Barbara Hollunder, Jill L Ostrem, Ilkem Aysu Sahin, Nanditha Rajamani, Simón Oxenford, Konstantin Butenko, Clemens Neudorfer, Pablo Reinhardt, Patricia Zvarova, Mircea Polosan, Harith Akram, Matteo Vissani, Chencheng Zhang, Bomin Sun, Pavel Navratil, Martin M Reich, Jens Volkmann, Fang-Cheng Yeh, Juan Carlos Baldermann, Till A Dembek, Veerle Visser-Vandewalle, Eduardo Joaquim Lopes Alho, Paulo Roberto Franceschini, Pranav Nanda, Carsten Finke, Andrea A Kühn, Darin D Dougherty, R Mark Richardson, Hagai Bergman, Mahlon R DeLong, Alberto Mazzoni, Luigi M Romito, Himanshu Tyagi, Ludvic Zrinzo, Eileen M Joyce, Stephan Chabardes, Philip A Starr, Ningfei Li, Andreas Horn
Frontal circuits play a critical role in motor, cognitive and affective processing, and their dysfunction may result in a variety of brain disorders. However, exactly which frontal domains mediate which (dys)functions remains largely elusive. We studied 534 deep brain stimulation electrodes implanted to treat four different brain disorders. By analyzing which connections were modulated for optimal therapeutic response across these disorders, we segregated the frontal cortex into circuits that had become dysfunctional in each of them...
February 22, 2024: Nature Neuroscience