Journals International Journal of Neuro...

International Journal of Neuropsychopharmacology
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December 27, 2023: International Journal of Neuropsychopharmacology
Nurhumar Kurban, Yu Qin, Hui-Ling Zhao, Xiao Hu, Xi Chen, Yi-Yi Zhao, Yu-Shuo Peng, Hong-Bo Wang, Su-Ying Cui, Yong-He Zhang
BACKGROUND: Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that projects throughout the central nervous system, including the noradrenergic locus coeruleus (LC). Our previous study suggested that MCH/MCH receptor 1 (MCHR1) in the LC may be involved in the regulation of depression. The present study investigated whether the role of MCH/MCHR1 in the LC in depression-like behaviors is associated with the regulation of norepinephrine. METHOD: Chronic unpredictable stress (CUS) and an acute intra-LC microinjection of MCH induced depression-like behaviors in rats...
December 22, 2023: International Journal of Neuropsychopharmacology
Joakim Ekstrand, Akihiro Takamiya, Axel Nordenskjold, George Kirov, Pascal Sienaert, Charles Kellner, Pouya Movahed Rad
Two recent clinical trials, KetECT and ELEKT-D, compared the effectiveness of ketamine and electroconvulsive therapy (ECT) for major depressive disorder. Notably, these trials reported marked differences in ECT's clinical outcomes of, with remission rates of 63% for KetECT and a strikingly lower rate of 22% for ELEKT-D, while the remission rates for ketamine were 46% and 38%, respectively. Considering that the primary objective of both trials was to compare the standard treatment (ECT) with an experimental intervention (ketamine), it is crucial to highlight the pronounced disparities in ECT's clinical outcomes...
December 19, 2023: International Journal of Neuropsychopharmacology
Ya-Bin Zheng, Xiao-Ming Sheng, Xiang Jin, Wei Guan
BACKGROUND: Depression is a neuropsychiatric disease with high disability rate and mainly caused by the chronic stresses or genetic factors. There is increasing evidences that miRNAs play a critical role in the pathogenesis of depression. However, the underlying molecular mechanism for the pathophysiology of depression of miRNA remains entirely unclear so far. METHODS: We first established a Chronic Social Defeat Stress (CSDS) mice model of depression, and depression-like behaviors of mice were evaluated by a series of behavioral tests...
December 1, 2023: International Journal of Neuropsychopharmacology
Suyi Shao, Yi Zou, Kody G Kennedy, Mikaela K Dimick, Bradley J MacIntosh, Benjamin I Goldstein
BACKGROUND: Inflammation is implicated in the neuropathology of bipolar disorder (BD). The association of C-reactive protein (CRP) with brain structure has been examined in relation to BD among adults but not youth. METHODS: Participants included 101 youth (BD, n=55; control group [CG], n=46; aged 13-20 years). Blood samples were assayed for levels of CRP. T1-weighted brain images were acquired to obtain cortical surface area (SA), volume, and thickness for three regions of interest (ROI; whole-brain cortical gray matter, prefrontal cortex (PFC), orbitofrontal cortex (OFC)) and for vertex-wise analyses...
November 8, 2023: International Journal of Neuropsychopharmacology
Guangfei Li, Dandan Zhong, Bao Li, Yu Chen, Lin Yang, Chiang-Shan R Li
BACKGROUND: The basal nucleus of Meynert (BNM), a primary source of cholinergic projections to the cortex, plays key roles in regulating sleep-wake cycle and attention. Sleep deficit is associated with impairment in cognitive and emotional functions. However, whether or how cholinergic circuit, sleep, cognitive/emotional dysfunction are inter-related remains unclear. METHODS: We curated the Human Connectome Project data and explored BNM resting state functional connectivities (rsFC) in relation to sleep deficit, based on the Pittsburgh Sleep Quality Index (PSQI), cognitive performance, and subjective reports of emotional states in 687 young adults (342 women)...
October 31, 2023: International Journal of Neuropsychopharmacology
Chieh-Hsin Lin, Hsin-Yi Liao, Hsien-Yuan Lane, Chao-Jung Chen
BACKGROUND: N-methyl-D-aspartate receptors (NMDARs) are crucial components of brain function involved in memory and neurotransmission. Sodium benzoate is a promising NMDAR enhancer and has been proven to be a novel, safe and efficient therapy for patients with Alzheimer's disease (AD). However, in addition to the role of sodium benzoate as an NMDA enhancer, other mechanisms of sodium benzoate in treating AD are still unclear. To elucidate the potential mechanisms of sodium benzoate in Alzheimer's disease, this study employed label-free quantitative proteomics to analyze serum samples from AD cohorts with and without sodium benzoate treatment...
October 24, 2023: International Journal of Neuropsychopharmacology
Rachal D Penrod, Makoto Taniguchi, Angela M Kearns, Jordan L Hopkins, Carmela M Reichel
BACKGROUND: Little is known about the specific roles of cortical and accumbal oxytocin receptors in drug use disorder. To better understand the importance of the endogenous oxytocin system in cocaine relapse behavior, we developed an adeno-associated viral vector (AAV) expressing short hairpin (sh) RNAs to selectively degrade the rat OxyR mRNA in vivo. METHODS: Male (Sprague-Dawley) rats received bilateral infusions of the shRNA for the oxytocin receptor (shOxyR) or an shRNA control virus (shCntrl) into the prefrontal cortex (PFC) or the nucleus accumbens core (NAc)...
October 24, 2023: International Journal of Neuropsychopharmacology
Joao Parente, Anna Carolyna Gianlorenco, Ingrid Rebello-Sanchez, Minkyung Kim, Jose Mario Prati, Chi Kyung Kim, Hyuk Choi, Jae-Jun Song, Felipe Fregni
OBJECTIVES: The discovery of effective treatments for major depressive disorder (MDD) may help target different brain pathways. Invasive vagus nerve stimulation (VNS) is an effective neuromodulation technique for the treatment of MDD; however, the effectiveness of the noninvasive technique, transauricular VNS (taVNS), remains unknown. Moreover, a mechanistic understanding of the neural effects behind its biological and therapeutic effects is lacking. This review aimed to evaluate the clinical evidence and the neural and anti-inflammatory effects of taVNS in MDD...
October 23, 2023: International Journal of Neuropsychopharmacology
Ewa Galaj, Eddy D Barrera, Kirk Persaud, Rudolf Nisanov, Apoorva Vashisht, Hindy Goldberg, Nima Patel, Hayley Lenhard, Zhi-Bing You, Eliot L Gardner, Robert Ranaldi
BACKGROUND: There is a strong link between chronic stress and vulnerability to drug abuse and addiction. Corticotropin releasing factor (CRF) is central to the stress response that contributes to continuation and relapse to heroin abuse. Chronic heroin exposure can exacerbate CRF production, leading to dysregulation of the midbrain CRF-dopamine-glutamate interaction. METHODS AND RESULTS: Here we investigated the role of midbrain CRF 1 receptors in heroin self-administration and assessed neuroplasticity in CRF1 receptor expression in key opioid addiction brain regions...
October 21, 2023: International Journal of Neuropsychopharmacology
Yalan Zhou, Lan Xiong, Jianhua Chen, Qingzhong Wang
BACKGROUND: Suicidal behaviors have become a serious public health concern globally due to the economic and human cost of suicidal behavior to individuals, families, communities, and society. However, the underlying etiology and biological mechanism of suicidal behavior remains poorly understood. METHODS: We collected different single omic data, including scRNA-seq, bulk mRNA-seq, DNA methylation microarrays from the cortex of MDD with suicide subjects' studies, as well as fluoxetine-treated rats brains...
September 29, 2023: International Journal of Neuropsychopharmacology
Richard Ågren, Nibal Betari, Marcus Saarinen, Hugo Zeberg, Per Svenningsson, Kristoffer Sahlholm
BACKGROUND: Trace amine-associated receptor-1 (TAAR1) agonists have been proposed as potential antipsychotics, with ulotaront and ralmitaront having reached clinical trials. While ulotaront demonstrated efficacy in a recent Phase II trial, a corresponding study studies of ralmitaront failed to show efficacy as a monotherapy or as an adjunct to atypical antipsychotics. In addition to TAAR1 agonism, ulotaront is a partial agonist at the serotonin 1A receptor (5-HT1AR). However, little is known about ralmitaront...
September 25, 2023: International Journal of Neuropsychopharmacology
Claudia Sagheddu, Enzo Cancedda, Farshid Bagheri, Predrag Kalaba, Anna Lisa Muntoni, Jana Lubec, Gert Lubec, Fabrizio Sanna, Marco Pistis
BACKGROUND: Dopamine plays a key role in several physiological functions such as motor control, learning and memory, motivation and reward. The atypical dopamine transporter inhibitor CE-158 has been recently reported to promote behavioral flexibility and restore learning and memory in aged rats. METHODS: Adult male rats were intraperitoneally administered for 1 or 10 days with CE-158 at the dose of 1 or 10 mg/kg, and tested for extracellular dopamine in the medial prefrontal cortex (mPFC) by means of intracerebral microdialysis and single unit cell recording in the same brain area...
September 19, 2023: International Journal of Neuropsychopharmacology
Liang Jing, Chen Ma, Lin Xu, Gal Richter-Levin
BACKGROUND: The high individual variability in coping with stress is often attributed to either genetic background differences, sustained environmental conditions, or a combination of both. However, the neural mechanisms underlying coping style variability are yet poorly understood. METHODS: Here we examined the impact of a single extended emotional challenge on coping style variability, and the associated involvement of the hippocampus, medial prefrontal cortex (mPFC) and periaqueductal gray (PAG)...
September 19, 2023: International Journal of Neuropsychopharmacology
Nada Sallam, Colleen Peterson, Samantha L Baglot, Yuta Kohro, Tuan Trang, Matthew N Hill, Stephanie L Borgland
BACKGROUND: Cannabis edibles are an increasingly popular form of cannabis consumption. Oral consumption of cannabis has distinct physiological and behavioural effects than injection or inhalation. An animal model is needed to understand the pharmacokinetics and physiological effects of oral cannabis consumption in rodents as a model for human cannabis edible use. METHODS: Adult male and female C57BL/6 mice received a single dose of commercially available cannabis oil (5 mg/kg THC) by oral gavage...
September 16, 2023: International Journal of Neuropsychopharmacology
(no author information available yet)
No abstract text is available yet for this article.
September 6, 2023: International Journal of Neuropsychopharmacology
Ta-Chun Lin, Ching-Hua Lin
BACKGROUND: Some schizophrenia patients treated with clozapine experience an inadequate response and adherence problems. The purpose of this study was to compare time to rehospitalization within 6 months in schizophrenia patients discharged on three clozapine regimens. Additionally, the temporal trend of prescription rate in each group was also explored. METHODS: Schizophrenia patients discharged from the study hospital from January 1, 2006, to December 31, 2021, (n = 3,271) were included in the analysis...
August 24, 2023: International Journal of Neuropsychopharmacology
María Hidalgo-Figueroa, Alejandro Salazar, Cristina Romero-López-Alberca, Karina S MacDowell, Borja Garcia-Bueno, Miquel Bioque, Miquel Bernardo, Mara Parellada, Ana Gonzalez-Pinto, M Paz Garcia-Portilla, Antonio Lobo, Roberto Rodriguez-Jiménez, Esther Berrocoso, Juan C Leza
BACKGROUND: The clinical debut of schizophrenia is frequently a first episode of psychosis (FEP). As such, there is considerable interest in identifying associations between biological markers and clinical or cognitive characteristics that help predict the progression and outcome of FEP patients. Previous studies showed that high prolactin, low oxytocin and high homocysteine are factors associated with FEP 6 months after diagnosis, at which point plasma levels were correlated with some clinical and cognitive characteristics...
August 21, 2023: International Journal of Neuropsychopharmacology
Jian-Bin Ge, Bo Jiang, Tian-Shun Shi, Wei-Yu Li, Wei-Jia Chen, Bao-Lun Zhu, Zheng-Hong Qin
BACKGROUND: Although depression has been a serious neuropsychiatric disorder worldwide, current antidepressants used in clinical practice have various weaknesses including delayed onset and low rates of efficacy. Recently, the development of new antidepressants from natural herbal medicine has become one of the important research hotspots. Cucurbitacin B is a natural compound widely distributed in the Cucurbitaceae and Cruciferae families and has many pharmacological activities. The present study aimed to investigate whether cucurbitacin B possess antidepressant-like effects in mice...
August 21, 2023: International Journal of Neuropsychopharmacology
Xue Dong, Simon Zhornitsky, Wuyi Wang, Thang M Le, Yu Chen, Shefali Chaudhary, Chiang-Shan R Li, Sheng Zhang
BACKGROUND: Previous studies have focused on both ventral striatum (VS) and dorsal striatum (DS) in characterizing dopaminergic deficits in addiction. Animal studies suggest VS and DS dysfunction each in association with impulsive and compulsive cocaine use during early and later stages of addiction. However, few human studies have aimed to distinguish the roles of VS and DS dysfunction in cocaine misuse. METHODS: We examined VS and DS resting-state functional connectivity (rsFC) of 122 recently abstinent cocaine-dependent individuals (CDs) and 122 healthy controls (HCs) in 2 separate cohorts...
August 14, 2023: International Journal of Neuropsychopharmacology
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