Haobo Li, Zhu Zhang, Yuting Qiu, Haoyi Weng, Shuai Yuan, Yunxia Zhang, Yu Zhang, Linfeng Xi, Feiya Xu, Xiaofan Ji, Risheng Hao, Peiran Yang, Gang Chen, Xianbo Zuo, Zhenguo Zhai, Chen Wang
Genome-wide association studies (GWAS) have identified numerous risk loci for venous thromboembolism (VTE), but it is challenging to decipher the underlying mechanisms. We employed an integrative analytical pipeline to transform genetic associations to identify novel plasma proteins for VTE. Proteome-wide association studies (PWAS) were determined by functional summary-based imputation leveraging data from a genome-wide association analysis (14,429 VTE patients, 267,037 controls), blood proteomes (1348 cases), followed by Mendelian randomization, Bayesian colocalization, protein-protein interaction, and pathway enrichment analysis...
August 3, 2023: Journal of Human Genetics