Takayuki Asayama, Ayaka Takada, Yoshikazu Mikami, Hirofumi Yamaguchi, Muneaki Tamura, Kunihito Matsumoto, Kiwa Miyake, Yoshiyuki Yonehara, Hiromasa Tsuda
PURPOSE: Alveolar osteitis (dry sockets) is a painful condition characterized by a limited immune response. It is typically caused by the removal of blood clots from extracted tooth sockets, which leads to the fermentation of trapped food remnants by oral bacteria in the cavities, producing high concentrations of short-chain fatty acids (SCFAs). This study examined the effects of SCFAs on immunity and bone metabolism. METHODS: Mouse macrophage Raw264.7 cells were treated with oral bacteria supernatants or SCFA mixtures, and inducible nitric oxide synthase (iNOS) levels were determined by western blot...
February 29, 2024: Journal of Oral Science