David M Smadja, Coralie L Guerin, Richard Chocron, Nader Yatim, Jeremy Boussier, Nicolas Gendron, Lina Khider, Jérôme Hadjadj, Guillaume Goudot, Benjamin Debuc, Philippe Juvin, Caroline Hauw-Berlemont, Jean-Loup Augy, Nicolas Peron, Emmanuel Messas, Benjamin Planquette, Olivier Sanchez, Bruno Charbit, Pascale Gaussem, Darragh Duffy, Benjamin Terrier, Tristan Mirault, Jean-Luc Diehl
BACKGROUND: Coronavirus disease-2019 (COVID-19), a respiratory disease has been associated with ischemic complications, coagulation disorders, and an endotheliitis. OBJECTIVES: To explore endothelial damage and activation-related biomarkers in COVID-19 patients with criteria of hospitalization for referral to intensive care unit (ICU) and/or respiratory worsening. METHODS: Analysis of endothelial and angiogenic soluble markers in plasma from patients at admission...
May 27, 2020: Angiogenesis
Lei Jiang, Nailin Li
Angiogenesis is critical for the initiation and progression of solid tumors, as well as hematological malignancies. While angiogenesis in solid tumors has been well characterized, a large body of investigation is devoted to clarify the impact of angiogenesis on lymphoma development. B-cell non-Hodgkin lymphoma (B-NHL) is the most common lymphoid malignancy with a highly heterogeneity. The malignancy remains incurable despite that the addition of rituximab to conventional chemotherapies provides substantial improvements...
May 25, 2020: Angiogenesis
Dirk Bausch, Stefan Fritz, Louisa Bolm, Ulrich F Wellner, Carlos Fernandez-Del-Castillo, Andrew L Warshaw, Sarah P Thayer, Andrew S Liss
INTRODUCTION: The inhibition of Hedgehog (Hh) signaling in pancreatic ductal adenocarcinoma (PDAC) reduces desmoplasia and promotes increased vascularity. In contrast to these findings, the Hh ligand Sonic Hedgehog (SHH) is a potent proangiogenic factor in non-tumor models. The aim of this study was to determine the molecular mechanisms by which SHH affects the tumor stroma and angiogenesis. METHODS: Mice bearing three different xenografted human PDAC (n = 5/group) were treated with neutralizing antibodies to SHH...
May 22, 2020: Angiogenesis
Qi Zhao, Maria Del Pilar Molina-Portela, Asma Parveen, Alexander Adler, Christina Adler, Hock E, Wei Wang, Min Ni, Yi Wei, Gurinder Atwal, Markus Mohrs, Gavin Thurston, Alexandra Eichten
The liver is a common host organ for cancer, either through lesions that arise in liver epithelial cells [e.g., hepatocellular carcinoma (HCC)] or as a site of metastasis by tumors arising in other organs (e.g., colorectal cancer). However, the changes that occur in liver stromal cells in response to cancer have not been fully characterized, nor has it been determined whether the different sources of liver cancer induce distinct stromal changes. Here, we performed single-cell profiling of liver stromal cells from mouse models of induced spontaneous liver cancer or implanted colorectal liver metastases, with a focus on tumor endothelial cells (ECs)...
May 21, 2020: Angiogenesis
Nils Ludwig, Saigopalakrishna S Yerneni, Juliana H Azambuja, Delbert G Gillespie, Elizabeth V Menshikova, Edwin K Jackson, Theresa L Whiteside
RATIONALE: One hallmark of tumor-derived exosomes (TEX) is the promotion of cancer progression by stimulating angiogenesis. This study was performed to evaluate the role of adenosine receptors in TEX-induced angiogenesis. METHODS: TEX produced by UMSCC47 head and neck cancer cell line were isolated by mini size exclusion chromatography (mini-SEC). Enzymatic activity of ectonucleotidases CD39/CD73 carried by TEX was measured by HPLC. Adenosine content of TEX was measured by UPLC-MS/MS...
May 18, 2020: Angiogenesis
Nicole Lustgarten Guahmich, Gregory Farber, Shiva Shafiei, Dylan McNally, David Redmond, Eleni Kallinos, Heidi Stuhlmann, Daniel Dufort, Daylon James, Carl P Blobel
During the initiation of pregnancy, the vasculature of the implantation site expands rapidly, yet little is known about this process or its role in fertility. Here, we report that endothelial-specific deletion of a disintegrin and metalloprotease 10 (ADAM10), an essential regulator of Notch signaling, results in severe subfertility in mice. We found that implantation sites develop until 5.5 days post conception (dpc) but are resorbed by 6.5 dpc in A10ΔEC mice. Analysis of the mutant implantation sites showed impaired decidualization and abnormal vascular patterning compared to controls...
May 8, 2020: Angiogenesis
Samuel M Santosa, Kai Guo, Michael Yamakawa, Evguenia Ivakhnitskaia, Neeraj Chawla, Tara Nguyen, Kyu-Yeon Han, Masatsugu Ema, Mark I Rosenblatt, Jin-Hong Chang, Dimitri T Azar
Blood vessels and nerve tissues are critical to the development and functionality of many vital organs. However, little is currently known about their interdependency during development and after injury. In this study, dual fluorescence transgenic reporter mice were utilized to observe blood vessels and nervous tissues in organs postnatally. Thy1-YFP and Flt1-DsRed (TYFD) mice were interbred to achieve dual fluorescence in the offspring, with Thy1-YFP yellow fluorescence expressed primarily in nerves, and Flt1-DsRed fluorescence expressed selectively in blood vessels...
May 5, 2020: Angiogenesis
Timothy D Le Cras, Jillian Goines, Nora Lakes, Patricia Pastura, Adrienne M Hammill, Denise M Adams, Elisa Boscolo
Capillary lymphatic venous malformations (CLVM) are complex vascular anomalies characterized by aberrant and enlarged lymphatic and blood vessels. CLVM appear during fetal development and enlarge after birth, causing life-long complications such as coagulopathy, pulmonary embolism, chronic pain, and disfigurement. Treatment includes surgical debulking, amputation, and recurrent sclerotherapy. Somatic, mosaic mutations in the 110-kD catalytic α-subunit of phosphoinositide-3-kinase (PIK3CA) gene have been previously identified in affected tissues from CLVM patients; however, the cell population harboring the mutation is still unknown...
April 30, 2020: Angiogenesis
Qian-Kun Yang, Tong Chen, Shi-Qi Wang, Xiao-Jing Zhang, Zhong-Xiang Yao
Bone and soft tissue sarcomas are rare malignant tumors originated from mesenchymal tissues. They harbor more than 50 distinct subtypes and differ in pathological features and clinical courses. Despite the significant improvements in modern multi-modality treatment, the outcomes and overall survival rates remain poor for patients with advanced, refractory, metastatic, or relapsed diseases. The growth and metastasis of bone and soft tissue sarcoma largely depend on angiogenesis, and VEGF/VEGFR pathway is considered as the most prominent player in angiogenesis...
April 24, 2020: Angiogenesis
Lothar C Dieterich, Carlotta Tacconi, Franziska Menzi, Steven T Proulx, Kübra Kapaklikaya, Michito Hamada, Satoru Takahashi, Michael Detmar
MAFB is a transcription factor involved in the terminal differentiation of several cell types, including macrophages and keratinocytes. MAFB is also expressed in lymphatic endothelial cells (LECs) and is upregulated by VEGF-C/VEGFR-3 signaling. Recent studies have revealed that MAFB regulates several genes involved in lymphatic differentiation and that global Mafb knockout mice show defects in patterning of lymphatic vessels during embryogenesis. However, it has remained unknown whether this effect is LEC-intrinsic and whether MAFB might also be involved in postnatal lymphangiogenesis...
April 19, 2020: Angiogenesis
Asha L Bayliss, Ananthalakshmy Sundararaman, Camille Granet, Harry Mellor
BACKGROUND: VEGFR2 (vascular endothelial growth factor receptor 2) is the major pro-angiogenic receptor in endothelial cells. Compared to other members of the receptor tyrosine kinase family, we know relatively few VEGFR2 signaling partners. Our objective was to use mass spectrometry-based proteomics to identify novel binding partners of activated VEGFR2. METHODS: We created an endothelial cell line stably expressing GFP-tagged VEGFR2 and isolated activated receptor complexes...
April 9, 2020: Angiogenesis
Jin Wang, Sam Toan, Hao Zhou
As reperfusion therapies have become more widely used in acute myocardial infarction patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion-induced cardiac injury has become increasingly evident. The features of cardiac ischemia-reperfusion (I/R) injury include microvascular perfusion defects, platelet activation and sequential cardiomyocyte death due to additional ischemic events at the reperfusion stage. Microvascular obstruction, defined as a no-reflow phenomenon, determines the infarct zone, myocardial function and peri-operative mortality...
April 3, 2020: Angiogenesis
Muhammad Torequl Islam
Anti-angiogenesis effect of ascorbic acid (AA) is still controversial. However, most of the scientific evidence suggests that AA has anti-angiogenesis effects on a number of test systems, including laboratory animals, human beings, and their derived cell lines. The information provided in this paper suggests that AA may be a hopeful angiostatic agent for the treatment of cancer.
April 2, 2020: Angiogenesis
Shuji Nakamoto, Yoshiya Ito, Nobuyuki Nishizawa, Takuya Goto, Ken Kojo, Yusuke Kumamoto, Masahiko Watanabe, Masataka Majima
Hepatic tissue repair plays a critical role in determining the outcome of hepatic ischemia-reperfusion (I/R) injury. Hepatic lymphatics participate in the clearance of dead tissues and contribute to the reparative process after acute hepatic injury; however, it remains unknown whether lymphangiogenesis in response to hepatic inflammation is involved in liver repair. Herein, we determined if hepatic lymphangiogenesis improves liver repair after hepatic I/R injury. Using a mouse model of hepatic I/R injury, we investigated hepatic lymphatic structure, growth, and function in injured murine livers...
March 11, 2020: Angiogenesis
Hua Zhou, Nada O Binmadi, Ying-Hua Yang, Patrizia Proia, John R Basile
The Editors-in-Chief have retracted this article [1] following an investigation by the University of Maryland. The institution found that in Figures 1B and 1D, the cell lines are different and all published histograms show SEMA4D mRNA level whereas Excel data have two histograms showing SEMA4D expression and two histograms showing VEGF expression. In Figure 2B, the metadata for one image shows different treatment conditions than those reported in the article. The published image labelled "VEGF + VEGFR-2 shRNA" has a metadata label of S4d-plexinB1 shRNA2"...
March 10, 2020: Angiogenesis
Mohd I Nawaz, Sara Rezzola, Chiara Tobia, Daniela Coltrini, Mirella Belleri, Stefania Mitola, Michela Corsini, Annamaria Sandomenico, Andrea Caporale, Menotti Ruvo, Marco Presta
N-formyl peptide receptors (FPRs) are G protein-coupled receptors involved in the recruitment and activation of immune cells in response to pathogen-associated molecular patterns. Three FPRs have been identified in humans (FPR1-FPR3), characterized by different ligand properties, biological function and cellular distribution. Recent findings from our laboratory have shown that the peptide BOC-FLFLF (L-BOC2), related to the FPR antagonist BOC2, acts as an angiogenesis inhibitor by binding to various angiogenic growth factors, including vascular endothelial growth factor-A165 (VEGF)...
March 9, 2020: Angiogenesis
Yohei Tomita, Bertan Cakir, Chi-Hsiu Liu, Zhongjie Fu, Shuo Huang, Steve S Cho, William R Britton, Ye Sun, Mark Puder, Ann Hellström, Saswata Talukdar, Lois E H Smith
To examine whether free fatty acid receptor 4 (FFAR4) activation can protect against choroidal neovascularization (CNV), which is a common cause of blindness, and to elucidate the mechanism underlying the inhibition, we used the mouse model of laser-induced CNV to mimic angiogenic aspects of age-related macular degeneration (AMD). Laser-induced CNV was compared between groups treated with an FFAR4 agonist or vehicle, and between FFAR4 wild-type (Ffar4+/+ ) and knock out (Ffar4-/- ) mice on a C57BL/6J/6N background...
March 5, 2020: Angiogenesis
D V C de Jel, F J M Disch, S Kroon, J J Mager, F J Verdam
BACKGROUND: Local application of fluorouracil (Efudix, 5-FU) induces sclerosis in patients with sinonasal tumors and superficial basocellular skin carcinoma. As a 'back against the wall' treatment, we investigated the local effect of nasally applied 5-FU and whether this could decrease the burden of severe epistaxis in patients with hereditary hemorrhagic telangiectasia (HHT). METHODS: HHT patients with severe and frequent epistaxis, subsequent anemia and a necessity for blood and/or iron infusions were treated with a nasal tampon with 5-FU...
February 28, 2020: Angiogenesis
Eun-Hye Moon, Yong Hwan Kim, Phuong-Nhung Vu, Hyunjin Yoo, Kwonho Hong, Young Jae Lee, S Paul Oh
BACKGROUND: TMEM100 is identified as a downstream gene of bone morphogenetic protein 9 (BMP9) signaling via activin receptor-like kinase 1 (ALK1), which is known to participate in lymphangiogenesis as well as angiogenesis. TMEM100 has been shown to be important for blood vessel formation and maintenance, but its role in the development of lymphatic vasculature remains unknown. The objective is to investigate the role of TMEM100 in development of the lymphatic system. METHODS AND RESULTS: Global Tmem100 gene deletion was induced by tamoxifen on 10...
February 28, 2020: Angiogenesis
Hua Zhou, Ying-Hua Yang, John R Basile
The Editors-in-Chief have retracted this article [1] following an investigation by the University of Maryland. The institution found that in Figure 1C, the graph showing PDGF-B does not match the original data for the 24-hour time point. The graph shows the value to be over 1000 pg/ml, but the original data have a value of 106.626. In Figure 1F, the data were entered manually to create the standard deviation bars. The data manually entered do not match the original data. When the standard deviations for the original data were calculated, the p values were no longer significant using a paired student t test...
February 26, 2020: Angiogenesis
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