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Journals Journal of Artificial Organs :...

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs

https://read.qxmd.com/read/38780672/introduction-of-ex-vivo-perfusion-of-extended-criteria-donor-hearts-in-a-single-center-in-asia
#1
JOURNAL ARTICLE
Oswald Joseph On Jing Lee, Inderjeet Bhatia, Sylvia Ho Yan Wan, Katherine Yue Yan Fan, Michael Ka Lam Wong, Timmy Wing Kuk Au, Cally Ka Lai Ho
The shortage of organs for heart transplantation has created a need to explore the use of extended-criteria organs. We report the preliminary use of normothermic TransMedics Organ Care System-an ex vivo approach to preserve extended-criteria brain-dead donor hearts. This System maintains a normal temperature, provides continuous perfusion and oxygenation, reduces ischemic time, and enables additional viability assessment options. In a retrospective single-centre study conducted from April 2020 to March 2023, four extended criteria brain-dead donor hearts were perfused and monitored using the Organ Care System...
May 23, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38780671/hypothermic-circulatory-arrest-at-20%C3%A2-%C3%A2-does-not-deteriorate-coagulopathy-compared-to-28%C3%A2-%C3%A2-in-a-pig-model
#2
JOURNAL ARTICLE
Hayato Ise, Kyohei Oyama, Ryohei Ushioda, Aina Hirofuji, Keisuke Kamada, Yuri Yoshida, Payam Akhyari, Hiroyuki Kamiya
It is believed that a lower temperature setting of hypothermic circulatory arrest (HCA) in thoracic aortic surgery causes coagulopathy, resulting in excessive bleeding. However, experimental studies that eliminate clinical factors are lacking. The objective of this study is to investigate the influence of the temperature setting of HCA on coagulation in a pig model. Ten pigs were divided into the following two groups: moderate temperature at 28 °C (group M, n = 5) or lower temperature at 20 °C (group L, n = 5)...
May 23, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38780670/caregivers-of-patients-with-long-term-implantable-ventricular-assist-device-a-republication-of-the-article-published-in-the-japanese-journal-of-artificial-organs
#3
REVIEW
Noriko Kikuchi
Implantable ventricular assist device (VAD) has enabled patients with severe heart failure to be discharged from the hospital and to continue their care at home. The presence of caregivers is essential to maintain home care of patients with VAD. The caregivers are mainly the family members who live with the patient with VAD. The caregivers need to be trained (1) VAD device management, (2) disinfection of driveline skin punctures, (3) medication management, and (4) responding to sudden changes. The caregivers' lifestyle is also forced to change...
May 23, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38771405/arterial-oxygen-pressure-during-veno-venous-extracorporeal-membrane-oxygenation-may-be-increased-by-advancing-the-tip-of-the-drainage-cannula-into-the-superior-vena-cava-a-case-report
#4
JOURNAL ARTICLE
Tomoyuki Nakamura, Naohide Kuriyama, Yoshitaka Hara, Hidefumi Komura, Naoki Hoshino, Soshi Miyamoto, Ken Sawada, Takahiro Kawaji, Satoshi Komatsu, Osamu Nishida
A simple and robust method for veno-venous extracorporeal membrane oxygenation (V-V ECMO) involves a drainage cannula into the inferior vena cava via the femoral vein (FV) and a reinfusion cannula into the right atrium (RA) via the internal jugular vein (IJV) (F-J configuration). However, with this method, the arterial oxygen (PaO2 ) is said to remain below 100 mmHg.Since recently, in our ICU, to prevent drainage failure, we apply a modification from the commonly practiced F-J configuration by advancing the tip of the drainage cannula inserted via the FV into the superior vena cava (SVC) and crossing the reinfusion cannula inserted via the IJV in the RA (F(SVC)-J(RA) configuration)...
May 21, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38769278/difference-in-coagulation-systems-of-large-animal-species-used-in-cardiovascular-research-a-systematic-review
#5
REVIEW
Louis Staelens, Tom Langenaeken, Filip Rega, Bart Meuris
Preclinical testing using animal models is indispensable in cardiovascular research. However, the translation to clinical practice of these animal models is questionable since it is not always clear how representative they are. This systematic review intends to summarize the interspecies differences in the coagulation profile of animal models used in cardiovascular research. It aims to guide future research in choosing the optimal animal species. A literature search of PubMed, Embase, Web of Science (Core Collection) and Cochrane Library was performed using a search string that was well defined and not modified during the study...
May 20, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38662142/percutaneous-intravascular-micro-axial-blood-pump-current-state-and-perspective-from-engineering-view
#6
REVIEW
Eiji Okamoto, Yoshinori Mitamura
The utilization of a minimally invasively placed catheter-mounted intravascular micro-axial flow blood pump (IMFBP) is increasing in the population with advanced heart failure. The current development of IMFBPs dates back around the 1990s, namely the Hemopump with a wire-drive system and the Valvopump with a direct-drive system. The wire-drive IMFBPs can use a brushless motor in an external console unit to transmit rotational force through the drive wire rotating the impeller inside the body. The direct-drive IMFBPs require an ultra-miniature and high-power brushless motor...
April 25, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38642185/feasibility-of-an-animal-model-for-long-term-mechanical-circulatory-support-with-impella-5-5-implanted-through-carotid-artery-access-in-sheep
#7
JOURNAL ARTICLE
Shusuke Imaoka, Tomohiro Nishinaka, Toshihide Mizuno, Akihide Umeki, Takashi Murakami, Tomonori Tsukiya, Masashi Kawamura, Shigeru Miyagawa
Impella is a mechanical circulatory support device of a catheter-based intravascular microaxial pump for left ventricular support and unloading. However, nonclinical studies assessing the effects of the extended duration of left ventricular unloading on cardiac recovery are lacking. An animal model using Impella implanted with a less invasive procedure to enable long-term support is required. This study aimed to evaluate the feasibility of an animal model for long-term support with Impella 5.5 implanted through carotid artery access in sheep...
April 20, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38609660/advance-care-planning-in-the-treatment-of-implantable-left-ventricular-assist-device-a-republication-of-the-review-published-in-japanese-journal-of-artificial-organs
#8
REVIEW
Yoko Sakamoto, Ryohei Matsuura, Daisuke Yoshioka, Ai Kawamura, Sumiharu Nakamae, Shigeru Miyagawa
Advance care planning (ACP) is essential in managing serious and chronic illnesses to ensure that patients receive care aligned with their personal values, goals, and preferences. This review focuses on integrating ACP in the treatment of patients receiving implantable left ventricular assist devices (VADs). The heart failure palliative care team developed a unique advance directive form and pamphlet to facilitate ACP discussions, emphasizing not only medical treatment preferences but also patients' values and life goals...
April 13, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38594483/management-of-aortic-valve-insufficiency-in-patients-with-continuous-flow-left-ventricular-assist-device-a-republication-of-the-review-published-in-japanese-journal-of-artificial-organs
#9
REVIEW
Naoki Tadokoro, Kohei Tonai, Satoshi Kainuma, Naonori Kawamoto, Kota Suzuki, Masaya Hirayama, Satsuki Fukushima
Since 2011, implantable ventricular assist devices have been a standard treatment for severe heart failure alongside heart transplantation in Japan. However, the limited availability of donors has led to a prolonged wait for transplants, now averaging 1719 days, intensifying the issue of aortic insufficiency in patients with continuous flow ventricular assist devices. These devices limit the opening of the aortic valve, leading to sustained closure and increased shear stress, which accelerates valve degradation...
April 10, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38581568/impact-of-inflammation-and-steroids-on-anti-coagulation-in-children-supported-on-a-ventricular-assist-device
#10
JOURNAL ARTICLE
Katie Brandewie, Angela Lorts, Lori Luchtman-Jones, Zhiqian Gao, Becca Geer, Chet Villa, Tanya Perry
Critically ill pediatric patients supported on ventricular assist devices (VADs) are increasingly being anticoagulated on bivalirudin, but with difficulty monitoring anticoagulation. Activated partial thromboplastin time (aPTT) has recently been shown to poorly correlate with bivalirudin plasma concentrations, while dTT had excellent correlation. However, aPTT is the more common monitoring test and dTT testing is rarely used. In addition, effects of frequent clinical VAD scenarios (such as inflammation) on the accuracy of aPTT and dTT testing remains uncertain...
April 6, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38548928/patient-management-important-for-long-term-support-beyond-5-years-in-the-btt-republication-of-the-article-published-in-the-japanese-journal-of-artificial-organs
#11
REVIEW
Masato Mutsuga
Heart transplantation is considered to be the best treatment for severe heart failure refractory to medical therapy, improving patients' survival and quality of life (QOL). However, the number of donors is smaller than the number of registered applicants for heart transplantation, which increases every year, and the waiting period for heart transplantation has been extended to more than 1700 days by 2022. Since 2011, reimbursement for the implantable left ventricular assist device (iLVAD) was established...
March 29, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38520590/left-ventricular-assist-device-temporary-explantation-as-a-strategy-for-infection-control-in-a-pediatric-patient
#12
JOURNAL ARTICLE
Akiko Umetsu, Masaki Taira, Moyu Hasegawa, Takuji Watanabe, Yuji Tominaga, Takayoshi Ueno, Daisuke Yoshioka, Kazuo Shimamura, Shigeru Miyagawa
We report a case of temporary Berlin Heart EXCOR® explantation in a pediatric patient with idiopathic dilated cardiomyopathy who suffered an uncontrollable inflow cannulation site infection while on bridge-to-transplantation. Despite failure to thrive and catheter-related infections, once free of the device, the patient was cured of infection using systemic antibiotics and surgical debridement. The patient underwent EXCOR® reimplantation after four months, and is awaiting heart transplantation in stable condition...
March 23, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38514529/effect-of-proactive-combination-therapy-with-peritoneal-dialysis-and-hemodialysis-on-technique-survival-and-mortality
#13
JOURNAL ARTICLE
Kei Nagai, Atsushi Ueda
PURPOSE: Clinically relevant evidence for the timing of starting combination therapy with peritoneal dialysis and hemodialysis remains scarce. We retrospectively examined whether combination therapy during the induction phase of dialysis prolongs peritoneal dialysis duration. METHODS: This retrospective study includes 160 patients who underwent combination therapy from 20 dialysis facilities. Four groups were categorized: combination at peritoneal dialysis induction (n = 12, Proactive combination group), and combination following peritoneal dialysis durations of < 2 years (n = 65), 2-5 years (n = 70), or > 5 years (n = 13)...
March 22, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38512476/utilizing-a-long-sheath-to-minimize-atheroma-manipulation-minimal-manipulation-approach-during-zone-1-and-2-thoracic-endovascular-aortic-repair-with-a-shaggy-aorta
#14
JOURNAL ARTICLE
Hidetake Kawajiri, Takuma Kobayashi, Kaichiro Manabe, Keiichi Kanda, Satoshi Numata
We have adopted a simple and reproducible approach, "minimal manipulation approach," since January 2021 in five patients to minimize the risk of thromboembolic events during Zone 1 and 2 thoracic endovascular aortic repair (TEVARs) with shaggy aorta. The approach consists of two parts: ① Use of a 65-cm-long sheath (dry seal) to deliver the endografts without touching the protruding atheroma. Covering the atheroma with the first endograft delivered at Zone 3 to the mid-descending aorta (paving the aorta), and second endograft insertion and deployment through the paved aorta with first endograft...
March 21, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38498214/predictive-role-of-regional-thigh-tissue-oxygen-saturation-monitoring-during-cardiopulmonary-bypass-in-lung-injury-after-cardiac-surgery
#15
JOURNAL ARTICLE
Tomoki Tamura, Fumiaki Shikata, Tadashi Kitamura, Masaomi Fukuzumi, Yuki Tanaka, Tomoyo Ebine, Kiyotaka Fujii, Satoshi Kohira, Kagami Miyaji
Acute respiratory distress syndrome (ARDS) is a serious complication following cardiac surgery mainly associated with the use of cardiopulmonary bypass (CPB), which could increase the risk of mortality and morbidity. This study investigated the association of regional oxygen saturation (rSO2 ) during CPB with postoperative outcomes, including respiratory function. Patients who underwent cardiac surgery with CPB from 2015 to 2019 were included. Near-infrared spectroscopy was used to monitor rSO2 at the forehead, abdomen, and thighs throughout the surgery...
March 18, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38451441/left-ventricular-assist-devices-yesterday-today-and-tomorrow
#16
REVIEW
Athanasios Tsiouris, Mark S Slaughter, Ashok Kumar Coimbatore Jeyakumar, Adam N Protos
The shortcomings of expense, power requirements, infection, durability, size, and blood trauma of current durable LVADs have been recognized for many years. The LVADs of tomorrow aspire to be fully implantable, durable, mitigate infectious risk, mimic the pulsatile nature of the native cardiac cycle, as well as minimize bleeding and thrombosis. Power draw, battery cycle lifespan and trans-cutaneous energy transmission remain barriers to completely implantable systems. Potential solutions include decreases in pump electrical draw, improving battery lifecycle technology and better trans-cutaneous energy transmission, potentially from Free-range Resonant Electrical Energy Delivery...
March 7, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38396198/successful-management-of-heartmate-3-in-a-patient-with-arrhythmogenic-right-ventricular-cardiomyopathy
#17
JOURNAL ARTICLE
Makiko Nakamura, Teruhiko Imamura, Yuki Hida, Toshihide Izumida, Masaki Nakagaito, Saori Nagura, Toshio Doi, Kazuaki Fukahara, Koichiro Kinugawa
The management of right heart failure during durable left ventricular assist device (LVAD) support remains an unsolved issue so far. We had a 44-year-old male patient who was diagnosed with arrhythmogenic right ventricular cardiomyopathy and received HeartMate 3 LVAD (Abbott, USA) implantation as a bridge-to-transplant indication. The pump speed was adjusted as low as 4500 rpm to avoid the left ventricular narrowing and interventricular septal leftward shift. Riociguat was administered to decrease the afterload of the right ventricle and increase the preload of the left ventricle, in addition to the combination of neurohormonal blockers...
February 24, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38396197/prevalence-of-bleeding-events-in-real-world-japanese-registry-for-percutaneous-ventricular-assist-device
#18
JOURNAL ARTICLE
Takashi Nishimura, Koichi Toda, Junya Ako, Atsushi Hirayama, Koichiro Kinugawa, Yoshio Kobayashi, Minoru Ono, Naoki Sato, Takahiro Shindo, Akira Shiose, Morimasa Takayama, Satoshi Yasukochi, Yoshiki Sawa
PURPOSE: Bleeding complication is a critical risk factor for outcomes of acute heart failure patients requiring mechanical circulatory support (MCS), including percutaneous catheter-type heart pumps (Impella). The Japanese registry for Percutaneous Ventricular Assist Device (J-PVAD) is an ongoing, large-scale, real-world registry to characterize Japanese patients requiring Impella. Here we analyzed bleeding complication profiles in patients who received Impella. METHODS: All consecutive Japanese patients who received Impella from October 2017 to January 2020 were enrolled...
February 24, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38367099/contributing-factors-to-heparin-resistance-during-cardiopulmonary-bypass
#19
JOURNAL ARTICLE
Tomoaki Yamashiro, Yoshiyuki Takami, Yasushi Takagi
Since the risk factors for heparin resistance (HR) before cardiopulmonary bypass (CPB) have not been fully clarified, this study investigated the contributing factors for HR after the initial unfractionated heparin (UFH) dose of 500 IU/kg. We retrospectively analyzed the data of 371 patients who underwent CPB surgery, with the initial UFH dose of 500 IU/kg, between May 2017 and December 2021. We defined HR as the failure to achieve activated clotting time (ACT) of > 480 s after the initial UFH dose of 500 IU/kg...
February 17, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://read.qxmd.com/read/38311666/3d-porous-structure-imaging-of-membranes-for-medical-devices-using-scanning-probe-microscopy-and-electron-microscopy-from-membrane-science-points-of-view
#20
REVIEW
Makoto Fukuda, Kiyotaka Sakai
The evolution of hemodialysis membranes (dialyzer, artificial kidney) was remarkable, since Dow Chemical began manufacturing hollow fiber hemodialyzers in 1968, especially because it involved industrial chemistry, including polymer synthesis and membrane manufacturing process. The development of hemodialysis membranes has brought about the field of medical devices as a major industry. In addition to conventional electron microscopy, scanning probe microscopy (SPM), represented by atomic force microscopy (AFM), has been used in membrane science research on porous membranes for hemodialysis, and membrane science contributes greatly to the hemodialyzer industry...
February 5, 2024: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
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