Cristina Martinez-Fernandez de la Camara, Tina Storm, Ahmed Salman, Thomas Burgoyne, Martin Qvist Rasmussen, Harry O Orlans, Angela J Russell, Stephen G Davies, Alun R Barnard, Robert E MacLaren
Retinal astrocytes are vital for neuronal homeostasis in the retina. Together with Müller glia, they provide retinal cells with neurotrophic factors, antioxidative support, and defense mechanisms such as the formation of the blood-retinal barrier. Substantial heterogeneity of astrocyte morphology and function represents a challenge for identification of distinct subtypes which may be potential targets for therapeutic purposes. Hence, identification of novel markers of astrocyte subpopulations is highly relevant to better understand the molecular mechanisms involved in retinal development, homeostasis, and pathology...
June 23, 2023: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society