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Journals International Journal of Molec...

International Journal of Molecular Medicine

https://read.qxmd.com/read/38963054/panoptosis-novel-insight-into-regulated-cell-death-and-its-potential-role-in-cardiovascular-diseases-review
#1
REVIEW
Xinyu Gao, Cuixue Ma, Shan Liang, Meihong Chen, Yuan He, Wei Lei
PANoptosis, a complex form of proinflammatory programmed cell death, including apoptosis, pyroptosis and necroptosis, has been an emerging concept in recent years that has been widely reported in cancer, infectious diseases and neurological disorders. Cardiovascular diseases (CVDs) are an important global health problem, posing a serious threat to individuals' lives. An increasing body of research shows that inflammation has a pivotal role in CVDs, which provides an important theoretical basis for PANoptosis to promote the progression of CVDs...
September 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38963051/salusin%C3%A2-%C3%AE-alleviates-lipid-metabolism-disorders-via-regulation-of-the-downstream-lipogenesis-genes-through-the-lkb1-ampk-pathway
#2
JOURNAL ARTICLE
Jintong Pan, Chao Yang, Aohong Xu, Huan Zhang, Ye Fan, Rong Zeng, Lin Chen, Xiang Liu, Yuxue Wang
Lipid metabolism disorders are a major cause of several chronic metabolic diseases which seriously affect public health. Salusin‑α, a vasoactive peptide, has been shown to attenuate lipid metabolism disorders, although its mechanism of action has not been reported. To investigate the effects and potential mechanisms of Salusin‑α on lipid metabolism, Salusin‑α was overexpressed or knocked down using lentiviral vectors. Hepatocyte steatosis was induced by free fatty acid (FFA) after lentiviral transfection into HepG2 cells...
September 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38963035/improved-efficacy-of-cisplatin-delivery-by-peanut-agglutinin%C3%A2-modified-liposomes-in-non%C3%A2-small-cell-lung-cancer
#3
JOURNAL ARTICLE
Ben Yang, Rongguan Kou, Hui Wang, Anping Wang, Lili Wang, Sipeng Sun, Mengqi Shi, Shouzhen Zhao, Yubing Wang, Yi Wang, Jingliang Wu, Fei Wu, Fan Yang, Meihua Qu, Wenjing Yu, Zhiqin Gao
Globally, non‑small cell lung cancer (NSCLC) is a significant threat to human health, and constitutes >80% of lung cancer cases. Cisplatin (CDDP), a commonly used drug in clinical treatment, has been the focus of research aiming to mitigate its potent toxicity through encapsulation within liposomes. However, challenges, such as a reduced drug loading efficiency and nonspecific release, have emerged as obstacles. The present study aimed to improve the encapsulation efficiency of CDDP within liposomes by pre‑preparation of CDDP and modifying the liposome surface through the incorporation of peanut agglutinin (PNA) as a ligand [CDDP‑loaded PNA‑modified liposomes (CDDP‑PNA‑Lip)]...
August 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38963023/metformin-prevents-the-onset-and-progression-of-intervertebral-disc-degeneration-new-insights-and-potential-mechanisms-review
#4
REVIEW
Wenzhi Yang, Yipin Yang, Yong Wang, Zongshi Gao, Jingtang Zhang, Weimin Gao, Yanjun Chen, You Lu, Haoyu Wang, Lingyan Zhou, Yifan Wang, Jie Li, Hui Tao
Metformin has been the go‑to medical treatment for addressing type 2 diabetes mellitus (T2DM) as a frontline oral antidiabetic. Obesity, cancer and bone deterioration are linked to T2DM, which is considered a metabolic illness. Numerous diseases associated with T2DM, such as tumours, cardiovascular disease and bone deterioration, may be treated with metformin. Intervertebral disc degeneration (IVDD) is distinguished by degeneration of the spinal disc, accompanied by the gradual depletion of proteoglycans and water in the nucleus pulposus (NP) of the IVD, resulting in lower back pain...
August 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38963019/roles-of-long-non%C3%A2-coding-rnas-in-esophageal-cell-squamous-carcinoma-review
#5
REVIEW
Qihang Yan, Wingshing Wong, Li Gong, Jie Yang, Dachuan Liang, Kok-Yong Chin, Shuqin Dai, Junye Wang
Esophageal squamous cell carcinoma (ESCC) is a prevalent and deadly malignancy of the digestive tract. Recent research has identified long non‑coding RNAs (lncRNAs) as crucial regulators in the pathogenesis of ESCC. These lncRNAs, typically exceeding 200 nucleotides, modulate gene expression through various mechanisms, including the competing endogenous RNA (ceRNA) pathway and RNA‑protein interactions. The current study reviews the multifaceted roles of lncRNAs in ESCC, highlighting their involvement in processes such as proliferation, migration, invasion, epithelial‑mesenchymal transition, cell cycle progression, resistance to radiotherapy and chemotherapy, glycolysis, apoptosis, angiogenesis, autophagy, tumor growth, metastasis and the maintenance of cancer stem cells...
August 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38940355/role-of-ubiquitination-in-the-occurrence-and-development-of-osteoporosis-review
#6
REVIEW
Xiaoxia Fan, Rong Zhang, Guocai Xu, Peiyun Fan, Wei Luo, Chunmei Cai, Ri-Li Ge
The ubiquitin (Ub)‑proteasome system (UPS) plays a pivotal role in maintaining protein homeostasis and function to modulate various cellular processes including skeletal cell differentiation and bone homeostasis. The Ub ligase E3 promotes the transfer of Ub to the target protein, especially transcription factors, to regulate the proliferation, differentiation and survival of bone cells, as well as bone formation. In turn, the deubiquitinating enzyme removes Ub from modified substrate proteins to orchestrate bone remodeling...
August 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38940352/-retracted-sirt1-inhibits-hg%C3%A2-induced-endothelial-injury-role-of-mff%C3%A2-based-mitochondrial-fission-and-f%C3%A2-actin-homeostasis%C3%A2-mediated-cellular-migration
#7
Ruijie Qin, Lina Zhang, Dong Lin, Fei Xiao, Lixin Guo
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the immunochemistry data shown in Figs. 4K and 7G were strikingly similar to data appearing in different form in other research articles written by different authors at different research institutes that had either already been published, or were submitted for publication at around the same time. Owing to the fact that contentious data in the above article had already been published elsewhere prior to its submission to International Journal of Molecular Medicine , the Editor has decided that this paper should be retracted from the Journal...
August 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38940336/therapeutic-impacts-of-gne%C3%A2-477%C3%A2-loaded-h-2-o-2-stimulus%C3%A2-responsive-dodecanoic-acid%C3%A2-phenylborate-ester%C3%A2-dextran-polymeric-micelles-on-osteosarcoma
#8
JOURNAL ARTICLE
Songmu Pan, Zhuan Zou, Xiaofeng Zhou, Jiyong Wei, Huijiang Liu, Zhongyi Su, Gui Liao, Guangyu Huang, Zonggui Huang, Yi Xu, Minan Lu, Ronghe Gu
Osteosarcoma (OS) is a highly malignant primary bone neoplasm that is the leading cause of cancer‑associated death in young people. GNE‑477 belongs to the second generation of mTOR inhibitors and possesses promising potential in the treatment of OS but dose tolerance and drug toxicity limit its development and utilization. The present study aimed to prepare a novel H2 O2 stimulus‑responsive dodecanoic acid (DA)‑phenylborate ester‑dextran (DA‑B‑DEX) polymeric micelle delivery system for GNE‑477 and evaluate its efficacy...
August 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38940332/naringenin-modulates-the-no%C3%A2-cgmp%C3%A2-pkg-signaling-pathway-by-binding-to-akt-to-enhance-osteogenic-differentiation-in-hpdlscs
#9
JOURNAL ARTICLE
Shenghong Li, Zhenqiang Xiong, Yuxin Lan, Qian Zheng, Li Zhang, Xiaomei Xu
Naringenin (NAR) is a prominent flavanone that has been recognized for its capacity to promote the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs). The present study aimed to explore how NAR promotes the osteogenic differentiation of hPDLSCs and to assess its efficacy in repairing alveolar bone defects. For this purpose, a protein‑protein interaction network of NAR action was established by mRNA sequencing and network pharmacological analysis. Gene and protein expression levels were evaluated by reverse transcription‑quantitative and western blotting...
August 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38904202/public-neoantigens-in-breast-cancer-immunotherapy-review
#10
REVIEW
Natthaporn Sueangoen, Peti Thuwajit, Pa-Thai Yenchitsomanus, Chanitra Thuwajit
Among women globally, breast cancer is the most prevalent cancer and the leading cause of cancer‑related death. Interestingly, though genetic mutations contribute to the disease, <15% of women diagnosed with breast cancer have a family history of the disease, suggesting a prevalence of sporadic genetic mutations in breast cancer development. In the rapidly rising field of cancer genomics, neoantigen‑based immunotherapy has come to the fore. The investigation of novel proteins arising from unique somatic mutations or neoantigens have opened a new pathway for both individualized and public cancer treatments...
July 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38904197/-retracted-knockdown-of-snhg16-suppresses-the-proliferation-and-induces-the-apoptosis-of-leukemia-cells-via-mir%C3%A2-193a%C3%A2-5p-cdk8
#11
Meihua Piao, Li Zhang
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the colony formation assay data shown in Fig. 7A on p. 1183 were strikingly similar to data appearing in different form in the following article written by different authors at different research institutes that had already been published prior to its date of submission: Lou L, Chen G, Zhong B and Liu F: Lycium barbarum polysaccharide induced apoptosis and inhibited proliferation in infantile hemangioma endothelial cells via down‑regulation of PI3K/AKT signaling pathway...
July 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38874017/anthrahydroquinone%C3%A2-2-6%C3%A2-disulfonate-attenuates-pq%C3%A2-induced-acute-lung-injury-through-decreasing-pulmonary-microvascular-permeability-via-inhibition-of-the-pi3k-akt-enos-pathway
#12
JOURNAL ARTICLE
Nan Li, Yang Yi, Jun Chen, Yue Huang, Jichao Peng, Zhao Li, Ying Wang, Jiadong Zhang, Chaoqun Xu, Haoran Liu, Jinghua Li, Xiaoran Liu
In paraquat (PQ)‑induced acute lung injury (ALI)/ acute respiratory distress syndrome, PQ disrupts endothelial cell function and vascular integrity, which leads to increased pulmonary leakage. Anthrahydroquinone‑2,6‑disulfonate (AH2QDS) is a reducing agent that attenuates the extent of renal injury and improves survival in PQ‑intoxicated Sprague‑Dawley (SD) rats. The present study aimed to explore the beneficial role of AH2QDS in PQ‑induced ALI and its related mechanisms...
July 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38847279/-corrigendum-resveratrol-upregulates-socs1-production-by-lipopolysaccharide%C3%A2-stimulated-raw264-7-macrophages-by-inhibiting-mir%C3%A2-155
#13
Chunfang Ma, Yin Wang, Aijuan Shen, Wanru Cai
Following the publication of the above article, an interested reader drew to the authors' attention that the gel slice shown for the p38MAPK bands in Fig. 2C on p. 234 was strikingly similar to the β‑actin bands shown in Fig. 3B on p. 235, albeit their orientations appeared to have been altered horizontally through 180°. The authors consulted their original data, and were able to determine that the duplication of these figure parts had inadvertently arisen during the process of compiling Fig...
July 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38818830/obesity-and-lipid-metabolism-in-the-development-of-osteoporosis-review
#14
REVIEW
Xiaochuan Wang, Chi Zhang, Guang Zhao, Keda Yang, Lin Tao
Osteoporosis is a common bone metabolic disease that causes a heavy social burden and seriously threatens life. Improving osteogenic capacity is necessary to correct bone mass loss in the treatment of osteoporosis. Osteoblasts are derived from the differentiation of bone marrow mesenchymal stem cells, a process that opposes adipogenic differentiation. The peroxisome proliferator‑activated receptor γ and Wnt/β‑catenin signaling pathways mediate the mutual regulation of osteogenesis and adipogenesis...
July 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38785162/role-of-lactate-and-lactate-metabolism-in-liver-diseases-review
#15
REVIEW
Shun Yao, Hongyu Chai, Ting Tao, Li Zhang, Xingyue Yang, Xin Li, Zhiqiang Yi, Yongfeng Wang, Jiaxin An, Guorong Wen, Hai Jin, Biguang Tuo
Lactate is a byproduct of glycolysis, and before the Warburg effect was revealed (in which glucose can be fermented in the presence of oxygen to produce lactate) it was considered a metabolic waste product. At present, lactate is not only recognized as a metabolic substrate that provides energy, but also as a signaling molecule that regulates cellular functions under pathophysiological conditions. Lactylation, a post‑translational modification, is involved in the development of various diseases, including inflammation and tumors...
July 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38785138/paeoniflorigenone-inhibits-ovarian-cancer-metastasis-through-targeting-the-muc1-wnt-%C3%AE-%C3%A2-catenin-pathway
#16
JOURNAL ARTICLE
Qingling Liu, Liqin Jiang, Yun Zhao, Fang Su, Junfeng Li, Xinxin Tian, Wenhong Liu, Xiawei Jiang, Ye Xu, Fangfang Tao
Ovarian cancer (OC) is one of the most common gynecological malignancies. Currently, chemoradiotherapy is the primary clinical treatment approach for OC; however, it has severe side effects and a high rate of recurrence. Thus, there is an urgent need to develop innovative therapeutic options. Paeoniflorigenone (PFG) is a monoterpene compound isolated from the traditional Chinese medicine Paeoniae Radix Rubra. PFG can inhibit the proliferation of tumor cells; however, its anticancer activity against OC has yet to be elucidated...
July 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38757359/-retracted-downregulation-of-cks1b-restrains-the-proliferation-migration-invasion-and-angiogenesis-of-retinoblastoma-cells-through-the-mek-erk-signaling-pathway
#17
Zhou Zeng, Zhao-Lin Gao, Zhi-Pei Zhang, Hai-Bo Jiang, Chang-Quan Yang, Jie Yang, Xiao-Bo Xia
Following the publication of the above paper, it has been drawn to the Editors' attention by a concerned reader that certain of the lumen formation assay data shown in Fig. 5A on p. 112 were strikingly similar to data appearing in different form in another article written by different authors at different research institute, which had already been published in the journal Biomedicine & Pharmacotherapy prior to the submission of this paper to International Journal of Molecular Medicine , and which has also subsequently been retracted...
July 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38757360/effects-of-pcsk9-on-thrombosis-and-haemostasis-in-a-variety-of-metabolic-states-lipids-and-beyond-review
#18
REVIEW
Shan Chong, Guangyan Mu, Xinan Cen, Qian Xiang, Yimin Cui
Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors are widely recognised as being able to induce a potent reduction in low‑density lipoprotein‑cholesterol. An increasing number of studies have suggested that PCSK9 also influences the haemostatic system by altering platelet function and the coagulation cascade. These findings have significant implications for anti‑PCSK9 therapy in patients with specific coagulation conditions, including expanded indications, dose adjustments and drug interactions...
June 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38695243/predictive-dna-damage-signaling-for-low%C3%A2-dose-ionizing-radiation
#19
JOURNAL ARTICLE
Jeong-In Park, Seung-Youn Jung, Kyung-Hee Song, Dong-Hyeon Lee, Jiyeon Ahn, Sang-Gu Hwang, In-Su Jung, Dae-Seog Lim, Jie-Young Song
Numerous studies have attempted to develop biological markers for the response to radiation for broad and straightforward application in the field of radiation. Based on a public database, the present study selected several molecules involved in the DNA damage repair response, cell cycle regulation and cytokine signaling as promising candidates for low‑dose radiation‑sensitive markers. The HuT 78 and IM‑9 cell lines were irradiated in a concentration‑dependent manner, and the expression of these molecules was analyzed using western blot analysis...
June 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38695222/effects-of-dna-methylation-and-its-application-in-inflammatory-bowel-disease-review
#20
REVIEW
Francis Atim Akanyibah, Yi Zhu, Aijun Wan, Dickson Kofi Wiredu Ocansey, Yuxuan Xia, An-Ning Fang, Fei Mao
Inflammatory bowel disease (IBD) is marked by persistent inflammation, and its development and progression are linked to environmental, genetic, immune system and gut microbial factors. DNA methylation (DNAm), as one of the protein modifications, is a crucial epigenetic process used by cells to control gene transcription. DNAm is one of the most common areas that has drawn increasing attention recently, with studies revealing that the interleukin (IL)‑23/IL‑12, wingless‑related integration site, IL‑6‑associated signal transducer and activator of transcription 3, suppressor of cytokine signaling 3 and apoptosis signaling pathways are involved in DNAm and in the pathogenesis of IBD...
June 2024: International Journal of Molecular Medicine
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