David Wilson, Dandan Chan, Lei Chang, Robert Mathis, Inge Verberk, Xavier Montalban, Manuel Comabella, Nicolas Fissolo, Bibi Bielekova, Ruturaj Masvekar, Tanuja Chitnis, Tjalf Ziemssen, Katja Akgün, Kaj Blennow, Henrik Zetterberg, Wolfgang Brück, Gavin Giovannoni, Sharmilee Gnanapavan, Stefan Bittner, Frauke Zipp, Giancarlo Comi, Roberto Furlan, Sylvain Lehmann, Simon Thebault, Mark Freedman, Amit Bar-Or, Marty Kramer, Markus Otto, Steffen Halbgebauer, Kevin Hrusovsky, Tatiana Plavina, Michael Khalil, Fredrik Piehl, Heinz Wiendl, Ludwig Kappos, Aleksandra Maceski, Eline Willemse, David Leppert, Charlotte Teunissen, Jens Kuhle
OBJECTIVES: Neurofilament light chain (NfL) has emerged as a promising biomarker for detecting and monitoring axonal injury. Until recently, NfL could only be reliably measured in cerebrospinal fluid, but digital single molecule array (Simoa) technology has enabled its precise measurement in blood samples where it is typically 50-100 times less abundant. We report development and multi-center validation of a novel fully automated digital immunoassay for NfL in serum for informing axonal injury status...
September 13, 2023: Clinical Chemistry and Laboratory Medicine: CCLM