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Journal of Medicinal Food

Ilmara Cecilia Pinheiro de Silva Morais, Iris Jordânia Luz Moura, Carla Kelly Barroso Sabino, Lucas Antonio Duarte Nicolau, Fabiana de Moura Souza, José Couras da Silva-Filho, Rita de Cássia Meneses Oliveira, Jand Venes Rolim Medeiros, Sidney Gonçalo de Lima, Aldeidia Pereira de Oliveira
Diosgenin is a phytoestrogen and a constituent of Dioscorea. It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant mechanisms of diosgenin in isolated rat aortic rings. Female rats weighing 200-220 g were subjected to sham or OVX operations at 8 weeks of age. Ovariectomy was performed for menopause induction after anesthesia. Diosgenin (10-9 M-3 × 10-4 M) produced a concentration-dependent relaxation in aortic rings precontracted with phenylephrine (1 μM), exhibiting Emax value of 55...
February 8, 2019: Journal of Medicinal Food
Ji Eun Kim, Woo Bin Yun, Mi Lim Lee, Jun Young Choi, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Jin Tae Hong, Hyun Keun Song, Dae Youn Hwang
Constipation is an acute or chronic illness attributed to various causes, ranging from lifestyle habits to side effects of a disease. To improve the laxative effects of some traditional medicines, herbal mixtures of Liriope platyphylla, Glycyrrhiza uralensis, and Cinnamomum cassia (LGC) were evaluated for their mechanism of action and therapeutic effects in loperamide (Lop)-induced constipated Sprague Dawley rats by examining alterations in excretion parameters, histological structure, mucin secretion, and related protein levels...
February 6, 2019: Journal of Medicinal Food
Byoung Wook Bang, Dongsun Park, Kye Sook Kwon, Don Haeng Lee, Min-Jung Jang, Sun Kyu Park, Jeom-Yong Kim
The gastroprotective effects of BST-104 (a water extract of Lonicera japonica) and the mechanisms involved were investigated in murine models of gastritis and peptic ulcer. The gastroprotective effects of BST-104 and its active components were evaluated in rat models of HCl/ethanol-induced gastritis and acetic acid-induced gastric ulcer. After orally administering BST-104, chlorogenic acid, rebamipide (positive control), or vehicle to each animal model, gastric lesion sizes, gastric mucus statuses, proinflammatory cytokine levels, and oxidative stress were measured...
January 24, 2019: Journal of Medicinal Food
Kyung Min Kim, Hee-Seop Lee, Min-Kyu Yun, Hong-Yon Cho, Heui-Jong Yu, Johann Sohn, Sung-Jin Lee
The anti-obesity effects of fermented Castanea crenata inner shell extract (FCCE) were investigated using high-fat diet (HFD)-induced obese mice. In the FCCE intake groups, body weight gain and adipocyte area were significantly reduced, especially body weight gain in the 250 mg/kg FCCE group (G4) decreased by 37%, respectively, compared with negative control group (G2, HFD group). After oral administration of the FCCE, the increase of serum low-density lipoprotein (LDL)-cholesterol induced by HFD was suppressed significantly, as well as the level of aspartate aminotransferase, and alanine aminotransferase, which are markers of hepatitis induced by obesity...
January 23, 2019: Journal of Medicinal Food
Kyung-Jin Jo, Jaewang Ghim, Jaeyoon Kim, Hyengji Lee, Taehoon G Lee, Jong-In Kim, Youngmi Kim, Jong Won Byun, Byung Sun Min, Jae Sun Son, Sang Gap Shim, Woo Jae Cheon, Sung Ho Ryu
Pleurotus eryngii var. ferulae (PEF) is traditionally used in the prevention and treatment of lifestyle-related diseases. In this study, we investigated the ability of PEF extract to prevent obesity and metabolic diseases and explored the underlying mechanism. Mice were fed a high-fat diet (HFD) containing PEF extract for 12 weeks, and their body weight, adipose tissue and liver weights, and lipid profiles and blood glucose levels, were monitored. Fecal triglyceride (TG) levels were also measured and olive oil-loading tests were performed...
January 18, 2019: Journal of Medicinal Food
Ana Carolina Delgado Lima, Clara Cecatti, Melaine Priscila Fidélix, Maria Angela Tallarico Adorno, Isabel Kimiko Sakamoto, Thais Borges Cesar, Katia Sivieri
Ingestion of bioactive compounds, such as hesperidin and naringin, found in citrus fruits and orange juice, can improve the homeostasis of gut microbiota. A controlled clinical study with temporal series intergroup design with 10 apparently healthy women (28.5 ± 8.4 years, 24.1 ± 3.3 kg/m2 ) were evaluated after continuous consumption of commercial pasteurized orange juice for 2 months. Samples of blood serum and stool were collected at basal time and periodically during the experiment for biochemical and microbiology assays...
January 14, 2019: Journal of Medicinal Food
Eunju Leem, Yong-Seok Oh, Won-Ho Shin, Byung Kwan Jin, Jae Yeong Jeong, Minsang Shin, Dong Woon Kim, Jin-Hyeok Jang, Hyung-Jun Kim, Chang Man Ha, Un Ju Jung, Gyeong Joon Moon, Sang Ryong Kim
Parkinson's disease (PD) and Alzheimer's disease exhibit common features of neurodegenerative diseases and can be caused by numerous factors. A common feature of these diseases is neurotoxic inflammation by activated microglia, indicating that regulation of microglial activation is a potential mechanism for preserving neurons in the adult brain. Recently, we reported that upregulation of prothrombin kringle-2 (pKr-2), one of the domains that make up prothrombin and which is cleaved and generated by active thrombin, induces nigral dopaminergic (DA) neuronal death through neurotoxic microglial activation in the adult brain...
January 11, 2019: Journal of Medicinal Food
Neha Bhaskar, Chandrakala Aluganti Narasimhulu, Esraa Keewan, Michael Rohr, Sampath Parthasarathy
Crohn's disease (CD) is a well-known subset of inflammatory bowel disease (IBD) that results in patchy inflammation through the entire thickness of the bowel wall, with the ability to target virtually any part of the gastrointestinal tract, but most commonly affecting the area between the ileum and the cecum. While a bacterial origin of Crohn's is well speculated, it is difficult to pinpoint what drives inflammation in these subjects, particularly the flare-ups or the sudden symptomatic intensification or recurrence...
January 11, 2019: Journal of Medicinal Food
Jung Min Chae, Moon Han Chang, Wan Heo, Hyung Taek Cho, Dong Hun Lee, Bo Byeol Hwang, Jin Woo Kim, Seok Min Yoon, Siyoung Yang, Jin Hyup Lee, Young Jun Kim
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease, is a group of chronic and relapsing inflammatory conditions within the gastrointestinal tract. An increase in intestinal epithelial cell (IEC) apoptosis is a major characteristic of UC. Tumor necrosis factor-α (TNF-α) plays an essential role in the regulation of apoptosis. Aberrant activation of the immune response to resident microflora contributes to overproduction of TNF-α in the mucosal tissue of the gastrointestinal tract; a hallmark of UC...
January 7, 2019: Journal of Medicinal Food
Sonam Tamrakar, Katsuya Fukami, Gopal Prasad Parajuli, Kuniyoshi Shimizu
In the present study, ethanol extracts of 90 wild mushroom samples from Nepal, and the pure compound hispidin, were screened for their ability to inhibit β-hexosaminidase release (BHR) from rat basophilic leukemia-2H3 cells. Simultaneously, the toxicity of the extracts toward the cells was also determined, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Samples belonging to the groups Hymenochaetales and Polyporales showed promising anti-allergic activity, with Phellinus adamantinus and Ganoderma lingzhi 3 allowing a mere 19...
December 31, 2018: Journal of Medicinal Food
Yan-Yan Hor, Cheong-Hwa Ooi, Boon-Yin Khoo, Sy-Bing Choi, Azman Seeni, Shaharum Shamsuddin, Chern-Ein Oon, Kee-Leong Ong, Woo-Sik Jeong, Min-Tze Liong
Aging is an inevitable and ubiquitous progress that affects all living organisms. A total of 18 strains of lactic acid bacteria (LAB) were evaluated on the activation of adenosine monophosphate-activated protein kinase (AMPK), an intracellular energy sensor mediating lifespan extension. The cell-free supernatant (CFS) of Lactobacillus fermentum DR9 (LF-DR9), Lactobacillus paracasei OFS 0291 (LP-0291), and Lactobacillus helveticus OFS 1515 (LH-1515) showed the highest activation of AMPK and was further evaluated...
December 28, 2018: Journal of Medicinal Food
Dongyup Hahn, Jong-Sup Bae
Cardiovascular disease (CVD)-associated thrombosis are the most threatening cause of death worldwide. To resolve this crisis, efforts must be made to discover antithrombotic compounds for development of therapeutic agents with novel mechanisms of action, higher efficacy, and less adverse effects. It might also impact on the development of nutraceuticals to ameliorate vascular disease, and the development of appropriate diets to prevent CVDs. Recently, the research on antithrombotic compounds from edible natural sources increased swiftly by demand, and there has been remarkable progress...
December 28, 2018: Journal of Medicinal Food
James W Daily, Byoung-Seob Ko, Jina Ryuk, Meiling Liu, Weijun Zhang, Sunmin Park
Soy isoflavones may benefit some, but not all, menopausal women, and the ability of the women to produce equol may be the major determinant of effectiveness. We assessed the efficacy of soy isoflavones and equol for alleviating menopausal symptoms, especially vasomotor symptoms, in postmenopausal women who were equol producers and nonproducers by using systematic review and meta-analysis of randomized clinical trials (RCTs). We searched 12 English, Korean, and Chinese language scientific and medical databases...
December 28, 2018: Journal of Medicinal Food
Hyesoo Jeong, Jimin Lee, Soolin Kim, Sujeong Park, Hwasun Yang, Byoung Ha Ahn, Chang Young Jang, Hyun Cheol Jeong, Sung-Jin Lee, Sun Lim Kim, Woo Duck Seo, Johann Sohn, Minsun Chang
Phytoestrogens possess beneficial effects in the management of menopausal symptoms with few side effects. Soybeans are major natural sources of isoflavones, with high estrogen receptor (ER)-β selectivity. The objective of this study therefore was to develop a solvent-mediated extraction method for soybean germinated embryos (SGEs) and to investigate the biological activities of the extract. Ethanolic extraction yielded the SGE extract (SGEE), which had a unique composition of biologically active aglycones and soyasaponins...
December 26, 2018: Journal of Medicinal Food
Hiroyuki Fukami, Taro Ueda, Nobuya Matsuoka
Compound K (CK) is a metabolite of a saponin in Panax ginseng, formed from ginsenoside, a triterpenoid glycoside, by human intestinal bacteria. Lactobacillus paracasei A221 isolated from fermented food can hydrolyze (deglycosylate) the main ginsenoside, ginsenoside Rb1, and generate CK. However, the pharmacokinetics of L. paracasei A221 fermented ginseng (FG) and nonfermented ginseng (NFG) have not been investigated so far. The aim of this study was to investigate the pharmacokinetics of CK after oral administration of single doses of FG and NFG in healthy Japanese adults...
December 13, 2018: Journal of Medicinal Food
Natiele Carla da Silva Ferreira, Rômulo José Soares-Bezerra, Rebeca Ferreira Couto da Silveira, Clayton Menezes da Silva, Carla Santos de Oliveira, Andrea Surrage Calheiros, Tânia Maria Alves, Carlos Leomar Zani, Luiz Anastacio Alves
P2Y2 and P2Y4 receptors are physiologically activated by uridine 5'-triphosphate (UTP) and are widely expressed in many cell types in humans. P2Y2 plays an important role in inflammation and proliferation of tumor cells, which could be attenuated with the use of antagonists. However, little is known about the physiological functions related to P2Y4, due to the lack of selective ligands for these receptors. This can be solved through the search for novel compounds with antagonistic activity. The aim of this study was to discover new potential antagonist candidates for P2Y2 and P2Y4 receptors from natural products...
December 8, 2018: Journal of Medicinal Food
Kibeum Park, Hyo-Jung Yoon, Jee-Young Imm, Gwang-Woong Go
The effects of dietary supplementation with aqueous Hovenia dulcis Thunb. extract (HDE) (20 weeks) on high-fat diet (HFD)-induced nonalcoholic fatty liver disease and dyslipidemia were evaluated in mice. Supplementation with 200 and 800 mg/kg feed HDE (HDE200 and HDE800, respectively) resulted in no significant difference in growth in the HFD-fed groups. The triglyceride (TG) levels and free fatty acids were significantly decreased, whereas high-density lipoprotein cholesterol was increased in the HDE800 group (P < ...
November 29, 2018: Journal of Medicinal Food
Alexandra R Vaughn, Ashley K Clark, Manisha Notay, Raja K Sivamani
To compare the effects of turmeric tablets and turmeric-containing herbal combination tablets versus placebo on skin barrier function and sebum production by measuring facial sebum and transepidermal water loss (TEWL) in healthy subjects. This study was a prospective, double-blinded, rater-blinded, randomized pilot study. Thirty-three generally healthy participants were recruited from the UC Davis Department of Dermatology clinic and the surrounding community from 2016 to 2017, 30 participants were enrolled, and 28 participants completed the study...
November 20, 2018: Journal of Medicinal Food
Jung-Hwan Ko, Isabel Rodriguez, Sun-Woo Joo, Hyoung-Geun Kim, Yeong-Geun Lee, Tong Ho Kang, Nam-In Baek
Malva verticillata (Chinese mallow) has long been used in traditional medicines and herbal teas in Asia. The n-BuOH fraction (Fr) from M. verticillata promoted significant recovery of alloxan-damaged (AXD) pancreatic islets (PIs) in zebrafish (ZF). Two major components were isolated from M. verticillata through repeated-column chromatography. Based on several spectroscopic methods, including nuclear magnetic resonance (NMR), infrared spectroscopy (IR), and fast atom bombardment-mass spectrometry (FAB-MS), the chemical structures of compounds 1 and 2 were determined...
February 2019: Journal of Medicinal Food
Tae-Sun Ha, Dong-Soo Ha
CD2-associated protein (CD2AP), an adaptor protein, plays several important roles in podocyte function, linking slit diaphragms to actin-based cytoskeleton and sending survival signals. Here, we investigated whether ginseng total saponin (GTS) had a protective role in the changes of podocyte CD2AP protein and podocyte apoptosis under in vitro diabetic conditions. Conditionally immortalized mouse podocytes cultured with normal glucose (5 mM) or high glucose (30 mM) and with or without advanced glycosylation end products were treated with GTS...
February 2019: Journal of Medicinal Food
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