Chloé Alberto, Nathalie Lambeng, Christine Deffert, Gautier Breville, Angèle Gayet-Ageron, Patrice Lalive, Alexandra Calmy, Alix Coste, Matthaios Papadimitriou-Olivgeris, Dominique Braun, Reto Lienhard, Philipp Peter Bosshard, Lionel Fontao, Laurence Toutous Trellu
BACKGROUND AND OBJECTIVES: The diagnosis of neurosyphilis (NS) lacks a true 'gold standard', making the diagnosis challenging while consequences of a misdiagnosis are potentially severe. The aim of this study was to evaluate the diagnostic performance of measuring an antibody index (AI) for the intrathecal synthesis of specific anti- Treponema pallidum ( T. pallidum ) IgG for the diagnosis of NS. METHODS: Specific anti- T. pallidum IgG were measured simultaneously in paired cerebrospinal fluid (CSF)-serum samples collected retrospectively and prospectively between 2007 and 2022, from patients suspected of NS, in Switzerland...
December 7, 2023: Sexually Transmitted Infections