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Iranian Biomedical Journal

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https://read.qxmd.com/read/30954030/pharmacokinetics-and-biodistribution-of-rhopalurus-junceus-scorpion-venom-in-tumor-bearing-mice-after-intravenous-and-oral-administration
#1
Alexis Díaz-García, Gilmara Pimentel González, Tais Basaco Bernabeu, Juan C. Rodríguez Aurrecochea, Hermis Rodríguez Sánchez, Iraida Sánchez Monzón, Maikel Hernández Gómez, Caridad Rodríguez Torres, Maria Regla Rodríguez Capote, Irania Guevara Orellanes
Background: Rhopalurus junceus scorpion venom has shown potential for anticancer treatment. However, there are no scientific evidence about venom pharmacokinetic (PK) and biodistribution (BD) in tumor-bearing mice. Methods: 131I-labeled venom was administrated by intravenous (IV) and oral (PO) routes at the single dose of 12.5 mg/kg. Mice were sacrificed and blood samples, major organs, and tumor were taken at 10, 20, 40, 90, 180, 300, 480, and 1440 min. Results: For IV route, maximum peak concentration (Cmax), elimination half-lives, total body clearance (CL), distribution volume (Vd), mean residence time (MRT), and area under curve (AUC) were 21...
April 7, 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/30954029/physicochemical-position-dependent-properties-in-the-protein-secondary-structures
#2
Ehsan Saghapour, Mohammadreza Sehhati
Background: Establishing theories for designing arbitrary protein structures is complicated and depends on understanding the principles for protein folding, which is affected by applied features. Computer algorithms can reach high precision and stability in computationally designed enzymes and binders by applying informative features obtained from natural structures. Methods: In this study, a position-specific analysis of secondary structures (α-helix, β-strand, and tight turn) was performed to reveal novel features for protein structure prediction and protein design...
April 7, 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/30797226/identification-of-a-novel-kcnq1-frameshift-mutation-and-review-of-the-literature-among-iranian-long-qt-families
#3
Azam Amirian, Zahra Zafari, Morteza Karimipoor, Alireza Kordafshari, Mohammad Dalili, Siamak Saber, Amir Farjam Fazelifar, Sirous Zeinali
Background: Long QT syndrome (LQTS) is characterized by the prolongation of QT interval, which results in syncope and sudden cardiac death in young people. KCNQ1 is the most common gene responsible for this syndrome. Methods: Molecular investigation was performed by DNA Sanger sequencing in Iranian families with a history of syncope. In silico examinations were performed for predicting the pathogenicity of the novel variant. Results: A novel homozygous KCNQ1 frameshift mutation, c...
February 24, 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/30797225/effects-of-environmental-conditions-on-high-yield-magnetosome-production-by-magnetospirillum-gryphiswaldense-msr-1
#4
Leila Hatami-Giklou Jajan, Seyed Nezamedin Hosseini, Masoud Ghorbani, Seyed Fazlollah Mousavi, Behzad Ghareyazie, Mohsen Abolhassani
Background: Magnetotactic bacteria are a heterogeneous group of Gram-negative prokaryote cells that produce linear chains of magnetic particles called magnetosomes, intracellular organelles composed of magnetic iron particles. Many important applications have been defined for magnetic nanoparticles in biotechnology, such as cell separation applications, as well as acting as carriers of enzymes, antibodies, or anti-cancer drugs. Since the bacterial growth is difficult and the yield of magnetosome production is low, the application of magnetosome has not been developed on a commercial scale...
February 24, 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/30797224/distribution-of-the-cm-dil-labeled-human-umbilical-cord-vein-mesenchymal-stem-cells-migrated-to-the-cyclophosphamide-injured-ovaries-in-c57bl-6-mice
#5
Ladan Jalalie, Mohammad Jafar Rezaie, Ali Jalili, Mohammad Ali Rezaee, Zakaria Vahabzadeh, Mohammad Reza Rahmani, Mojtaba Karimipoor, Mohammad Saeed Hakhamaneshi
Background: Mesenchymal stem cells (MSCs) can be used to treat premature ovarian failure (POF). Different methods have already been applied to detect MSCs in tissues. This study aimed to investigate the quantitative distribution of CM-DiI-labeled human umbilical cord vein MSCs (hUCV-MSCs) in different regions of the ovarian tissue of the cyclophosphamide (CTX)-induced POF in mice. Methods: Adult female C57BL/6 mice (n = 40) were divided into four groups: (1) Mice receiving PBS as control (Ctrl) group; (2) mice receiving hUCV-MSCs intravenously as Ctrl + hUCV-MSCs group; (3) mice receiving CTX intraperitoneally (i...
February 24, 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/30797223/factor-vii-gene-defects-review-of-functional-studies-and-their-clinical-implications
#6
Shirin Shahbazi, Reza Mahdian
Coagulation factors belong to a family of plasma glycosylated proteins that should be activated for appropriate blood coagulation. Congenital deficiencies of these factors cause inheritable hemorrhagic diseases. Factor VII (FVII) deficiency is a rare bleeding disorder with variable clinical symptoms. Various mutations have been identified throughout the F7 gene and can affect all the protein domains. The results of previous experiments have partly revealed the correlation between genotype and phenotype in patients with FVII deficiency...
February 24, 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/30665275/comparison-of-ompa-gene-targeted-real-time-pcr-with-the-conventional-culture-method-for-detection-of-acinetobacter-baumanii-in-pneumonic-balb-c-mice
#7
Niloofar Hassannejad, Abbas Bahador, Nasim Hayati Rudbari, Mohammad Hossein Modarressi, Kazem Parivar
Background: Acinetobacter baumannii is an important pathogen in health care and is responsible for severe nosocomial and community-acquired pneumonia. To design novel therapeutic agents, a mouse model for A. baumannii pneumonia is essential. Methods: We described a mouse model of A. baumannii using clinical and 19606R standard strains for developing a quantitative real-time PCR (qRT-PCR) for rapid identification of A. baumannii infection from lung tissues of BALB/c mice...
March 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/30458600/bioprinting-in-vascularization-strategies
#8
Mahboubeh Jafarkhani, Zeinab v, Amir Aidun, Mohammad Ali Shokrgozar
Three-dimensional (3D) printing technology has revolutionized tissue engineering field because of its excellent potential of accurately positioning cell-laden constructs. One of the main challenges in the formation of functional engineered tissues is the lack of an efficient and extensive network of microvessels to support cell viability. By printing vascular cells and appropriate biomaterials, the 3D printing could closely mimic in vivo conditions to generate blood vessels. In vascular tissue engineering, many various approaches of 3D printing have been developed, including selective laser sintering and extrusion methods, etc...
January 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/30447061/study-break-recent-advances-in-hemophilia-gene-therapy
#9
M Karimipoor
No abstract text is available yet for this article.
January 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/30056690/design-and-development-of-modified-mrna-encoding-core-antigen-of-hepatitis-c-virus-a-possible-application-in-vaccine-production
#10
Zarin Sharifnia, Mojgan Bandehpour, Bahram Kazemi, Nosratollah Zarghami
Background: Hepatitis C virus (HCV) is a ‎blood-borne pathogen, resulting in liver cirrhosis and liver cancer. Despite of many efforts in development of treatments for HCV, no vaccine has been licensed yet. The purpose of this study was ‎to design and prepare a specific mRNA, without 5' cap and poly (A) tail transcribed in vitro capable of coding core protein and also to determine its functionality. Methods: Candidate mRNA was prepared by in vitro transcription of the designed construct consisting of ‎‎5ʹ and 3ʹ untranslated regions of heat shock proteins 70 (hsp70) mRNA, T7 promoter, internal ribosome entry site (IRES) sequences of eIF4G related to human dendritic cells (DCs), and the ‎Core gene of HCV...
January 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/30041514/anti-mucin1-aptamer-conjugated-chitosan-nanoparticles-for-targeted-co-delivery-of-docetaxel-and-igf-1r-sirna-to-skbr3-metastatic-breast-cancer-cells
#11
Reza Jafari, Naime Majidi Zolbanin, Jafar Majidi, Fatemeh Atyabi, Mehdi Yousefi, Farhad Jadidi-Niaragh, Leili Aghebati-Maleki, Dariush Shanehbandi, Mohammad-Sadegh Soltani Zangbar, Houshang Rafatpanah
Background: Targeted co-delivery of siRNA and a chemotherapeutic drug is an attractive approach to cancer drug design and treatment. This study was carried out to design an anti-Mucin1 aptamer (Apt)-conjugated chitosan nanoparticle (NP) for targeted co-delivery of insulin-like growth factor receptor 1 (IGF-1R) Silencer siRNA and docetaxel (DTX) to SKBR3 cells. Methods: Characterization of nano-drugs, cellular uptake of NPs, cell viability, and gene expression studies were evaluated based on metastatic breast cancer cells...
January 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/30011425/influence-of-preparation-and-exposure-periods-of-eluates-from-ocular-prosthesis-acrylic-resin-in-human-conjunctival-cell-line
#12
Emily Vivianne Freitas da Silva, Daniela Micheline dos Santos, Liliane da Rocha Bonatto, Victor Gustavo Balera Brito, Sandra Helena Penha de Oliveira, Marcelo Coelho Goiato
Background: This study was undertaken to analyze if different preparation and exposure periods of eluates from ocular prosthesis acrylic resin influence the cytotoxicity for conjunctival cells. Methods: Twenty-four acrylic resin specimens were divided, according to the period of eluate exposure to Chang conjunctival cells (24 and 72 hours). Eluates were prepared in four different ways: 24, 48, and 72 hours of resin specimen immersion in medium and 24 hours of immersion in water, followed by 24 hours of immersion in medium...
January 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/29843204/differential-connectivity-in-colorectal-cancer-gene-expression-network
#13
Fereshteh Izadi
Background: Colorectal cancer (CRC) is one of the challenging types of cancers; thus, exploring effective biomarkers related to colorectal could lead to significant progresses toward the treatment of this disease. Methods: In the present study, CRC gene expression datasets have been reanalyzed. Mutual differentially expressed genes across 294 normal mucosa and adjacent tumoral samples were then utilized in order to build two independent transcriptional regulatory networks...
January 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/29803203/the-effects-of-lactobacillus-casei-on-glycemic-response-serum-sirtuin1-and-fetuin-a-levels-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-trial
#14
Leila Khalili, Beitullah Alipour, Mohammad Asghari Jafar-Abadi, Ismail Faraji, Tohid Hassanalilou, Mehran Mesgari Abbasi, Elnaz Vaghef-Mehrabany, Mahmood Alizadeh Sani
Background: Type 2 diabetes mellitus (T2DM) is related to the gut microbiota with numerous molecular mechanisms. Modulating the gut microbiota by probiotics could be effective in management of T2DM. The aim of the present trial was to evaluate the effect of Lactobacillus casei on glycemic control and serum sirtuin1 (SIRT1) and fetuin-A in patients with T2DM. Methods: Forty patients with T2DM (n = 20 for each group) were divided into intervention (probiotic) and placebo groups...
January 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/29753316/differential-expression-profile-of-zfx-variants-discriminates-breast-cancer-subtypes
#15
Fatemeh Pourkeramati, Malek Hossein Asadi, Shahryar Shakeri, Alireza Farsinejad
Background: ZFX is a transcriptional regulator in embryonic stem cells and plays an important role in pluripotency and self-renewal. ZFX is widely expressed in pluripotent stem cells and is down-regulated during differentiation of embryonic stem cells. ZFX has five different variants that encode three different protein isoforms. While several reports have determined the overexpression of ZFX in a variety of somatic cancers, the expression of ZFX-spliced variants in cancer cells is not well-understood...
January 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/29704890/pik3ca-mutation-analysis-in-iranian-patients-with-gastric-cancer
#16
Mostafa Iranpour, Mahyar Nourian, Sana Saffari, Esmaeil Samizadeh, Mahdieh Mirghafori, Shahrokh Iravani, Soudeh Ghafouri-Fard
Backgrounda: Aberrant activation of phosphatidylinositol-3 kinases (PI3K)/AKT/mTOR (mammalian target of rapamycin) pathway is a critical event during gastric cancer progression. Selective function of AKT inhibitor AZD5363 in PI3KCA mutant gastric cancer necessitates the assessment of PI3KCA mutations in these patients. Methods: The study included 100 patients with gastric cancer who underwent surgical resection at Imam Reza Hospital, Tehran, Iran, between January 2009 and December 2016...
January 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/29380589/scientists-and-science-advocates-dr-younes-karimi-1929-2008-the-prominent-iranian-physician-in-the-field-of-plague-and-other-infectious-diseases
#17
Sepideh Mahdavi, Alzira MP de Almeida, Ehsan Mostafavi
No abstract text is available yet for this article.
January 2019: Iranian Biomedical Journal
https://read.qxmd.com/read/30501144/immunohistochemical-analysis-of-lgr5-and-troy-expression-in-gastric-carcinogenesis-demonstrates-an-inverse-trend
#18
Samaneh Saberi, Abbas Piryaei, Esmat Mirabzadeh, Maryam Esmaeili, Toktam Karimi, Sara Momtaz, Afshin Abdirad, Niloofar Sodeifi, Mohammad Ali Mohagheghi, Hossein Baharvand, Marjan Mohammadi
Background: Two of the Wnt signaling pathway target genes; tumor necrosis factor receptor family member (TROY) and leucine-rich G-protein coupled receptor (LGR5), are involved in the generation and maintenance of gastrointestinal epithelium. A negative modulatory role has recently been assigned to TROY, in this pathway. Here, we have examined their simultaneous expression in gastric carcinogenesis. Methods: Tumor and paired adjacent tissues of intestinal-type gastric cancer (GC) patients (n = 30) were evaluated for LGR5 and TROY expression by immunohistochemistry...
December 3, 2018: Iranian Biomedical Journal
https://read.qxmd.com/read/30388886/hydroalcoholic-extract-of-levisticum-officinale-increases-cgmp-signaling-pathway-by-down-regulating-pde5-expression-and-induction-of-apoptosis-in-mcf-7-and-mda-mb-468-breast-cancer-cell-lines
#19
Marzieh Lotfian Sargazi, Ramin Saravani, Ali Shahraki
Background: This study aimed to investigate Levisticum officinale hydroalcoholic extract (LOHE) effect on both cGMP signaling pathway and phosphodiesterase 5 (PDE5) gene expression pattern and to examine the role of LOHE in apoptosis induction of MCF-7 and MDA-MB-468 cell lines. Methods: The half maximal inhibitory concentration (IC50) of LOHE was examined in both cell lines using the MTT assay. Using IC50 values of LOHE on both cells, the type of cell death was detected by flowcytometric analysis...
November 3, 2018: Iranian Biomedical Journal
https://read.qxmd.com/read/30121054/the-productivity-and-characteristics-of-iranian-biomedical-journal-a-scientometric-analysis
#20
Hassan Asadi, Ehsan Mostafavi
Background: Scientometrics is a discipline that analyzes scientific publications to explore the structure and growth of science. In this work, the quantitative evaluation of the productivity of the Iranian Biomedical Journal (IBJ) is reviewed. Methods: The analysis was done based on a cross-sectional descriptive and an analytical scientometric study. Data were collected from PubMed, Scopus, and Scimago Databases (2000-2017). Scopus and Scimago were used for data search and feature analysis...
November 2018: Iranian Biomedical Journal
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