journal
https://read.qxmd.com/read/33909153/the-role-of-redox-system-in-metastasis-formation
#1
REVIEW
Chiara Cencioni, Valentina Comunanza, Emanuele Middonti, Edoardo Vallariello, Federico Bussolino
The metastatic cancer disease represents the real and urgent clinical need in oncology. Therefore, an understanding of the complex molecular mechanisms sustaining the metastatic cascade is critical to advance cancer therapies. Recent studies highlight how redox signaling influences the behavior of metastatic cancer cells, contributes to their travel in bloodstream from the primary tumor to the distant organs and conditions the progression of the micrometastases or their dormant state. Radical oxygen species not only regulate intracellular processes but participate to paracrine circuits by diffusion to nearby cells, thus assuming unpredicted roles in the communication between metastatic cancer cells, blood circulating cells, and stroma cells at site of colonization...
April 28, 2021: Angiogenesis
https://read.qxmd.com/read/33844116/vascular-endothelial-cell-specification-in-health-and-disease
#2
REVIEW
Corina Marziano, Gael Genet, Karen K Hirschi
There are two vascular networks in mammals that coordinately function as the main supply and drainage systems of the body. The blood vasculature carries oxygen, nutrients, circulating cells, and soluble factors to and from every tissue. The lymphatic vasculature maintains interstitial fluid homeostasis, transports hematopoietic cells for immune surveillance, and absorbs fat from the gastrointestinal tract. These vascular systems consist of highly organized networks of specialized vessels including arteries, veins, capillaries, and lymphatic vessels that exhibit different structures and cellular composition enabling distinct functions...
April 12, 2021: Angiogenesis
https://read.qxmd.com/read/33843032/adieu-to-parting-editor-in-chief-and-pioneering-scientist-dr-joyce-bischoff
#3
EDITORIAL
Juan M Melero-Martin, Andrew C Dudley, Arjan W Griffioen
No abstract text is available yet for this article.
April 11, 2021: Angiogenesis
https://read.qxmd.com/read/33825109/mechanisms-and-cell-lineages-in-lymphatic-vascular-development
#4
REVIEW
Daniyal J Jafree, David A Long, Peter J Scambler, Christiana Ruhrberg
Lymphatic vessels have critical roles in both health and disease and their study is a rapidly evolving area of vascular biology. The consensus on how the first lymphatic vessels arise in the developing embryo has recently shifted. Originally, they were thought to solely derive by sprouting from veins. Since then, several studies have uncovered novel cellular mechanisms and a diversity of contributing cell lineages in the formation of organ lymphatic vasculature. Here, we review the key mechanisms and cell lineages contributing to lymphatic development, discuss the advantages and limitations of experimental techniques used for their study and highlight remaining knowledge gaps that require urgent attention...
April 6, 2021: Angiogenesis
https://read.qxmd.com/read/33783643/first-blood-the-endothelial-origins-of-hematopoietic-progenitors
#5
REVIEW
Giovanni Canu, Christiana Ruhrberg
Hematopoiesis in vertebrate embryos occurs in temporally and spatially overlapping waves in close proximity to blood vascular endothelial cells. Initially, yolk sac hematopoiesis produces primitive erythrocytes, megakaryocytes, and macrophages. Thereafter, sequential waves of definitive hematopoiesis arise from yolk sac and intraembryonic hemogenic endothelia through an endothelial-to-hematopoietic transition (EHT). During EHT, the endothelial and hematopoietic transcriptional programs are tightly co-regulated to orchestrate a shift in cell identity...
March 30, 2021: Angiogenesis
https://read.qxmd.com/read/33779885/smad6-transduces-endothelial-cell-flow-responses-required-for-blood-vessel-homeostasis
#6
Dana L Ruter, Ziqing Liu, Kimlynn M Ngo, Shaka X, Allison Marvin, Danielle B Buglak, Elise J Kidder, Victoria L Bautch
Fluid shear stress provided by blood flow instigates a transition from active blood vessel network expansion during development, to vascular homeostasis and quiescence that is important for mature blood vessel function. Here we show that SMAD6 is required for endothelial cell flow-mediated responses leading to maintenance of vascular homeostasis. Concomitant manipulation of the mechanosensor Notch1 pathway and SMAD6 expression levels revealed that SMAD6 functions downstream of ligand-induced Notch signaling and transcription regulation...
March 29, 2021: Angiogenesis
https://read.qxmd.com/read/33770321/depletion-of-arg-abl2-improves-endothelial-cell-adhesion-and-prevents-vascular-leak-during-inflammation
#7
Joana Amado-Azevedo, Anne-Marieke D van Stalborch, Erik T Valent, Kalim Nawaz, Jan van Bezu, Etto C Eringa, Femke P M Hoevenaars, Iris M De Cuyper, Peter L Hordijk, Victor W M van Hinsbergh, Geerten P van Nieuw Amerongen, Jurjan Aman, Coert Margadant
Endothelial barrier disruption and vascular leak importantly contribute to organ dysfunction and mortality during inflammatory conditions like sepsis and acute respiratory distress syndrome. We identified the kinase Arg/Abl2 as a mediator of endothelial barrier disruption, but the role of Arg in endothelial monolayer regulation and its relevance in vivo remain poorly understood. Here we show that depletion of Arg in endothelial cells results in the activation of both RhoA and Rac1, increased cell spreading and elongation, redistribution of integrin-dependent cell-matrix adhesions to the cell periphery, and improved adhesion to the extracellular matrix...
March 26, 2021: Angiogenesis
https://read.qxmd.com/read/33755876/circulating-level-of-angiopoietin-2-is-associated-with-acute-kidney-injury-in-coronavirus-disease-2019-covid-19
#8
LETTER
Brandon Michael Henry, Maria Helena Santos de Oliveira, Isaac Cheruiyot, Justin L Benoit, David S Cooper, Giuseppe Lippi, Timothy D Le Cras, Stefanie W Benoit
No abstract text is available yet for this article.
March 23, 2021: Angiogenesis
https://read.qxmd.com/read/33745018/angiodiversity-and-organotypic-functions-of-sinusoidal-endothelial-cells
#9
REVIEW
Philipp-Sebastian Koch, Ki Hong Lee, Sergij Goerdt, Hellmut G Augustin
'Angiodiversity' refers to the structural and functional heterogeneity of endothelial cells (EC) along the segments of the vascular tree and especially within the microvascular beds of different organs. Organotypically differentiated EC ranging from continuous, barrier-forming endothelium to discontinuous, fenestrated endothelium perform organ-specific functions such as the maintenance of the tightly sealed blood-brain barrier or the clearance of macromolecular waste products from the peripheral blood by liver EC-expressed scavenger receptors...
March 21, 2021: Angiogenesis
https://read.qxmd.com/read/33742265/hydrogel-mediated-delivery-of-microrna-92a-inhibitor-polyplex-nanoparticles-induces-localized-angiogenesis
#10
Fatemeh Radmanesh, Hamid Sadeghi Abandansari, Mohammad Hossein Ghanian, Sara Pahlavan, Fahimeh Varzideh, Saeed Yakhkeshi, Mehdi Alikhani, Sharif Moradi, Thomas Braun, Hossein Baharvand
Localized stimulation of angiogenesis is an attractive strategy to improve the repair of ischemic or injured tissues. Several microRNAs (miRNAs) such as miRNA-92a (miR-92a) have been reported to negatively regulate angiogenesis in ischemic disease. To exploit the clinical potential of miR-92a inhibitors, safe and efficient delivery needs to be established. Here, we used deoxycholic acid-modified polyethylenimine polymeric conjugates (PEI-DA) to deliver a locked nucleic acid (LNA)-based miR-92a inhibitor (LNA-92a) in vitro and in vivo...
March 19, 2021: Angiogenesis
https://read.qxmd.com/read/33730293/phosphorylation-of-pericyte-fak-y861-affects-tumour-cell-apoptosis-and-tumour-blood-vessel-regression
#11
Delphine M Lees, Louise E Reynolds, Ana Rita Pedrosa, Marina Roy-Luzarraga, Kairbaan M Hodivala-Dilke
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that is overexpressed in many cancer types and in vivo studies have shown that vascular endothelial cell FAK expression and FAK-phosphorylation at tyrosine (Y) 397, and subsequently FAK-Y861, are important in tumour angiogenesis. Pericytes also play a vital role in regulating tumour blood vessel stabilisation, but the specific involvement of pericyte FAK-Y397 and FAK-Y861 phosphorylation in tumour blood vessels is unknown. Using PdgfrβCre + ;FAKWT/WT , PdgfrβCre + ;FAKY397F/Y397F and PdgfrβCre + ;FAKY861F/Y861F mice, our data demonstrate that tumour growth, tumour blood vessel density, blood vessel perfusion and pericyte coverage were affected only in late stage tumours in PdgfrβCre + ;FAKY861F/Y861F but not PdgfrβCre + ;FAKY397F/Y397F mice...
March 17, 2021: Angiogenesis
https://read.qxmd.com/read/33677657/the-adaptor-protein-grb2b-is-an-essential-modulator-for-lympho-venous-sprout-formation-in-the-zebrafish-trunk
#12
Cristina Mauri, Andreas van Impel, Eirinn William Mackay, Stefan Schulte-Merker
Vegfc/Vegfr3 signaling is critical for lymphangiogenesis, the sprouting of lymphatic vessels. In zebrafish, cells sprouting from the posterior cardinal vein can either form lymphatic precursor cells or contribute to intersegmental vein formation. Both, the Vegfc-dependent differential induction of Prox1a in sprouting cells as well as a Notch-mediated pre-pattern within intersegmental vessels have been associated with the regulation of secondary sprout behavior. However, how exactly a differential lymphatic versus venous sprout cell behavior is achieved is not fully understood...
March 7, 2021: Angiogenesis
https://read.qxmd.com/read/33656628/endothelial-trpv4-channels-prevent-tumor-growth-and-metastasis-via-modulation-of-tumor-angiogenesis-and-vascular-integrity
#13
Anantha K Kanugula, Ravi K Adapala, Anurag Jamaiyar, Nina Lenkey, Brianna D Guarino, Wolfgang Liedtke, Liya Yin, Sailaja Paruchuri, Charles K Thodeti
Transient receptor potential vanilloid 4 (TRPV4) is a ubiquitously expressed polymodally activated ion channel. TRPV4 has been implicated in tumor progression; however, the cell-specific role of TRPV4 in tumor growth, angiogenesis, and metastasis is unknown. Here, we generated endothelial-specific TRPV4 knockout (TRPV4ECKO ) mice by crossing TRPV4lox/lox  mice with Tie2-Cre mice. Tumor growth and metastasis were significantly increased in a syngeneic Lewis lung carcinoma tumor model of TRPV4ECKO mice compared to TRPV4l ox/lox mice...
March 3, 2021: Angiogenesis
https://read.qxmd.com/read/33655414/linalool-inhibits-the-angiogenic-activity-of-endothelial-cells-by-downregulating-intracellular-atp-levels-and-activating-trpm8
#14
Vivien Becker, Xin Hui, Lisa Nalbach, Emmanuel Ampofo, Peter Lipp, Michael D Menger, Matthias W Laschke, Yuan Gu
Angiogenesis crucially contributes to various diseases, such as cancer and diabetic retinopathy. Hence, anti-angiogenic therapy is considered as a powerful strategy against these diseases. Previous studies reported that the acyclic monoterpene linalool exhibits anticancer, anti-inflammatory and anti-oxidative activity. However, the effects of linalool on angiogenesis still remain elusive. Therefore, we investigated the action of (3R)-(-)-linalool, a main enantiomer of linalool, on the angiogenic activity of human dermal microvascular endothelial cells (HDMECs) by a panel of angiogenesis assays...
March 2, 2021: Angiogenesis
https://read.qxmd.com/read/33650028/loss-of-endothelial-glucocorticoid-receptor-promotes-angiogenesis-via-upregulation-of-wnt-%C3%AE-catenin-pathway
#15
Bing Liu, Han Zhou, Tiening Zhang, Xixiang Gao, Bo Tao, Hao Xing, Zhenwu Zhuang, Alan Dardik, Themis R Kyriakides, Julie E Goodwin
OBJECTIVE: The glucocorticoid receptor (GR) is a member of the nuclear receptor family that controls key biological processes in the cardiovascular system and has recently been shown to modulate Wnt signaling in endothelial cells. Wnt/β-catenin signaling has been demonstrated to be crucial in the process of angiogenesis. In the current study, we studied whether GR could regulate angiogenesis via the Wnt/β-catenin pathway. APPROACH AND RESULTSA: Key components of the Wnt/β-catenin pathway were evaluated using quantitative PCR and Western blot in the presence or absence of GR...
March 2, 2021: Angiogenesis
https://read.qxmd.com/read/33646466/7-ketocholesterol-induces-endothelial-mesenchymal-transition-and-promotes-fibrosis-implications-in-neovascular-age-related-macular-degeneration-and-treatment
#16
Haibo Wang, Aniket Ramshekar, Eric Kunz, M Elizabeth Hartnett
Oxidized cholesterols and lipids accumulate in Bruch's membrane in age-related macular degeneration (AMD). It remains unknown what causal relationship exists between these substances and AMD pathophysiology. We addressed the hypothesis that a prevalent form, 7-ketocholesterol (7KC), promotes choroidal endothelial cell (CEC) migration and macular neovascularization in AMD. Compared to control, 7KC injection caused 40% larger lectin-stained lesions, but 70% larger lesions measured by optical coherence tomography one week after laser-injury...
February 28, 2021: Angiogenesis
https://read.qxmd.com/read/33629198/dysbiotic-stress-increases-the-sensitivity-of-the-tumor-vasculature-to-radiotherapy-and-c-met-inhibitors
#17
Samir V Jenkins, Mohammad Alimohammadi, Alexia S Terry, Robert J Griffin, Alan J Tackett, Justin W Leung, Kieng B Vang, Stephanie D Byrum, Ruud P M Dings
Antibiotic-induced microbial imbalance, or dysbiosis, has systemic and long-lasting effects on the host and response to cancer therapies. However, the effects on tumor endothelial cells are largely unknown. Therefore, the goal of the current study was to generate matched B16-F10 melanoma associated endothelial cell lines isolated from mice with and without antibiotic-induced dysbiosis. After validating endothelial cell markers on a genomic and proteomic level, functional angiogenesis assays (i.e., migration and tube formation) also confirmed their vasculature origin...
February 24, 2021: Angiogenesis
https://read.qxmd.com/read/33550461/atorvastatin-pleiotropically-decreases-intraplaque-angiogenesis-and-intraplaque-haemorrhage-by-inhibiting-angpt2-release-and-ve-cadherin-internalization
#18
Fabiana Baganha, Rob C M de Jong, Erna A Peters, Wietske Voorham, J Wouter Jukema, Mirela Delibegovic, Margreet R de Vries, Paul H A Quax
OBJECTIVE: Statins pleiotropically provide additional benefits in reducing atherosclerosis, but their effects on intraplaque angiogenesis (IPA) and hemorrhage (IPH) remain unclear. Therefore, we discriminated statin's lipid-lowering dependent and independent effects on IPA and IPH. APPROACH AND RESULTS: ApoE3*Leiden mice are statin-responsive due to ApoE and LDLR presence, but also allow to titrate plasma cholesterol levels by diet. Therefore, ApoE3*Leiden mice were fed a high-cholesterol-inducing-diet (HCD) with or without atorvastatin (A) or a moderate-cholesterol-inducing-diet (MCD)...
February 7, 2021: Angiogenesis
https://read.qxmd.com/read/33550460/refractory-severe-idiopathic-systemic-capillary-leak-syndrome-successfully-treated-with-bevacizumab-a-case-report
#19
LETTER
G Kouadri, N Perzo, G Sauvetre, H Lévesque, E Besnier
No abstract text is available yet for this article.
February 7, 2021: Angiogenesis
https://read.qxmd.com/read/33548004/the-dock-protein-family-in-vascular-development-and-disease
#20
REVIEW
Clare E Benson, Laura Southgate
The vascular network is established and maintained through the processes of vasculogenesis and angiogenesis, which are tightly regulated during embryonic and postnatal life. The formation of a functional vasculature requires critical cellular mechanisms, such as cell migration, proliferation and adhesion, which are dependent on the activity of small Rho GTPases, controlled in part by the dedicator of cytokinesis (DOCK) protein family. Whilst the majority of DOCK proteins are associated with neuronal development, a growing body of evidence has indicated that members of the DOCK family may have key functions in the control of vasculogenic and angiogenic processes...
February 6, 2021: Angiogenesis
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