Rebecca Green, Adeeb Ahmed, Ben Fleming, Anna-May Long, Sam Behjati, Jamie Trotman, Patrick Tarpey, James C Nicholson, Nicholas Coleman, C Elizabeth Hook, Matthew J Murray
Wilms tumor (WT) is the commonest cause of renal cancer in children. In Europe, a diagnosis is made for most cases on typical clinical and radiological findings, prior to pre-operative chemotherapy. Here, we describe a case of a young boy presenting with a large abdominal tumor, associated with raised serum alpha-fetoprotein (AFP) levels at diagnosis. Given the atypical features present, a biopsy was taken, and histology was consistent with WT, showing triphasic WT, with epithelial, stromal, and blastemal elements present, and positive WT1 and CD56 immunohistochemical staining...
December 14, 2023: Pediatric and Developmental Pathology