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Journals Clinical Chemistry and Laborat...

Clinical Chemistry and Laboratory Medicine : CCLM

https://read.qxmd.com/read/37736000/rapid-rule-in-and-rule-out-protocols-of-acute-myocardial-infarction-using-hs-ctni-and-hs-ctnt-methods
#1
EDITORIAL
Aldo Clerico, Martina Zaninotto, Mario Plebani
No abstract text is available yet for this article.
September 25, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37732424/performance-evaluation-of-alternate-esr-measurement-method-using-bc-780-automated-hematology-analyzer-a-comparison-study-with-the-westergren-reference-method
#2
JOURNAL ARTICLE
Eakachai Prompetchara, Chalisa Parnsamut, Nathawit Wangviwat, Patrawadee Pitakpolrat, Kwanlada Chaiwong, Orakarn Limpornpukdee, Surapat Tanticharoenkarn, Chutitorn Ketloy
OBJECTIVES: Implementation of alternate erythrocyte sedimentation rate (ESR) measurement method is increasing worldwide due to its various advantages. In this study, we aim to evaluate the analytical performance of the BC-780 automated hematology analyzer in measurement of ESR value. METHODS: Analyzer performance including precision study, carryover, sample stability and potential interferences are examined. Samples with ESR values spanning the whole analytical ESR range are included for method comparison study...
September 22, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37731388/combined-deficient-response-to-polysaccharide-based-and-protein-based-vaccines-predicts-a-severe-clinical-phenotype
#3
JOURNAL ARTICLE
Maaike Cockx, Filomeen Haerynck, Levi Hoste, Rik Schrijvers, Jutte Van der Werff Ten Bosch, Doreen Dillaerts, Debby Thomas, Heidi Schaballie, Giorgia Bucciol, Wiert Robberechts, Dina Patel, Guy Berbers, Isabelle Desombere, Nick Geukens, Isabelle Meyts, Xavier Bossuyt
OBJECTIVES: Antibody response on polysaccharide- and protein-based vaccines is useful to test B cell functionality. As only few studies have explored the value of studying immune response to both vaccines, we evaluated the clinical value of anti-polysaccharide and anti-protein Luminex-based multiplex assays in context of primary immunodeficiency (PID) diagnosis. METHODS: A 10-plex Luminex-based assay detecting antibodies to ten pneumococcal polysaccharide (PnPS) serotypes [present in unconjugated Pneumovax, not in 13-valent pneumococcal conjugated vaccine (PCV)] and a 5-plex assay detecting antibodies to five protein antigens (present in DTap/Tdap) were clinically validated in healthy individuals (n=99) and in retrospective (n=399) and prospective (n=108) patient cohorts...
September 21, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37728871/concerning-quality-demands-of-arterial-partial-pressure-of-oxygen
#4
LETTER
Eva Rabing Brix Petersen, Morten Pedersen, Helle Tanderup Kristensen, Lise Pedersen, Marianne Benn, Ole Winther Rasmussen, Ivan Brandslund
No abstract text is available yet for this article.
September 21, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37727133/abo-blood-group-related-mechanism-of-infection-of-sars-cov-2-an-overview-of-systematic-reviews
#5
JOURNAL ARTICLE
Massimo Franchini, Fabrizio Maggi, Daniele Focosi
Among the host genetic factors playing a role in the susceptibility to infectious diseases, the ABO blood group system is of utmost importance. Following the first reports in early 2020, the association between ABO blood groups and SARS-CoV-2 infection or COVID-19 severity has been thoroughly investigated. The aim of this narrative review is to provide an overview of systematic reviews regarding the link between ABO blood groups and such risks. The possible molecular mechanisms underlying these associations will also be discussed...
September 21, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37725416/platelet-distribution-width-pdw-as-a-significant-correlate-of-covid-19-infection-severity-and-mortality
#6
REVIEW
Daniela Ligi, Chiara Della Franca, Kin Israel Notarte, Nathaniel Goldrich, David Kavteladze, Brandon Michael Henry, Ferdinando Mannello
SARS-CoV-2 infection may cause a wide spectrum of symptoms, from asymptomatic, to mild respiratory symptoms and life-threatening sepsis. Among the clinical laboratory biomarkers analyzed during COVID-19 pandemic, platelet indices have raised great interest, due to the critical involvement of platelets in COVID-19-related thromboinflammation. Through an electronic literature search on MEDLINE, CINAHL, PubMed, EMBASE, Web of Science, and preprint servers we performed and updated a systematic review aimed at providing a detailed analysis of studies addressing the potential clinical utility of platelet distribution width, platelet distribution width (PDW), in laboratory medicine, exploring the possible association between increased PDW levels, disease severity, and mortality in COVID-19...
September 20, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37725415/a-sex-specific-association-of-leukocyte-telomere-length-with-thigh-muscle-mass
#7
JOURNAL ARTICLE
Eva Maria Hassler, Gunter Almer, Gernot Reishofer, Hannes Deutschmann, Harald Mangge, Markus Herrmann, Stefan L Leber, Felix Gunzer F, Tanja Langsenlehner, Wilfried Renner
OBJECTIVES: Telomeres are DNA-protein complexes at the ends of linear chromosomes that protect against DNA degradation. Telomeres shorten during normal cell divisions and therefore, telomere length is an indicator of mitotic-cell age. In humans, telomere shortening is a potential biomarker for disease risk, progression and premature death. Physical activity has been associated with longer leukocyte telomere length (LTL) in some studies. In the current study the relationship between LTL, thigh muscle mass and adipose tissue distribution was explored...
September 20, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37725405/the-added-value-of-automated-hpc-count-detecting-clinically-important-interferences-on-the-flow-cytometric-cd34-cell-count
#8
LETTER
Alice Brochier, Mattias Hofmans, Stijn Lambrecht, Pauline Breughe, Barbara Denys, Sander De Bruyne, Malicorne Buysse, Anna Vantilborgh, Carolien Bonroy
No abstract text is available yet for this article.
September 20, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37724812/quality-assurance-programs-for-vitamin-a-and-e-in-serum-are-we-doing-enough-to-assess-laboratory-performance
#9
JOURNAL ARTICLE
Michael Fitzpatrick, Trisha Andersen, Jonathan Bush, Ronda F Greaves, Gerald Woollard, Kirsten Hoad, Jake T B Collie, Sarah Browning, Tamantha Harrower, Peter Graham, Wilson Punyalack
OBJECTIVES: Monitoring serum vitamin A (retinol) and vitamin E (α-tocopherol) concentrations is common practice for assessing nutritional status. Measurement of these vitamins can be challenging due to several factors. Whilst the RCPAQAP Vitamins: Serum Program assists participating laboratories in harmonisation, the materials provided do not contain the analogues of retinol and α-tocopherol that may be present in real patient samples. We aimed to assess participants' capacity to accurately report retinol and α-tocopherol in the presence of the vitamin E analogues tocopherol acetate and γ-tocopherol...
September 19, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37702323/development-and-multi-center-validation-of-a-fully-automated-digital-immunoassay-for-neurofilament-light-chain-toward-a-clinical-blood-test-for-neuronal-injury
#10
JOURNAL ARTICLE
David Wilson, Dandan Chan, Lei Chang, Robert Mathis, Inge Verberk, Xavier Montalban, Manuel Comabella, Nicolas Fissolo, Bibi Bielekova, Ruturaj Masvekar, Tanuja Chitnis, Tjalf Ziemssen, Katja Akgün, Kaj Blennow, Henrik Zetterberg, Wolfgang Brück, Gavin Giovannoni, Sharmilee Gnanapavan, Stefan Bittner, Frauke Zipp, Giancarlo Comi, Roberto Furlan, Sylvain Lehmann, Simon Thebault, Mark Freedman, Amit Bar-Or, Marty Kramer, Markus Otto, Steffen Halbgebauer, Kevin Hrusovsky, Tatiana Plavina, Michael Khalil, Fredrik Piehl, Heinz Wiendl, Ludwig Kappos, Aleksandra Maceski, Eline Willemse, David Leppert, Charlotte Teunissen, Jens Kuhle
OBJECTIVES: Neurofilament light chain (NfL) has emerged as a promising biomarker for detecting and monitoring axonal injury. Until recently, NfL could only be reliably measured in cerebrospinal fluid, but digital single molecule array (Simoa) technology has enabled its precise measurement in blood samples where it is typically 50-100 times less abundant. We report development and multi-center validation of a novel fully automated digital immunoassay for NfL in serum for informing axonal injury status...
September 13, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37698363/documenting-and-validating-metrological-traceability-of-serum-alanine-aminotransferase-measurements-a-priority-for-medical-laboratory-community-for-providing-high-quality-service-in-hepatology
#11
JOURNAL ARTICLE
Mauro Panteghini
Alanine aminotransferase (ALT) represents the first-level test to detect individuals with hepatocellular damage of any etiology. However, it has been highlighted that the lack of assay harmonization may lead to overdiagnosis and unnecessary further testing if guideline-recommended fixed cut-offs are uncritically employed. To solve the issue of ALT (dis)harmonization and improve the interpretation of its values, a series of urgent actions for documenting and validating metrological traceability of serum ALT measurements, as described in this paper, are no longer postponeable...
September 13, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37682288/assessment-of-the-lipemia-index-determined-by-the-atellica-ch-930-analyzer-for-the-detection-of-monoclonal-immunoglobulins
#12
LETTER
Luc Thouault, Cyril Leven, Jean-Richard Eveillard, Hélène Kerspern, Emmanuelle Plée-Gautier, Jean-Christophe Ianotto, Jean-Luc Carre, Clément Capaldo
No abstract text is available yet for this article.
September 11, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37682246/biological-management-of-diabetes-mellitus-the%C3%A2-laboratory-medicine-specialist-and-the-patient
#13
EDITORIAL
Philippe Gillery
No abstract text is available yet for this article.
September 11, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37678263/assessment-of-three-equations-to-calculate-plasma-ldl-cholesterol-concentration-in-fasting-and-non-fasting-hypertriglyceridemic-patients
#14
JOURNAL ARTICLE
Joséphine Vasse, Audrey Lassartesse, Oriane Marmontel, Sybil Charrière, Caroline Bouveyron, Nathanaël Marrié, Philippe Moulin, Mathilde Di Filippo
OBJECTIVES: Low-density lipoprotein cholesterol (LDL-C) concentration was calculated for many years using the Friedewald equation, but those from Sampson and extended-Martin-Hopkins perform differently. Their accuracy in fasting hypertriglyceridemia and non-fasting state were compared and the clinical impact of implementing these equations on risk classification and on the setting of lipid treatment goals was assessed. METHODS: Seven thousand six standard lipid profiles and LDL-C concentrations measured after ultracentrifugation (uLDL-C) were retrospectively included...
September 8, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37678194/ultra-short-cell-free-dna-fragments-enhance-cancer-early-detection-in-a-multi-analyte-blood-test-combining-mutation-protein-and-fragmentomics
#15
JOURNAL ARTICLE
Fenfen Wang, Xinxing Li, Mengxing Li, Wendi Liu, Lingjia Lu, Yang Li, Xiaojing Chen, Siqi Yang, Tao Liu, Wen Cheng, Li Weng, Hongyan Wang, Dongsheng Lu, Qianqian Yao, Yingyu Wang, Johnny Wu, Tobias Wittkop, Malek Faham, Huabang Zhou, Heping Hu, Hai Jin, Zhiqian Hu, Ding Ma, Xiaodong Cheng
OBJECTIVES: Cancer morbidity and mortality can be reduced if the cancer is detected early. Cell-free DNA (cfDNA) fragmentomics emerged as a novel epigenetic biomarker for early cancer detection, however, it is still at its infancy and requires technical improvement. We sought to apply a single-strand DNA sequencing technology, for measuring genetic and fragmentomic features of cfDNA and evaluate the performance in detecting multiple cancers. METHODS: Blood samples of 364 patients from six cancer types (colorectal, esophageal, gastric, liver, lung, and ovarian cancers) and 675 healthy individuals were included in this study...
September 8, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37673465/improving-regional-medical-laboratory-center-report-quality-through-a-report-recall-management-system
#16
JOURNAL ARTICLE
Chuang Zhang, Xiang Ji, Jiehong Wei, Xiaowen Dou, Dayang Chen, Xiuming Zhang
OBJECTIVES: Currently, most medical laboratories do not have a dedicated software for managing report recalls, and relying on traditional manual methods or laboratory information system (LIS) to record recall data is no longer sufficient to meet the quality management requirements in the large regional laboratory center. The purpose of this article was to describe the research process and preliminary evaluation results of integrating the Medical Laboratory Electronic Record System (electronic record system) laboratory report recall function into the iLab intelligent management system for quality indicators (iLab system), and to introduce the workflow and methods of laboratory report recall management in our laboratory...
September 7, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37673419/bland-and-altman-agreement-method-to-plot-differences-against-means-or-differences-against-standard-an-endless-tale
#17
JOURNAL ARTICLE
Bruno Mario Cesana, Paolo Antonelli
OBJECTIVES: In the Bland and Altman analysis of agreement studies, there is some controversy whether "to plot the differences between the Standard/actual measurement method and the test/new measurement method against their mean" or "to plot the differences against the standard method". Of course, this is not just a "graphic dispute" as a regression model is inherent in the graphical choice to test the proportional and systematic biases. METHODS: We revised two relevant papers claiming to plot the differences against the standard and outlined their pitfalls taking into account the underlying statistical methodology...
September 6, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37665315/diagnostic-and-prognostic-value-of-quantitative-detection-of-antimitochondrial-antibodies-subtype-m2-using-chemiluminescence-immunoassay-in-primary-biliary-cholangitis
#18
LETTER
Miaochan Wang, Yujiao Jin, Aifang Xu
No abstract text is available yet for this article.
September 5, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37665170/adherence-to-recommendations-and-clinical-practice-guidelines-not-an-easy-task
#19
EDITORIAL
Mario Plebani
No abstract text is available yet for this article.
September 5, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37656487/csf-and-plasma-a%C3%AE-42-40-across-alzheimer-s-disease-continuum-comparison-of-two-ultrasensitive-simoa-%C3%A2-assays-targeting-distinct-amyloid-regions
#20
JOURNAL ARTICLE
Anna Lidia Wojdała, Giovanni Bellomo, Andrea Toja, Lorenzo Gaetani, Lucilla Parnetti, Davide Chiasserini
OBJECTIVES: Decreased cerebrospinal fluid (CSF) amyloid beta 42/40 ratio (Aβ42/40) is one of the core Alzheimer's disease (AD) biomarkers. Measurement of Aβ42/40 in plasma has also been proposed as a surrogate marker for amyloidosis, however the validity and the diagnostic performance of this biomarker is still uncertain. Here we evaluated two immunoassays targeting distinct regions of the amyloid peptides by (a) performing a method comparison in both CSF and plasma, and (b) assessing the diagnostic performance across the AD continuum...
September 4, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
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