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International Journal of Molecular Medicine

https://read.qxmd.com/read/38516776/circular-rnas-and-the-regulation-of-gene-expression-in-diabetic-nephropathy-review
#1
JOURNAL ARTICLE
Maximo Berto Martinez Benitez, Yussel Pérez Navarro, Elisa Azuara-Liceaga, Angeles Tecalco Cruz, Jesús Valdés Flores, Lilia Lopez-Canovas
Circular RNAs (circRNAs) are non‑coding single‑stranded covalently closed RNA molecules that are considered important as regulators of gene expression at the transcriptional and post‑transcriptional levels. These molecules have been implicated in the initiation and progression of multiple human diseases, ranging from cancer to inflammatory and metabolic diseases, including diabetes mellitus and its vascular complications. The present article aimed to review the current knowledge on the biogenesis and functions of circRNAs, as well as their role in cell processes associated with diabetic nephropathy...
May 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38516769/-retracted-sulforaphane-regulates-apoptosis%C3%A2-and-proliferation%C3%A2-related-signaling-pathways-and-synergizes-with-cisplatin-to-suppress-human-ovarian-cancer
#2
Shi-Feng Kan, Jian Wang, Guan-Xing Sun
Following the publication of this paper, the authors realized that they had made an error in assembling the data shown in Fig. 6B on p. 2455, and requested the publication of a corrigendum to rectify this error. However, following an independent investigation of the data published in this paper made by the Editorial Office, it was noted that one set of the immunofluorescence assay images shown in Fig. 4A appeared to be strikingly similar to data appearing in different form in a paper published previously in the journal BMC Medicine by different authors at different research institutes [Jing Y‑Y, Han Z‑P, Sun K, Zhang S‑S, Hou J, Liu Y, Li R, Gao L, Zhao X, Zhao Q‑D et al: Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK‑Mff signaling pathways...
May 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38488030/methylation%C3%A2-sensitive-restriction-enzyme%C3%A2-droplet-digital-pcr-assay-for-the-one%C3%A2-step-highly-sensitive-analysis-of-dna-methylation-hotspots
#3
JOURNAL ARTICLE
Giuseppe Gattuso, Alessandro Lavoro, Rosario Caltabiano, Gabriele Madonna, Mariaelena Capone, Paolo Antonio Ascierto, Luca Falzone, Massimo Libra, Saverio Candido
DNA methylation is an epigenetic modification that plays a key role in several cellular processes mediating the fine regulation of gene expression. Aberrant DNA methylation is observed in a wide range of pathologies, including cancer. Since these DNA modifications are transferred to the cell progenies and are stable over the time, the analysis of DNA methylation status has been proposed for diagnostic and prognostic purposes in cancer. Currently, DNA bisulfite conversion is the gold standard method for the high‑throughput analysis of DNA methylation alterations...
May 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38456562/role-of-circular-rna-as-competing-endogenous-rna-in-ovarian-cancer-review
#4
JOURNAL ARTICLE
Wanlu Ye, Nan Xiang, Qing Wang, Yanming Lu
Circular RNA (circRNA), a type of non‑coding RNA, plays a regulatory role in biological processes. The special loop structure of circRNA makes it highly stable and specific in diseased tissues and cells, especially in tumors. Competing endogenous RNAs (ceRNAs) compete for the binding of microRNA (miRNA) at specific binding sites and thus regulate gene expression. ceRNAs play an important role in various diseases and are currently recognized as the most prominent mechanism of action of circRNAs. circRNAs can modulate the proliferation, migration, invasion and apoptosis of tumor cells through the ceRNA mechanism...
May 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38426604/adipocyte%C3%A2-rich-microenvironment-promotes-chemoresistance-via-upregulation-of-peroxisome-proliferator%C3%A2-activated-receptor-gamma-abcg2-in-epithelial-ovarian-cancer
#5
JOURNAL ARTICLE
Siqi Chen, Zixuan Liu, Haixia Wu, Bo Wang, Yuqing Ouyang, Junru Liu, Xiaoyan Zheng, Haoke Zhang, Xueying Li, Xiaofan Feng, Yan Li, Yangyang Shen, Hong Zhang, Bo Xiao, Chunyan Yu, Weimin Deng
The effects of adipocyte‑rich microenvironment (ARM) on chemoresistance have garnered increasing interest. Ovarian cancer (OVCA) is a representative adipocyte‑rich associated cancer. In the present study, epithelial OVCA (EOC) was used to investigate the influence of ARM on chemoresistance with the aim of identifying novel targets and developing novel strategies to reduce chemoresistance. Bioinformatics analysis was used to explore the effects of ARM‑associated mechanisms contributing to chemoresistance and treated EOC cells, primarily OVCAR3 cells, with human adipose tissue extracts (HATES) from the peritumoral adipose tissue of patients were used to mimic ARM in vitro...
April 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38426579/cytoplasmic-localization-of-setdb1%C3%A2-induced-warburg-effect-via-c%C3%A2-myc%C3%A2-ldha-axis-enhances-migration-and-invasion-in-breast-carcinoma
#6
JOURNAL ARTICLE
Wenlin Yang, Yingze Wei, Ting Wang, Ying Xu, Xiaoxia Jin, Hongyan Qian, Shuyun Yang, Song He
SET domain bifurcated 1 (SETDB1), a pivotal histone lysine methyltransferase, is transported to the cytoplasm via a chromosome region maintenance 1 (CMR1)‑dependent pathway, contributing to non‑histone methylation. However, the function and underlying mechanism of cytoplasmic SETDB1 in breast cancer remain elusive. In the present study, immunohistochemistry revealed that elevated cytoplasmic SETDB1 was correlated with lymph node metastasis and more aggressive breast cancer subtypes. Functionally, wound healing and Transwell assays showed that cytoplasmic SETDB1 is key for cell migration and invasion, as well as induction of epithelial‑mesenchymal transition (EMT), which was reversed by leptomycin B (LMB, a CMR1 inhibitor) treatment...
April 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38426556/-corrigendum-bax-inhibitor%C3%A2-1-suppresses-early-brain-injury-following-experimental-subarachnoid-hemorrhage-in-rats
#7
Jiaxin Liu, Shuai Zhou, Yueting Zhang, Xiuying Li, Xiying Qian, Weihua Tao, Lide Jin, Jianhua Zhao
Following the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 6 on p. 2898, the 'SAH' and 'SAH+NC' data panels contained an apparently overlapping section of data, such that these data appeared to have been derived from the same original source, even though they were intended to show the results from differently performed experiments. The authors have examined their original data, and realize that the 'SAH+NC' data panel had inadvertently been selected incorrectly for this figure...
April 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38426543/identification-of-novel-molecules-and-pathways-associated-with-fascin-actin%C3%A2-bundling-protein-1-in-laryngeal-squamous-cell-carcinoma-through-comprehensive-transcriptome-analysis
#8
JOURNAL ARTICLE
Hongliang Liu, Wenjing Hao, Xinfang Wang, Yuliang Zhang, Long He, Xuting Xue, Jiao Yang, Chunming Zhang
Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin‑bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells in which FSCN1 was knocked down. A total of 462 up and 601 downregulated mRNA transcripts were identified...
April 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38391090/vestibular-dysfunction-leads-to-cognitive-impairments-state%C3%A2-of%C3%A2-knowledge-in-the-field-and-clinical-perspectives-review
#9
JOURNAL ARTICLE
Jiaqi Guo, Jun Wang, Pei Liang, E Tian, Dan Liu, Zhaoqi Guo, Jingyu Chen, Yuejin Zhang, Zhanghong Zhou, Weijia Kong, Debbie C Crans, Yisheng Lu, Sulin Zhang
The vestibular system may have a critical role in the integration of sensory information and the maintenance of cognitive function. A dysfunction in the vestibular system has a significant impact on quality of life. Recent research has provided evidence of a connection between vestibular information and cognitive functions, such as spatial memory, navigation and attention. Although the exact mechanisms linking the vestibular system to cognition remain elusive, researchers have identified various pathways. Vestibular dysfunction may lead to the degeneration of cortical vestibular network regions and adversely affect synaptic plasticity and neurogenesis in the hippocampus, ultimately contributing to neuronal atrophy and cell death, resulting in memory and visuospatial deficits...
April 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38391009/lymphangiogenesis-a-new-strategy-for-heart-disease-treatment-review
#10
JOURNAL ARTICLE
Liding Bai, Yanyan Wang, Siqi Du, Yumeng Si, Lu Chen, Lin Li, Yuhong Li
Heart disease remains a global health challenge, contributing notably to morbidity and mortality. The lymphatic vasculature, an integral component of the cardiovascular system, plays a crucial role in regulating essential physiological processes, including fluid balance, transportation of extravasated proteins and immune cell trafficking, all of which are important for heart function. Through thorough scientometric analysis and extensive research, the present review identified lymphangiogenesis as a hotspot in cardiovascular disease research, and the mechanisms underlying impaired cardiac lymphangiogenesis and inadequate lymph drainage in various cardiovascular diseases are discussed...
April 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38390952/elimination-of-intracellular-ca-2-overload-by-bapta%C3%A2-am-liposome-nanoparticles-a-promising-treatment-for-acute-pancreatitis
#11
JOURNAL ARTICLE
Zailin Fu, Dingsheng Wang, Caiyun Zheng, Minghua Xie, Yifang Chen, Yi Zhou, Yan Huang, Ying Song, Weiyong Hong
Calcium overload, a notable instigator of acute pancreatitis (AP), induces oxidative stress and an inflammatory cascade, subsequently activating both endogenous and exogenous apoptotic pathways. However, there is currently lack of available pharmaceutical interventions to alleviate AP by addressing calcium overload. In the present study, the potential clinical application of liposome nanoparticles (LNs) loaded with 1,2‑bis(2‑aminophenoxy)ethane‑N,N,N',N'‑tetraacetic acid tetrakis (acetoxymethyl ester) (BAPTA‑AM), a cell‑permeant calcium chelator, was investigated as a therapeutic approach for the management of AP...
April 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38362962/research-progress-challenges-and-perspectives-of-phospholipids-metabolism-in-the-lxr%C3%A2-lpcat3-signaling-pathway-and-its-relation-to-nafld-review
#12
JOURNAL ARTICLE
Junmin Wang, Jiacheng Li, Yugang Fu, Yingying Zhu, Liubing Lin, Yong Li
Phospholipids (PLs) are principle constituents of biofilms, with their fatty acyl chain composition significantly impacting the biophysical properties of membranes, thereby influencing biological processes. Recent studies have elucidated that fatty acyl chains, under the enzymatic action of lyso‑phosphatidyl‑choline acyltransferases (LPCATs), expedite incorporation into the sn‑2 site of phosphatidyl‑choline (PC), profoundly affecting pathophysiology. Accumulating evidence suggests that alterations in LPCAT activity are implicated in various diseases, including non‑alcoholic fatty liver disease (NAFLD), hepatitis C, atherosclerosis and cancer...
April 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38362920/protein-aggregation-and-biomolecular-condensation-in-hypoxic-environments-review
#13
JOURNAL ARTICLE
Chaoqun Li, Bingjie Hao, Haiguang Yang, Kai Wang, Lihong Fan, Weihua Xiao
Due to molecular forces, biomacromolecules assemble into liquid condensates or solid aggregates, and their corresponding formation and dissolution processes are controlled. Protein homeostasis is disrupted by increasing age or environmental stress, leading to irreversible protein aggregation. Hypoxic pressure is an important factor in this process, and uncontrolled protein aggregation has been widely observed in hypoxia‑related conditions such as neurodegenerative disease, cardiovascular disease, hypoxic brain injury and cancer...
April 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38334226/-retracted-long-non%C3%A2-coding-rna-kcnq1ot1-promotes-nasopharyngeal-carcinoma-cell-cisplatin-resistance-via-the-mir%C3%A2-454-usp47-axis
#14
Feng Yuan, Zhiping Lou, Zhifeng Zhou, Xiaojun Yan
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the colony formation assay data shown in Figs. 4C and 6D and the Transwell migration and invasion assay data shown in Figs. 4D, 6E and 6F were strikingly similar to data appearing in different form in other research articles written by different authors at different research institutes that had either already been published, or were submitted for publication at around the same time. Owing to the fact that contentious data in the above article had already been published elsewhere prior to its submission to International Journal of Molecular Medicine , the Editor has decided that this paper should be retracted from the Journal...
April 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38299238/-retracted-antagonist-targeting-mir%C3%A2-106b%C3%A2-5p-attenuates-acute-renal-injury-by-regulating-renal-function-apoptosis-and-autophagy-via-the-upregulation-of-tcf4
#15
Jing-Meng Hu, Li-Jie He, Peng-Bo Wang, Yan Yu, Ya-Ping Ye, Li Liang
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the EdU staining assay data shown in Figs. 4C and 5C and the western blotting data shown in Fig. 4E were strikingly similar to data appearing in different form in other research articles written by different authors at different research institutes that had either already been published, or were submitted for publication at around the same time. Owing to the fact that contentious data in the above article had already been submitted for publication elsewhere prior to its submission to International Journal of Molecular Medicine , the Editor has decided that this paper should be retracted from the Journal...
March 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38299237/a-mid%C3%A2-pandemic-night-s-dream-melatonin-from%C3%A2-harbinger-of-anti%C3%A2-inflammation-to-mitochondrial-savior-in-acute-and-long-covid%C3%A2-19-review
#16
JOURNAL ARTICLE
Ioannis G Lempesis, Vasiliki Epameinondas Georgakopoulou, Russel J Reiter, Demetrios A Spandidos
Coronavirus disease 2019 (COVID‑19), a systemic illness caused by severe acute respiratory distress syndrome 2 (SARS‑CoV‑2), has triggered a worldwide pandemic with symptoms ranging from asymptomatic to chronic, affecting practically every organ. Melatonin, an ancient antioxidant found in all living organisms, has been suggested as a safe and effective therapeutic option for the treatment of SARS‑CoV‑2 infection due to its good safety characteristics and broad‑spectrum antiviral medication properties...
March 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38299236/influence-of-the-brain%C3%A2-gut-axis-on-neuroinflammation-in-cerebral-ischemia%C3%A2-reperfusion-injury-review
#17
JOURNAL ARTICLE
Yifeng Zhang, Hang Yang, Shuai Hou, Yulei Xia, Yan-Qiang Wang
Stroke, a debilitating cerebrovascular ailment, poses significant threats to human life and health. The intricate interplay between the gut‑brain‑microbiota axis (GBMA) and cerebral ischemia‑reperfusion has increasingly become a focal point of scientific exploration, emerging as a pivotal research avenue in stroke pathophysiology. In the present review, the authors delved into the nexus between the GBMA and neuroinflammation observed post‑stroke. The analysis underscored the pivotal roles of histone deacetylase 3 and neutrophil extracellular traps subsequent to stroke incidents...
March 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38275122/-corrigendum-propofol%C3%A2-induced-hoxa11%C3%A2-as-promotes-proliferation-migration-and-invasion-but-inhibits-apoptosis-in-hepatocellular-carcinoma-cells-by-targeting-mir%C3%A2-4458
#18
Furong Song, Jun Liu, Yawei Feng, Yi Jin
Following the publication of the above article, an interested reader drew to the authors' attention that the western blots for the PCNA and cyclin D1 bands appeared to be strikingly similar. The authors were able to re‑examine their original data, and recognize how the error was made with respect to the compilation of this figure (they were also able to demonstrate to the Editorial Office how the error occurred). The revised version of Fig. 3, now incorporating the correct data for the PCNA bands in Fig...
March 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38240118/senolytic-combination-of-dasatinib-and-quercetin-protects-against-diabetic-kidney-disease-by-activating-autophagy-to%C3%A2-alleviate-podocyte-dedifferentiation-via-the-notch-pathway
#19
JOURNAL ARTICLE
Xinwang Zhu, Congxiao Zhang, Linlin Liu, Li Xu, Li Yao
The senolytics dasatinib and quercetin (DQ) alleviate age‑related disorders. However, limited information is available regarding the effects of DQ on diabetic kidney disease (DKD). The present study aimed to explore the effects of DQ on DKD and its potential molecular mechanism(s). Dasatinib (5 mg/kg) and quercetin (50 mg/kg) were administered to diabetic db/db mice by gavage for 20 weeks. Body weight, urine albumin‑creatinine ratio (ACR), serum creatinine (Scr), and blood urea nitrogen (BUN) were recorded at the indicated time periods...
March 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38240105/-retracted-microrna%C3%A2-15a%C3%A2-5p%C3%A2-targeting-oncogene-yap1-inhibits-cell-viability-and-induces-cell-apoptosis-in-cervical-cancer-cells
#20
Xu Chen, Ruiqin Cao, Haifang Liu, Tuanying Zhang, Xinrong Yuan, Shuxiang Xu
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell invasion assay data shown in Fig. 3A and B on p. 1306 were strikingly similar to data appearing in different form in a paper by different authors at a different research institute that had already been submitted for publication. Owing to the fact that the contentious data in the above article had already been submitted for publication prior to its submission to International Journal of Molecular Medicine , the Editor has decided that this paper should be retracted from the Journal...
March 2024: International Journal of Molecular Medicine
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