenesis, no single microorganism has been identified as a pathogenic agent in IBD...
January 19, 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30756232/endoscopic-retrograde-cholangiopancreatography-in-pediatric-populations
#12
REVIEW
Mayssan Muftah, Rushikesh Shah, Chris Fritzen, Cary G Sauer, Alvin J Freeman, Field F Willingham
No abstract text is available yet for this article.
March 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30685838/esophageal-third-space-endoscopy-recent-advances
#13
REVIEW
Malav P Parikh, Niyati M Gupta, Madhusudhan R Sanaka
PURPOSE OF THE REVIEW: The novel concept of third space endoscopy was first applied to humans in 2008 for the management of achalasia through peroral endoscopic myotomy (POEM) procedure. Over the ensuing 10 years, this revolutionary procedure, which started in Japan, has been adopted and mastered by surgeons and gastroenterologists across the globe. In this article, we review the recent innovations and applications of third space endoscopy in the management of esophageal disorders. RECENT FINDINGS: With experience and innovation, the application of third-space endoscopy has extended beyond achalasia, and currently, it is used in the management of other esophageal disorders including, spastic esophageal disorders, subepithelial tumors, complete esophageal obstruction, and esophageal diverticula...
March 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30421297/gastroduodenal-dysbiosis-a-new-clinical-entity
#14
REVIEW
Ayesha Shah, Mark Morrison, Gerald J Holtmann
PURPOSE OF REVIEW: Like the rest of the gastrointestinal tract, the small intestine is colonised by microbes, but how this "microbiome" affects the immune system and digestive functions has largely been overlooked, especially in the "omics" era. Here, we present recent findings that show that the diversity, density and interactions of these microbes in the small intestine can play an important role in the pathogenesis of a number of gastrointestinal and extraintestinal disorders...
December 2018: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30415359/helicobacter-pylori-infection-new-facts-in-clinical-management
#15
REVIEW
Peter Malfertheiner, Marino Venerito, Christian Schulz
PURPOSE: The global prevalence of Helicobacter pylori remains high in spite of its significant downwards trajectory in many regions. The clinical management of H. pylori infection merits guidance to meet ongoing challenges on whom and how to test, prevent, and cure related diseases. RECENT FINDINGS: Several international guidelines and consensus reports have updated the management strategies for cure of the H. pylori infection. The definition of H. pylori gastritis as an infectious disease independent of whether or not presenting with clinical manifestations and symptoms has broadened the use of the test and treat strategy...
December 2018: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30406479/the-role-of-botulinum-toxin-injections-for-esophageal-motility-disorders
#16
REVIEW
Jessica L Sterling, Ron Schey, Zubair Malik
PURPOSE OF REVIEW: The advancement of high-resolution esophageal manometry has led to improvement in the diagnosis of esophageal motility disorders. We reviewed the recent medical literature regarding the use of botulinum toxin (BTx) injections in the esophagus and the indications, current outcomes, and reported complications of this therapy. RECENT FINDINGS: The response rates of BTx injection therapy vary depending on the esophageal motility disorder. Studies have shown that response is transient in achalasia patients and given the more effective therapies available, it is only recommended in patients who are not surgical candidates...
December 2018: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30397849/the-role-of-botox-in-colorectal-disorders
#17
REVIEW
Dan Carter, Ram Dickman
PURPOSE OF REVIEW: To overview the current medical literature on the efficacy of botulism toxin treatment (BTX-A) for lower gastrointestinal disorders (GIT). RECENT FINDINGS: BTX-A was found to have a short-term efficacy for the treatment of dyssynergic defecation. Surgical treatment was found to be more effective than BTX-A for the healing of chronic anal fissures, and BTX-A can be considered when surgery is undesirable. Data regarding the effects of BTX-A injection for the treatment of chronic anal pain is limited...
December 2018: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30390208/which-patient-related-factors-determine-optimal-bowel-preparation
#18
REVIEW
Myriam Martel, Charles Ménard, Sophie Restellini, Omar Kherad, Majid Almadi, Maïté Bouchard, Alan N Barkun
PURPOSE OF REVIEW: Adequate bowel cleansing before colonoscopy is a simple concept but the high rate of inadequate or incomplete bowel cleanliness and its consequences have been the subject of many studies, guidelines, and meta-analysis. The complexity resides in all the factors surrounding preparation intake such as type and regimen of bowel preparation, diets, compliance, and also patient-related factors that all influence quality of the bowel preparation. The purpose of this review is to focus specifically on patient-related factors and their challenges...
December 2018: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30382573/opioid-induced-esophageal-dysfunction-an-emerging-entity-with-sweeping-consequences
#19
REVIEW
Dhyanesh Patel, Michael Vaezi
Adverse effects of opioids on the gastrointestinal tract are well known. However, with the rising epidemic of opioids, its detrimental effects on esophageal physiology are now being increasingly recognized. In this commentary, we briefly review the current evidence behind opioid-induced esophageal dysfunction with potential pathophysiology and treatment options.
December 2018: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30382572/endoscopic-full-thickness-defects-and-closure-techniques
#20
REVIEW
Diogo T H de Moura, Amit H Sachdev, Christopher C Thompson
PURPOSE OF REVIEW: Gastrointestinal transmural defects are defined as total rupture of the gastrointestinal wall and can be divided into three main categories: perforations, leaks, and fistulas. Due to an increase in the number of therapeutic endoscopic procedures including full-thickness resections and the increase incidence of complications related to bariatric surgeries, there has been an increase in the number of transmural defects seen in clinical practice and the number of non-invasive endoscopic treatment procedures used to treat these defects...
December 2018: Current Treatment Options in Gastroenterology
journal
journal
33149
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"