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Journal of Alzheimer's Disease: JAD

P Hemachandra Reddy, Russell H Swerdlow, John Culberson, David Kang, Tedd L Mitchell, Quentin Smith, Sanoj Suneja, Marcia G Ory, Subodh Kumar, Murali Vijayan, Ahmed Morsy, Gabriela Arandia, J Josh Lawrence, Elizabeth George, Darryll Oliver, Jangampalli Adi Pradeepkiran, Xiangling Yin, Arubala P Reddy, Maria Manczak, Pelin Cengiz, Vardan T Karamyan, Ramesh Kandimalla, Chandra Sekhar Kuruva, Joshua Willms, Bhagavathi Ramasubramanian, Neha Sawant, Divya Burugu, Annette N Boles, Veronica Lopez, Rocio Carrasco, Cordelia Aguirre, Susan Thompson, Joan Blackmon, Clay Ament, Rui Wang, Emily R Stephens, Brittney Hoang, Kevin Bass, Paul C Trippier, Christopher Hornback, Pratibha Kottapalli, Kameswara Rao Kottapalli, Salvatore Oddo
The purpose of the 'First Regional Healthy Aging and Dementia Research Symposium' was to discuss the latest research in healthy aging and dementia research, public health trends related to neurodegenerative diseases of aging, and community-based programs and research studying health, nutrition, and cognition. This symposium was organized by the Garrison Institute on Aging (GIA) of the Texas Tech University Health Sciences Center (TTUHSC), and was held in Lubbock, Texas, October 24-25, 2018. The Symposium joined experts from educational and research institutions across the United States...
May 17, 2019: Journal of Alzheimer's Disease: JAD
Hanna Bozkurt Åhman, Vilmantas Giedraitis, Ylva Cedervall, Björn Lennhed, Lars Berglund, Kevin McKee, Lena Kilander, Erik Rosendahl, Martin Ingelsson, Anna Cristina Åberg
BACKGROUND: Tools to identify individuals at preclinical stages of dementia disorders are needed to enable early interventions. Alterations in dual-task performance have been detected early in progressive neurodegenerative disorders. Hence, dual-task testing may have the potential to screen for cognitive impairment caused by neurodegeneration. Exploring correlations between dual-task performance and biomarkers of neurodegeneration is therefore of interest. OBJECTIVE: To investigate correlations between Timed Up-and-Go dual-task (TUGdt) outcomes and Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers amyloid-β 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau)...
May 16, 2019: Journal of Alzheimer's Disease: JAD
Julie M Robillard, Julia M Wu, Tanya L Feng, Mallorie T Tam
BACKGROUND: As the global prevalence of dementia rises, care costs impose a large burden on healthcare systems. Technology solutions in dementia care have the potential to ease this burden. While policies exist to guide and govern the use of dementia care technologies, little is known about how ethical considerations are incorporated into these documents. OBJECTIVE: The goal of this study was to examine ethics-related content in dementia care technology policies...
May 16, 2019: Journal of Alzheimer's Disease: JAD
Cheshire Hardcastle, Hua Huang, Sam Crowley, Jared Tanner, Carlos Hernaiz, Mark Rice, Hari Parvataneni, Mingzhou Ding, Catherine C Price
BACKGROUND: Research shows that older adults can have a decline in three key resting state networks (default mode network, central executive network, and salience network) after total knee arthroplasty and that patients' pre-surgery brain and cognitive integrity predicts decline. OBJECTIVES: First, to assess resting state network connectivity decline from the perspective of nodal connectivity changes in a larger older adult surgery sample. Second, to compare pre-post functional connectivity changes in mild cognitive impairment (MCI) versus non-MCI...
May 16, 2019: Journal of Alzheimer's Disease: JAD
Rachel H Tan, Yue Yang, Heather McCann, Claire Shepherd, Glenda M Halliday
The selective loss of von Economo neurons has been linked to the behavioral deficits in behavioral variant frontotemporal dementia (bvFTD) but whether these neurons are affected in bvFTD patients with underlying Alzheimer's disease (AD) has yet to be established. The present study assesses the von Economo neurons in pathological AD cases clinically diagnosed with either AD or bvFTD. Our results demonstrate no significant loss of von Economo neurons in all pathological AD cases, irrespective of clinical diagnosis or co-existing Lewy body pathology...
May 16, 2019: Journal of Alzheimer's Disease: JAD
Richard J Elsworthy, Sarah Aldred
 Depression is a common co-morbidity seen in people with Alzheimer's disease (AD). However, the successful treatment of depressive symptoms in people with AD is rarely seen. In fact, multiple randomized controlled trials have shown selective serotonin reuptake inhibitors (SSRIs), the current best recommended treatment for depression, to be ineffective in treating depressive symptoms in people with AD. One explanation for this lack of treatment effect may be that depressive symptoms can reflect the progression of AD, rather than clinical depression and are a consequence of more severe neurodegeneration...
May 16, 2019: Journal of Alzheimer's Disease: JAD
Karel Kostev, Jens Bohlken, Louis Jacob
BACKGROUND: Previous studies focusing on the association between antidepressant use and dementia have reported controversial findings. OBJECTIVE: This study aimed to compare the associations between the prescription of selective serotonin reuptake inhibitors (SSRIs) or serotonin and noradrenaline reuptake inhibitors (SNRIs) and the occurrence of dementia in patients with depression followed in Germany. METHODS: This study included 20,215 patients aged 70-90 diagnosed with depression and treated in general or neuropsychiatric practices in Germany between 2010 and 2015 (index date)...
May 13, 2019: Journal of Alzheimer's Disease: JAD
Kimberley Yuen, Neda Rashidi-Ranjbar, Nicolaas Paul L G Verhoeff, Sanjeev Kumar, Damien Gallagher, Alastair J Flint, Nathan Herrmann, Bruce G Pollock, Benoit H Mulsant, Tarek K Rajji, Aristotle N Voineskos, Corinne E Fischer, Linda Mah
BACKGROUND: Previous studies examining the link between neuropsychiatric symptoms (NPS) and biomarkers of Alzheimer's disease (AD) may be confounded by remitted or past history of psychiatric illness, which in itself is associated with AD biomarkers such as reduced medial temporal lobe (MTL) volume. OBJECTIVE: We examined associations between mood and anxiety-related NPS and MTL in older adults with mild cognitive impairment (MCI) free of lifetime history of depression...
May 13, 2019: Journal of Alzheimer's Disease: JAD
Tobias Skillbäck, Johannes Kornhuber, Kaj Blennow, Henrik Zetterberg, Piotr Lewczuk
BACKGROUND: To alleviate the interpretation of the core Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers, amyloid β1-42 (Aβ42), total tau (T-tau), and phosphorylated tau (P-tau), the Erlangen Score (ES) interpretation algorithm has been proposed. OBJECTIVE: In this study, we aim to assess the predictive properties of the ES algorithm on cognitive and neuroimaging outcomes in mild cognitive impairment (MCI). METHODS: All MCI subjects with an available baseline CSF sample from ADNI-1 were included (n = 193), and assigned an ES between 0 and 4 based on their baseline CSF biomarker profile...
May 13, 2019: Journal of Alzheimer's Disease: JAD
Sunkuk Kwon, Ines Moreno-Gonzalez, Kathleen Taylor-Presse, George Edwards Iii, Nazaret Gamez, Olivia Calderon, Banghe Zhu, Fred Christian Velasquez, Claudio Soto, Eva M Sevick-Muraca
 Cerebrospinal fluid (CSF) outflow from the brain occurs through absorption into the arachnoid villi and, more predominantly, through meningeal and olfactory lymphatics that ultimately drain into the peripheral lymphatics. Impaired CSF outflow has been postulated as a contributing mechanism in Alzheimer's disease (AD). Herein we conducted near-infrared fluorescence imaging of CSF outflow into the peripheral lymph nodes (LNs) and of peripheral lymphatic function in a transgenic mouse model of AD (5XFAD) and wild-type (WT) littermates...
May 13, 2019: Journal of Alzheimer's Disease: JAD
Tommaso Bucci, Danilo Menichelli, Pasquale Pignatelli, Massimo Triggiani, Francesco Violi, Daniele Pastori
 Antiphospholipid antibodies (aPL) are well-known risk factors for venous and arterial thrombosis, but their association with cognitive dysfunction has not been widely investigated in the general population and in patients with primary and secondary antiphospholipid syndrome (APS). We performed a systematic review searching MEDLINE via PubMed and Cochrane (CENTRAL) databases for observational studies reporting on the association between aPL and dementia in the general population, in subjects carrying aPL, in patients with cognitive disorder/dementia, and in primary and secondary APS...
May 13, 2019: Journal of Alzheimer's Disease: JAD
Tomoyasu Bunai, Akihiro Kakimoto, Etsuji Yoshikawa, Tatsuhiro Terada, Yasuomi Ouchi
BACKGROUND: Amyloid imaging with positron emission tomography (PET) often comes with glucose metabolic imaging in diagnosis of Alzheimer's disease (AD). OBJECTIVE: The present purpose was to explore the clinical valence of early amyloid-β (Aβ) PET scans to determine whether they could substitute for other imaging biomarkers (early and delayed Aβ images of 11C-Pittsburgh compound B (PIB) and 18F-fluorodeoxyglucose (FDG) images) in the AD spectrum. METHODS: Thirty healthy control subjects, 20 patients with mild cognitive impairment, and 45 patients with AD underwent 11C-PIB and 18F- FDG PET...
May 13, 2019: Journal of Alzheimer's Disease: JAD
Marcia Cristina Nascimento Dourado, Bianca Torres Mendonça de Melo Fdel, JosPedro Simões Neto, Gilberto Alves, Cândida Alves
 Facial expression recognition is one of the essential abilities for social cognition. We aimed to compare facial expression recognition among people with mild and moderate Alzheimer's disease (AD) and to identify which factors were associated with impairment according to disease severity. We included 52 participants with either mild or moderate AD. FACES includes four subtasks requiring matching expressions with picture stimuli (tasks 1 and 2), labelling emotions (task 3), and recognizing situations with evident emotional content (task 4)...
May 13, 2019: Journal of Alzheimer's Disease: JAD
Hugo McGurran, Jordan M Glenn, Erica N Madero, Nicholas T Bott
 Alzheimer's disease (AD) is the most common form of dementia. With an aging population and no disease modifying treatments available, AD is quickly becoming a global pandemic. A substantial body of research indicates that lifestyle behaviors contribute to the development of AD, and that it may be worthwhile to approach AD like other chronic diseases such as cardiovascular disease, in which prevention is paramount. Exercise is an important lifestyle behavior that may influence the course and pathology of AD, but the biological mechanisms underpinning these effects remain unclear...
May 13, 2019: Journal of Alzheimer's Disease: JAD
Anna Fischer, Jesus Landeira-Fernandez, Flavia Sollero de Campos, Daniel C Mograbi
Empathy is essential for social interaction and a crucial trait to understand the intentions and behaviors of others and to react accordingly. Alzheimer's disease (AD) affects both cognitive and emotional processes and can lead to social dysfunction. Empathy results from the interaction of four components: shared neural representation, self-awareness, mental flexibility, and emotion regulation. This review discusses the abilities and deficits of patients with AD from the perspective of subcomponents of empathy and integrates these facets into a model of human empathy...
May 13, 2019: Journal of Alzheimer's Disease: JAD
Daniel A Nation, Jean K Ho, Shubir Dutt, S Duke Han, Mark H C Lai
BACKGROUND: A clinical diagnosis of cognitive impairment is traditionally based on a single cognitive exam, but serial cognitive testing can be sensitive to subtle cognitive changes in asymptomatic individuals and inform cognitive trajectory. OBJECTIVE: We evaluated the prognostic utility of identifying longitudinal neuropsychological decline along with single cognitive exam and Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers in predicting dementia...
May 13, 2019: Journal of Alzheimer's Disease: JAD
Philippos Koulousakis, Pablo Andrade, Veerle Visser-Vandewalle, Thibaut Sesia
The nucleus basalis of Meynert (nbM) was first described at the end of the 19th century and named after its discoverer, Theodor Meynert. The nbM contains a large population of cholinergic neurons that project their axons to the entire cortical mantle, the olfactory tubercle, and the amygdala. It has been functionally associated with the control of attention and maintenance of arousal, both key functions for appropriate learning and memory formation. This structure is well-conserved across vertebrates, although its degree of organization varies between species...
May 13, 2019: Journal of Alzheimer's Disease: JAD
Monique J Bignoux, Katelyn Cuttler, Tyrone C Otgaar, Eloise Ferreira, Boitelo T Letsolo, Stefan F T Weiss
Alzheimer's disease (AD) represents the most common form of neurodegenerative disorders with only palliative treatments currently available. Amyloid plaque formation caused by amyloid-β (Aβ) aggregation and neurofibrillary tangle formation caused by hyperphosphorylated tau are hallmarks for the development of AD. The 37 kDa/67 kDa laminin receptor (LRP/LR) has been implicated in AD and tools blocking or downregulating LRP/LR impede amyloid plaque formation in vitro and in vivo. We have recently shown that LRP::FLAG enhances telomerase activity with a concomitant reduction of senescent markers...
May 8, 2019: Journal of Alzheimer's Disease: JAD
Anselm B M Fuermaier, Dafne Piersma, Dick de Waard, Ragnhild J Davidse, Jolieke de Groot, Michelle J A Doumen, Ruud A Bredewoud, René Claesen, Afina W Lemstra, Philip Scheltens, Annemiek Vermeeren, Rudolf Ponds, Frans Verhey, Peter Paul De Deyn, Wiebo H Brouwer, Oliver Tucha
BACKGROUND/OBJECTIVE: Neurodegenerative disorders impact fitness to drive of older drivers, but on-road driving studies investigating patients with different neurodegenerative disorders are scarce. A variety of driving errors have been reported in patients with Alzheimer's disease (AD), but it is unclear which types of driving errors occur most frequently. Moreover, patients with other neurodegenerative disorders than AD typically present with different symptoms and impairments, therefore different driving errors may be expected...
April 30, 2019: Journal of Alzheimer's Disease: JAD
Marte Kvello-Alme, Geir Bråthen, Linda R White, Sigrid Botne Sando
BACKGROUND: Young onset dementia poses several challenges for the individual, health care, and society that are not normally relevant for late onset dementia, but is little researched. OBJECTIVE: To determine the prevalence and subtypes of young onset dementia in a defined catchment area in central Norway. METHODS: The main sources of patient identification were the databases at the Department of Neurology, University Hospital of Trondheim (St...
April 17, 2019: Journal of Alzheimer's Disease: JAD
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