journal
https://read.qxmd.com/read/38656635/quality-of-life-in-prolactinoma-a-systematic-review
#21
JOURNAL ARTICLE
Mendel Castle-Kirszbaum, Nienke Biermasz, Jeremy Kam, Tony Goldschlager
BACKGROUND: Prolactinomas are common tumours that significantly reduce quality-of-life (QOL) due to sellar mass effect, secondary hypogonadism, and the peripheral effects of prolactin. Understanding the factors that influence QOL would provide insights into therapeutic targets to optimise patient outcomes and improve wellbeing in prolactinoma. METHODS: A systematic review was performed in accordance with the PRISMA statement. Studies that reported patient QoL using validated metrics were included...
April 24, 2024: Pituitary
https://read.qxmd.com/read/38521837/changes-in-multi-modality-management-of-acromegaly-in-a-tertiary-centre-over-2-decades
#22
JOURNAL ARTICLE
V Amodru, N Sahakian, C Piazzola, R Appay, T Graillon, T Cuny, I Morange, F Albarel, M Vermalle, J Regis, H Dufour, T Brue, F Castinetti
PURPOSE: Acromegaly is a rare disease associated with chronic multisystem complications. New therapeutic strategies have emerged in the last decades, combining pituitary transsphenoidal surgery (TSS), radiotherapy or radiosurgery (RXT) and medical treatments. METHODS: This retrospective monocentric study focused on presentation, management and outcome of acromegaly patients diagnosed between 2000 and 2020, still followed up in 2020, with a minimum follow-up of 1 year, and comparison of the first vs...
March 23, 2024: Pituitary
https://read.qxmd.com/read/38713317/bone-health-and-skeletal-fragility-in-second-and-third-line-medical-therapies-for-acromegaly-preliminary-results-from-a-pilot-single-center-experience
#23
LETTER
Sabrina Chiloiro, Antonella Giampietro, Amato Infante, Pier Paolo Mattogno, Liverana Lauretti, Alessandro Olivi, Laura De Marinis, Alfredo Pontecorvi, Francesco Doglietto, Antonio Bianchi
INTRODUCTION: Skeletal fragility is a clinically relevant and not-reversible complication of acromegaly, involving around 30-40% of patients since the disease diagnosis. Few studies have investigated the effects on skeletal health of medical therapies for acromegaly. In this retrospective longitudinal monocentre study, we investigated the outcome of skeletal fragility in patients treated with Pasireotide Lar in combination with Pegvisomant (Pasi-Lar + Peg-V), also comparing those observed in patients treated with conventional therapies...
June 2024: Pituitary
https://read.qxmd.com/read/38499816/prolactin-secreting-tumors-dopamine-agonists-and-pregnancy-a-longitudinal-experience-of-a-tertiary-neuroendocrine-center
#24
JOURNAL ARTICLE
Nunzia Prencipe, Chiara Bona, Daniela Cuboni, Alessandro Maria Berton, Fabio Bioletto, Emanuele Varaldo, Luigi Simone Aversa, Michela Sibilla, Valentina Gasco, Ezio Ghigo, Silvia Grottoli
PURPOSE: Prolactin (PRL)-secreting tumours are associated with infertility and can be reverted by dopamine agonist (DA) therapy. The suspension of DA is recommended once pregnancy is established, as all DAs cross the placenta. The aim of the study was to evaluate the rate of maternal-foetal complications in women treated with cabergoline (CAB) or bromocriptine (BRM) for prolactinoma during gestation and the effect of pregnancy on prolactinoma progression. METHODS: This was a retrospective observational study involving 43 women affected by prolactinoma who became pregnant during therapy with CAB or BRM for a total of 58 pregnancies...
June 2024: Pituitary
https://read.qxmd.com/read/38270722/successful-treatment-of-medically-and-surgically-refractory-lymphocytic-hypophysitis-with-fractionated-stereotactic-radiotherapy-a-single-center-experience-and-systematic-literature-review
#25
JOURNAL ARTICLE
Mehdi Khaleghi, Guilherme Finger, Kyle C Wu, Vikas Munjal, Luma Ghalib, Peter Kobalka, Dukagjin Blakaj, Khaled Dibs, Ricardo Carrau, Daniel Prevedello
PURPOSE: To explore the potential role of focused radiotherapy in managing the lymphocytic hypophysitis (LH) refractory to medical therapy and surgery. METHOD: A systematic literature review was conducted following PRISMA guidelines to identify the studies on radiation treatment for hypophysitis, along with the experience in our institution. RESULTS: The study included eight patients, three from our institution and five from existing literature...
April 2024: Pituitary
https://read.qxmd.com/read/38183582/current-status-of-artificial-intelligence-technologies-in-pituitary-adenoma-surgery-a-scoping-review
#26
REVIEW
Seyed Farzad Maroufi, Yücel Doğruel, Ahmad Pour-Rashidi, Gurkirat S Kohli, Colson Tomberlin Parker, Tatsuya Uchida, Mohamed Z Asfour, Clara Martin, Mariagrazia Nizzola, Alessandro De Bonis, Mamdouh Tawfik-Helika, Amin Tavallai, Aaron A Cohen-Gadol, Paolo Palmisciano
PURPOSE: Pituitary adenoma surgery is a complex procedure due to critical adjacent neurovascular structures, variations in size and extensions of the lesions, and potential hormonal imbalances. The integration of artificial intelligence (AI) and machine learning (ML) has demonstrated considerable potential in assisting neurosurgeons in decision-making, optimizing surgical outcomes, and providing real-time feedback. This scoping review comprehensively summarizes the current status of AI/ML technologies in pituitary adenoma surgery, highlighting their strengths and limitations...
April 2024: Pituitary
https://read.qxmd.com/read/38159126/acromegaly-increases-depressive-symptoms-and-reduces-quality-of-life-of-cohabitants
#27
JOURNAL ARTICLE
Serhat Uysal, Cem Sulu, Zehra Kara, Ilker Ihtiyaroglu, Irem Ozkal, Serdar Sahin, Sabriye Sibel Taze, Mehmet Murat Kirpinar, Senol Turan, Pinar Kadioglu
PURPOSE: To assess how living with patients with acromegaly affects people's psychology and quality of life (QoL). METHODS: Acromegaly patients and their cohabitants included in this study. Patients were administered Acromegaly Quality of Life Questionnaire (AcroQoL), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). Cohabitants were administered quality of life questionnaire (SF-36), BAI, BDI, and Zarit Caregiver Burden Interview (ZBI). RESULTS: This study included 84 patients with acromegaly and 84 cohabitants...
April 2024: Pituitary
https://read.qxmd.com/read/38483762/pituitary-tumours-without-distinct-lineage-differentiation-express-stem-cell-marker-sox2
#28
JOURNAL ARTICLE
Nèle F Lenders, Tanya J Thompson, Jeanie Chui, Julia Low, Warrick J Inder, Peter E Earls, Ann I McCormack
CONTEXT: The recent WHO 2022 Classification of pituitary tumours identified a novel group of 'plurihormonal tumours without distinct lineage differentiation (WDLD)'. By definition, these express multiple combinations of lineage commitment transcription factors, in a monomorphous population of cells. OBJECTIVES: To determine the expression of stem cell markers (SOX2, Nestin, CD133) within tumours WDLD, immature PIT-1 lineage and acidophil stem cell tumours, compared with committed cell lineage tumours...
March 14, 2024: Pituitary
https://read.qxmd.com/read/38478212/correction-impulse-control-disorders-in-patients-with-dopamine-agonist-treated-pituitary-adenomas-a-cross-sectional-multicenter-study
#29
Mussa H Almalki, Moayad A Alsuraikh, Eyad Almalki, Faisal Aziz, Raya Almazrouei, Khaled M AlDahmani, Fahad Alshahrani, Meshal Alaqeel, Moeber Mahzari, Aishah Ekhzaimy
No abstract text is available yet for this article.
March 13, 2024: Pituitary
https://read.qxmd.com/read/38381238/glucose-intolerance-in-acromegaly-is-driven-by-low-insulin-secretion-results-from-an-intravenous-glucose-tolerance-test
#30
JOURNAL ARTICLE
Laura Georgiana Zaifu, Dan Alexandru Niculescu, Andreea Elena Kremer, Andra Caragheorgheopol, Mariana Sava, Carmen Nicoleta Iordachescu, Roxana Dusceac, Iulia Florentina Burcea, Catalina Poiana
PURPOSE: Insulin sensitivity (Si ) and its role in glucose intolerance of acromegaly has been extensively evaluated. However, data on insulin secretion is limited. We aimed to assess stimulated insulin secretion using an intravenous glucose tolerance test (IVGTT) in active acromegaly. METHODS: We performed an IVGTT in 25 patients with active acromegaly (13 normal glucose tolerance [NGT], 6 impaired glucose tolerance [IGT] and 6 diabetes mellitus [DM]) and 23 controls (8 lean NGT, 8 obese NGT and 7 obese IGT)...
February 21, 2024: Pituitary
https://read.qxmd.com/read/38345720/elevated-risk-of-recurrence-and-retreatment-for-silent-pituitary-adenomas
#31
JOURNAL ARTICLE
Saksham Gupta, Samantha E Hoffman, Neel H Mehta, Blake Hauser, Marcelle Altshuler, Joshua D Bernstock, Timothy R Smith, Omar Arnaout, Edward R Laws
PURPOSE: Pituitary adenomas are the most common tumor of the pituitary gland and comprise nearly 15% of all intracranial masses. These tumors are stratified into functional or silent categories based on their pattern of hormone expression and secretion. Preliminary evidence supports differential clinical outcomes between some functional pituitary adenoma (FPA) subtypes and silent pituitary adenoma (SPA) subtypes. METHODS: We collected and analyzed the medical records of all patients undergoing resection of SPAs or FPAs from a single high-volume neurosurgeon between 2007 and 2018 at Brigham and Women's Hospital...
February 12, 2024: Pituitary
https://read.qxmd.com/read/38345719/impulse-control-disorders-in-patients-with-dopamine-agonist-treated-pituitary-adenomas-a-cross-sectional-multicenter-study
#32
JOURNAL ARTICLE
Mussa H Almalki, Moayad A Alsuraikh, Eyad Almalki, Faisal Aziz, Raya Almazrouei, Khaled M AlDahmani, Fahad Alshahrani, Meshal Alaqeel, Moeber Mahzari, Aishah Ekhzaimy
BACKGROUND: Impulse control disorders (ICDs) have been described as underrecognized side effects of dopamine agonists (DAs) in neurological disorders but are not sufficiently understood in endocrine conditions. OBJECTIVE: To identify the prevalence of DAs induced ICDs and determine potential risk factors related to these disorders in patients with prolactinoma and non-function pituitary adenomas (NFPAs). METHODS: This is a cross-sectional multicenter study involving 200 patients with prolactinoma and NFPAs, who received follow-ups in tertiary referral centers...
February 12, 2024: Pituitary
https://read.qxmd.com/read/38315244/different-patient-versus-provider-perspectives-on-living-with-cushing-s-disease
#33
JOURNAL ARTICLE
Amanda Halstrom, I-Hsin Lin, Andrew Lin, Marc Cohen, Viviane Tabar, Eliza B Geer
CONTEXT: Patients with Cushing's disease (CD) face challenges living with and receiving appropriate care for this rare, chronic condition. Even with successful treatment, many patients experience ongoing symptoms and impaired quality of life (QoL). Different perspectives and expectations between patients and healthcare providers (HCPs) may also impair well-being. OBJECTIVE: To examine differences in perspectives on living with CD between patients and HCPs, and to compare care goals and unmet needs...
February 5, 2024: Pituitary
https://read.qxmd.com/read/38151529/idiopathic-isolated-adrenocorticotropic-hormone-deficiency-a-systematic-review-of-a-heterogeneous-and-underreported-disease
#34
REVIEW
E Van Mieghem, C De Block, C De Herdt
Isolated adrenocorticotropic hormone deficiency (IAD) is considered to be a rare disease. Due to the nonspecific clinical presentation, precise data on the prevalence and incidence are lacking. In this systematic review, we aimed to analyse the clinical characteristics, association with autoimmune diseases, and management of acquired idiopathic IAD cases. A structured search was conducted after developing a search strategy combining terms for acquired (idiopathic) IAD. Articles describing an adult case with a diagnosis of ACTH deficiency using dynamic testing, no deficiency of other pituitary axes, and MRI of the brain/pituitary protocolled as normal, were included...
February 2024: Pituitary
https://read.qxmd.com/read/38150169/pituitary-apoplexy-score-toward-standardized-decision-making-a-descriptive-study
#35
JOURNAL ARTICLE
Henri Salle, Mathilde Cane, Maxime Rocher, Emilie Auditeau, Marie-Pierre Teissier, Gerald Raverot, Laurence Salle
Pituitary apoplexy (PA), a rare and life-threatening complication of pituitary adenomas, prompts urgent glucocorticoid administration. The optimal surgical approach is debated, and the Pituitary Apoplexy Score (PAS) aids decision-making. Our retrospective study (2003-2022) assesses variables in PA patient groups (surgical vs. non-surgical), applying PAS to establish a significant threshold for surgical decisions. Additionally, we aim to compare the rates of ophthalmological and endocrine deficit between both groups and identify any associated variables...
February 2024: Pituitary
https://read.qxmd.com/read/38064148/cabergoline-treatment-for-surgery-na%C3%A3-ve-non-functioning-pituitary-macroadenomas
#36
JOURNAL ARTICLE
Irit Ayalon-Dangur, Adi Turjeman, Dania Hirsch, Eyal Robenshtok, Gloria Tsvetov, Alexander Gorshtein, Hiba Masri, Ilana Shraga-Slutzky, Yossi Manisterski, Amit Akirov, Ilan Shimon
PURPOSE: The treatment strategy of non-functioning pituitary adenomas (NFPAs) includes surgery, radiotherapy, medical therapy, or observation without intervention. Cabergoline, a dopaminergic agonist, was suggested for the treatment of NFPA remnants after trans-sphenoidal surgery. This study investigates the efficacy of cabergoline in surgery-naive patients with NFPA. METHODS: Retrospective cohort study including surgery-naive patients with NFPA ≥ 10 mm, treated with cabergoline at a dose of ≥ 1 mg/week for at least 24 months...
February 2024: Pituitary
https://read.qxmd.com/read/38052967/correction-consensus-on-criteria-for-acromegaly-diagnosis-and-remission
#37
Andrea Giustina, Nienke Biermasz, Felipe F Casanueva, Maria Fleseriu, Pietro Mortini, Christian Strasburger, A J van der Lely, John Wass, Shlomo Melmed
No abstract text is available yet for this article.
February 2024: Pituitary
https://read.qxmd.com/read/38006472/incidence-of-postoperative-hyponatremia-after-endoscopic-endonasal-pituitary-transposition-for-skull-base-pathologies
#38
JOURNAL ARTICLE
Francesca Galbiati, Sharini Venugopal, Hussam Abou-Al-Shaar, Georgios A Zenonos, Paul A Gardner, Pouneh K Fazeli, Hussain Mahmud
PURPOSE: Pituitary transposition is a novel surgical approach to access the retroinfundibular space and interpeduncular cistern. Few studies have evaluated post-surgical outcomes, including incidence of hyponatremia, following pituitary transposition. METHODS: This is a retrospective study including 72 patients who underwent endoscopic endonasal surgery involving pituitary transposition for non-pituitary derived tumors over a decade at the University of Pittsburgh Medical Center...
February 2024: Pituitary
https://read.qxmd.com/read/38296897/pituitary-hypophysitis-in-granulomatosis-with-polyangiitis-gpa-a-case-series
#39
JOURNAL ARTICLE
Majid Alameri, Abdulla Alnuaimi, Niamh M Martin, Karim Meeran, Anastasia Gontsarova, Tara D Barwick, Spencer Ellis, Stephen McAdoo, James Tomlinson, Florian Wernig
Granulomatosis with polyangiitis (GPA) rarely involves the pituitary gland. Pituitary involvement has been reported in ~ 1% of all cases of GPA. Most commonly, pituitary swelling and inflammation results in symptoms due to pituitary mass effect and arginine vasopressin deficiency. To date, there are no pituitary-specific treatment guidelines for this rare condition. We present three patients with GPA-related hypophysitis highlighting the spectrum of pituitary involvement. All three patients were successfully treated with immunosuppressive regimens that included rituximab (RTX)...
January 31, 2024: Pituitary
https://read.qxmd.com/read/38273189/diffusion-weighted-imaging-does-not-seem-to-be-a-predictor-of-consistency-in-pituitary-adenomas
#40
JOURNAL ARTICLE
Monique Alvares Barbosa, Eduardo Giardini Rodovalhe Pereira, Paulo José da Mata Pereira, André Accioly Guasti, Felipe Andreiuolo, Leila Chimelli, Leandro Kasuki, Nina Ventura, Monica R Gadelha
PURPOSE: To prospectively evaluate the usefulness of T1-weighted imaging (T1WI) and diffusion-weighted imaging (DWI) sequences in predicting the consistency of macroadenomas. In addition, to determine their values ​​as prognostic factors of surgical outcomes. METHODS: Patients with pituitary macroadenoma and surgical indication were included. All patients underwent pre-surgical magnetic resonance imaging (MRI) that included the sequences T1WI before and after contrast administration and DWI with the apparent diffusion coefficient (ADC) map...
January 25, 2024: Pituitary
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