journal
Journals Pediatric and Developmental Pa...

Pediatric and Developmental Pathology

https://read.qxmd.com/read/38616607/renal-pathology-of-ciliopathies
#1
JOURNAL ARTICLE
Thivya Sekar, Neil J Sebire
Renal ciliopathies are a group of genetic disorders that affect the function of the primary cilium in the kidney, as well as other organs. Since primary cilia are important for regulation of cell signaling pathways, ciliary dysfunction results in a range of clinical manifestations, including renal failure, cyst formation, and hypertension. We summarize the current understanding of the pathophysiological and pathological features of renal ciliopathies in childhood, including autosomal dominant and recessive polycystic kidney disease, nephronophthisis, and Bardet-Biedl syndrome, as well as skeletal dysplasia associated renal ciliopathies...
April 14, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38616568/reply-to-addressing-chatbots-as-artificial-intelligence-aids-in-pediatric-pathology
#2
LETTER
Ananda van der Kamp, Tomas J Waterlander, Thomas de Bel, Jeroen van der Laak, Marry M van den Heuvel-Eibrink, Annelies M C Mavinkurve-Groothuis, Ronald R de Krijger
No abstract text is available yet for this article.
April 14, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38616561/syndecan-1-level-a-marker-of-endothelial-glycocalyx-degradation-is-associated-with-fetal-exposure-to-chorioamnionitis-and-is-a-potential-biomarker-for-early-onset-neonatal-sepsis
#3
JOURNAL ARTICLE
Michaela O'Neil, Sasha K Demeulenaere, Phillip J DeChristopher, Emily Holthaus, Walter Jeske, Loretto Glynn, Aliya Husain, Jonathan Muraskas
The goal of this investigation was to identify the association between Syndecan-1 (S1) serum levels in preterm newborns exposed to chorioamnionitis (CA) in utero and the potential of S1 as a biomarker of early-onset neonatal sepsis. A cohort of preterm newborns born <33 weeks gestational age was recruited. Within 48 hours of birth, 0.5 mL of blood was drawn to obtain S1 levels, measured via ELISA. Placentas were examined and classified as having (1) no CA, (2) CA without umbilical cord involvement, or (3) CA with inflammation of the umbilical cord (funisitis)...
April 14, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38576417/stillbirth-associated-with-anomalous-origin-and-course-of-the-left-coronary-artery-a-report-of-2-cases
#4
JOURNAL ARTICLE
Erica Price, Kristen M Thomas, Linda M Ernst
Coronary artery anomalies and their potential sequelae are not well studied in association with stillbirth. Herein, we report the autopsy findings in two term stillborn fetuses with coronary artery anomalies. Both fetuses showed identical findings consisting of an abnormal origin of the left coronary artery from the right sinus of Valsalva and an interarterial course of the left coronary artery. Histologic vascular and myocardial changes were also present. These coronary artery findings are associated with sudden death in adults and neonates, and therefore, their potential to be a cause and/or contributor to fetal death is suspected...
April 5, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38576404/reference-values-for-placental-weight-and-placental-fetal-weight-ratio-in-a-swedish-population
#5
JOURNAL ARTICLE
Frida Waldheim, Meeli Sirotkina, Karin Pettersson, Marius Kublickas, Nikos Papadogiannakis
INTRODUCTION: There is important clinical information from placental weight and its ratio to the fetal weight. The aim with this study was to establish reference values for the placental weight and the placental:fetal weight ratio for gestational weeks 13-43 in a Swedish population. MATERIALS AND METHODS: Cases were retrospectively collected from the database used at the Pathology Department at Karolinska University Hospital and information about the placental weight, fetal weight, and gestational age was retrieved...
April 5, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38576387/diagnostic-challenges-and-emerging-pathogeneses-of-selected-glomerulopathies
#6
JOURNAL ARTICLE
Nicole K Andeen, Jean Hou
Recent progress in glomerular immune complex and complement-mediated diseases have refined diagnostic categories and informed mechanistic understanding of disease development in pediatric patients. Herein, we discuss selected advances in 3 categories. First, membranous nephropathy antigens are increasingly utilized to characterize disease in pediatric patients and include phospholipase A2 receptor (PLA2R), Semaphorin 3B (Sema3B), neural epidermal growth factor-like 1 (NELL1), and protocadherin FAT1, as well as the lupus membranous-associated antigens exostosin 1/2 (EXT1/2), neural cell adhesion molecule 1 (NCAM1), and transforming growth factor beta receptor 3 (TGFBR3)...
April 5, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38549266/rising-prevalence-of-mild-chronic-gastritis-in-children-a-single-center-experience
#7
JOURNAL ARTICLE
Rohit Josyabhatla, Mary Lauren Wood, Amber Gafur, Nina Tatevian, Amanda S Tchakarov, Syed Shahrukh Hashmi, Jon Marc Rhoads, Melissa Renee Van Arsdall
OBJECTIVES AND METHODS: We analyzed upper endoscopic and histological findings in 3 cohorts of children undergoing upper gastrointestinal endoscopy over a 10-year period. Five hundred seventy-nine patients were identified, with 244 (42%), 199 (35%), and 136 (23%) in the 2011, 2015, and 2019 cohorts, respectively. The most common symptoms and signs were abdominal pain, vomiting, failure to thrive, and diarrhea. RESULTS: The number of patients who had histological evidence of chronic gastritis increased from 2011 (n = 70, 29%) to 2015 (n = 106, 53%) and 2019 (n = 92, 68%; P  < ...
March 28, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38549265/expression-of-calretinin-in-the-cecal-muscularis-interna-observation-and-hypothetical-relevance-to-appendicitis
#8
JOURNAL ARTICLE
Raj P Kapur
BACKGROUND: The unexpected observation of calretinin immunoreactivity in smooth muscle cells in the muscularis propria of the cecum led to a more detailed examination of calretinin expression and its possible relationship to propulsive contractile activity around the vermiform appendix. METHODS: Immunohistochemistry and RNA in situ hybridization were performed to analyze calretinin expression in intestinal samples from 33 patients at ages ranging from mid-gestation fetuses to adults, as well as in some potentially relevant animal models...
March 28, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38512910/immunohistochemical-expression-of-lymphatic-endothelial-markers-in-blue-rubber-bleb-nevus-syndrome
#9
JOURNAL ARTICLE
Andrea C Bakker, Steven J Fishman, Marilyn G Liang, Alyaa Al-Ibraheemi, Harry P Kozakewich, John B Mulliken, Jonathan C Slack
INTRODUCTION: Blue rubber bleb nevus syndrome (BRBNS) is an uncommon vascular anomaly characterized by multifocal cutaneous, visceral, and other soft tissue or solid organ venous malformations. We observed that BRBNS lesions express immunohistochemical markers of lymphatic differentiation. METHODS: BRBNS histopathologic specimens assessed at our institution during the past 27 years were reviewed. Slides from 19 BRBNS lesions were selected from 14 patients (9 cutaneous, 9 gastrointestinal, and 1 hepatic)...
March 21, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38468555/childhood-and-adolescent-relapsed-refractory-aggressive-b-cell-lymphomas-with-t-8-14-and-bcl2-expression-burkitt-lymphoma-versus-diffuse-large-b-cell-lymphoma-a-diagnostic-challenge
#10
JOURNAL ARTICLE
Fouad El Dana, Sofia Alexandra Garces Narvaez, Nader K El-Mallawany, Jennifer E Agrusa, ZoAnn E Dreyer, Andrea N Marcogliese, Mohamed Tarek Elghetany, Jyotinder N Punia, Chi Young Ok, Keyur P Patel, Dolores H Lopez-Terrada, Kevin E Fisher, Choladda V Curry
We present 2 diagnostically challenging cases of pediatric/adolescent relapsed/refractory aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) within the spectrum of Burkitt lymphoma and diffuse large B-cell lymphoma and illustrate the different therapeutic regimens that are employed for pediatric and adult cancer centers. Both cases displayed varying-sized lymphoma cells with occasional single prominent nucleoli and heterogeneous BCL2 expression. Cytogenetics revealed complex karyotypes with t(8:14)(q24.2;q32) and IGH::MYC rearrangement by FISH...
March 11, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38468551/pediatric-rectosigmoid-atypical-juvenile-polyps-presenting-with-rectal-prolapse-and-acute-bleeding-a-case-report-and-a-comprehensive-literature-review
#11
JOURNAL ARTICLE
Javier Arredondo Montero, Elena Carracedo Vega, Socorro Razquin Lizarraga, Mónica Bronte Anaut, Sara Hernández-Martín, Gina de Lima Piña, Rosa Guarch Troyas
Rectosigmoid solitary juvenile polyps are benign lesions, relatively frequent in childhood. The clinical debut of a pediatric polyp with bleeding is relatively frequent, but there are very few reports of rectal prolapse of polyps. We present the case of a 7-year-old female patient with no previous history who presented with rectal prolapse of a polyp with acute bleeding. An urgent endoscopic examination was performed and 2 rectosigmoid polypoid lesions were found and resected. The anatomopathological study showed that these were 2 hamartomatous polyps with mild dysplasia...
March 11, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38468494/response-to-letter-to-the-editor-remote-placental-sign-out-what-digital-pathology-can-offer-for-pediatric-pathologists
#12
LETTER
Stefano Marletta, Liron Pantanowitz, Nicola Santonicco, Alessandro Caputo, Emma Bragantini, Matteo Brunelli, Ilaria Girolami, Albino Eccher
No abstract text is available yet for this article.
March 11, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38468487/remote-placental-sign-out-what-digital-pathology-can-offer-for-pediatric-pathologists
#13
LETTER
Casey P Schukow, Jacqueline K Macknis
No abstract text is available yet for this article.
March 11, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38468389/interfollicular-classic-hodgkin-lymphoma-report-of-a-case-and-a-brief-review-of-literature
#14
JOURNAL ARTICLE
Kristina Brannock, Samir B Kahwash
Interfollicular Hodgkin lymphoma (IHL) has been rarely reported in the literature and is recognized by the WHO Classification as a morphologic pattern sometimes seen in mixed cellularity classic Hodgkin lymphoma (CHL). The changes may be subtle due to preservation of architecture. We report a case of a 9-year-old male with IHL showing preserved follicular architecture but with the presence of interfollicular infiltrates consisting of eosinophils, plasma cells, and Hodgkin-Reed-Sternberg (HRS) cells. Immunophenotyping confirmed the morphologic suspicion for IHL...
March 11, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38401151/founders-of-pediatric-pathology-dr-ron-jaffe-1943-2022-an-appreciation
#15
JOURNAL ARTICLE
Laura S Finn, Jennifer Picarsic, A S Knisely
No abstract text is available yet for this article.
February 24, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38401149/a-pediatric-primary-cardiac-spindle-cell-neoplasm-with-a-rare-pdgfra-usp8-gene-fusion-a-case-report
#16
JOURNAL ARTICLE
Ariel Gershon, Anita Nagy, Gino R Somers, Shi-Joon Yoo, Furqan Shaikh, Osami Honjo, Robert Siddaway, Haiying Chen
We report a case of a primary cardiac spindle cell neoplasm with concerning histological features and a rare PDGFRA::USP8 gene fusion in a 3 year old boy. The patient presented with a large cardiac mass predominantly in the right ventricle, originating from the ventricular septum. The mass was resected with grossly negative margins. Pathology revealed an unclassified spindle cell neoplasm with a PDGFRA::USP8 gene fusion. This gene fusion has only been previously reported twice in the medical literature, one in a pediatric cardiac sarcoma and the other in an abdominal soft tissue tumor in an adult woman...
February 24, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38360554/is-mycn-overexpression-associated-with-poor-outcome-in-mycn-non-amplified-neuroblastomas
#17
LETTER
Alicia Andrews, Jefferson Terry
No abstract text is available yet for this article.
February 15, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38360532/author-s-reply-is-mycn-overexpression-associated-with-poor-outcome-in-mycn-non-amplified-neuroblastomas
#18
LETTER
Manli Zhao, Yan Shu, Weizhong Gu, Hongfeng Tang, Jianhua Mao
No abstract text is available yet for this article.
February 15, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38291872/perfusion-pressure-and-the-histology-of-brain-death-a-unique-case-in-an-infant-maintained-on-life-support
#19
JOURNAL ARTICLE
Meagan Chambers, Gail Deutsch
Brain death is a not uncommon phenomena in the adult and pediatric population. Most cases are removed from life support soon after brain death is declared. Less commonly, systemic perfusion is maintained by life support for some time after neurologic function stops. These cases present uncommon opportunities to explore the histology of necrosis and autolysis in the context of global hypoxic ischemic damage. Here, we describe the unusual case of an infant maintained on life support for 2 weeks after brain death was declared with an emphasis on the resulting gross and histologic findings including a discussion of their underlying physiology...
January 30, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38291869/nephrotic-syndrome-in-a-child-with-nphs2-mutation
#20
JOURNAL ARTICLE
Ross Tollaksen, Randall D Craver, Ihor V Yosypiv
Steroid resistant nephrotic syndrome (SRNS) accounts for 30% of all cases of nephrotic syndrome (NS) in children and frequently leads to end stage kidney disease (ESKD). About 30% of children with SRNS demonstrate causative mutations in podocyte- associated genes. Early identification of genetic forms of SRNS is critical to avoid potentially harmful immunosuppressive therapy. A 2-year-old male patient with NS and no family history of renal disease did not respond to 4-week steroid treatment. Kidney biopsy demonstrated mesangial proliferative glomerulopathy with basement membrane dysmorphism...
January 30, 2024: Pediatric and Developmental Pathology
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