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Journals Clinical Chemistry and Laborat...

Clinical Chemistry and Laboratory Medicine : CCLM

https://read.qxmd.com/read/38615368/ismd2024-thirteenth-international-symposium-on-molecular-diagnostics
#1
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 16, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38618746/potential-medical-impact-of-unrecognized-in%C3%A2-vitro-hypokalemia-due-to-hemolysis-a-case-series
#2
JOURNAL ARTICLE
Alan H B Wu, W Franklin Peacock
OBJECTIVES: The destruction of red cells during blood collection or with the processing of the sample continues to occur at a high rate, especially among emergency department (ED) patients. This can produce pre-analytical laboratory errors, particularly for potassium. We determined the incidence of hemolyzed samples and discuss the potential medical impact for hypokalemic patients who potassium level is artificially normal (pseudoeukalemia). METHODS: Potassium results were obtained for a 6-month period...
April 15, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38607854/comprehensive-analysis-and-clinical-case-studies-on-pseudoeosinophilia-insights-and-implications%C3%A2-unraveling-the-complexity-analytical-approaches-and-clinical-significance
#3
LETTER
Yonggang Hu, Yong Chen
No abstract text is available yet for this article.
April 15, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38607814/first-reported-co-occurrence-of-philadelphia-chromosome-positive-b-cell-acute-lymphoblastic-leukemia-with-pseudo-chediak-higashi-anomaly-and-complex-karyotype
#4
LETTER
Ziyi An, Xuening Hou, Yiping Yang, Jie Gao, Jihong Hao
No abstract text is available yet for this article.
April 15, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38602283/facing-the-new-ivd-regulation-2017-746-contract-research-organizations-cros-key-partners-of-ivds-manufacturers-for-compliance
#5
LETTER
Sabrina Kali, Chloé Puisney, Marie-Laure Delalande, Guillaume Franc, Christiane Buisson, Sébastien Barradeau
No abstract text is available yet for this article.
April 12, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38593236/add-on-testing-stability-assessment-of-63-biochemical-analytes-in-centrifuged-and-capped-samples-stored-at-16%C3%A2-%C3%A2-c
#6
JOURNAL ARTICLE
Anne J Nielsen, Søren A Ladefoged, Jeppe B Madsen
OBJECTIVES: Integration of add-on testing in high-scale automated clinical laboratories constitute a valuable instrument not only for the clinicians and the general patient care, but also for the laboratory itself. Knowledge on sample quality and analytical stability upon storage is necessary to be able to offer add-on testing. The objectives of this study were to examine the analytical stability of 63 biochemical analytes in plasma and urine samples stored at 16 °C. METHODS: Samples were collected by professional laboratory technicians, analyzed at automated analyzers and stored in their primary, capped tube without separator for 10, 12, 16, 20 or 24 h at 16 °C...
April 10, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38584471/evaluation-of-analytical-performance-of-aquios-cl-flow-cytometer-and-method-comparison-with-bead-based-flow-cytometry-methods
#7
JOURNAL ARTICLE
Andrada S Chiron, Lucy Locher, Aurélie Sarthou, Aude Gleizes, Roman Krzysiek, Pascale Chretien, Salima Hacein-Bey-Abina
OBJECTIVES: Given that method validation is mandatory for compliance with the International Organization for Standardization (ISO) 15,189 standard requirements, we evaluated the analytical performance of the AQUIOS CL system (Beckman Coulter) and compared it with two bead-based flow cytometry (FCM) protocols (BD FACSCAntoTM- II and Beckman Coulter DxFLEX). There are no comparative literature data on standardized protocols for counting lymphocyte subsets on the new-generation cytometer DxFLEX...
April 8, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38582971/-14th-national-congress-of-the-portuguese-society-of-clinical-chemistry-genetics-and-laboratory-medicine
#8
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 8, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38581294/recommendations-for-blood-sampling-in-emergency-departments-from-the-european-society-for-emergency-medicine-eusem-european-society-for-emergency-nursing-eusen-and-european-federation-of-clinical-chemistry-and-laboratory-medicine-eflm-working-group-for-the
#9
JOURNAL ARTICLE
Luis Garcia-Castrillo, Janne Cadamuro, Christoph Dodt, Door Lauwaert, Said Hachimi-Idrissi, Christien Van Der Linden, Jochen Bergs, Sean Costelloe, Florian Grossmann, Ayca Koca, Ari Palomäki, Jose Luis Ruiz, Ricardas Stonys, Thordís Katrín Thorsteinsdottir, Alexander von Meyer, Pieter Vermeersch, Maria Concepción Abellas Alvarez, Pinar Eker, Adela Golea, Lisa Kurland, Giuseppe Lippi, Yulia Zhilenkova, Kawaldip Sehmi
AIM: Blood Sampling Guidelines have been developed to target European emergency medicine-related professionals involved in the blood sampling process (e.g. physicians, nurses, phlebotomists working in the ED), as well as laboratory physicians and other related professionals. The guidelines population focus on adult patients. The development of these blood sampling guidelines for the ED setting is based on the collaboration of three European scientific societies that have a role to play in the preanalytical phase process: EuSEN, EFLM, and EUSEM...
April 8, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38581293/diagnostic-challenge-between-a-frequent-polygenic-hypocholesterolemia-and-an-unusual-smith-lemli-opitz-syndrome-related-to-bi-allelic-dhcr7-mutations
#10
LETTER
Mathilde Bonnot Ruget, Philippe Moulin, Cécile Pagan, David Cheillan, Oriane Marmontel, Gerald Raverot, Pascale Benlian, Mathilde Di Filippo
No abstract text is available yet for this article.
April 8, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38579344/-15th-national-congress-of-the-portuguese-society-of-clinical-chemistry-genetics-and-laboratory-medicine
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 8, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38579121/the-role-of-analytical-performance-specifications-in-international-guidelines-and-standards-dealing-with-metrological-traceability-in-laboratory-medicine
#12
JOURNAL ARTICLE
W Greg Miller
The goal of metrological traceability is to have equivalent results for a measurand in clinical samples (CSs) irrespective of the in-vitro diagnostic medical device (IVD-MD) used for measurements. The International Standards Organization standard 17511 defines requirements for establishing metrological traceability of values assigned to calibrators, trueness control materials and human samples used with IVD-MDs. Each step in metrological traceability has an uncertainty associated with the value assigned to a material...
April 8, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38578968/smartphone-swabs-as-an-emerging-tool-for-toxicology-testing-a-proof-of-concept-study-in-a-nightclub
#13
JOURNAL ARTICLE
Théo Willeman, Justine Grunwald, Marc Manceau, Frédéric Lapierre, Lila Krebs-Drouot, Coralie Boudin, Virginie Scolan, Hélène Eysseric-Guerin, Françoise Stanke-Labesque, Bruno Revol
OBJECTIVES: Smartphones have become everyday objects on which the accumulation of fingerprints is significant. In addition, a large proportion of the population regularly uses a smartphone, especially younger people. The objective of this study was to evaluate smartphones as a new matrix for toxico-epidemiology. METHODS: This study was conducted during two separate events (techno and trance) at an electronic music nightclub in Grenoble, France. Data on reported drug use and whether drugs were snorted directly from the surface of the smartphone were collected using an anonymous questionnaire completed voluntarily by drug users...
April 5, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38577791/exploring-evolutionary-trajectories-in-ovarian-cancer-patients-by-longitudinal-analysis-of-ctdna
#14
JOURNAL ARTICLE
Oliver Kutz, Stephan Drukewitz, Alexander Krüger, Daniela Aust, Doreen William, Sandra Oster, Evelin Schröck, Gustavo Baretton, Theresa Link, Pauline Wimberger, Jan Dominik Kuhlmann
OBJECTIVES: We analysed whether temporal heterogeneity of ctDNA encodes evolutionary patterns in ovarian cancer. METHODS: Targeted sequencing of 275 cancer-associated genes was performed in a primary tumor biopsy and in ctDNA of six longitudinal plasma samples from 15 patients, using the Illumina platform. RESULTS: While there was low overall concordance between the mutational spectrum of the primary tumor biopsies vs. ctDNA, TP53 variants were the most commonly shared somatic alterations...
April 5, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38565134/understanding-the-limitations-of-your-assay-using-eqa-data-with-serum-creatinine-as-an-example
#15
JOURNAL ARTICLE
Rachel Marrington, Finlay MacKenzie
OBJECTIVES: Laboratories need to take into consideration the specificity and imprecision of assays not only in verification, but also of quality assessment. This study investigates the composition of serum used in EQA materials by comparing material from a single and multiple donors (pooled material), across multiple methods, using creatinine as an example. METHODS: Sixteen different serum matrices were distributed as 36 specimens through the UK NEQAS for Acute and Chronic Kidney Disease Scheme from March 2022 to March 2023...
April 4, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38564810/igg-and-kappa-free-light-chain-csf-serum-indices-evaluating-intrathecal-immunoglobulin-production-in-hiv-infection-in-comparison-with-multiple-sclerosis
#16
JOURNAL ARTICLE
Lars Hagberg, Igal Rosenstein, Jan Lycke, Henrik Zetterberg, Aylin Yilmaz, Arvid Edén, Magnus Gisslén
OBJECTIVES: To study intrathecal kappa free light chain (KFLC) synthesis in people living with HIV (PLWH) in comparison with multiple sclerosis (MS). METHODS: Cross-sectional analysis including 56 untreated and 150 well treated PLWH, and compared with 58 controls, and 223 MS patients. RESULTS: Elevated serum/cerebrospinal fluid (CSF) IgG and KFLC indices were observed in untreated PLWH. Seventy percent of untreated PLWH had KFLC index above 6...
April 4, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38564801/reference-intervals-of-circulating-secretoneurin-concentrations-determined-in-a-large-cohort-of-community-dwellers-the-hunt-study
#17
JOURNAL ARTICLE
Kristin M Aakre, Magnus N Lyngbakken, Arne L Faaren, Helge Røsjø, Håvard Dalen, Torbjørn Omland
OBJECTIVES: Secretoneurin (SN) is a novel cardiac biomarker that associates with the risk of mortality and dysfunctional cardiomyocyte Ca2+ handling in heart failure patients. Reference intervals for SN are unknown. METHODS: SN was measured with a CE-marked ELISA in healthy community dwellers from the fourth wave of the Trøndelag Health Study (HUNT4) conducted in 2017-2019. The common, sex and age specific 90th, 95th, 97.5th and 99th percentiles were calculated using the non-parametric method and outlier exclusion according to the Reed test...
April 4, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38563053/evaluation-of-effects-from-hemoglobin-variants-on-hba-1c-measurements-by-different-methods
#18
JOURNAL ARTICLE
Yichuan Song, Anping Xu, Mo Wang, Jie Shi, Wenxuan Fu, Ling Ji, Rui Zhang
OBJECTIVES: The impact of seven hemoglobin variants (Hb Q-Thailand, Hb G-Honolulu, Hb Ube-2, Hb New York, Hb J-Bangkok, Hb G-Coushatta, and Hb E) on the outcome of HbA1c was investigated for six methods by comparing with liquid chromatography-tandem mass spectrometry (LC/MS/MS) reference method. METHODS: Twenty-nine normal and 112 variant samples were measured by LC/MS/MS, Sebia Capillarys 3 TERA, Intelligene Biosystems QuanTOF, Premier Hb9210, Arkray HA-8190V, Bio-Rad D-100, and Tosoh G11, then evaluated for correlation, consistency, and mean relative bias among six methods...
April 3, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38562079/assessing-post-analytical-phase-harmonization-in-european-laboratories-a-survey-promoted-by-the-eflm-working-group-on-harmonization
#19
JOURNAL ARTICLE
Martina Zaninotto, Luisa Agnello, Lora Dukic, Leila Akhvlediani
OBJECTIVES: Harmonization of the laboratory total testing process (TTP) is critical to improving patient outcome. In 2016, an EFLM survey on the harmonization of TTP underlined the serious shortcomings pertaining to the post-analytical phase. In 2023, the WG-H conducted a new survey aiming to update information in the 2016 harmonization report in order to ascertain whether countries that had declared they were keen to adopt SI units had continued with this program, the aim being to verify the state-of art in harmonization units in areas of laboratory medicine not included in the previous survey...
April 3, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38557642/familial-dysalbuminemic-hyperthyroxinemia-coexisting-with-a-grave-s-disease-a-belgian-case-report
#20
LETTER
Fleur Wolff, Françoise Fery, Julie Désir, Romy Gadisseur, Etienne Cavalier, Frédéric Cotton
No abstract text is available yet for this article.
April 2, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
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