Irenaeus C C Chan, Alex Panchot, Evelyn Schmidt, Samantha McNulty, Brian J Wiley, Jie Liu, Kimberly Turner, Lea Moukarzel, Wendy S W Wong, Duc Tran, J Scott Beeler, Armel Landry Batchi-Bouyou, Mitchell J Machiela, Danielle M Karyadi, Benjamin J Krajacich, Junhua Zhao, Semyon Kruglyak, Bryan Lajoie, Shawn Levy, Minal Patel, Philip W Kantoff, Christopher E Mason, Daniel C Link, Todd E Druley, Konrad H Stopsack, Kelly L Bolton
MOTIVATION: The acquisition of somatic mutations in hematopoietic stem and progenitor stem cells (HSPCs) with resultant clonal expansion, termed clonal hematopoiesis (CH), is associated with increased risk of hematologic malignancies and other adverse outcomes. CH is generally present at low allelic fractions, but clonal expansion and acquisition of additional mutations leads to hematologic cancers in a small proportion of individuals. With high depth and high sensitivity sequencing, CH can be detected in most adults and its clonal trajectory mapped over time...
March 14, 2024: Bioinformatics