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Clinical Chemistry and Laboratory Medicine: CCLM

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https://read.qxmd.com/read/30763263/evaluation-of-procalcitonin-immunoassay-concordance-near-clinical-decision-points
#1
Allison B Chambliss, Joshua Hayden, Jennifer M Colby
Background Procalcitonin (PCT) is a biomarker for systemic bacterial infections and may aid in decision making for antimicrobial stewardship. Numerous PCT assays are available on common clinical immunoassay platforms. However, questions remain about the harmonization of these assays and whether the same clinical decision points may be used with all methods. Methods Thirty-seven remnant patient serum samples were analyzed across four different PCT assays: Abbott ARCHITECT i2000, bioMérieux MINI VIDAS, Roche Elecsys cobas e 411, and BRAHMS KRYPTOR...
February 14, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30763262/measurement-of-s100b-protein-evaluation-of-a-new-prototype-on-a-biom%C3%A3-rieux-vidas%C3%A2-3-analyzer
#2
Charlotte Oris, Russel Chabanne, Julie Durif, Samy Kahouadji, Marina Brailova, Vincent Sapin, Damien Bouvier
Background The addition of S100B protein to guidelines for the management of mild traumatic brain injury (mTBI) decreases the amount of unnecessary computed tomography (CT) scans with a significant decrease in radiation exposure and an increase in cost savings. Both DiaSorin and Roche Diagnostics have developed automated assays for S100B determination. Recently, bioMérieux developed a prototype immunoassay for serum S100B determination. For the first time, we present the evaluation of the S100B measurement using a bioMérieux Vidas® 3 analyzer...
February 14, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30763261/the-effect-of-doac-stop-on-lupus-anticoagulant-testing-in-plasma-samples-of-venous-thromboembolism-patients-receiving-direct-oral-anticoagulants
#3
Michał Ząbczyk, Magdalena Kopytek, Joanna Natorska, Anetta Undas
Background Direct oral anticoagulants (DOACs) cause false positive lupus anticoagulant (LA) results. We assessed the impact of DOAC-Stop, reversing in vitro effects of DOACs, on LA testing in anticoagulated patients. Methods We assessed 75 venous thromboembolism patients aged 44.5±14.6 years. Blood samples were collected 2-28 h since intake of DOACs, including 50 patients on rivaroxaban, 20 on dabigatran and five on apixaban. LA testing was performed at baseline and after DOAC-Stop treatment. Positive LA was defined as the normalized (patient/standard plasma clotting time) LA screening and screening (LA1)/confirmation (LA2) ratios exceeding 1...
February 14, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30763260/rapid-susceptibility-testing-of-multi-drug-resistant-escherichia-coli-and-klebsiella-by-glucose-metabolization-monitoring
#4
Maximilian Kittel, Peter Findeisen, Beniam Ghebremedhin, Thomas Miethke, Alexander Grundt, Parviz Ahmad-Nejad, Michael Neumaier
Background The increasing number of multi-drug resistant (MDR) bacteria provides enormous challenges for choosing an appropriate antibiotic therapy in the early phase of sepsis. While bacterial identification has been greatly accelerated by the introduction of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), the antibiotic susceptibility testing (AST) remains time-consuming. Here, we present a rapid susceptibility testing method for testing Gram-negative bacteria, exemplarily validated for Escherichia coli and Klebsiella spp...
February 14, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30763259/inherited-bisalbuminemia-with-growth-hormone-deficiency
#5
LETTER
Rym Dabboubi, Yessine Amri, Chaima Sahli, Sondess Hadj Fredj, Leila Essaddam, Ala Zoghlami, Saida Ben Becher, Taieb Messaoud
No abstract text is available yet for this article.
February 14, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30763258/accuracy-assessment-of-consecutive-test-strip-lots-for-whole-blood-inr-point-of-care-instruments-clarifying-the-role-of-frozen-plasma-pools
#6
Antonius M H P van den Besselaar, Charmane F Abdoel, Claudia J J van Rijn, Felix J M van der Meer, Christa M Cobbaert
Background In the Netherlands, each new lot of test strips for the CoaguChek XS is validated by a group of collaborating centers. The purpose of this study was to assess the accuracy of the international normalized ratio (INR) measured with consecutive test strip lots and the suitability of frozen plasma pools for accuracy evaluation. Methods Each year, a particular lot of CoaguChek XS test strips is used as reference lot. The reference lots have been validated with the International Standard for thromboplastin rTF/09, yielding a mathematical relationship (R1) between reference lot INR and International Standard INR...
February 14, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30759066/uncovering-the-clinical-impact-of-kallikrein-related-peptidase-5-klk5-mrna-expression-in-the-colorectal-adenoma-carcinoma-sequence
#7
Georgia Papachristopoulou, Apostolos Malachias, Marina Devetzi, Evdoxia Kamouza, Andreas Scorilas, Dimitris Xynopoulos, Maroulio Talieri
Background Kallikrein-related peptidases (KLKs) are a subgroup of serine proteases located on chromosome 19q13.3. Most KLKs have been extensively studied as potential biomarkers for several carcinomas and other diseases. KLK5 was originally identified from a keratinocyte library, and its enzyme was purified from the stratum corneum of human skin. KLK5 was shown to be differentially expressed in a variety of endocrine tumors, although it is not as yet examined widely in colorectal cancer (CRC). Methods In this study, we quantitatively assessed the mRNA expression status of KLK5 in 197 colorectal tissues from 133 patients (70 cancerous and their paired normal colonic mucosa for 64 of them, as well as 63 colorectal adenomas) by quantitative real-time PCR (qPCR) using TaqMan probes...
February 13, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30753156/estimated-urinary-osmolality-based-on-combined-urinalysis-parameters-a-critical-evaluation
#8
Matthijs Oyaert, Marijn M Speeckaert, Joris R Delanghe
Background Urinary conductivity allows a coarse prediction of urinary osmolality in most cases but is insensitive to the osmolal contribution of uncharged particles and the presence of roentgen contrast media. Urinary osmolality can be estimated on the recently introduced Sysmex UF-5000 urine analyzer using conductivity. In this study, we evaluated the analytical performance of this research parameter. Secondly, we aimed to improve the manufacturer's algorithm for estimating urinary osmolality, based on standard urinalysis parameters (creatinine, glucose, relative density)...
February 12, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30753155/narrowed-reference-intervals-for-complete-blood-count-in-a-multiethnic-population
#9
Seungok Lee, Chui Mei Ong, Yu Zhang, Alan H B Wu
Background Biological variation studies have shown that the complete blood count (CBC) has narrow within-individual variation and wide group variation, indicating that the use of reference intervals (RIs) is challenging. The aim of this study was to examine differences in CBC RIs according to race/ethnicity in a multiethnic population at a hospital in San Francisco in hopes of improving the medical utility of CBC testing. Methods Subject data were obtained by screening CBC results from the medical records of outpatients meeting certain criteria who visited Zuckerberg San Francisco General Hospital from April 2017 to January 2018...
February 12, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30753154/urine-chloride-self-measurement-to-monitor-sodium-chloride-intake-in-patients-with-chronic-kidney-disease
#10
Vincenzo Panuccio, Patrizia Pizzini, Giovanna Parlongo, Graziella Caridi, Rocco Tripepi, Angela Mafrica, Sebastiano Cutrupi, D'Arrigo Grazia, Porto Gaetana, Carlo Garofalo, Michele Provenzano, Giovanni Tripepi, Francesca Mallamaci, Mario Plebani, Carmine Zoccali
Background Excessive sodium intake is a risk factor for hypertension, cardiovascular disease and the risk for kidney failure in chronic kidney disease (CKD) patients. Methods We tested the diagnostic performance and the feasibility of an inexpensive method based on urine chloride strips for self-monitoring sodium intake in a series of 72 CKD patients. Results Twenty-four hour urinary chloride as measured by the reactive strips and 24 h urinary sodium were interrelated (r=0.59, p<0.001). Forty-nine out of 72 patients (78%) had a 24 h urinary sodium >100 mmol/24 h, i...
February 12, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30753153/human-chorionic-gonadotropin-suspected-heterophile-interference-investigations-in-immunoassays-a-recommended-approach
#11
Jose C Jara-Aguirre, Nikola A Baumann, Darci R Block, Alicia Algeciras-Schimnich
Background Heterophile antibody (HAb) interferences in immunoassays can cause falsely elevated hCG concentrations leading to incorrect diagnosis and treatments options. When results are not consistent with the clinical findings, hCG HAb interference investigation may be requested by the physician. A retrospective evaluation of the frequency of HAb interference was performed among cases of physician-requested investigations and the effectiveness of commercially available blocking reagents to detect HAb interference in two immunoassay systems was evaluated...
February 12, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30753152/monitoring-the-effectiveness-of-hypothermia-in-perinatal-asphyxia-infants-by-urinary-s100b-levels
#12
Iliana Bersani, Fabrizio Ferrari, Licia Lugli, Giorgio Ivani, Alessandra Conio, Bashir Moataza, Hanna Aboulgar, Hala Mufeed, Iman Iskander, Maria Kornacka, Darek Gruzfeld, Andrea Dotta, Immacolata Savarese, Natalia Chukhlantseva, Lucia Gabriella Tina, Francesco Nigro, Giovanni Livolti, Fabio Galvano, Laura Serpero, Micaela Colivicchi, Patrizia Ianniello, Francesca Pluchinotta, Luigi Anastasia, Ekaterina Baryshnikova, Diego Gazzolo
Background Perinatal asphyxia is a major cause of mortality and morbidity in neonates: The aim of the present study was to investigate, by means of longitudinal assessment of urinary S100B, the effectiveness of hypothermia, in infants complicated by perinatal asphyxia and hypoxic-ischemic encephalopathy. Methods We performed a retrospective case-control study in 108 asphyxiated infants, admitted to nine tertiary departments for neonatal intensive care from January 2004 to July 2017, of whom 54 underwent hypothermia treatment and 54 did not...
February 12, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30739098/implementation-of-an-automated-method-for-direct-quantification-of-urinary-ammonium
#13
LETTER
Leire Cardo, Helena Gil-Peña, María García-García, Juan C Fernández, Fernando Santos, Francisco V Álvarez
No abstract text is available yet for this article.
February 11, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30739097/increased-prevalence-of-anti-dfs70-antibodies-in-young-females-experience-from-a-large-international-multi-center-study-on-blood-donors
#14
Roger Albesa, Ulrich Sachs, Maria Infantino, Mariangela Manfredi, Maurizio Benucci, Yvonne Baus, Silke Lutterbeck, Luis Andrade, Kieran Morris, Alice Friedenberg, Silvia Casas, Xavier Bossuyt, Michael Mahler
Background Isolated antibodies to DFS70 have been described in healthy individuals and are rarely found in patients with antinuclear antibody-associated autoimmune rheumatic diseases (AARD). However, no data is available on geographic differences in the prevalence of anti-DFS70 antibodies. We aimed to study the prevalence of anti-DFS70 antibodies in blood donor samples from several countries representing various ethnical backgrounds and geographic regions in the world. Methods Sera from apparently healthy blood donors (n≥300 per site) were collected in seven countries (USA, Italy, Spain, Germany, UK, Belgium and Brazil)...
February 11, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30739096/instrument-dependent-erroneous-sodium-measurements-in-hypoproteinemic-critically-ill-patients-are-causing-significant-misclassification-of-dysnatremias
#15
LETTER
Nina Tel-Karthaus, G Astrid M Salet, Leo H J Jacobs, Karin C A M Nabbe, Christian H H Schoenmakers, Rick H A van der Doelen, Nienke Geerts, Rein M J Hoedemakers
No abstract text is available yet for this article.
February 11, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30738014/value-based-healthcare-the-role-of-laboratory-medicine
#16
REVIEW
Federico Pennestrì, Giuseppe Banfi
The global increase of health demands pushes administrators and policy makers to provide good quality health care at sustainable costs. Many approaches have been developed, among which value-based health care (VBHC) is one of the most promising: value is given by outcomes achieved per dollar spent. Best value is given by shared benefits between all the stakeholders involved in the process: patients, providers, suppliers, payers and citizens. However, VBHC implementation is a current challenge for hospitals and healthcare providers, that may find it difficult to adapt their organization into a patient-centered clinical pathway based on both classical outcomes and innovative patient-evaluation...
February 9, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30721141/procalcitonin-pct-guided-antibiotic-stewardship-an-international-experts-consensus-on-optimized-clinical-use
#17
Philipp Schuetz, Albertus Beishuizen, Michael Broyles, Ricard Ferrer, Gaetan Gavazzi, Eric Howard Gluck, Juan González Del Castillo, Jens-Ulrik Jensen, Peter Laszlo Kanizsai, Andrea Lay Hoon Kwa, Stefan Krueger, Charles-Edouard Luyt, Michael Oppert, Mario Plebani, Sergey A Shlyapnikov, Giulio Toccafondi, Jennifer Townsend, Tobias Welte, Kordo Saeed
Background Procalcitonin (PCT)-guided antibiotic stewardship (ABS) has been shown to reduce antibiotics (ABxs), with lower side-effects and an improvement in clinical outcomes. The aim of this experts workshop was to derive a PCT algorithm ABS for easier implementation into clinical routine across different clinical settings. Methods Clinical evidence and practical experience with PCT-guided ABS was analyzed and discussed, with a focus on optimal PCT use in the clinical context and increased adherence to PCT protocols...
February 6, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30721142/reference-values-of-a-new-serum-folate-assay-traceable-to-the-who-international-standard
#18
LETTER
Judith C A Cluitmans, Jody M W van den Ouweland
No abstract text is available yet for this article.
February 5, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30721140/serum-protein-electrophoresis-and-complement-deficiencies-a-veteran-but-very-versatile-test-in-clinical-laboratories
#19
LETTER
Clara Franco-Jarava, Romina Dieli-Crimi, Gemma Vila-Pijoan, Roger Colobran, Ricardo Pujol-Borrell, Manuel Hernández-González
No abstract text is available yet for this article.
February 5, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30721139/practical-problems-when-incorporating-rapidly-changing-microbial-taxonomy-into-clinical-practice
#20
LETTER
Alexander J Fenwick, Karen C Carroll
No abstract text is available yet for this article.
February 5, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
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