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International Journal of Neuropsychopharmacology

Todd Zorick, Kyoji Okita, Mark A Mandelkern, Edythe D London, Arthur L Brody
Background: Selective serotonin reuptake inhibitors (SSRIs) are often used in alcohol use disorders. Clinical trials with SSRIs for alcohol use disorders, however, have yielded mixed results. The goal of this project was to assess whether a single iv dose of an SSRI reduces craving for alcohol and/or simultaneously increases striatal dopamine concentration in individuals with alcohol dependence. Methods: Alcohol dependent (DSM-IV-TR criteria) volunteers and matched controls (n=10/group) underwent a double-blind, placebo-controlled, within-subjects study...
February 12, 2019: International Journal of Neuropsychopharmacology
Fabrizio Schifano, Stefania Chiappini, John M Corkery, Amira Guirguis
Background: Although originally marketed as safe alternatives to the habit-forming benzodiazepines, growing numbers of zaleplon, zolpidem, and zopiclone ('Z-drugs') clinical concerns relating to their potential of abuse, dependence and withdrawal have been reported overtime.  We aimed here at assessing these issues analysing datasets of Adverse Drug Reactions (ADR) provided by the European Medicines Agency (EMA) through the EudraVigilance (EV) system. Methods: Analysing the ADR databases of each Z-drug, descriptive analyses have been performed on cases, and Proportional Reporting Ratios (PRRs) computed...
February 5, 2019: International Journal of Neuropsychopharmacology
Kei Itagaki, Minoru Takebayashi, Hiromi Abe, Chiyo Shibasaki, Naoto Kajitani, Mami Okada-Tsuchioka, Kotaro Hattori, Sumiko Yoshida, Hiroshi Kunugi, Shigeto Yamawaki
Background: The autotaxin (ATX)/lysophosphatidic acid (LPA) axis is involved in diverse biological processes including neurodevelopment, inflammation, and immunological functioning. The LPA1 receptor has been implicated in the pathophysiology of major depressive disorder (MDD) and in the mechanism of action of antidepressants. However, it is unclear whether central or peripheral ATX levels are altered in patients with MDD. Methods: Serum ATX levels were measured by an enzyme-linked immunosorbent assay in 37 patients with MDD diagnosed using DSM-IV-TR who underwent electroconvulsive therapy (ECT) and compared with those of 47 nondepressed controls matched for age and sex between January 2011 and December 2015...
February 2, 2019: International Journal of Neuropsychopharmacology
Zhenhao Shi, Kanchana Jagannathan, An-Li Wang, Victoria P Fairchild, Kevin G Lynch, Jesse J Suh, Anna Rose Childress, Daniel D Langleben
Adherence is a major factor in the effectiveness of the injectable extended-release naltrexone (XR-NTX) as a relapse prevention treatment in opioid use disorder (OUD). We examined the value of a variant of the Go/No-go paradigm in predicting XR-NTX adherence in twenty-seven detoxified OUD patients who were offered up to three monthly XR-NTX injections. Before XR-NTX, participants performed a Go/No-go task that comprised positively valenced Go trials and negatively valenced No-go trials during a functional magnetic resonance imaging (fMRI) scan...
January 23, 2019: International Journal of Neuropsychopharmacology
Anupam Sah, Sergey Sotnikov, Maria Kharitonova, Claudia Schmuckermair, Rebekka P Diepold, Rainer Landgraf, Nigel Whittle, Nicolas Singewald
Background: Pathological anxiety originates from a complex interplay of genetic predisposition and environmental factors, acting via epigenetic mechanisms. Epigenetic processes that can counteract detrimental genetic risk towards innate high anxiety are not well characterized. Methods: We used female mouse lines of selectively bred high-(HAB) vs low-(LAB) innate anxiety and performed select environmental and pharmacological manipulations to alter anxiety levels as well as brain-specific manipulations and immunohistochemistry to investigate neuronal mechanisms associated with alterations in anxiety-related behavior...
January 21, 2019: International Journal of Neuropsychopharmacology
Peng Yan, Dan Xu, Yuanyuan Ji, Fangyuan Yin, Jingjing Cui, Rui Su, Yunpeng Wang, Yongsheng Zhu, Shuguang Wei, Jianghua Lai
Background: Adolescent methamphetamine (METH) exposure causes a broad range of neurobiological deficits in adulthood. Glycogen synthase kinase-3β (GSK3β) is involved in various cognitive and behavioral processes associated with METH exposure. This study aims to investigate the protective effects of the GSK3β inhibitor lithium chloride (LiCl) on adolescent METH exposure-induced long-term alterations in emotion, cognition, behavior, molecule and hippocampal ultrastructure in adulthood...
January 10, 2019: International Journal of Neuropsychopharmacology
Ryosuke Arakawa, Per Stenkrona, Akihiro Takano, Jonas Svensson, Max Andersson, Sangram Nag, Yuko Asami, Yoko Hirano, Christer Halldin, Johan Lundberg
Background: The in vivo binding of clinical dose of venlafaxine on norepinephrine transporter (NET) has been questioned because venlafaxine has higher in vitro affinity to serotonin transporter (5-HTT) than that to NET. While 5-HTT occupancy of clinically relevant doses of venlafaxine has been reported, there has been no report of NET occupancy in the human brain. Methods: This was an open-label, single center, exploratory PET study. Twelve major depressive disorder (MDD) patients who had responded to venlafaxine extended-release (ER) and nine control subjects were recruited...
January 10, 2019: International Journal of Neuropsychopharmacology
Tiffani D M Berkel, Huaibo Zhang, Tara Teppen, Amul Sakharkar, Subhash C Pandey
Background: Tolerance to ethanol-induced anxiolysis promotes alcohol intake, thus contributing to alcohol use disorder (AUD) development. Recent studies implicate histone deacetylase-mediated histone H3K9 deacetylation in regulating neuropeptide Y (NPY) expression during rapid ethanol tolerance (RET) to the anxiolytic effects of ethanol. Furthermore, the histone methyltransferase, G9a, and G9a-mediated H3K9 dimethylation (H3K9me2) have recently emerged as regulators of addiction and anxiety; however, their role in RET is unknown...
December 24, 2018: International Journal of Neuropsychopharmacology
Ignazio S Piras, Mirko Manchia, Matthew J Huentelman, Federica Pinna, Clement C Zai, James L Kennedy, Bernardo Carpiniello
Background: Schizophrenia (SCZ) is a severe psychiatric disorder with a complex pathophysiology. Given its prevalence, high risk of mortality, early onset, and high levels of disability, researchers have attempted to develop early detection strategies for facilitating timely pharmacological and/or non-pharmacological interventions. Here, we performed a meta-analysis of publicly available gene expression datasets in peripheral tissues in SCZ and healthy controls (HC) to detect consistent patterns of illness-associated gene expression...
December 20, 2018: International Journal of Neuropsychopharmacology
Andreas Hahn, Rupert Lanzenberger, Siegfried Kasper
In addition to the assessment of local alterations of specific brain regions, the investigation of entire networks with in vivo neuroimaging techniques has gained increasing attention. In general, connectivity analysis refers to the investigation of links between brain regions, with the aim to characterize their interactions and information transfer. These may represent or relate to different physiological characteristics (structural, functional or metabolic information) and can be calculated across different levels of granularity (two regions vs...
December 13, 2018: International Journal of Neuropsychopharmacology
John E Donello, Pradeep Banerjee, Yong-Xin Li, Yuan-Xing Guo, Takashi Yoshitake, Xiao-Lei Zhang, Omid Miry, Jan Kehr, Patric K Stanton, Amanda L Gross, Jeffery S Burgdorf, Roger A Kroes, Joseph R Moskal
Background: Modulation of glutamatergic synaptic transmission by N-methyl-D-aspartate receptors (NMDARs) can produce rapid and sustained antidepressant effects. Rapastinel (GLYX-13), initially described as a NMDAR partial glycine site agonist, exhibits rapid antidepressant effect in rodents without the accompanying dissociative effects of NMDAR antagonists. Methods: The relationship between rapastinel's in vitro NMDAR pharmacology and antidepressant efficacy was determined by brain microdialysis and subsequent pharmacological characterization of therapeutic rapastinel concentrations in NMDAR-specific radioligand displacement, calcium mobilization, and mPFC electrophysiology assays...
December 13, 2018: International Journal of Neuropsychopharmacology
T Lee Gilman, Nathan C Mitchell, Lynette C Daws, Glenn M Toney
High dietary salt intake (HDSI) increases risk of stress-related neuropsychiatric disorders. Here, we explored the contribution of HDSI-induced neuroinflammation in key stress-responsive brain regions, the hypothalamic paraventricular nucleus (PVN) and basolateral amygdala (BLA), in promoting exaggerated neuronal activation and coping behaviors in response to acute psychogenic stress. Mice that underwent HDSI exhibited increased active stress coping behaviors during and after an acute swim stress, and these were reduced by concurrent administration of minocycline, an inhibitor of microglial activation, without affecting body fluid hyperosmolality caused by HDSI...
December 8, 2018: International Journal of Neuropsychopharmacology
Cristóbal Gómez-Molina, Mauricio Sandoval, Roberto Henzi, Juan Pablo Ramírez, Manuel Varas-Godoy, Alejandro Luarte, Carlos Andres Lafourcade, Alejandra Lopez-Verrilli, Karl-Heinz Smalla, Thilo Kaehne, Ursula Wyneken
Background: Stress precipitates mood disorders, characterized by a range of symptoms present in different combinations, suggesting the existence of disease subtypes. Using an animal model, we previously described that repetitive stress via restraint or immobilization induced depressive-like behaviors in rats that were differentially reverted by a serotonin- or noradrenaline-based antidepressant drug, indicating that different neurobiological mechanisms may be involved. The forebrain astrocyte protein aldolase C, contained in small extracellular vesicles (sEVs), was identified as a potential biomarker in the cerebrospinal fluid, however its specific origin remains unknown...
December 8, 2018: International Journal of Neuropsychopharmacology
Matthew R Hudson, Anthony J Hannan PhD, Terence J O'Brien, Nigel C Jones
Background: Schizophrenia is a complex neuropsychiatric disorder characterised by psychoses, socioaffective disturbances and cognitive deficits. The phosphodiesterase enzyme phospholipase C-β1 (PLC-β1) has been reported to be reduced in post-mortem tissue of schizophrenia patients. Dysregulation of neuronal oscillations, particularly those in the higher frequency range, such as beta (12-30 Hz) and gamma (30-80 Hz), are also associated with this disorder. We investigated the influence of PLC-β1 gene deletion on cortical oscillatory activity and sensorimotor gating behavior...
December 4, 2018: International Journal of Neuropsychopharmacology
Mary Hobart, Peter Zhang, Catherine Weiss, Stine Rasmussen Meehan, Hans Eriksson
Background: Patients with major depressive disorder (MDD) and inadequate response to antidepressant treatments (ADTs) may experience a prolonged loss of functioning. This post hoc analysis aimed to determine the effect of adjunctive brexpiprazole on functioning in such patients. Methods: A pooled analysis of data from the 6-week, randomized, double-blind treatment phases of six studies of adjunctive brexpiprazole (2 and 3 mg/day in fixed-dose studies; 1-3 mg/day in flexible-dose studies) versus placebo in patients with MDD and inadequate response to ADTs (NCT01360645, NCT01360632, NCT02196506, NCT01727726, NCT00797966, NCT01052077)...
December 2, 2018: International Journal of Neuropsychopharmacology
Yoko Nawata, Taku Yamaguchi, Ryo Fukumori, Tsuneyuki Yamamoto
Background: Methamphetamine is a highly addictive psychostimulant with reinforcing properties. Our laboratory previously found that Δ8-tetrahydrocannabinol, an exogenous cannabinoid, suppressed the reinstatement of methamphetamine-seeking behavior. The purpose of this study was to determine whether the elevation of endocannabinoids modulates the reinstatement of methamphetamine-seeking behavior and emotional changes in methamphetamine self-administered rats. Methods: Rats were tested for the reinstatement of methamphetamine-seeking behavior following methamphetamine self-administration and extinction...
November 27, 2018: International Journal of Neuropsychopharmacology
Siegfried Kasper, Alan Frazer
No abstract text is available yet for this article.
February 1, 2019: International Journal of Neuropsychopharmacology
Han Wang, Ji-Tao Li, Yue Zhang, Rui Liu, Xiao-Dong Wang, Tian-Mei Si, Yun-Ai Su
Background: With the growing use of second-generation antipsychotics for the treatment of a spectrum of psychiatric illnesses in pregnancy, concerns have been raised about the long-term impact of these medications on offspring neurodevelopment. However, preclinical and clinical evidence on the lasting effects of prenatal antipsychotic exposure is still sparse. Methods: Risperidone, a widely used second-generation antipsychotic, and haloperidol, a representative first-generation antipsychotic, were administered to pregnant C57BL/6N mice from embryonic day 6 to 16...
January 1, 2019: International Journal of Neuropsychopharmacology
Limin Wang, Zhenxiang Zhu, Wenjuan Hou, Xueni Zhang, Zhixiong He, Wei Yuan, Yang Yang, Siyi Zhang, Rui Jia, Fadao Tai
Background: Most previous studies have focused on the effects of social defeat in male juvenile individuals. Whether chronic social defeat stress (CSDS) in adulthood affects female emotion and the underlying mechanisms remains unclear. Methods: Using highly aggressive adult female mandarin voles (Microtus mandarinus), the present study aimed to determine the effects of CSDS on anxiety- and depression-like behaviours in adult female rodents and investigate the neurobiological mechanisms underlying these effects...
November 16, 2018: International Journal of Neuropsychopharmacology
Bashkim Kadriu, Laura Musazzi, Ioline D Henter, Morgan Graves, Maurizio Popoli, Carlos A Zarate
The underlying neurobiological basis of major depressive disorder (MDD) remains elusive due to the severity, complexity, and heterogeneity of the disorder. While the traditional monoaminergic hypothesis has largely fallen short in its ability to provide a complete picture of MDD, emerging preclinical and clinical findings suggest that dysfunctional glutamatergic neurotransmission may underlie the pathophysiology of both MDD and bipolar depression. In particular, recent studies showing that a single intravenous infusion of the glutamatergic modulator ketamine elicits fast-acting, robust, and relatively sustained antidepressant, anti-suicidal, and anti-anhedonic effects in individuals with treatment-resistant depression (TRD) have prompted tremendous interest in understanding the mechanisms responsible for ketamine's clinical efficacy...
November 16, 2018: International Journal of Neuropsychopharmacology
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