Olivia Tausendfreund, Martin Bidlingmaier, Sebastian Martini, Katharina Müller, Michaela Rippl, Katharina Schilbach, Ralf Schmidmaier, Michael Drey
OBJECTIVE: Hormonal substitution with growth hormone in aged patients remains a debated research topic and is rarely initiated in clinical practice. This reluctance may originate from concerns about adverse effects and the uncritical use as an anti-aging agent. Nevertheless, beneficial effects for selected patients suffering from certain acute and chronic illnesses could justify its use at an advanced age. This systematic review analyzes randomized controlled studies of GH interventions in older patients with different comorbidities to assess both, beneficial and harmful effects...
March 9, 2024: Growth Hormone & IGF Research
Xiaoyan Zhu, Fei Liang, Jieyun Yin, Xiaoliang Li, Lai Jiang, Yan Gao, Yan Lu, Yihe Hu, Ningbin Dai, Jian Su, Zhuoqiao Yang, Mengxin Yao, Yue Xiao, Wenxin Ge, Yue Zhang, Yi Zhong, Jun Zhang, Ming Wu
OBJECTIVE: Insulin-like growth factor binding protein 7 (IGFBP7) has a strong affinity to insulin. This study aimed to evaluate the relationship between IGFBP7 and complications among type 2 diabetes mellitus (T2DM) patients. DESIGN: A total of 1449 T2DM patients were selected from a cross-sectional study for disease management registered in the National Basic Public Health Service in Changshu, China, and further tested for their plasma IGFBP7 levels. Logistic regressions and Spearman's rank correlation analyses were used to explore the associations of IGFBP7 with diabetic complications and clinical characteristics, respectively...
February 21, 2024: Growth Hormone & IGF Research
Craig Alter, Margaret Boguszewski, David Clemmons, Georgiana A Dobri, Mitchell E Geffner, Nicky Kelepouris, Bradley S Miller, Richard Oh, Heidi Shea, Kevin C J Yuen
OBJECTIVE: Children with growth hormone deficiency (GHD) face multiple challenges that can negatively impact the transition from pediatric to adult endocrinology care. For children with GHD resulting from brain cancer or its treatment, the involvement of oncology care providers and possible disease-related comorbidities add further complexity to this transition. DESIGN: An advisory board of pediatric and adult endocrinologists was convened to help better understand the unique challenges faced by childhood cancer survivors with GHD, and discuss recommendations to optimize continuity of care as these patients proceed to adulthood...
February 15, 2024: Growth Hormone & IGF Research
Mana Mitsutani, Midori Matsushita, Mei Yokoyama, Ayumu Morita, Hiromi Hano, Tomomi Fujikawa, Tetsuya Tagami, Kenji Moriyama
OBJECTIVE: GATA2 is a key transcription factor involved in the differentiation and determination of thyrotrophs and gonadotrophs in pituitary and hematopoietic development. However, studies on the upstream ligands of the GATA2 signal transduction pathway have been limited. To identify upstream ligands, we examined growth hormone (GH) as a plausible stimulator. DESIGN: We evaluated GH-induced GATA2 expression in murine TtT/GF thyrotrophic pituitary tumor cells and its direct impact on the GHR/JAK/STAT5 pathway using a combination of a reporter assay, real-time quantitative polymerase chain reaction, and western blotting...
January 24, 2024: Growth Hormone & IGF Research
Mehmet Serif Ortac, Aysa Hacioglu, Semih Zeki Uludag, Zuleyha Karaca, Kursad Unluhizarci, Fahrettin Kelestimur, Fatih Tanriverdi
PURPOSE: Growth hormone (GH) has been recognized to play a regulatory role in female reproduction. It has been reported that infertile GH deficient patients regained fertility after GH replacement. The frequency of GH deficiency is not established in patients diagnosed with unexplained infertility. Here, we aim to present the prevalence of GH deficieny in this patient group. METHODS: We included patients diagnosed with unexplained infertility throughout 18 months...
January 23, 2024: Growth Hormone & IGF Research
Eran Lavi, Amitay Cohen, Abdulsalam Abu Libdeh, Reuven Tsabari, David Zangen, Talya Dor
OBJECTIVE: To evaluate the outcome of recombinant human Growth Hormone (rhGH) therapy in patients with Duchene Muscular Dystrophy (DMD) and glucocorticoid treatment with compromised growth. DESIGN: Four DMD patients on Deflzacort 0.6-0.85 mg/kg/day or prednisolone 0.625 mg/kg/day recieved rhGH (0.24 mg/kg/week) for 6-18 months. Primary outcomes were Growth velocity and Height for age Z-scores (Height SD). RESULTS: Growth velocity increased from 0 to 3...
August 30, 2023: Growth Hormone & IGF Research
Zvi Laron, Haim Werner
Insulin like growth factor I (IGFI) secreted by the liver upon stimulation by pituitary growth hormone (GH) acts as the most important growth stimulating hormone in children. The present review presents evidence that among its additional metabolic effects, IGF-I suppresses the synthesis of lipoprotein(a) [Lp(a)], an independent risk factor for atherosclerotic cardiovascular disease. In view of this property, it is suggested that the addition of IGF-I to the armamentarium of hyperlipoproteinemia treatment should be considered...
August 2023: Growth Hormone & IGF Research
Selmen Wannes, Ikram El Ahmer, Khouloud Rjiba, Nessrine Jemmali, Hamza Haj Abdallah, Rania Bel Haj, Asma Achour, Hassan Bouzidi, Ali Saad, Soumaya Mougou, Bahri Mahjoub
UNLABELLED: Type 1 Insulin-like Growth Factor Receptor(IGF1R) plays a fundamental role in normal growth and development. Its disruption is usually characterized by severe intrauterine and postnatal growth retardation, microcephaly and neurodevelopmental delay.The efficacy of recombinant human growth hormone treatment remains a challenge for children with IGF1 resistance and pathogenic mutations of IGF1R, with limited data in patients carrying the most severe form of IGF1R defect, the ring chromosome 15...
July 25, 2023: Growth Hormone & IGF Research
Camilla Borghammar, Victoria Boije, Charlotte Becker, Bengt Lindberg, Maria Elfving
OBJECTIVE: Late night spontaneous growth hormone (GH) pulses may influence the pituitary GH response to provocation tests. We evaluated GH response during arginine-insulin-tolerance test (AITT) after a GH peak during a short spontaneous nocturnal profile (SSNP) in children with short stature or low growth velocity. DESIGN: Using SSNP and subsequent AITT, we examined 257 children 4-18 years old (138 (53.7%) males) recruited from three hospitals. Medical records were reviewed retrospectively...
July 24, 2023: Growth Hormone & IGF Research
Shinichiro Teramoto, Shigeyuki Tahara, Yujiro Hattori, Akihide Kondo, Akio Morita
OBJECTIVE: The growth hormone (GH)-releasing peptide-2 (GHRP-2) test is relatively safe among endocrine stimulation tests for the elderly. We investigated whether anterior pituitary function in elderly patients could be assessed on the basis of GH response to the GHRP-2 test. DESIGN: Sixty-five elderly patients aged 65 years and older with non-functioning pituitary neuroendocrine tumor (PitNET) who underwent pituitary surgery and preoperative endocrine stimulation tests were classified into the "GH normal group" and "GH deficiency group" based on GH response to the GHRP-2 test...
June 2, 2023: Growth Hormone & IGF Research
Megan Herodes, Nancy Le, Lindsey J Anderson, Dorota Migula, Gary Miranda, Lauren Paulsen, Jose M Garcia
OBJECTIVE: Traumatic brain injury (TBI), a common cause of adult growth hormone deficiency (AGHD), affects 20% of Veterans returning from Iraq and Afghanistan (OEF/OIF/OND). Growth hormone replacement therapy (GHRT) improves quality of life (QoL) in AGHD but remains unexplored in this population. This pilot, observational study investigates the feasibility and efficacy of GHRT in AGHD following TBI. DESIGN: In this 6-month study of combat Veterans with AGHD and TBI starting GHRT (N = 7), feasibility (completion rate and rhGH adherence) and efficacy (improvements in self-reported QoL) of GHRT were measured (primary outcomes)...
June 1, 2023: Growth Hormone & IGF Research
Nektarios Barabutis, Agnieszka Siejka, Mohammad S Akhter
Growth Hormone-Releasing Hormone (GHRH) is a hypothalamic peptide which regulates the release of Growth Hormone from the anterior pituitary gland, and has been involved in inflammatory processes. On the other hand, GHRH antagonists (GHRHAnt) were developed to counteract those effects. Herein we demonstrate for the first time that GHRHAnt can suppress hydrogen peroxide (H2 O2 ) - induced paracellular hyperpermeability in bovine pulmonary artery endothelial cells. Increased production of reactive oxygen species (ROS) and barrier dysfunction have been associated with the development of potentially lethal disorders, including sepsis and acute respiratory distress syndrome (ARDS)...
May 18, 2023: Growth Hormone & IGF Research
Rachel Barker, Kalina Biernacka, Georgina Kingshott, Alex Sewell, Paida Gwiti, Richard M Martin, J Athene Lane, Lucy McGeagh, Anthony Koupparis, Edward Rowe, Jon Oxley, Claire M Perks, Jeff M P Holly
AIMS: To examine associations between the transcription factors CCCTC-binding factor (CTCF) and forkhead box protein A1 (FOXA1) and the androgen receptor (AR) and their association with components of the insulin-like growth factor (IGF)-pathway in a cohort of men with localized prostate cancer. METHODS: Using prostate tissue samples collected during the Prostate cancer: Evidence of Exercise and Nutrition Trial (PrEvENT) trial (N = 70 to 92, depending on section availability), we assessed the abundance of CTCF, FOXA1, AR, IGFIR, p-mTOR, PTEN and IGFBP-2 proteins using a modified version of the Allred scoring system...
April 14, 2023: Growth Hormone & IGF Research
Helena-Jamin Ly, Anders Lindberg, Hans Fors, Jovanna Dahlgren
OBJECTIVE: Prediction models that calculate the growth response in children on recombinant growth hormone (GH) have shown to be helpful tools in deciding who should start treatment, as identifying GH deficiency can be a challenge. The aim of the study is to compare two prediction models; the KIGS (Pfizer International Growth Study) prediction models which are more accessible and the Gothenburg model which has previously been clinically validated. DESIGN: All prepubertal patients who commenced GH treatment at Queen Silvia Children's Hospital in Gothenburg during a 13-year-period were candidates for the study...
February 2023: Growth Hormone & IGF Research
Giorgio Sodero, Francesco Mariani, Michela Caprarelli, Cristiana Agazzi, Ludovica Quarta, Luca Benacquista, Donato Rigante, Cipolla Clelia
BACKGROUND: Children with auxological parameters defining a 'short stature' is routinely subjected to various blood tests and, if necessary, to growth hormone stimulation test (GHST) for differentiating GH deficiency (GHD) and other causes of stunted growth. AIM: This retrospective monocentric study aimed to evaluate any correlations between GH peaks during GHST in children assessed for short stature and their auxological/metabolic parameters, highlighting differences between GHD and idiopathic short stature...
February 2023: Growth Hormone & IGF Research
Emre Urhan, Aysa Hacioglu, Izzet Okcesiz, Zuleyha Karaca, Canan Sehit Kara, Kursad Unluhizarci
OBJECTIVE: We investigated the coexistence of newly diagnosed acromegaly with primary empty sella (ES), which is considered to be a rare association, and the impact of ES on the laboratory, radiological and prognostic status of acromegaly. DESIGN: Acromegaly patients diagnosed and followed-up between 2012 and 2021 were included. Empty sella was defined as the pituitary gland and adenoma filling <50% of the sella turcica on preoperative T1 magnetic resonance imaging (MRI)...
February 2023: Growth Hormone & IGF Research
Tathyana Benetis Piau, Aline de Queiroz Rodrigues, Fernanda Paulini
The role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream and promoting IGF storage in specific tissue niches. IGF1 has an important part in cell proliferation, differentiation and apoptosis...
2023: Growth Hormone & IGF Research
Sophia Krombholz, Andreas Thomas, Philippe Delahaut, Martin Bidlingmaier, Katharina Schilbach, Geoffrey Miller, Mario Thevis
OBJECTIVE: The precise and accurate quantification of human growth hormone (GH) in plasma/ serum is crucial for the diagnosis and treatment of diseases like GH deficiency or acromegaly. However, the ligand-binding assays (LBAs) currently used for routine testing show considerable methodological variability. Here, we present a complementary, combined top-down and bottom-up LC-MS-based method to quantify (intact) GH in plasma and serum, which concurrently provides a basis for a MS-based analysis of GH in doping controls...
2023: Growth Hormone & IGF Research
Charles L Cai, Matthew Marcelino, Jacob V Aranda, Kay D Beharry
OBJECTIVE: Extremely low gestational age neonates requiring oxygen therapy for chronic lung disease experience repeated fluctuations in arterial oxygen saturation, or intermittent hypoxia (IH), during the first few weeks of life. These events are associated with a high risk for reduced growth, hypertension, and insulin resistance in later life. This study tested the hypothesis that IH, or intermittent hyperoxia have similar negative effects on the liver; somatic growth; and liver insulin-like growth factor (IGF)-I, IGF binding protein (BP)-3, and growth hormone binding protein (GHBP), regardless of resolution in normoxia or hyperoxia between episodes...
2023: Growth Hormone & IGF Research
Fengping Sun, Liqin Chao, Junxia Zhang, Xiaoli Pan
OBJECTIVE: This study was aimed to systematically determine the effect of exercise combined with lysine-inositol vitamin B12 (VB12) therapy on the height of children with idiopathic short stature (ISS). METHODS: Sixty children with ISS were randomly divided into observation and control groups (N = 30). Each group was given lysine-inositol VB12 oral solution (10 mL bid). Simultaneously, the observation group exercised following the "ISS exercise instruction sheet"...
2023: Growth Hormone & IGF Research
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