Federico G Baudou, Nancy L Charó, Marco A Scheidegger, Juan C Stupirski, Juan M Pérez Sáez, María F Troncoso, Mora Massaro, Adolfo R de Roodt, Mauricio C De Marzi, Mirta Schattner, Gabriel A Rabinovich
Snake venoms are intricate mixtures of enzymes and bioactive factors that induce a range of detrimental effects in afflicted hosts. Certain Viperids, including Bothrops jararacussu, harbor C-type lectins (CTLs) known for their modulation of a variety of host cellular responses. In this study, we isolated and purified BjcuL, a CTL from B. jararacussu venom and investigated its impact on endothelial cell behavior, contrasting it with human galectin-1 (Gal-1), a prototype member of the galectin family with shared β-galactoside-binding activity...
June 15, 2024: Angiogenesis
Jie Yin, Gabriel Forn-Cuní, Akshaya Mahalakshmi Surendran, Bruno Lopes-Bastos, Niki Pouliopoulou, Martine J Jager, Sylvia E Le Dévédec, Quanchi Chen, B Ewa Snaar-Jagalska
Conjunctival melanoma (CoM) is a rare but potentially lethal cancer of the eye, with limited therapeutic option for metastases. A better understanding how primary CoM disseminate to form metastases is urgently needed in order to develop novel therapies. Previous studies indicated that primary CoM tumors express Vascular Endothelial Growth Factor (VEGF) and may recruit pro-tumorigenic M2-like macrophages. However, due to a lack of proper models, the expected role of angiogenesis in the metastatic dissemination of CoM is still unknown...
June 6, 2024: Angiogenesis
M Zohaib Iqbal, Mahrukh Riaz, Thomas Biedermann, Agnes S Klar
Tissue-engineered skin substitutes (TESS) emerged as a new therapeutic option to improve skin transplantation. However, establishing an adequate and rapid vascularization in TESS is a critical factor for their clinical application and successful engraftment in patients. Therefore, several methods have been applied to improve the vascularization of skin substitutes including (i) modifying the structural and physicochemical properties of dermal scaffolds; (ii) activating biological scaffolds with growth factor-releasing systems or gene vectors; and (iii) developing prevascularized skin substitutes by loading scaffolds with capillary-forming cells...
June 6, 2024: Angiogenesis
Ziqing Liu, Natalie T Tanke, Alexandra Neal, Tianji Yu, Tershona Branch, Arya Sharma, Jean G Cook, Victoria L Bautch
Cell cycle regulation is critical to blood vessel formation and function, but how the endothelial cell cycle integrates with vascular regulation is not well-understood, and available dynamic cell cycle reporters do not precisely distinguish all cell cycle stage transitions in vivo. Here we characterized a recently developed improved cell cycle reporter (PIP-FUCCI) that precisely delineates S phase and the S/G2 transition. Live image analysis of primary endothelial cells revealed predicted temporal changes and well-defined stage transitions...
May 25, 2024: Angiogenesis
Timo Rademakers, Marco Manca, Han Jin, Tanguy Orban, Ljubica Matic Perisic, Hubertus J M Frissen, Frank Rühle, Petra Hautvast, Jos van Rijssel, Kim van Kuijk, Barend M E Mees, Carine J Peutz-Kootstra, Sylvia Heeneman, Mat J A P Daemen, Gerard Pasterkamp, Monika Stoll, Marc A M J van Zandvoort, Ulf Hedin, Franck Dequiedt, Jaap D van Buul, Judith C Sluimer, Erik A L Biessen
The presence of atherosclerotic plaque vessels is a critical factor in plaque destabilization. This may be attributable to the leaky phenotype of these microvessels, although direct proof for this notion is lacking. In this study, we investigated molecular and cellular patterns of stable and hemorrhaged human plaque to identify novel drivers of intraplaque vessel dysfunction. From transcriptome data of a human atherosclerotic lesion cohort, we reconstructed a co-expression network, identifying a gene module strongly and selectively correlated with both plaque microvascular density and inflammation...
May 23, 2024: Angiogenesis
Qasim A Majid, Bishwa R Ghimire, Bela Merkely, Anna M Randi, Sian E Harding, Virpi Talman, Gábor Földes
Coronary microvascular disease (CMD) and its progression towards major adverse coronary events pose a significant health challenge. Accurate in vitro investigation of CMD requires a robust cell model that faithfully represents the cells within the cardiac microvasculature. Human pluripotent stem cell-derived endothelial cells (hPSC-ECs) offer great potential; however, they are traditionally derived via differentiation protocols that are not readily scalable and are not specified towards the microvasculature...
May 22, 2024: Angiogenesis
Bojana Lazovic, Hoang-Tuan Nguyen, Mohammadhassan Ansarizadeh, Leif Wigge, Franziska Kohl, Songyuan Li, Miguel Carracedo, Jere Kettunen, Luc Krimpenfort, Ramy Elgendy, Kati Richter, Laknee De Silva, Bilada Bilican, Prateek Singh, Pratik Saxena, Xuechong Hong, Lauri Eklund, Ryan Hicks
Induced pluripotent stem cell (iPSC) derived endothelial cells (iECs) have emerged as a promising tool for studying vascular biology and providing a platform for modelling various vascular diseases, including those with genetic origins. Currently, primary ECs are the main source for disease modelling in this field. However, they are difficult to edit and have a limited lifespan. To study the effects of targeted mutations on an endogenous level, we generated and characterized an iPSC derived model for venous malformations (VMs)...
May 21, 2024: Angiogenesis
Ting-Ting Chang, Liang-Yu Lin, Ching Chen, Jaw-Wen Chen
Aging is a natural process associated with chronic inflammation in the development of vascular dysfunction. We hypothesized that chemokine C-C motif ligands 4 (CCL4) might play a vital role in aging-related vascular dysfunction. Circulating CCL4 was up-regulated in elderly subjects and in aged animals. CCL4 inhibition reduced generation of reactive oxygen species (ROS), attenuated inflammation, and restored cell functions in endothelial progenitor cells from elderly subjects and in aged human aortic endothelial cells...
May 13, 2024: Angiogenesis
Jilai Zhao, Laura Sormani, Sebastien Jacquelin, Haiming Li, Cassandra Styke, Chenhao Zhou, Jonathan Beesley, Linus Oon, Simranpreet Kaur, Seen-Ling Sim, Ho Yi Wong, James Dight, Ghazaleh Hashemi, Abbas Shafiee, Edwige Roy, Jatin Patel, Kiarash Khosrotehrani
Regenerative capabilities of the endothelium rely on vessel-resident progenitors termed endothelial colony forming cells (ECFCs). This study aimed to investigate if these progenitors are impacted by conditions (i.e., obesity or atherosclerosis) characterized by increased serum levels of oxidized low-density lipoprotein (oxLDL), a known inducer of Endothelial-to-Mesenchymal Transition (EndMT). Our investigation focused on understanding the effects of EndMT on the self-renewal capabilities of progenitors and the associated molecular alterations...
May 11, 2024: Angiogenesis
Anthony R Anzell, Amy B Kunz, James P Donovan, Thanhlong G Tran, Xinyan Lu, Sarah Young, Beth L Roman
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease characterized by the development of arteriovenous malformations (AVMs) that can result in significant morbidity and mortality. HHT is caused primarily by mutations in bone morphogenetic protein receptors ACVRL1/ALK1, a signaling receptor, or endoglin (ENG), an accessory receptor. Because overexpression of Acvrl1 prevents AVM development in both Acvrl1 and Eng null mice, enhancing ACVRL1 expression may be a promising approach to development of targeted therapies for HHT...
May 10, 2024: Angiogenesis
Huijun Yuan, Shaoyi Chen, Matthew R Duncan, Juan Pablo de Rivero Vaccari, Robert W Keane, W Dalton Dietrich, Tsung-Han Chou, Merline Benny, Augusto F Schmidt, Karen Young, Kevin K Park, Vittorio Porciatti, M Elizabeth Hartnett, Shu Wu
BACKGROUND: Retinopathy of prematurity (ROP), which often presents with bronchopulmonary dysplasia (BPD), is among the most common morbidities affecting extremely premature infants and is a leading cause of severe vision impairment in children worldwide. Activations of the inflammasome cascade and microglia have been implicated in playing a role in the development of both ROP and BPD. Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is pivotal in inflammasome assembly...
May 6, 2024: Angiogenesis
Gideon Obasanmi, Manjosh Uppal, Jing Z Cui, Jeanne Xi, Myeong Jin Ju, Jun Song, Eleanor To, Siqi Li, Wania Khan, Darian Cheng, John Zhu, Lyden Irani, Isa Samad, Julie Zhu, Hyung-Suk Yoo, Alexandre Aubert, Jonathan Stoddard, Martha Neuringer, David J Granville, Joanne A Matsubara
No abstract text is available yet for this article.
May 3, 2024: Angiogenesis
Tianqi Tu, Jiaxing Yu, Chendan Jiang, Shikun Zhang, Jingwei Li, Jian Ren, Shiju Zhang, Yuan Zhou, Ziwei Cui, Haohan Lu, Xiaosheng Meng, Zhanjing Wang, Dong Xing, Hongqi Zhang, Tao Hong
Current treatments of brain arteriovenous malformation (BAVM) are associated with considerable risks and at times incomplete efficacy. Therefore, a clinically consistent animal model of BAVM is urgently needed to investigate its underlying biological mechanisms and develop innovative treatment strategies. Notably, existing mouse models have limited utility due to heterogenous and untypical phenotypes of AVM lesions. Here we developed a novel mouse model of sporadic BAVM that is consistent with clinical manifestations in humans...
May 3, 2024: Angiogenesis
T Kuchler, C Schmaderer
No abstract text is available yet for this article.
May 3, 2024: Angiogenesis
Qian Yang, Cai Yun Xia, Ying Cai, Yan Fang Zhang, Dao Ting Li, Shu Qi Wu, Peng Hu
No abstract text is available yet for this article.
April 24, 2024: Angiogenesis
Carolin Christina Drost, Alexandros Rovas, Irina Osiaevi, Klaus Schughart, Alexander Lukasz, Wolfgang A Linke, Hermann Pavenstädt, Philipp Kümpers
Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ damage during systemic inflammation. However, the specific signalling pathways for eGC damage remain poorly defined. Aim of this study was to combine sublingual video-microscopy, plasma proteomics and live cell imaging to uncover further pathways of eGC damage in patients with coronavirus disease 2019 (COVID-19) or bacterial sepsis. This secondary analysis of the prospective multicenter MICROCODE study included 22 patients with COVID-19 and 43 patients with bacterial sepsis admitted to intermediate or intensive care units and 10 healthy controls...
April 10, 2024: Angiogenesis
Fan Yang, Gloria Lee, Yi Fan
Sustained angiogenesis stands as a hallmark of cancer. The intricate vascular tumor microenvironment fuels cancer progression and metastasis, fosters therapy resistance, and facilitates immune evasion. Therapeutic strategies targeting tumor vasculature have emerged as transformative for cancer treatment, encompassing anti-angiogenesis, vessel normalization, and endothelial reprogramming. Growing evidence suggests the dynamic regulation of tumor angiogenesis by infiltrating myeloid cells, such as macrophages, myeloid-derived suppressor cells (MDSCs), and neutrophils...
April 6, 2024: Angiogenesis
Maximilian Ackermann, Christopher Werlein, Edith Plucinski, Sophie Leypold, Mark P Kühnel, Stijn E Verleden, Hassan A Khalil, Florian Länger, Tobias Welte, Steven J Mentzer, Danny D Jonigk
In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension, IPF or lung cancer. The contribution of blood vessels and angiogenesis to lung regeneration, remodeling and disease progression has been increasingly appreciated. The vascular supply of the lung shows the peculiarity of dual perfusion of the pulmonary circulation (vasa publica), which maintains a functional blood-gas barrier, and the bronchial circulation (vasa privata), which reveals a profiled capacity for angiogenesis (namely intussusceptive and sprouting angiogenesis) and alveolar-vascular remodeling by the recruitment of endothelial precursor cells...
April 5, 2024: Angiogenesis
Aiyan Hu, Mirko H H Schmidt, Nora Heinig
Diabetic retinopathy has a high probability of causing visual impairment or blindness throughout the disease progression and is characterized by the growth of new blood vessels in the retina at an advanced, proliferative stage. Microglia are a resident immune population in the central nervous system, known to play a crucial role in regulating retinal angiogenesis in both physiological and pathological conditions, including diabetic retinopathy. Physiologically, they are located close to blood vessels and are essential for forming new blood vessels (neovascularization)...
April 2, 2024: Angiogenesis
Anita Senk, Jennifer Fazzari, Valentin Djonov
Vascular mimicry has been thoroughly investigated in tumor angiogenesis. In this study, we demonstrate for the first time that a process closely resembling tumor vascular mimicry is present during physiological blood vessel formation in tissue regeneration using the zebrafish fin regeneration assay. At the fin-regenerating front, vasculature is formed by mosaic blood vessels with endothelial-like cells possessing the morphological phenotype of a macrophage and co-expressing both endothelial and macrophage markers within single cells...
March 28, 2024: Angiogenesis
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