journal
https://read.qxmd.com/read/38108311/berberine-decreases-s100b-generation-to-regulate-gut-vascular-barrier-permeability-in-mice-with-burn-injury
#21
JOURNAL ARTICLE
Aiwen Feng, Shaosheng Su, Cheng Li, Yutian Kang, Jiasheng Qiu, Jun Zhou
Context: Berberine (BBR) can regulate enteric glial cells (EGCs) and the gut vascular barrier (GVB). Objective: To explore whether BBR regulates GVB permeability via the S100B pathway. Materials and methods: GVB hyperpermeability in C57BL/6J mice was induced by burns or S100B enema. BBR (25 or 50 mg/kg/d, 3 d) was gavaged preburn. S100B monoclonal antibody (S100BmAb) was i.v. injected postburn. Mouse intestinal microvascular endothelial cells (MIMECs) were treated with S100B, S100B plus BBR, or Z-IETD-FMK...
December 2024: Pharmaceutical Biology
https://read.qxmd.com/read/38100537/nicotinamide-mononucleotide-alleviates-endotoxin-induced-acute-lung-injury-by-modulating-macrophage-polarization-via-the-sirt1-nf-%C3%AE%C2%BAb-pathway
#22
JOURNAL ARTICLE
Simeng He, Xianhong Jiang, Jing Yang, Ya Wu, Jia Shi, Xiaoyang Wu, Shihan Du, Yuan Zhang, Lirong Gong, Shuan Dong, Jianbo Yu
CONTEXT: Sepsis-induced acute lung injury (ALI) is a severe condition with limited effective therapeutics; nicotinamide mononucleotide (NMN) has been reported to exert anti-inflammatory activities. OBJECTIVE: This study explores the potential mechanisms by which NMN ameliorates sepsis-induced ALI in vivo and in vitro . MATERIALS AND METHODS: Cultured MH-S cells and a murine model were used to evaluate the effect of NMN on sepsis-induced ALI...
December 2024: Pharmaceutical Biology
https://read.qxmd.com/read/38100532/shenqi-fuzheng-injection-restores-the-sensitivity-to-gefitinib-in-non-small-cell-lung-cancer-by-inhibiting-the-il-22-stat3-akt-pathway
#23
JOURNAL ARTICLE
Jiali Wang, Xianhai He, Zhirong Jia, Aiwen Yan, Kang Xiao, Shuo Liu, Mengjun Hou, Yaling Long, Xuansheng Ding
CONTEXT: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Gefitinib is a first-line treatment for NSCLC. However, its effectiveness is hindered by the development of drug resistance. At present, Shenqi Fuzheng injection (SFI) is widely accepted as an adjuvant therapy in NSCLC. OBJECTIVE: This study investigates the molecular mechanism of SFI when combined with gefitinib in regulating cell progression among EGFR-TKI-resistant NSCLC. MATERIALS AND METHODS: We established gefitinib-resistant PC9-GR cells by exposing gefitinib escalation from 10 nM with the indicated concentrations of SFI in PC9 cells (1, 4, and 8 mg/mL)...
December 2024: Pharmaceutical Biology
https://read.qxmd.com/read/38088354/bibliometric-analysis-of-research-trends-and-topic-areas-in-traditional-chinese-medicine-therapy-for-lymphoma
#24
JOURNAL ARTICLE
Gaofeng Zhang, Yanmei Qin, Shaobing Liu, Xi Chen, Wenwen Zhang
CONTEXT: Traditional Chinese Medicine (TCM) is effective as a cancer treatment modality. However, this is the first bibliometric analysis of TCM in lymphoma treatment. OBJECTIVE: This study explores the current trends and research topics of TCM in treating lymphoma from 2000 to 2023. MATERIALS AND METHODS: We searched within the Web of Science Core Collection (WoSCC) for publications on TCM in lymphoma treatment, spanning 2000 to 2023. Subsequently, we employed a comprehensive approach utilizing CiteSpace software and VOSviewer to visually analyze research trends, authors, institutions, co-cited references, and keywords...
December 2024: Pharmaceutical Biology
https://read.qxmd.com/read/38084911/shenxiang-suhe-pill-improves-cardiac-function-through-modulating-gut-microbiota-and-serum-metabolites-in-rats-after-acute-myocardial-infarction
#25
JOURNAL ARTICLE
Xinqin Zhong, Junyuan Yan, Xing Wei, Tian Xie, Zhaojian Zhang, Kaiyue Wang, Congying Sun, Wei Chen, Jiaming Zhu, Xin Zhao, Xiaoying Wang
CONTEXT: Shenxiang Suhe pill (SXSH), a traditional Chinese medicine, is clinically effective against coronary heart disease, but the mechanism of cardiac-protective function is unclear. OBJECTIVE: We investigated the cardiac-protective mechanism of SXSH via modulating gut microbiota and metabolite profiles. MATERIALS AND METHODS: Sprague-Dawley (SD) male rats were randomly divided into 6 groups ( n  = 8): Sham, Model, SXSH (Low, 0...
December 2024: Pharmaceutical Biology
https://read.qxmd.com/read/38069821/network-pharmacology-identification-and-in-vivo-validation-of-key-pharmacological-pathways-of-qin-jiao-for-gout-and-arthritis
#26
JOURNAL ARTICLE
Xiaoxiong Yang, Yu Wang, Xueli Ding, Shanshan Ju, Xiaoye An, Bing Zhang, Zhijian Lin
Context: Gout is a chronic disease that imposes a huge financial and health burden on patients, which might diminish quality of life. Qin Jiao, a perennial herb found in northwestern China and Japan, is commonly used for treating various ailments. Objective: This study investigates the effects of Qin Jiao on gout and joint inflammation and elucidates its potential mechanism for gouty arthritis. Materials and methods: Study 1, a literature review was conducted using PubMed, Web of Science, and CNKI to assess the applications of Qin Jiao in arthritis treatment...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/38069658/network-pharmacology-integrated-with-experimental-verification-reveals-the-antipyretic-characteristics-and-mechanism-of-zi-xue-powder
#27
JOURNAL ARTICLE
Hanyu Zhang, Shining Ge, Fengyin Diao, Wen Song, Ying Zhang, Pengwei Zhuang, Yanjun Zhang
CONTEXT: Zi Xue Powder (ZXP) is a traditional formula for the treatment of fever. However, the potential mechanism of action of ZXP remains unknown. OBJECTIVE: This study elucidates the antipyretic characteristics of ZXP and the mechanism by which ZXP alleviates fever. MATERIALS AND METHODS: The key targets and underlying fever-reducing mechanisms of ZXP were predicted using network pharmacology and molecular docking. The targets of ZXP anti-fever active ingredient were obtained by searching TCMSP, STITCH and HERB...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37990887/chemical-profile-of-the-anatolian-sideritis-species-with-bioactivity-studies
#28
REVIEW
Sema Çarıkçı, Turgut Kılıç, Ahmet C Gören, Tuncay Dirmenci, Gülbahar Özge Alim Toraman, Gülaçtı Topçu
CONTEXT: The genus Sideritis L. (Lamiaceae) is represented by 46 species in Turkey with an 79% endemism ratio, 42 of 46 belonging to the section Empodoclia. OBJECTIVE: In this review article, Sideritis species growing in Turkey have been evaluated for phytochemical constituents and biological activities. METHODS: The data for the isolates, components and extracts of the Anatolian Sideritis species and their bioactivity studies were retrieved from the main databases WoS, Scopus and PubMed from 1975 until 31 December 2022...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37855412/efficacy-and-safety-of-berberine-for-premature-ventricular-contractions-a-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#29
REVIEW
Meng Qiao, Chao Lei, Chaoren Tan, Cuncun Lu, Zijia Chen, Qiang Zhang, Zhifei Wang
CONTEXT: Berberine is a potential drug that can effectively treat cardiovascular diseases, including premature ventricular contractions (PVCs). OBJECTIVE: This study was conducted to assess the efficacy and safety of berberine for PVCs. METHODS: The literature was searched using PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang, and Chinese Biomedical Literature Database (CBM) for randomized controlled trials (RCTs) from inception to October 1, 2022...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37691404/evaluation-of-topical-methylene-blue-nanoemulsion-for-wound-healing-in-diabetic-mice
#30
JOURNAL ARTICLE
Yu Gao, Zhounan Jiang, Bin Xu, Ran Mo, Shiyan Li, Yanan Jiang, Demei Zhao, Wangbin Cao, Bin Chen, Meng Tian, Qian Tan
CONTEXT: Diabetic wounds (DW) are a complication of diabetes and slow wound healing is the main manifestation. Methylene blue (MB) has been shown to exhibit therapeutic effects on diabetes-related diseases. OBJECTIVE: To investigate the mechanisms of action of MB-nanoemulsion (NE) in the treatment of DW. MATERIALS AND METHODS: The concentration of MB-NE used in the in vivo and in vitro experiments was 0.1 mg/mL. Streptozocin-induced diabetic mice were used as models...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37688460/integrating-serum-metabolomics-and-network-analysis-to-explore-the-antidepressant-activity-of-crocin-in-rats-with-chronic-unexpected-mild-stress-induced%C3%A2-depression
#31
JOURNAL ARTICLE
Yan Luo, Ziyan Zhong, Huan Li, Le Wang, Dongwei Guo, Xuanqi Dong, Jian Liu, Mingxia Xie, Mei Wu, Yun Xiang, Xi Zhang, Pan Meng
CONTEXT: Crocin exhibits anti-depressant properties. However, its underlying mechanisms and its relationship with metabolomics remain unclear. OBJECTIVE: This study elucidates the mechanism of action and potential targets of crocin in treating chronic unexpected mild stress (CUMS)-induced depression in rats. MATERIALS AND METHODS: Male Sprague-Dawley (SD) rats underwent 4 weeks of CUMS to establish the depression model. The normal control (distilled water), crocin (25 mg/kg), and fluoxetine (5...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37674371/mechanism-investigation-of-duhuo-jisheng-pill-against-rheumatoid-arthritis-based-on-a-strategy-for-the-integration-of-network-pharmacology-molecular-docking-and-in%C3%A2-vivo-experimental-verification
#32
JOURNAL ARTICLE
Ping Xin, Xiaoyun Xu, Huaxi Zhang, Yuezhou Hu, Chengjie Deng, Shiqin Sun, Shuang Liu, Xuegang Zhou, Hongxing Ma, Xiaoliang Li
CONTEXT: Duhuo Jisheng pill (DHJS) is a classic traditional Chinese medicine (TCM) formula for rheumatoid arthritis (RA). The effective components and therapeutic mechanisms of DHJS for treating RA are still unclear. OBJECTIVE: To explore the potential mechanism of DHJS against RA by means of network pharmacology and experimental verification. MATERIALS AND METHODS: A network pharmacology and molecular docking analysis based on phytochemistry was used to elucidate the mechanism of DHJS against RA...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37674320/paeoniflorin-suppresses-the-apoptosis-and-inflammation-of-human-coronary-artery-endothelial-cells-induced-by-oxidized-low-density-lipoprotein-by-regulating-the-wnt-%C3%AE-catenin-pathway
#33
JOURNAL ARTICLE
Shasha Liu, Ying Li, Caojie Wu
CONTEXT: Paeoniflorin (PF) contributes to improving coronary artery disease (CAD). OBJECTIVE: This study clarified the efficiency of PF in CAD and the molecular mechanism. MATERIALS AND METHODS: Human coronary artery endothelial cells (HCAECs) were treated with oxidized low-density lipoprotein (ox-LDL; 20, 40, 80 and 160 μg/mL) and PF (0.05, 0.1 0.2 and 0.4 mM). To study cell phenotypes, HCAECs were treated with 80 μg/mL ox-LDL with or without 0...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37667488/saponins-from-panax-japonicus-improve-neuronal-mitochondrial-injury-of-aging-rats
#34
JOURNAL ARTICLE
Cheng Fan, Jin-Xin Wang, Zhang-E Xiong, Shan-Shan Hu, Ao-Jia Zhou, Ding Yuan, Chang-Cheng Zhang, Zhi-Yong Zhou, Ting Wang
CONTEXT: Panax japonicus is the dried rhizome of Panax japonicus C.A. Mey. (Araliaceae). Saponins from Panax japonicus (SPJ) exhibit anti-oxidative and anti-aging effects. OBJECTIVE: We evaluated the neuroprotective effects of SPJ on aging rats. MATERIALS AND METHODS: Sprague-Dawley rats (18-months-old) were randomly divided into aging and SPJ groups ( n  = 8). Five-month-old rats were taken as the adult control ( n  = 8)...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37665171/correction
#35
(no author information available yet)
No abstract text is available yet for this article.
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37655754/bu-shen-tian-jing-formulas-alleviate-the-mitochondrial-damage-induced-by-oxidative-stress-in-ovarian-granulosa-cells-exposed-to-dehp-through-the-hdac3-hsp90aa-pathway
#36
JOURNAL ARTICLE
Hui Zhang, Huihua Wang, Qing Zhang, Hui Wang, Yuhang Zhu, Fangfang Wang, Jun Lin, Jue Zhou, Fan Qu
CONTEXT: di-(2-Ethylhexyl) phthalate (DEHP) has potential reproductive toxicity. Bu-Shen-Tian-Jing formulations (BSTJFs) are beneficial for female reproductive capacity. However, BSTJF2 has much lower cytotoxicity than BSTJF1. OBJECTIVE: To investigate the effects of BSTJFs on ovarian granulosa cells exposed to DEHP and determine the potential molecular mechanisms. METHODS AND MATERIALS: Human granulosa-like tumor cell line (KGN) cells were divided into control, DEHP, BSTJF1 and BSTJF2 groups...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37655554/optimization-of-the-proportions-of-advantageous-components-in-the-hypolipidemic%C3%A2-bioequivalent-substance-system-of-jiang-zhi-ning-and-its-mechanism-of-action
#37
JOURNAL ARTICLE
Yumiao Li, Yan Zhang, Yu Zhang, Tianfeng Lin, Yanyan Gao, Yuan Cai, Chang Zhou, Leyi Yang, Bin Liu, Shifen Dong, Yanyan Jiang
CONTEXT: Jiang-Zhi-Ning (JZN), a traditional Chinese medicinal formula, is used to treat hyperlipidemia in clinics. OBJECTIVE: To screen the hypolipidemic "bioequivalent substance system (BSS)" of JZN and elucidate the potential hypolipidemic mechanism. MATERIALS AND METHODS: In vitro , the TG content in HepG2 cells was determined after the intervention of the combination of advantageous components (CAC) by uniform design. In vivo , hyperlipidemia models were established by Triton WR-1339 (400 mg/kg; i...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37655452/loke-zupa-decoction-attenuates-bronchial-emt-mediated-airway-remodelling-in-chronic-asthma-through-the-pi3k-akt-hif-1%C3%AE-signaling-pathway
#38
JOURNAL ARTICLE
Jiani Liu, Li Li, Xue Han, Yue Chen, Juanjuan Diao
CONTEXT: Loke zupa decoction (Lok) is a well-established classic Chinese folk remedy for asthma. OBJECTIVE: We sought to investigate the effect and mechanism of Lok on asthma airway remodelling and provide novel insights for the prevention and treatment of asthma. MATERIALS AND METHODS: For in vitro experiments, BEAS-2B cells were assigned into six groups: Control, TGF-β1 (10 μM), TGF-β1 + Lok-20, TGF-β1 + Lok-40, TGF-β1 + Lok-80 μg/mL and TGF-β1 + SB431542 (5 μM)...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37651108/novel-treatment-from-a-botanical-formulation-si-miao-yong-an-decoction-inhibits-vasa-vasorum-angiogenesis-and-stabilizes-atherosclerosis-plaques-via-the-wnt1-%C3%AE-catenin-signalling-pathway
#39
JOURNAL ARTICLE
Zhongwen Qi, Zhipeng Yan, Ke Zhu, Yueyao Wang, Yajie Fan, Tingting Li, Junping Zhang
CONTEXT: Si-Miao-Yong-An (SMYA) has been widely used for the clinical treatment of atherosclerosis (AS). Yet, its complete mechanism of action is not fully understood. OBJECTIVE: To investigate the mechanism by which SMYA stabilizes AS plaques from the perspective of inhibiting vasa vasorum (VV) angiogenesis. MATERIALS AND METHODS: We used male ApoE-/- mice to establish an AS model. The mice were divided into model, SMYA (11.7 mg/kg/d), and simvastatin (SVTT) (2...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37623313/tormentic-acid-a-triterpenoid-isolated-from-the-fruits-of-chaenomeles-speciose-protected-indomethacin-induced-gastric-mucosal-lesion-via-modulating-mir-139-and-the-cxcr4-cxcl12-plc-pkc-rho-a-mlc-pathway
#40
JOURNAL ARTICLE
Jun-Yu He, Jie Li, Yuan-Yuan Zhang, Hai-Bo He, Yu-Min He, Dao-Xiang Xu, Xiao Wang, Hao-Yang Wu, Ji-Hong Zhang, Hasan Jahid, Akter Sadia, Hui-Fan Yu, Jun-Zhi Wang, Kun Zou
CONTEXT: Tormentic acid (TA), an effective triterpenoid isolated from Chaenomeles speciosa (Sweet) Nakai (Rosaceae) fruits, exerts an effective treatment for gastric damage. OBJECTIVE: To investigate the gastroprotective effect of TA on indomethacin (IND) damaged GES-1 cells and rats, and explore potential mechanisms. MATERIALS AND METHODS: TA concentrations of 1.563-25 µM were used. Cell proliferation, apoptosis and migration were performed using MTT, colony formation, wound healing, migration, Hoechst staining assays...
December 2023: Pharmaceutical Biology
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