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Brazilian Journal of Infectious Diseases

Luciana Antoniolli, Camila Rodrigues, Rafael Borges, Luciano Z Goldani
BACKGROUND: There is little information on herpes zoster from hospital registries in South America. The aim of this study was to describe the epidemiological and clinical aspects of herpes zoster (HZ) in hospitalized patients.' METHODS: We searched for hospital-based records during the period from March 2000 to January 2017 in a 700-bed tertiary-care hospital located in southern Brazil. The medical records of all eligible patients were reviewed, and data regarding demographics, medical history, clinical and laboratory characteristics, treatment regimens, and clinical outcomes were collected...
March 29, 2019: Brazilian Journal of Infectious Diseases
Xiuying Deng, Ying Hu, Peishan Lu, Ming-Hao Zhou, Hongxiong Guo
Here we reported the outbreak of measles cases caused by the genotype D8 measles virus for the first time in Jiangsu province in China, which was possibly imported by a foreign student from Laos. Throat swab specimens were collected, and used to isolate virus. 634-bp fragment of the N gene and 1854-bp fragment of H gene were amplified by reverse transcription-PCR and sequenced, respectively. Phylogenetic results indicated that they belonged to genotype D8 measles virus. Further epidemiology investigation showed that the adults with D8 measles virus infection did not receive measles vaccine before having measles...
March 12, 2019: Brazilian Journal of Infectious Diseases
Alisson de Aquino Firmino, Adenilda Lima Lopes Martins, Luana Leandro Gois, Taiane Silva Paixão, Everton da Silva Batista, Bernardo Galvão-Castro, Maria Fernanda Rios Grassi
INTRODUCTION: Human T-cell lymphotropic virus type 1 (HTLV-1) is sexually transmitted and causes persistent infection. This virus induces activation of the immune system and production of inflammatory cytokines. This study aimed to assess the cytokine profile and cytopathological findings in the cervicovaginal fluid of asymptomatic HTLV-1-infected women. METHODS: HTLV-1-infected and uninfected women were selected at the Centro de Atendimento ao Portador de HTLV in Salvador-Brazil...
March 6, 2019: Brazilian Journal of Infectious Diseases
Luiz H Portari-Filho, Mario R Álvares-da-Silva, Aline Gonzalez, Adalgisa P Ferreira, Cristiane V Nogueira, Maria C Mendes-Correa, José M Lima, Edmundo P Lopes, Carlos E Brandão, Cláudia Ivantes, André Lyra, Andreia Lindenberg, Maria L Ferraz
BACKGROUND: Hepatitis C is an important health problem. In Brazil, 1-2 million people are infected. Despite this expressive number, and the availability of very successful treatment, many patients remained undiagnosed mainly because of the asymptomatic nature of the infection. OBJECTIVES: To describe epidemiological characteristics of HCV-infected patients seen at referral centers in Brazil, the source of referral, and the time spanned to reach a reference center, in order to improve the identification of undiagnosed patients...
March 5, 2019: Brazilian Journal of Infectious Diseases
Veraluce Paolini Cavalcanti, Leandro Azevedo de Camargo, Fabiano Santana Moura, Edson Júnior de Melo Fernandes, Juliana Lamaro-Cardoso, Carla Afonso da Silva Bitencourt Braga, Maria Cláudia Porfirio André
INTRODUCTION: Bacterial tonsillitis is an upper respiratory tract infection that occurs primarily in children and adolescents. Staphylococcus aureus is one of the most frequent pathogens in the etiology of tonsillitis and its relevance is due to its antimicrobial resistance and persistence in the internal tissues of the tonsils. Tonsillectomy is indicated in cases of recurrent tonsillitis after several failures of antibiotic therapy. MATERIAL AND METHODS: In this study we evaluated 123 surgically removed tonsils from patients who had history of recurrent tonsillitis...
March 5, 2019: Brazilian Journal of Infectious Diseases
Guilherme Bricks, Jorge Figueiredo Senise, Henrique Pott-Jr, Giuliano Grandi, Dimas Carnaúba-Jr, Hamilton Antonio Bonilha de Moraes, Celso Franscisco Hernandes Granato, Adauto Castelo
BACKGROUND: Hepatitis E virus (HEV) infection in patients with pre-existing liver disease has shown high morbidity and lethality. The consequences of HEV superinfection in patients with chronic hepatitis C virus (HCV) infection are not fully understood. This study aimed to evaluate the association between the presence of anti-HEV antibodies, liver cirrhosis, and insulin resistance. METHODS: A total of 618 patients chronically infected with HCV were included from three reference centers for viral hepatitis in São Paulo, Brazil...
March 2, 2019: Brazilian Journal of Infectious Diseases
Doaa Abdelmawla, Dalia Moemen, Ahmad Darwish, Wafaa Mowafy
Hepatitis E virus (HEV) infection is one of the major public health problems in developing countries. HEV can cause chronic infections in immunocompromised individuals e.g. thalassemic patients with increased risk of morbidity and mortality. In addition there is possibility of HEV transmission through blood transfusion. Therefore, the present study aimed to investigate the seroprevalence and risk factors of HEV infection in β-thalassemic children. METHODS: This cross-sectional study was conducted on 140 Egyptian children suffering from β-thalassemia, attending the hematology outpatient clinic from April to October 2016...
February 28, 2019: Brazilian Journal of Infectious Diseases
Malihe Fathi Haghighi, Noorossadat Seyyedi, Ali Farhadi, Farahnaz Zare, Leila Kasraian, Gholam Reza Refiei Dehbidi, Reza Ranjbaran, Abbas Behzad-Behbahani
OBJECTIVES: To investigate the prevalence of human polyomavirus (BK and JC viruses) infection in peripheral blood mononuclear cells (PBMC) of healthy blood donors. METHODS: The study included 250 healthy blood donors. Five-milliliter blood was drawn into sterile EDTA tubes and PBMCs were isolated from whole blood. The isolated PBMCs were counted and stored at -70°C for future investigation. DNA was extracted and subjected to simple, sensitive and specific semi-nested PCR as well as QPCR using both general and specific primers for different assays...
February 23, 2019: Brazilian Journal of Infectious Diseases
Qiqiang Liang, Man Huang, Zhijiang Xu
Polymyxin B is one of the last resort option for carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection in China. Therefore, the timing of administration of polymyxin is frequently delayed. We collected 40 cases of CRKP bloodstream infections (BSIs) treated with combinations based on polymyxin B over 30 months. The primary outcome, 30-day mortality rate, was 52.5% (21/40). Early administration of polymyxin B is meant to administer the drug within 48h of diagnosing bacteremia. Delayed administration was considered when polymyxin B was administered after 48h of bacteremia onset...
February 21, 2019: Brazilian Journal of Infectious Diseases
Guofeng Dong, Jiahui Li, Lijiang Chen, Wenzi Bi, Xiaoxiao Zhang, Haiyang Liu, Xiaoyang Zhi, Tieli Zhou, Jianming Cao
OBJECTIVE: To evaluate the influence of sub-minimum inhibitory concentrations (MICs) of ciprofloxacin (CIP) on biofilm formation and virulence factors of Escherichia coli clinical isolates. METHODS: Sub-MICs of CIP were determined using growth curve experiments. The biofilm-forming capacity of E. coli clinical isolates and E. coli ATCC 25922 treated or untreated with sub-MICs of CIP was assessed using a crystal violet staining assay. The biofilm structure of E. coli isolate was assessed with scanning electron microscopy (SEM)...
February 20, 2019: Brazilian Journal of Infectious Diseases
Juan Manuel Cubillos Angulo, Taryn Ariadna Castro Cuesta, Eliane Pereira Menezes, Celia Pedroso, Carlos Brites
BACKGROUND: Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection. OBJECTIVE: To evaluate which polymorphisms of HLA-B are involved in HIV-1 MTCT. METHODS: Two independent reviewers performed a systematic review on search engines PubMed, Europe PMC, Cochrane, Scientific Electronic Library Online (SciELO), and Literatura Latino-americana e do Caribe em Ciências da Saúde (Lilacs), using the following key terms: "HIV infection", "HIV newborn", "HLA polymorphisms", "HLA-B", and "Mother to child transmission"...
February 14, 2019: Brazilian Journal of Infectious Diseases
Monica Baumgardt Bay, Marise Reis de Freitas, Marcia Cavalcante Vinhas Lucas, Elizabeth Cristina Fagundes de Souza, Angelo Giuseppe Roncalli
BACKGROUND: Men who have sex with men (MSM) account for the highest prevalence of HIV in Brazil. HIV testing allows to implement preventive measures, reduces transmission, morbidity, and mortality. METHODS: We conducted a cross-sectional study to evaluate HIV testing during lifetime, factors associated with the decision to test, knowledge about HIV transmission, and use of condoms between MSM from the city of Natal, northeast Brazil. RESULTS: Out of 99 participants, 62...
February 10, 2019: Brazilian Journal of Infectious Diseases
Luciano Z Goldani
No abstract text is available yet for this article.
January 2019: Brazilian Journal of Infectious Diseases
Xuehan Li, Fang Fang, Jin Zhao, Ning Lou, Chenglin Li, Tao Huang, Yirong Li
BACKGROUND: The rate of methicillin-resistant Staphylococcus aureus (MRSA) among the total of S. aureus isolated decreased to 35.3% in 2017 in China. It is unclear whether the molecular characteristics of S. aureus isolates have changed as the rate decreased. OBJECTIVE: This study aimed to investigate the molecular characteristics and virulence genes profile of S. aureus isolates causing bloodstream infection and analyze the correlation between the prevalence rates of the common ST types and MRSA...
December 27, 2018: Brazilian Journal of Infectious Diseases
Jingmin Zhang, Yafeng Wang, Youmei Peng, Chongzhen Qin, Yixian Liu, Jingjing Li, Jinhua Jiang, Yubing Zhou, Junbiao Chang, Qingduan Wang
Antiviral drug resistance is the most important factor contributing to treatment failure using nucleos(t)ide analogs such as lamivudine for chronic infection with hepatitis B virus (HBV). Development of a system supporting efficient replication of clinically resistant HBV strains is imperative, and new antiviral drugs are needed urgently to prevent selection of drug-resistant HBV mutants. A novel fluorinated cytidine analog, NCC (N-cyclopropyl-4'-azido-2'-deoxy-2'-fluoro-β-d-cytidine), was recently shown to strongly inhibit human HBV in vitro and in vivo...
December 23, 2018: Brazilian Journal of Infectious Diseases
Natanael Sutikno Adiwardana, Juliana de Angelo Morás, Leandro Lombo Bernardo, Giselle Burlamaqui Klautau, Wladimir Queiroz, Jose Ernesto Vidal
No abstract text is available yet for this article.
December 6, 2018: Brazilian Journal of Infectious Diseases
Jiazhen Chen, Qiaoling Ruan, Yaojie Shen, Sen Wang, Lingyun Shao, Wenhong Zhang
The Region of D eletion 2 (RD2) of Mycobacterium tuberculosis encodes reserved antigens that contribute to bacterial virulence. Among these antigens, Rv1983, Rv1986, Rv1987, and Rv1989c have been shown to be immunodominant in infected cattle; however, their diagnostic utility has not been evaluated in humans. In this study, we screened 87 overlapping synthetic peptides encoded by five RD2 proteins for diagnosing tuberculosis epitopes in 50 active tuberculosis (TB) cases, 31 non-tuberculosis patients and 36 healthy individuals...
December 5, 2018: Brazilian Journal of Infectious Diseases
Lisie Souza Castro, Grazielli Rocha de Rezende, Fernanda Rodas Pires Fernandes, Larissa Melo Bandeira, Marco Antonio Moreira Puga, Tayana Serpa Ortiz Tanaka, Sabrina Moreira Dos Santos Weis, Ana Carolina Paulo Vicente, Koko Otsuki, Ana Rita Coimbra Motta-Castro
Human T-cell lymphotropic virus type 1 (HTLV-1) was the first retrovirus discovered in humans and is endemic in several parts of the world. Because of risk behaviors, mainly sexual, men who have sex with men (MSM) are at high risk of acquiring HTLV-1 infection. A cross-sectional study was performed to estimate the prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) infection, to characterize genetically HTLV-1 sequences and to identify risk behaviors associated with this infection among MSM in Central Brazil...
December 5, 2018: Brazilian Journal of Infectious Diseases
Fernanda Wirth, Maria Isabel Azevedo, Luciano Z Goldani
There are limited data on the molecular epidemiology of cryptococcosis in Brazil. Here, we report on the identification of the molecular pattern of the Cryptococcus species that caused meningitis in patients admitted in a Brazilian reference tertiary care hospital, and review the published studies addressing the molecular epidemiology of Cryptococcus in Brazil. Our study has shown the predominance of molecular type VNII in HIV-infected patients with cryptococcal meningoencephalitis. Molecular types VNII and VGII were occasionally detected in HIV-infected and non-infected patients with meningoencephalitis...
November 30, 2018: Brazilian Journal of Infectious Diseases
Rachel Gimenes Albuquerque, Jane Tomimori, Lucile Maria Floeter-Winter, Sergio Tufik, Monica Levy Andersen
No abstract text is available yet for this article.
November 27, 2018: Brazilian Journal of Infectious Diseases
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