journal
Journals Journal of Alzheimer's Disease...

Journal of Alzheimer's Disease : JAD

https://read.qxmd.com/read/38607759/the-importance-of-pet-imaging-to-understanding-whole-body-cortisol-metabolism-in-alzheimer-s-disease
#1
JOURNAL ARTICLE
Jason Bini
Excess cortisol is associated with more severe cognitive decline, Alzheimer's disease, and related dementia phenotypes. The intracellular enzyme 11β-HSD1 regenerates active cortisol from inactive cortisone. In this current issue, high regional brain occupancy of Xanamemtrademark, determined by [11C]TARACT PET imaging of 11β-HSD1, in cognitively normal individuals and mild cognitive impartment/Alzheimer's disease (AD) patients is presented. In the future, comprehensive kinetic modeling using arterial sampling for occupancy studies, and whole-body PET imaging of 11β-HSD1 enzyme levels, in combination with stable isotope studies of cortisol metabolism, can provide broad insight into enzyme levels and activity in AD and other relevant diseases...
April 11, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38607758/sparse-asymmetry-in-locus-coeruleus-pathology-in-alzheimer-s-disease
#2
JOURNAL ARTICLE
Elise Beckers, Joost M Riphagen, Maxime Van Egroo, David A Bennett, Heidi I L Jacobs
 Tau accumulation in and neurodegeneration of locus coeruleus (LC) neurons is observed in Alzheimer's disease (AD). We investigated whether tangle and neuronal density in the rostral and caudal LC is characterized by an asymmetric pattern in 77 autopsy cases of the Rush Memory and Aging Project. We found left-right equivalence for tangle density across individuals with and without AD pathology. However, neuronal density, particularly in the caudal-rostral axis of the LC, is asymmetric among individuals with AD pathology...
April 11, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38607757/incidence-and-risk-factors-epilepsy-in-patients-with-dementia-a-population-based-study-using-regional-healthcare-databases-in-umbria
#3
JOURNAL ARTICLE
Cinzia Costa, Elena Nardi Cesarini, Paolo Eusebi, David Franchini, Paola Casucci, Marcello F De Giorgi, Carmen Calvello, Federico Paolini Paoletti, Michele Romoli, Lucilla Parnetti
BACKGROUND: Dementia is prevalent among the elderly, also representing a risk for seizures/epilepsy. Estimations of epilepsy risk in dementia patients are not widely available. OBJECTIVE: Our research aims to ascertain the incidence of epilepsy and its associated risk factors in subjects with dementia in the Umbria region, based on data from healthcare databases. METHODS: In this retrospective study based on the healthcare administrative database of Umbria, we identified all patients diagnosed with dementia from 2013 to 2017, based on ICD-9-CM codes...
April 6, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38607756/factors-associated-with-lower-social-activity-in-german-older-adults-at-increased-risk-of-dementia-a-cross-sectional-analysis
#4
JOURNAL ARTICLE
Maresa Buchholz, Isabel Zöllinger, Jochen René Thyrian, Melanie Luppa, Andrea Zülke, Juliane Döhring, Laura Lunden, Linda Sanftenberg, Christian Brettschneider, David Czock, Thomas Frese, Jochen Gensichen, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Hans-Helmut König, Birgitt Wiese, Steffi G Riedel-Heller, Iris Blotenberg
BACKGROUND: Studies demonstrate associations between low social activity in older adults and cognitive decline. Little has been investigated regarding which factors are associated with low social activity in older adults at increased risk of dementia. OBJECTIVE: We investigate which sociodemographic, psychological, health-related, and environmental factors are associated with low social activity in older adults at increased risk of dementia. Additionally, we describe the stages of health behavior change, the types of social activities, and the duration of the current level of social activity...
April 6, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38607755/recent-advances-in-drug-delivery-systems-targeting-insulin-signalling-for-the-treatment-of-alzheimer-s-disease
#5
REVIEW
Punya Sachdeva, Kannan Badri Narayanan, Jitendra Kumar Sinha, Saurabh Gupta, Shampa Ghosh, Krishna Kumar Singh, Rakesh Bhaskar, Abdulmajeed G Almutary, James H Zothantluanga, Kranthi Kumar Kotta, Vinod Kumar Nelson, Ana Cláudia Paiva-Santos, Mosleh Mohammad Abomughaid, Mehnaz Kamal, Danish Iqbal, Mohammed Hamoud ALHarbi, Awadh Aedh ALMutairi, Saikat Dewanjee, Mohana Vamsi Nuli, Shanmugam Vippamakula, Saurabh Kumar Jha, Shreesh Ojha, Niraj Kumar Jha
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by the accumulation of neurofibrillary tangles and amyloid-β plaques. Recent research has unveiled the pivotal role of insulin signaling dysfunction in the pathogenesis of AD. Insulin, once thought to be unrelated to brain function, has emerged as a crucial factor in neuronal survival, synaptic plasticity, and cognitive processes. Insulin and the downstream insulin signaling molecules are found mainly in the hippocampus and cortex...
April 6, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38578891/sex-differences-in-the-association-between-ldl-hdl-with-cognitive-decline-in-older-adults-national-health-and-nutrition-examination-survey
#6
JOURNAL ARTICLE
Jiaqi Wen, Xiwa Hao, Yanhong Jia, Baojun Wang, Jiangxia Pang, Furu Liang
BACKGROUND: Lipids have a significant impact on the development and functioning of the nervous system, but the sex differences between the association of LDL/HDL, which reflects lipid metabolic status, and cognitive impairment remains unclear. OBJECTIVE: We aimed to determine if there were sex differences between the association of LDL/HDL and cognitive function in US older adults. METHODS: This population-based cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) 2011-2012 and 2013-2014 cycles...
April 5, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38578888/clusterization-of-behavioral-and-psychological-symptoms-of-dementia-as-assessed-by-neuropsychiatric-inventory-a-case-against-the-use-of-principal-component-analysis
#7
JOURNAL ARTICLE
Timofey L Galankin, Anton Y Bespalov, Hans Y Moebius
BACKGROUND: The term Behavioral and Psychological Symptoms of Dementia (BPSD) covers a group of phenomenologically and medically distinct symptoms that rarely occur in isolation. Their therapy represents a major unmet medical need across dementias of different types, including Alzheimer's disease. Understanding of the symptom occurrence and their clusterization can inform clinical drug development and use of existing and future BPSD treatments. OBJECTIVE: The primary aim of the present study was to investigate the ability of a commonly used principal component analysis to identify BPSD patterns as assessed by Neuropsychiatric Inventory (NPI)...
April 5, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38578886/effects-of-exercise-training-on-immune-related-genes-and-pathways-in-the-cortex-of-animal-models-of-alzheimer-s-disease-a-systematic-review
#8
Michael Anekson Widjaya, Shin-Da Lee, Wei-Chung Cheng, Bor-Tsang Wu
BACKGROUND: Alzheimer's disease (AD) is a chronic neurodegenerative disease that affects the immune system due to the accumulation of amyloid-β (Aβ) and tau associated molecular pathology and other pathogenic processes. To address AD pathogenesis, various approaches had been conducted from drug development to lifestyle modification to reduce the prevalence of AD. Exercise is considered a prominent lifestyle modification to combat AD. OBJECTIVE: This observation prompted us to review the literature on exercise related to immune genes in the cortex of animal models of AD...
April 5, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38578894/the-5ht2b-receptor-in-alzheimer-s-disease-increased-levels-in-patient-brains-and-antagonist-attenuation-of-amyloid-and-tau-induced-dysfunction
#9
JOURNAL ARTICLE
Erica Acquarone, Elentina K Argyrousi, Ottavio Arancio, D Martin Watterson, Saktimayee M Roy
BACKGROUND: Background: Neurodegenerative diseases manifest behavioral dysfunction with disease progression. Intervention with neuropsychiatric drugs is part of most multi-drug treatment paradigms. However, only a fraction of patients responds to the treatments and those responding must deal with drug-drug interactions and tolerance issues generally attributed to off-target activities. Recent efforts have focused on the identification of underexplored targets and exploration of improved outcomes by treatment with selective molecular probes...
April 3, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38578892/towards-a-unitary-hypothesis-of-alzheimer-s-disease-pathogenesis
#10
JOURNAL ARTICLE
Estela Area-Gomez, Eric A Schon
The "amyloid cascade" hypothesis of Alzheimer's disease (AD) pathogenesis invokes the accumulation in the brain of plaques (containing the amyloid-β protein precursor [AβPP] cleavage product amyloid-β [Aβ]) and tangles (containing hyperphosphorylated tau) as drivers of pathogenesis. However, the poor track record of clinical trials based on this hypothesis suggests that the accumulation of these peptides is not the only cause of AD. Here, an alternative hypothesis is proposed in which the AβPP cleavage product C99, not Aβ, is the main culprit, via its role as a regulator of cholesterol metabolism...
April 3, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38578887/contactin-5-and-apolipoproteins-interplay-in-alzheimer-s-disease
#11
JOURNAL ARTICLE
Marina Tedeschi Dauar, Cynthia Picard, Anne Labonté, John Breitner, Pedro Rosa-Neto, Sylvia Villeneuve, Judes Poirier
BACKGROUND: Apolipoproteins and contactin 5 are proteins associated with Alzheimer's disease (AD) pathophysiology. Apolipoproteins act on transport and clearance of cholesterol and phospholipids during synaptic turnover and terminal proliferation. Contactin 5 is a neuronal membrane protein involved in key processes of neurodevelopment. OBJECTIVE: To investigate the interactions between contactin 5 and apolipoproteins in AD, and the role of these proteins in response to neuronal damage...
April 3, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38578895/could-the-historical-transition-from-segmented-to-monophasic-sleep-explain-the-modern-insurgence-of-alzheimer-s-disease-and-related-dementias
#12
JOURNAL ARTICLE
Nicola Luigi Bragazzi, Ayoub Boulares, Sergio Garbarino
 In their article, Finch and Burstein explore the hypothesis that Alzheimer's disease and related dementias (ADRD) may predominantly be phenomena of the modern era. Through a review of classical Greek and Latin literature, they found minimal reference to conditions akin to ADRD, suggesting a historical rarity of severe cognitive decline. Instead, ancient texts focused on physical aspects of aging, with cognitive changes, when noted, not resembling modern-day dementia. Finch and Burstein further extend their analysis by drawing parallels with the Tsimane people of Bolivia, known for their low prevalence of dementia and cardiovascular diseases, attributed to lifestyle factors such as diet and physical activity...
March 30, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38578893/frontal-cortex-lipid-alterations-during-the-onset-of-alzheimer-s-disease
#13
JOURNAL ARTICLE
Marta Moreno-Rodriguez, Sylvia E Perez, Jonatan Martinez-Gardeazabal, Ivan Manuel, Michael Malek-Ahmadi, Rafael Rodriguez-Puertas, Elliott J Mufson
BACKGROUND: Although sporadic Alzheimer's disease (AD) is a neurodegenerative disorder of unknown etiology, familial AD is associated with specific gene mutations. A commonality between these forms of AD is that both display multiple pathogenic events including cholinergic and lipid dysregulation. OBJECTIVE: We aimed to identify the relevant lipids and the activity of their related receptors in the frontal cortex and correlating them with cognition during the progression of AD...
March 30, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38578890/association-between-composite-dietary-antioxidant-index-and-cognitive-function-among-aging-americans-from-nhanes-2011-2014
#14
JOURNAL ARTICLE
Jiesheng Mao, Haoxiang Hu, Yunhan Zhao, Mi Zhou, Xiaokai Yang
BACKGROUND: Antioxidant diets are considered to be protective factors for cognitive function. However, comprehensive measures of antioxidant diets are lacking. OBJECTIVE: To examine the association between the Composite Dietary Antioxidant Index (CDAI) and cognitive function in the elderly. METHODS: This cross-sectional study included a total of 2,456 participants (≥60 years old) from NHANES 2011-2014. Calculation of CDAI based on 6 minerals and vitamins (manganese, selenium, zinc, vitamins A, C, and E)...
March 30, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38578889/combining-blood-based-biomarkers-and-structural-mri-measurements-to-distinguish-persons-with-and-without-significant-amyloid-plaques
#15
JOURNAL ARTICLE
Yanxi Chen, Yi Su, Jianfeng Wu, Kewei Chen, Alireza Atri, Richard J Caselli, Eric M Reiman, Yalin Wang
BACKGROUND: Amyloid-β (Aβ) plaques play a pivotal role in Alzheimer's disease. The current positron emission tomography (PET) is expensive and limited in availability. In contrast, blood-based biomarkers (BBBMs) show potential for characterizing Aβ plaques more affordably. We have previously proposed an MRI-based hippocampal morphometry measure to be an indicator of Aβ plaques. OBJECTIVE: To develop and validate an integrated model to predict brain amyloid PET positivity combining MRI feature and plasma Aβ42/40 ratio...
March 30, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38578885/metabolites-and-cognitive-decline-in-a-puerto-rican-cohort
#16
JOURNAL ARTICLE
Scott Gordon, Jong Soo Lee, Tammy M Scott, Shilpa Bhupathiraju, Jose Ordovas, Rachel S Kelly, Katherine L Tucker, Natalia Palacios
BACKGROUND: Recent studies have identified plasma metabolites associated with cognitive decline and Alzheimer's disease; however, little research on this topic has been conducted in Latinos, especially Puerto Ricans. OBJECTIVE: This study aims to add to the growing body of metabolomics research in Latinos to better understand and improve the health of this population. METHODS: We assessed the association between plasma metabolites and global cognition over 12 years of follow-up in 736 participants of the Boston Puerto Rican Health Study (BPRHS)...
March 30, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38552116/remote-associations-between-tau-and-cortical-amyloid-%C3%AE-are-stage-dependent
#17
JOURNAL ARTICLE
Seyed Hani Hojjati, Gloria C Chiang, Tracy A Butler, Mony de Leon, Ajay Gupta, Yi Li, Mert R Sabuncu, Farnia Feiz, Siddharth Nayak, Jacob Shteingart, Sindy Ozoria, Saman Gholipour Picha, Yaakov Stern, José A Luchsinger, Davangere P Devanand, Qolamreza R Razlighi
BACKGROUND: Histopathologic studies of Alzheimer's disease (AD) suggest that extracellular amyloid-β (Aβ) plaques promote the spread of neurofibrillary tau tangles. However, these two proteinopathies initiate in spatially distinct brain regions, so how they interact during AD progression is unclear. OBJECTIVE: In this study, we utilized Aβ and tau positron emission tomography (PET) scans from 572 older subjects (476 healthy controls (HC), 14 with mild cognitive impairment (MCI), 82 with mild AD), at varying stages of the disease, to investigate to what degree tau is associated with cortical Aβ deposition...
March 29, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38552112/traumatic-brain-injury-and-post-traumatic-stress-disorder-and-their-influence-on-development-and-pattern-of-alzheimer-s-disease-pathology-in-later-life
#18
JOURNAL ARTICLE
Susanne G Mueller
BACKGROUND: Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) are potential risk factors for the development of dementia including Alzheimer's disease (AD) in later life. The findings of studies investigating this question are inconsistent though. OBJECTIVE: To investigate if these inconsistencies are caused by the existence of subgroups with different vulnerability for AD pathology and if these subgroups are characterized by atypical tau load/atrophy pattern...
March 29, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38552111/high-contrast-pet-imaging-of-subcortical-and-allocortical-amyloid-%C3%AE-in-early-alzheimer-s-disease-using-11c-azd2184
#19
JOURNAL ARTICLE
Patrik Mattsson, Zsolt Cselényi, Anton Forsberg Morén, Yvonne Freund-Levi, Lars-Olof Wahlund, Christer Halldin, Lars Farde
BACKGROUND: Deposits of amyloid-β (Aβ) appear early in Alzheimer's disease (AD). OBJECTIVE: The aim of the present study was to compare the presence of cortical and subcortical Aβ in early AD using positron emission tomography (PET). METHODS: Eight cognitively unimpaired (CU) subjects, 8 with mild cognitive impairment (MCI) and 8 with mild AD were examined with PET and [11C]AZD2184. A data driven cut-point for Aβ positivity was defined by Gaussian mixture model of isocortex binding potential (BPND) values...
March 29, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38552117/self-reported-late-life-hypertension-is-associated-with-a-healthy-cognitive-status-and-reduced-alzheimer-s-disease-pathology-burden
#20
JOURNAL ARTICLE
Andrew C Robinson, Tawfique Bin Rizwan, Yvonne S Davidson, James Minshull, Phillip Tinkler, Antony Payton, David M A Mann, Federico Roncaroli
BACKGROUND: While mid-life hypertension represents a risk factor for the development of Alzheimer's disease (AD), the risk after the age of 65 is less certain. Establishing relationships between late life hypertension and the pathological changes of AD could be crucial in understanding the relevance of blood pressure as a risk factor for this disorder. OBJECTIVE: We investigated associations between self-reported late-life hypertension, cognitive status and AD pathology at death...
March 25, 2024: Journal of Alzheimer's Disease: JAD
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