journal
Journals Clinical Chemistry and Laborat...

Clinical Chemistry and Laboratory Medicine : CCLM

https://read.qxmd.com/read/38680064/macroprolactin-in-mothers-and-their-babies-what-is-its-origin
#21
JOURNAL ARTICLE
Norito Nishiyama, Naoki Hattori, Kohozo Aisaka, Masayuki Ishihara, Takanori Saito
OBJECTIVES: Macroprolactinemia is one of the major causes of hyperprolactinemia. The aim of this study was to clarify the origin of macroprolactin (macro-PRL). METHODS: We examined macro-PRL in the sera of 826 pregnant women and in those of their babies' umbilical cords at delivery. Macro-PRL was evaluated by precipitation with polyethylene glycol (PEG), gel filtration chromatography (GFC), and absorption with protein G (PG). RESULTS: We detected macro-PRL in 16 out of the 826 pregnant women (1...
April 30, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38669209/diagnostic-performance-of-a-point-of-care-high-sensitivity-cardiac-troponin-i-assay-and-single-measurement-evaluation-to-rule-out-and-rule-in-acute-coronary-syndrome
#22
JOURNAL ARTICLE
Vincenzo De Iuliis, Anna Rita Gabriele, Francesca De Santis, Roberta De Rugeriis, Luigi Di Quinzio, Steeve Aloisi, Anna Carla Rosati, Manuela Benvenuto, Donatello Fabiani, Sofia Chiatamone Ranieri
OBJECTIVES: About 10 million individuals in USA presented annually in the emergency department (ED) with chest pain or with signs and symptoms of acute coronary syndrome (ACS). The advent of point of care (POC) devices, able to measure high sensitivity troponin, are a very interesting tool in the ED setting for its rapid turnaround time (<10 min). METHODS: The present study evaluates the diagnostic performance of the Atellica VTLi (Siemens) in real life setting using the clinical data derived from integrated diagnoses of emergency room staff and cardiologist and in comparison with standard laboratory hs-cTnT assay (Cobas 8000, Elecsys, Roche)...
April 29, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38661453/novel-thiopurine-s-methyltransferase-tpmt-variant-identified-in-malay-individuals
#23
LETTER
Chun Kiat Lee, Pei Tee Huan, Chean Nee Chai, Li Jie Ng, Evelyn Siew-Chuan Koay, Ogestelli Fabia Lee, Malcolm Tan, Tze Ping Loh
No abstract text is available yet for this article.
April 26, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38661089/quality-control-in-the-netherlands-todays-practices-and-starting-points-for-guidance-and-future-research
#24
JOURNAL ARTICLE
Huub H van Rossum, Marith van Schrojenstein Lantman, Michel Severens, Henricus J Vermeer, Wilhelmine P H G Verboeket-van de Venne, Wytze Oosterhuis, Niels de Jonge
OBJECTIVES: Adequate analytical quality of reported results is primarily ensured by performing internal quality control (iQC). Currently, several different iQC practices are in use. As a prelude to the revision of a Dutch guidance document on analytical QC, a questionnaire was sent out to gain insights in the applied practices and the need for guidance. METHODS: A questionnaire, containing 20 multiple-choice questions with possibilities for explanation and comment on iQC practices and aspects was distributed to all clinical chemistry laboratories within the Netherlands...
April 26, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38656304/skin-in-the-game-a-review-of-single-cell-and-spatial-transcriptomics-in-dermatological-research
#25
JOURNAL ARTICLE
Samuel Schepps, Jonathan Xu, Henry Yang, Jenna Mandel, Jaanvi Mehta, Julianna Tolotta, Nicole Baker, Volkan Tekmen, Neda Nikbakht, Paolo Fortina, Ignacia Fuentes, Bonnie LaFleur, Raymond J Cho, Andrew P South
Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are two emerging research technologies that uniquely characterize gene expression microenvironments on a cellular or subcellular level. The skin, a clinically accessible tissue composed of diverse, essential cell populations, serves as an ideal target for these high-resolution investigative approaches. Using these tools, researchers are assembling a compendium of data and discoveries in healthy skin as well as a range of dermatologic pathophysiologies, including atopic dermatitis, psoriasis, and cutaneous malignancies...
April 25, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38646706/computational-pathology-an-evolving-concept
#26
JOURNAL ARTICLE
Ioannis Prassas, Blaise Clarke, Timothy Youssef, Juliana Phlamon, Lampros Dimitrakopoulos, Andrew Rofaeil, George M Yousef
The initial enthusiasm about computational pathology (CP) and artificial intelligence (AI) was that they will replace pathologists entirely on the way to fully automated diagnostics. It is becoming clear that currently this is not the immediate model to pursue. On top of the legal and regulatory complexities surrounding its implementation, the majority of tested machine learning (ML)-based predictive algorithms do not display the exquisite performance needed to render them unequivocal, standalone decision makers for matters with direct implications to human health...
April 23, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38643415/confounding-factors-of-the-expression-of-mtbi-biomarkers-s100b-gfap-and-uch-l1-in-an-aging-population
#27
JOURNAL ARTICLE
Emma Calluy, Charlotte Beaudart, Majed S Alokail, Nasser M Al-Daghri, Olivier Bruyère, Jean-Yves Reginster, Etienne Cavalier, Aurélie Ladang
OBJECTIVES: To evaluate some confounding factors that influence the concentrations of S100 calcium binding protein B (S100B), glial fibrillary acidic protein (GFAP), and ubiquitin carboxyl-terminal hydrolase L-1 (UCH-L1) in older individuals. Indeed, recent guidelines have proposed the combined use of S100B and the "GFAP-UCH-L1" mTBI test to rule out mild traumatic brain injuries (mTBI). As older adults are the most at risk of mTBI, it is particularly important to understand the confounding factors of those mTBI rule-out biomarkers in aging population...
April 22, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38641917/web-accessible-critical-limits-and-critical-values-for-urgent-clinician-notification
#28
JOURNAL ARTICLE
Gerald J Kost, Jenna Dohner, Janet Liu, Dean Ramos, Nabiya Haider, Varsha Thalladi
OBJECTIVES: To survey the World Wide Web for critical limits/critical values, assess changes in quantitative low/high thresholds since 1990-93, streamline urgent notification practices, and promote global accessibility. METHODS: We identified Web-posted lists of critical limits/values at university hospitals. We compared 2023 to 1990-93 archived notification thresholds. RESULTS: We found critical notification lists for 26 university hospitals...
April 22, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38641868/reference-values-for-plasma-and-urine-trace-elements-in-a-swiss-population-based-cohort
#29
JOURNAL ARTICLE
Maïwenn Perrais, Bastien Trächsel, Sébastien Lenglet, Menno Pruijm, Belen Ponte, Bruno Vogt, Marc Augsburger, Valentin Rousson, Murielle Bochud, Aurélien Thomas
OBJECTIVES: Trace elements (TEs) are ubiquitous. TE concentrations vary among individuals and countries, depending on factors such as living area, workplaces and diet. Deficit or excessive TEs concentrations have consequences on the proper functioning of human organism so their biomonitoring is important. The aim of this project was to provide reference values for TEs concentrations in the Swiss population. METHODS: The 1,078 participants to the SKiPOGH cohort included in this study were aged 18-90 years...
April 22, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38639193/the-role-of-killer-immunoglobulin-like-receptors-kirs-in-the-genetic-susceptibility-to-non-celiac-wheat-sensitivity-ncws
#30
JOURNAL ARTICLE
Caterina Maria Gambino, Luisa Agnello, Matteo Vidali, Bruna Lo Sasso, Pasquale Mansueto, Aurelio Seidita, Alessandra Giuliano, Concetta Scazzone, Davide Massa, Anna Masucci, Martina Tamburello, Roberta Vassallo, Anna Maria Ciaccio, Giuseppina Candore, Antonio Carroccio, Marcello Ciaccio
OBJECTIVES: Non-celiac wheat sensitivity (NCWS) is an emerging clinical condition characterized by gastrointestinal and extraintestinal symptoms following the ingestion of gluten-containing foods in patients without celiac disease (CD) or wheat allergy. Despite the great interest for NCWS, the genetic risk factors still need to be fully clarified. In this study, we first assessed the possible contribution of KIR genes and KIR haplotypes on the genetic predisposition to NCWS. METHODS: Fifty patients with NCWS, 50 patients with CD, and 50 healthy controls (HC) were included in this study...
April 22, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38634552/salivary-fatty-acids-in-humans-a-comprehensive-literature-review
#31
REVIEW
Martina Abodi, Alessandra Mazzocchi, Patrizia Risé, Franca Marangoni, Carlo Agostoni, Gregorio Paolo Milani
Fatty acids (FAs) exert diverse biological functions in humans, influencing physiological responses and, ultimately, health and disease risk. The analysis of FAs in human samples has significant implications and attracts interest in diagnostics and research. The standard method for assessing FA profiles involves the collection of blood samples, which can be inconvenient, invasive, and potentially painful, particularly for young individuals outside hospital settings. Saliva emerged as a promising alternative for evaluating FA profiles in both clinical and research settings...
April 19, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38634229/stimulating-thyrotropin-receptor-antibodies-in-early-pregnancy
#32
JOURNAL ARTICLE
Nanna Maria Uldall-Torp, Lærke Andersen, Hannah Jaekyung Kim, Niels Henrik Bruun, Jesper Karmisholt, Stig Andersen, Stine Linding Andersen
OBJECTIVES: Thyrotropin-receptor antibodies (TRAb) are used to diagnose Graves' hyperthyroidism in pregnant women. Bioassays provide a measure of thyrotropin-receptor stimulatory antibodies (TSI) specifically. The objective was to measure TSI in pregnant women for establishment of a pregnancy-specific cut-off and comparison with immunoassay measurements of TRAb. METHODS: The retrospective Danish study was performed within the North Denmark Region Pregnancy Cohort (2011-2015) that includes stored biobank samples from early pregnancy (median week 10) with immunoassay measurements of thyroid function parameters and TRAb...
April 19, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38630027/evaluating-the-hydrashift-2-4-daratumumab-assay-a-powerful-approach-to-assess-treatment-response-in-multiple-myeloma
#33
JOURNAL ARTICLE
Hyun-Woo Lee, Sang-Mi Kim, Hyung-Doo Park
OBJECTIVES: This study evaluates the HYDRASHIFT assay's effectiveness in mitigating daratumumab interference on serum protein tests during multiple myeloma (MM) treatment, aiming to ensure an accurate assessment of treatment response. METHODS: We analyzed 113 serum samples from 68 MM patients undergoing daratumumab treatment, employing both standard IF and the HYDRASHIFT assay. The assay's precision was determined through intra-day and inter-day variability assessments, while its specificity was verified using serum samples devoid of daratumumab...
April 18, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38624006/using-analytical-performance-specifications-in-a-medical-laboratory
#34
JOURNAL ARTICLE
Graham Ross Dallas Jones
Analytical performance specifications (APS) are used for the quantitative assessment of assay analytical performance, with the aim of providing information appropriate for clinical care of patients. One of the major locations where APS are used is in the routine clinical laboratory. These may be used to assess and monitor assays in a range of settings including method selection, method verification or validation, external quality assurance, internal quality control and assessment of measurement uncertainty...
April 16, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38615368/ismd2024-thirteenth-international-symposium-on-molecular-diagnostics
#35
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 16, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38618746/potential-medical-impact-of-unrecognized-in%C3%A2-vitro-hypokalemia-due-to-hemolysis-a-case-series
#36
JOURNAL ARTICLE
Alan H B Wu, W Franklin Peacock
OBJECTIVES: The destruction of red cells during blood collection or with the processing of the sample continues to occur at a high rate, especially among emergency department (ED) patients. This can produce pre-analytical laboratory errors, particularly for potassium. We determined the incidence of hemolyzed samples and discuss the potential medical impact for hypokalemic patients who potassium level is artificially normal (pseudoeukalemia). METHODS: Potassium results were obtained for a 6-month period...
April 15, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38607854/comprehensive-analysis-and-clinical-case-studies-on-pseudoeosinophilia-insights-and-implications%C3%A2-unraveling-the-complexity-analytical-approaches-and-clinical-significance
#37
LETTER
Yonggang Hu, Yong Chen
No abstract text is available yet for this article.
April 15, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38607814/first-reported-co-occurrence-of-philadelphia-chromosome-positive-b-cell-acute-lymphoblastic-leukemia-with-pseudo-chediak-higashi-anomaly-and-complex-karyotype
#38
LETTER
Ziyi An, Xuening Hou, Yiping Yang, Jie Gao, Jihong Hao
No abstract text is available yet for this article.
April 15, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38602283/facing-the-new-ivd-regulation-2017-746-contract-research-organizations-cros-key-partners-of-ivds-manufacturers-for-compliance
#39
LETTER
Sabrina Kali, Chloé Puisney, Marie-Laure Delalande, Guillaume Franc, Christiane Buisson, Sébastien Barradeau
No abstract text is available yet for this article.
April 12, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38593236/add-on-testing-stability-assessment-of-63-biochemical-analytes-in-centrifuged-and-capped-samples-stored-at-16%C3%A2-%C3%A2-c
#40
JOURNAL ARTICLE
Anne J Nielsen, Søren A Ladefoged, Jeppe B Madsen
OBJECTIVES: Integration of add-on testing in high-scale automated clinical laboratories constitute a valuable instrument not only for the clinicians and the general patient care, but also for the laboratory itself. Knowledge on sample quality and analytical stability upon storage is necessary to be able to offer add-on testing. The objectives of this study were to examine the analytical stability of 63 biochemical analytes in plasma and urine samples stored at 16 °C. METHODS: Samples were collected by professional laboratory technicians, analyzed at automated analyzers and stored in their primary, capped tube without separator for 10, 12, 16, 20 or 24 h at 16 °C...
April 10, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
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