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Combinatorial Chemistry & High Throughput Screening

Chaohui Duan, Yang Li, Xiaorui Dong, Weibin Xu, Yingli Ma
AIM AND OBJECTIVE: Avicularin has been found to inhibit the proliferation of HepG-2 cells in vitro in the screening of our laboratory. And we intended to explain the molecular mechanism of this effect. Therefore, the combined methods of reverse molecular docking and network pharmacology were used in order to illuminate the molecular mechanisms for Avicularin against cancer. MATERIALS AND METHODS: Potential targets associated with anti-tumor effects of Avicularin were screened by reverse molecular docking, then a protein database was established through constructing the drug-protein network from literature mining data, and the protein-protein network was built through an in-depth exploration of the relationships between the proteins, and then the network topology analysis was performed...
February 6, 2019: Combinatorial Chemistry & High Throughput Screening
Yunhua Zhang, Dong Dong, Dai Li, Lin Lu, JiaRui Li, YuHang Zhang, Lijuan Chen
BACKGROUND: Cereal hull color is an important quality specification characteristic. Many studies were conducted to identify genetic changes underlying cereal hull color diversity. However, these studies mainly focused on the gene level. Recent studies have suggested that metabolomics can accurately reflect the integrated and real-time cell processes that contribute to the formation of different cereal colors. METHODS: In this study, we exploited published metabolomics databases and applied several advanced computational methods, such as minimum redundancy maximum relevance (mRMR), incremental forward search (IFS), random forest (RF) to investigate cereal hull color at metabolic level...
January 28, 2019: Combinatorial Chemistry & High Throughput Screening
Jing Zhong, Jian-Ming Chen, Song-Lin Chen, Yun-Feng Yi
AIM AND OBJECTIVE: A significant proportion of patients with early non-small cell lung cancer (NSCLC) can be cured by surgery. The distant metastasis of tumors is the most common cause of treatment failure. Precisely predicting the likelihood that a patient develops distant metastatic risk will help identify patients who can further intervene, such as conventional adjuvant chemotherapy or experimental drugs. MATERIALS AND METHODS: Current molecular biology techniques enable the whole genome screening of differentially expressed genes, and rapid development of a large number of bioinformatics methods to improve prognosis...
January 28, 2019: Combinatorial Chemistry & High Throughput Screening
Wei-Yuan Xu, Wei-Liang Tang, Min Yuan, Yong Sun, Feng Xu, Fang Peng
BACKGROUND: Circulating endothelial progenitor cells (EPCs) have regenerative capacities and play an important role in vessel wall homeostasis. When attracted to the site of vessel wall injury, EPCs rapidly differentiate into a functional layer as part of the healing process. The Genous TM endothelial progenitor cell (EPC) capturing stent is coated with anti-human CD34+ antibodies which combine with circulating EPCs from the peripheral blood to the stent surface. OBJECTIVE: This meta-analysis aims to explore the Genous TM endothelial progenitor cell capturing stent in coronary artery disease (CAD) adverse event rate after one year follow-up...
January 28, 2019: Combinatorial Chemistry & High Throughput Screening
Chu-Hui Ru, Yan-Bing Zhuang
BACKGROUND: Patients with previously treated non-small-cell lung cancer (NSCLC) have limited treatment options. A novel treatment based on programed death 1 (PD-1)/programed death ligand 1 (PD-L1) inhibitors has emerged as promising therapeutic options for advanced NSCLC. We assessed oncological outcomes of PD-L1 antibody versus docetaxel in previously treated NSCLC. OBJECTIVES: The purpose of this meta-analysis was to analysis the oncological outcomes of anti-PD1 to chemotherapy in treatment of non-small-cell lung cancer...
January 25, 2019: Combinatorial Chemistry & High Throughput Screening
Baoling Guo, Qiuxiang Zheng
AIM AND OBJECTIVE: Lung cancer is a highly heterogeneous cancer, due to the significant differences in molecular levels, resulting in different clinical manifestations of lung cancer patients there is a big difference. Including disease characterization, drug response, risk of recurrence, survival, etc. Method: Clinical patients with lung cancer is not yet particularly effective treatment options, while patients with lung cancer resistance not only delayed the treatment cycle, but also caused a strong side effects...
January 25, 2019: Combinatorial Chemistry & High Throughput Screening
Zhi-Hong Yu, Miao Chen, Qing-Qian Zhang, Xun Hu
The association between vitamin D receptor (VDR) genetic polymorphism and lung cancer risk has been evaluated by previous meta-analyses. Due to emergence of novel studies and inappropriate inclusion of overlapping populations, an update meta-analysis on recent evidences is necessarily needed. We comprehensively searched databases of PubMed, Web of Science and Chinese National Knowledge Infrastructure and finally obtained 7 eligible studies according to the inclusion criteria. Four positions on VDR gene, namely ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810) and TaqI (rs731236), were considered in this investigation...
January 25, 2019: Combinatorial Chemistry & High Throughput Screening
Yin Wang, Zhenhao Liu, Baofeng Lian, Lei Liu, Lu Xie
AIM AND OBJECTIVE: Integrating multi-omics data to identify driver genes and key biological functions for tumorigenesis remains a major challenge. METHOD: A new computational pipeline was developed to identify the Driver Mutation-Differential Co-Expresison (DM-DCE) modules based on dysfunctional networks across 11 TCGA cancers. RESULTS: Functional analyses provided insight into properties of various cancers, and found common cellular signals / pathways of cancers...
January 21, 2019: Combinatorial Chemistry & High Throughput Screening
Dan Zhu, Long Yu, Hui Chen
OBJECTIVE: Explored the application and diagnostic value of high-resolution CT in the process of lymphocytic interstitial pneumonia clinical diagnosis, and analyzed one case of CT-guided percutaneous lung biopsy lymphocytic interstitial pneumonia. METHODS: The medical record of a patient with lymphocyte interstitial pneumonia (LIP) who came to the clinic on 2014-04-22 were analyzed and summarized retrospectively. RESULTS: The patient is a 55 years old female farmer...
January 21, 2019: Combinatorial Chemistry & High Throughput Screening
Yu-Fen Xu, Yao Xu, Xia Li, Xin-Mei Yang
OBJECTIVE: To determine the levels of α-1 acid glycoprotein (ORM1) in the sera of advanced lung adenocarcinoma (LUAD) patients with epidermal growth factor receptor (EGFR) mutation before treatment and after acquirement of EGFR tyrosine kinase inhibitor (EGFR-TKI) resistance, and to explore the clinical cut off value of ORM1 for targeted therapy resistance in LUAD. METHODS: Enzyme-linked immunosorbent assay was used to determine serum ORM1 levels. Receiver operating characteristic curve was applied to evaluate the serum ORM1 level in the resistance of EGFR-TKI and the cut off value of ORM1 for the diagnosis of EGFR-TKI resistance...
January 19, 2019: Combinatorial Chemistry & High Throughput Screening
Wen-Cong Ruan, Yue-Ping Che, Li Ding, Hai-Feng Li
BACKGROUND: Pre-treated patients with first-line treatment can be offered a second treatment with the aim of improving their poor clinicalprognosis. The therapy of metastatic colorectal cancer (CRC) patients who did not respond to first-line therapy has limited treatment options. Recently, many studies have paid much attention on the efficacy of bevacizumab as adjuvant treatment for metastatic colorectal cancer. OBJECTIVES: We aim to evaluate the efficacy and toxicity of bevacizumab plus chemotherapy compared with bevacizumab-naive based chemotherapy as second-line treatment in people with metastatic CRC...
January 19, 2019: Combinatorial Chemistry & High Throughput Screening
Chen X Chen Yuan, Fang-Mei Min, Yin-Jie Ling, Gang Li, Hong-Zhou Ye, Jia-Hui Pan, Ling Wang, Yan-Ping Xie
Aim To analyze the clinical characteristics and antibiotic resistance of Mycoplasma pneumoniae pneumonia (MP) in Chinese patients, providing valuable information for the management of patients with MP. Methods A total of 120 children who were hospitalized in The First Hospital of Huzhou between January and December 2016 for respiratory tract infection due to M. pneumoniae were enrolled in this study. Infection with M. pneumoniae was confirmed by ELISA for M. pneumoniae antibody, PCR, and throat culture. Antibiotic resistance was measured from the minimum inhibitory concentrations (MICs) of antibiotics...
January 10, 2019: Combinatorial Chemistry & High Throughput Screening
Hong Hu, Jing Wang, Xiao-Yun Zhou, Meng-Ting Tong, Chong-Ya Zhai, Xin-Bing Sui, Yan-Hua Zhang, Xiao-Xi Xie, Hao Liu, Jian-Sheng Xie, Hong-Ming Pan, Da Li
BACKGROUND: Esophageal cancer (EC) is a common digestive system tumor, characterized by high invasion, apparent lethality, and poor prognosis. Direct diffusion is the major metastatic mechanism of early EC, whereas advanced EC is spread mainly by lymphatic metastasis, but also can be transferred to the liver, lungs, bones, and so on, by hematogenous metastasis. The incidence of bone metastasis in esophageal cancer is low, and maxillary metastasis of EC is more rare. OBJECTIVE: To explore the differential diagnosis in ECMM, the rare metastasis of EC, and the possible mechanisms and predictors of bone metastasis...
January 2, 2019: Combinatorial Chemistry & High Throughput Screening
Zhijun Zhang, Qinghong Ke, Weiliang Xia, Xiuming Zhang, Yan Shen, Shusen Zheng
BACKGROUND: Hemolymphangioma is a rare benign tumor. To the best of our knowledge, there were only 10 reports of this tumor of the pancreas until March 2018. CASE REPORT: Here, we reported a large invasive hemolymphangioma of the pancreas in a young woman with a complaint of abdominal distension and an epigastric mass about 3 weeks. She was found to have a huge multilocular cystic tumor at the neck and body of pancreas on computed tomography. She was eventually diagnosed with hemolymphangioma of the pancreas after operation...
January 2, 2019: Combinatorial Chemistry & High Throughput Screening
Jing Lu, Yu-Hang Zhang, ShaoPeng Wang, Yi Bi, Tao Huang, Xiaomin Luo, Yu-Dong Cai
AIM AND OBJECTIVE: Leukemia is the second common blood cancer after lymphoma, and its incidence rate has an increasing trend in recent years. Leukemia can be classified into four types: acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myelogenous leukemia (CML). More than forty drugs are applicable for different types of leukemia based on the discrepant pathogenesis. Therefore, the identification of specific drug-targeted biological processes and pathways is helpful to determinate the underlying pathogenesis among such four types of leukemia...
December 31, 2018: Combinatorial Chemistry & High Throughput Screening
Hua Zhang, Jie Yang, Yan-Ming Deng, Ning Zhao, Jian-Miao Liang, Shuang Yang, Shun-da Zhang, Wei-Neng Feng
AIM: To analyse the clinical outcomes of patients with lung cancer treated with first and multiple-line chemotherapy and tyrosine kinase inhibitor (TKI). PATIENTS & METHODS: A total of 89 patients of whom lung cancer was histologically confirmed between July 2016 and September 2017. Patients' demographics, chemotherapy/TKI treatment details and clinical outcomes were retrieved. The progression-free survivals (PFS) after first-line and multiple-line treatments were evaluated using Kaplan-Meier analysis with log-rank test...
December 31, 2018: Combinatorial Chemistry & High Throughput Screening
ShaoPeng Wang, JiaRui Li, Xijun Sun, Yu-Hang Zhang, Tao Huang, Yudong Cai
BACKGROUND: As a newly uncovered post-translational modification on the ε-amino group of lysine residue, protein malonylation was found to be involved in metabolic pathways and certain diseases. Aside from experimental approaches, several computational methods based on machine learning algorithms were recently proposed to predict malonylation sites. However, previous methods failed to address imbalanced data sizes between positive and negative samples. OBJECTIVE: In this study, we identified the significant features of malonylation sites in a novel computational method which applied machine learning algorithms and balanced data sizes by applying synthetic minority over-sampling technique...
December 27, 2018: Combinatorial Chemistry & High Throughput Screening
Tianyun Wang, Lei Chen, Xian Zhao
AIM AND OBJECTIVE: There are several diseases having a complicated mechanism. For such complicated diseases, a single drug cannot treat them very well because these diseases always involve several targets and single targeted drugs cannot modulate these targets simultaneously. Drug combination is an effective way to treat such diseases. However, determination of effective drug combinations is time- and cost-consuming via traditional methods. It is urgent to build quick and cheap methods in this regard...
December 26, 2018: Combinatorial Chemistry & High Throughput Screening
Cheng Cai, Zhihui Dai, Zhifeng Zhong, Jianping Wang, Jinlin Du
Background Transverse colostomy is commonly performed to create temporary stoma in rectal cancer patients after neoadjuvant chemoradiotherapy. Conventional methods are either difficulty to implement or to care for. To resolve these problems, we herein describe a modified transverse colostomy method. MATERIAL AND METHODS: Two sutures of peritoneum were made as "bridges" to support the stoma. Absorbable sutures were utilized to reinforce the stoma. Once the stoma was created, the stoma bag was immediately placed on the skin...
December 21, 2018: Combinatorial Chemistry & High Throughput Screening
Ying Chen, Yang Ning, Qinghua Zhang, Ying Xie
BACKGROUND: Lymphadenectomy has been widely used in the treatment of malignant germ cell tumor of the ovary (OGCT), which is a kind of ovarian cancers occurred mostly in young women and adolescent girls. But the clinical decision mainly depends on the doctor's experience without a well-defined guideline. This population-based study was to evaluate the prognostic impact of lymphadenectomy in different stages of malignant germ cell tumors of the ovary. METHODS: Patients with known status of lymphadenectomy in different stages of OGCT were explored from the Surveillance, Epidemiology, and End Results (SEER) program database from 1973 to 2013...
December 20, 2018: Combinatorial Chemistry & High Throughput Screening
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